Category: 321-28-8

Nagaki, Aiichiro; Uesugi, Yuki; Kim, Heejin; Yoshida, Jun-ichi published an article in 2013, the title of the article was Synthesis of Functionalized Aryl Fluorides Using Organolithium Reagents in Flow Microreactors.COA of Formula: C7H7FO And the article contains the following content:

We have developed a method for preparing aryl fluorides based on organolithium chem. in flow microreactors. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).COA of Formula: C7H7FO

The Article related to aryl fluoride preparation organolithium chem flow microreactor, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.COA of Formula: C7H7FO

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 22, 2022, Zhou, Jun; Jiang, Bingyao; Zhao, Zhengyu; Shibata, Norio published an article.COA of Formula: C7H7FO The title of the article was Etherification of Fluoroarenes with Alkoxyboronic Acid Pinacol Esters via C-F Bond Cleavage. And the article contained the following:

Potassium-base-mediated defluoroetherification of aryl and heteroaryl fluorides with alkoxyboronic acid pinacol esters under transition-metal-free conditions is reported. This protocol efficiently and safely provides a wide variety of aryl ethers in high yields without using metal catalysts, specific ligands, and harsh conditions to selectively forge Csp2-O bonds via the Csp2-F cleavage. This method can be applied to the late-stage etherification of structurally complex Csp2-fluorides and bioactive alcs., such as å°?estradiol, calciferol, and tocopherol. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).COA of Formula: C7H7FO

The Article related to alkyl aryl ether preparation, fluoroarene alkoxyboronic acid pinacol ester etherification bond cleavage, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Esters, Acyl Peroxides, Acyl Halides and other aspects.COA of Formula: C7H7FO

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 5, 2021, Hong Nguyen, Thi Anh; Hou, Duen-Ren published an article.Recommanded Product: 1-Fluoro-2-methoxybenzene The title of the article was Metal-free, Direct Acetoxylation of Arenes. And the article contained the following:

A metal-free, direct acetoxylation reaction using sodium nitrate under an anhydrous environment of trifluoroacetic acid, acetic acid and acetic anhydride was reported. Arenes (31 examples), with oxidation potentials (Eox, in V vs SCE) lower than benzene (2.48 V), were acetoxylated with good yields and regioselectivity. A stepwise, single electron-transfer mechanism was proposed. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Recommanded Product: 1-Fluoro-2-methoxybenzene

The Article related to arene acetic acid regioselective acetoxylation, aryl acetate preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Esters, Acyl Peroxides, Acyl Halides and other aspects.Recommanded Product: 1-Fluoro-2-methoxybenzene

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On December 31, 2019, Ozcelik, Azime Berna; Ozdemir, Zeynep; Sari, Suat; Utku, Semra; Uysal, Mehtap published an article.Synthetic Route of 321-28-8 The title of the article was A new series of pyridazinone derivatives as cholinesterases inhibitors: Synthesis, in vitro activity and molecular modeling studies. And the article contained the following:

AChE and BChE are known to be serine hydrolase enzymes responsible for the hydrolysis of ACh. Here, we prepared 12 new 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(nonsubstituted/4-substituted benzenesulfonohydrazide) derivatives and evaluated their inhibitory effects on AChE/BChE in pursuit of potent dual inhibitors for Alzheirmer’s Disease. We also tried to get insights into binding interactions of the synthesized compounds in the active site of both enzymes by using mol. docking approach. We obtained our compounds by the reaction of various substituted/nonsubstituted benzenesulfonic acid derivatives with 6-substitutedphenyl-3(2H)-pyridazinone-2-yl acetohydrazide and determined their anticholinesterase activities according to the Ellman’s method. Mol. docking studies were done using Glide and the results were evaluated on Maestro. The title compounds showed moderate inhibition at 100渭g/mL against both enzymes, yet with better activity against BChE. Compound VI2a emerged as a dual inhibitor with 25.02% and 51.70% inhibition against AChE and BChE, resp. This study supports that novel pyridazinone derivates may be used for the development of new BChE inhibitory agents. It was less potent than the reference drugs, yet promising for further modifications as a lead. The ability of the compounds to adopt energetically more favorable conformations and to engage in more key interactions in the ECBChE active gorge explains their better activity profile against ECBChE. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Synthetic Route of 321-28-8

The Article related to alzheirmers disease pyridazinone cholinesterases inhibitor mol modeling, 3(2h)-pyridazinone, ache inhibitor, bche inhibitor, hydrazone, molecular modelling, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Synthetic Route of 321-28-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tian, Ze-Yu; Zhang, Cheng-Pan published an article in 2022, the title of the article was Visible-light-initiated catalyst-free trifluoromethylselenolation of arylsulfonium salts with [Me4N][SeCF3].Category: ethers-buliding-blocks And the article contains the following content:

The redox potential gap between arylsulfonium salts and [Me4N][SeCF3] has been clearly revealed by CV measurements. Construction of the carbon-selenium bond by overcoming this gap without using catalysts and additives is a challenging task. Here, the authors report an efficient visible-light-induced cross-coupling of arylsulfonium triflates, e.g., 5-[4-(4-cyanophenoxy)phenyl]-5H-thianthren-5-ium triflate, with [Me4N][SeCF3] by simply mixing these two species, which allowed the facile synthesis of various aryl trifluoromethyl selenoethers, e.g., ArSeCF3 (Ar = 2-formyl-4-methoxyphenyl, N-methylcarbazol-6-yl, benzodioxol-5-yl, etc.) under catalyst- and additive-free conditions. The mechanistic study indicated that aryl and SeCF3 radicals might be formed as key intermediates in the reactions. Merits of the reactions include operational simplicity, high efficiency, visible-light irradiation, good functional group tolerance, a wide range of substrates, excellent chemoselectivity, and good yields of (trifluoromethyl)selenolated products, which combined with a sulfenylation process enabled the selective and practical installation of SeCF3 moieties onto complex arenes, including drug mols., via a formal C-H functionalization. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Category: ethers-buliding-blocks

The Article related to trifluoromethyl selenoether preparation regioselective chemoselective, arylsulfonium salt selenide trifluoromethylselenolation visible light, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: (This Subsection Discontinued) and other aspects.Category: ethers-buliding-blocks

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On September 1, 2021, Toriumi, Naoyuki; Yamashita, Kazuya; Iwasawa, Nobuharu published an article.Recommanded Product: 321-28-8 The title of the article was Metal-Free Photoredox-Catalyzed Hydrodefluorination of Fluoroarenes Utilizing Amide Solvent as Reductant. And the article contained the following:

A metal-free photoredox-catalyzed hydrodefluorination of fluoroarenes was achieved by using N,N,N’,N’-tetramethyl-para-phenylenediamine as a strong photoreduction catalyst. This reaction was applicable not only to electron-rich monofluoroarenes but also to polyfluoroarenes to afford non-fluorinated arenes. The exptl. mechanistic studies indicated that the amide solvent NMP plays an important role for regeneration of the photocatalyst, enabling additive-free photoreduction catalysis. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Recommanded Product: 321-28-8

The Article related to fluoroarene hydrodefluorination metal free photoredox catalyst, amides, hydrodefluorination, metal-free, phenylenediamine, photocatalysis, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Recommanded Product: 321-28-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Spencer, Andrew R. A.; Korde, Rishi; Font, Marc; Larrosa, Igor published an article in 2020, the title of the article was meta-Selective olefination of fluoroarenes with alkynes using CO2 as a traceless directing group.Computed Properties of 321-28-8 And the article contains the following content:

Herein, it is reported that meta-selective olefination of fluoroarenes can be achieved via the use of CO2 as a traceless directing group, which can be easily installed and removed in a one-pot process. Furthermore, this approach avoids the use of stoichiometric Ag(I)-salts, commonly used in C-H olefinations, and affords complete meta- over ortho/para-regioselectivity. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Computed Properties of 321-28-8

The Article related to fluoroarene alkyne meta olefination diastereoselective regioselective ruthenium catalyst, carbon dioxide directing group, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Computed Properties of 321-28-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 27, 2020, Deichert, Julie A.; Mizufune, Hideya; Patel, Jignesh J.; Hurst, Timothy E.; Maheta, Ashish; Kitching, Mathew O.; Ross, Avena C.; Snieckus, Victor published an article.Synthetic Route of 321-28-8 The title of the article was Expedient Pd-Catalyzed α-Arylation towards Dibenzoxepinones: Pivotal Manske’s Ketone for the Formal Synthesis of Cularine Alkaloids. And the article contained the following:

The general synthesis of diversely substituted dibenzoxepinones by a combined Pd-catalyzed α-arylation and SNAr strategy is reported and applied to the synthesis of Manske’s ketone, a key intermediate en route to the total synthesis of cularine alkaloids. In the course of this work, an unanticipated ring contraction reaction to a xanthone was observed and serves as a caveat for the conditions of the widely used α-arylation reaction. Thus, e.g., o-(2-bromophenoxy)acetophenone â†?dibenzoxepinone I (72%) in presence of Pd2(dba)3 and XantPhos, Cs2CO3 as base and toluene as solvent. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Synthetic Route of 321-28-8

The Article related to palladium catalyzed arylation benzoxepinone manske ketone synthesis, cularine alkaloid formal synthesis, Alkaloids: Alkaloids Containing One Nitrogen Atom In A Ring and other aspects.Synthetic Route of 321-28-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 29, 2020, Hassine, Manel; Ben Jannet, Hichem; Ghermani, NourEddine; Alami, Mouad; Messaoudi, Samir published an article.Reference of 1-Fluoro-2-methoxybenzene The title of the article was Synthesis of N-(Hetero)arylconvolvine Derivatives through a Palladium-Catalyzed Buchwald-Hartwig Cross-Coupling. And the article contained the following:

The present study describes the isolation of convolvine from the roots of the Tunisian plant Convolvulus dorycnium L. and its synthesis through a four-step sequence starting from tropine. Then, an efficient synthesis of N-(het)aryltropanes derivatives by a sequence of a palladium-catalyzed N-arylation of convolvine has been established. This strategy enabled access to unknown tropane scaffolds of biol. interests. The antitumor activity of the derivatives against HCT-116 cell line was tested. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Reference of 1-Fluoro-2-methoxybenzene

The Article related to convolvine aryl derivative preparation buchwald hartwig cross coupling antitumor, Alkaloids: Alkaloids Containing One Nitrogen Atom In A Ring and other aspects.Reference of 1-Fluoro-2-methoxybenzene

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Ether – Wikipedia,
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Li, Yi-Xian; Ren, Iwaki; Kato, Atsushi; Jia, Yue-Mei; Fleet, George W. J.; Zhao, Xuan; Xiao, Min; Yu, Chu-Yi published an article in 2016, the title of the article was Fluorinated Radicamine A and B: Synthesis and Glycosidase Inhibition.Computed Properties of 321-28-8 And the article contains the following content:

Fluorinated derivatives of radicamine A and radicamine B, I (R1 = F, R2 = R3 = H, R4 = OH; R1 = R3 = H, R2 = F, R4 = OH; R1 = R2 = H, R3 = F, R4 = OH; R1 = R2 = R3 = H, R4 = F) and II (R1 = F, R2 = H; R1 = H, R2 = F), resp., have been synthesized from D-arabinose-derived cyclic nitrone III. Structure-activity relationship studies showed that glycosidase inhibition of these fluorinated derivatives was significantly influenced by the position of the fluorine atom. C-7 or C-11 fluorination of the aromatic ring decreased α-glucosidase inhibition of the derivatives, whereas C-8 or C-10 fluorination preserved glycosidase inhibitory activities. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Computed Properties of 321-28-8

The Article related to radicamine a b fluorinated preparation glycosidase inhibitor structure activity, Alkaloids: Alkaloids Containing One Nitrogen Atom In A Ring and other aspects.Computed Properties of 321-28-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem