Category: 2235-01-0

Thomas, Bejoy;Prathapan, Sreedharan;Sugunan, Sankaran published 《Synthesis of dimethyl acetal of ketones: design of solid acid catalysts for one-pot acetalization reaction》. The research results were published in《Microporous and Mesoporous Materials》 in 2005.Quality Control of Dimethoxydiphenylmethane The article conveys some information:

The synthesis of di-Me acetals of carbonyl compounds such as cyclohexanone, acetophenone, and benzophenone has successfully been carried out by the reaction between ketones and methanol using different solid acid catalysts. The strong influence of the textural properties of the catalysts such as acid amount and adsorption properties (surface area and pore volume) determine the catalytic activity. The mol. size of the reactants and products determine the acetalization ability of a particular ketone. The hydrophobicity of the various rare earth exchanged Mg-Y zeolites, K-10 montmorillonite clay, and cerium exchanged montmorillonite (which shows maximum activity) is more determinant than the number of active sites present on the catalyst. The optimum number of acidic sites as well as dehydrating ability of Ce³⁺-montmorillonite and K-10 montmorillonite clays and various rare earth exchanged Mg-Y zeolites seem to work well in shifting the equilibrium to the product side. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Quality Control of Dimethoxydiphenylmethane The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Category: ethers-buliding-blocksIn 2010, Jung, Misuk;Yoon, Jieun;Kim, Hak Sung;Ryu, Jae-Sang published 《Mild and chemoselective synthesis and deprotection of geminal diacetates catalyzed by titanium(IV) halides》. 《Synthesis》published the findings. The article contains the following contents:

A novel, mild, and chemoselective method was developed for the preparation of gem-diacetates from aldehydes and Ac₂O in the presence of TiF₄ (1-5 mol%) under solvent-free conditions at room temperature The reaction showed a high chemoselectivity toward aldehydes in the presence of ketones. Moreover, TiF₄ also catalyzed the deprotection of gem-diacetates to the corresponding aldehydes in water. .This efficient and simple method has several benefits, including the use of an inexpensive catalyst, solvent-free conditions, mild reaction temperatures, and high yields, which make it both cost-effective and environmentally friendly. And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Category: ethers-buliding-blocks The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Etayo, Pablo;Badorrey, Ramon;Diaz-de-Villegas, Maria D.;Galvez, Jose A. published 《Chiral Amino Diol Derivatives as New Modular Organocatalysts for the Enantioselective α-Chlorination of Cyclic β-Keto Esters》. The research results were published in《Advanced Synthesis & Catalysis》 in 2010.Reference of Dimethoxydiphenylmethane The article conveys some information:

Highly modular chiral amino diol derivatives, e.g. I, have been used as organocatalysts in the enantioselective α-chlorination of cyclic β-keto esters. Optimization of the catalyst structure and the reaction conditions has allowed the synthesis of optically active α-chlorinated products with high enantioselectivities (up to 96% ee) using inexpensive com. available N-chlorosuccinimide (NCS) as the chlorine source under mild conditions.Dimethoxydiphenylmethane (cas: 2235-01-0) were involved in the experimental procedure.

For example, the most common synthesis of ethers involves the attack of an alkoxide ion on an alkyl halide. This method is called Williamson ether synthesis.Reference of Dimethoxydiphenylmethane

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ye, Baihua;Cramer, Nicolai published 《Chiral Cyclopentadienyl Ligands as Stereocontrolling Element in Asymmetric C-H Functionalization》. The research results were published in《Science (Washington, DC, United States)》 in 2012.Product Details of 2235-01-0 The article conveys some information:

Metal complexes coordinated by a single cyclopentadienyl (Cp) ligand are widely used, versatile catalysts, but their application to asym. reactions has been hindered by the difficulty of designing Cp substituents that effectively bias the coordination sphere. Here, we report on a class of simple C₂-sym. Cp derivatives that finely control the spatial arrangement of the transiently coordinated reactants around the central metal atom. Rhodium(III) complexes bearing these ligands proved to be highly enantioselective catalysts for directed carbon-hydrogen (C-H) bond functionalizations of hydroxamic acid derivatives To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Product Details of 2235-01-0

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Aepkers, Marion;Wuensch, Bernhard published 《Synthesis and NMDA-receptor affinity of ring and side chain homologous dexoxadrol derivatives》. The research results were published in《Archiv der Pharmazie (Weinheim, Germany)》 in 2004.Computed Properties of C15H16O2 The article conveys some information:

The regioselectivity during transacetalization of benzophenone di-Me acetal with butane-1,2,4-triol is controlled by the reaction conditions. Thermodn. control leads predominantly to the 1,3-dioxolanes whereas kinetic control favors the six-membered acetals. The amines were investigated in receptor binding studies with radioligands for their affinity to the phencyclidine binding site of the NMDA-receptor. In both series the primary amines show the highest NMDA-receptor affinity (K_i = 3.38-1.45 μM). Surprisingly, the piperidine derivative (I) binds with high affinity at σ₁-receptors and, therefore, represents a novel lead compound for high affinity σ₁-receptor ligands. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Computed Properties of C15H16O2 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem