Category: 37466-89-0

Related Products of 37466-89-0,Some common heterocyclic compound, 37466-89-0, name is 3-Methoxybenzene-1,2-diamine, molecular formula is C7H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 2-methoxy-6-nitroaniline (1 g, 5.95 mmol), 10% palladium carbon (300 mg) and methanol (25 ml) was stirred in a hydrogen atmosphere for 4 hours. The reaction vessel was purged with nitrogen and a catalyst was removed by filtration. To the reaction mixture, carbon disulfide (15 ml) was added and the mixture was stirred at room temperature overnight. Triethylamine (1 ml) was added to the reaction mixture, which was stirred at 50 C. for 3 hours. After the reaction mixture was concentrated, methanol (2 ml) and diethyl ether (20 ml) were added to the residue. The generated solid was collected by filtration to obtain the title compound (950 mg, yield: 88.6%) as a light orange solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Methoxybenzene-1,2-diamine, its application will become more common.

Reference:
Patent; Eisai Co., Ltd.; US2007/10542; (2007); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 37466-89-0, These common heterocyclic compound, 37466-89-0, name is 3-Methoxybenzene-1,2-diamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The reaction mixture of 3-methoxy-o-phenylenediamine (2, 190mg, 1.37mmol)and HCOOH (5mL) was refluxed for 4h, then cooled to room temperature and poured into ice/ water (20mL). The mixture was treated with 10% NaOH aqueous solution to pH?8 and then extracted with ethyl ether (15mL×3). The combined extracts were washed with water and brine, then dried over anhydrous MgSO4. The organic phase was concentrated to give the crude product, which was purified by column chromatography with CH2Cl2-MeOH (v/v=60/1). The desired product 4-methoxy-1H-benzo[d]imidazole (162mg) was afforded as white powder with 83.9% yield. M.p. 165-167C; 1H NMR (acetone-d6, 300MHz, delta ppm): 8.08 (1H, s), 7.21 (1H, d, J=7.8Hz), 7.11 (1H, t, J=7.8Hz), 6.73 (1H, d, J=7.8Hz), 3.97 (3H, s); HRMS (ESI): m/z, calcd. For C8H9N2O [M+H]+ 149.0709 found 149.0707.

The synthetic route of 37466-89-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhou, Jie; Jin, Jing; Zhang, Yi; Yin, Yuwen; Chen, Xiaoguang; Xu, Bailing; European Journal of Medicinal Chemistry; vol. 68; (2013); p. 222 – 232;,
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Ether | (C2H5)2O – PubChem

Electric Literature of 37466-89-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 37466-89-0, name is 3-Methoxybenzene-1,2-diamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

3-Methoxybenzene-1,2-diamine dihydrochloride (Example 54(a)) was partitioned between 10% aq. Na2CO3 and CH2Cl2. The aqueous layer was extracted with CH2Cl2 (2¡Á). The combined organic extracts were dried over Na2SO4, filtered and evaporated to yield 3-methoxybenzene-1,2-diamine. A mixture of the diamine (912 mg, 6.6 mmol) and diethyl oxalate (9.0 mL, 66 mmol, Aldrich) was heated at 185 C. for 18 h. The reaction mixture was left to reach room temperature and the solid precipitate was filtered. The filter cake was washed with EtOH and dried in vacuo to give the title compound. MS (ESI, pos. ion.) m/z: 191 (M+1).

The synthetic route of 3-Methoxybenzene-1,2-diamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Wang, Hui-Ling; Balan, Chenera; Doherty, Elizabeth M.; Falsey, James R.; Gore, Vijay Keshav; Katon, Jodie; Norman, Mark H.; US2005/176726; (2005); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 37466-89-0, name is 3-Methoxybenzene-1,2-diamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37466-89-0, name: 3-Methoxybenzene-1,2-diamine

At room temperature, a solution of oxaldehyde in H20 (40%, 4 mL) was added to a solution of 3-methoxybenzene-1,2-diamine (3.66 g, 26.53 minol) in water (100.00 mL). Then NaHSO3 (7.59 g, 72.94 minol) was added slowly. The resulting solution was stirred for 15 min at room temperature. When the reaction was done, the insoluable solids in the reactionminxture were filtered out. The filtrate was extracted with DCM (300 mL x 3), and the organic phases were combined, washed with brine and dried over Na2SO4. The solvent was removed under reduced pressure and the residue was purified by flash chromatography eluting with EtOAc in hexane (0% to 100% gradient) to yield 5-methoxyquinoxaline as dark red oil (3.02 g, 71%). MS: m/z = 161.0 [M+Hj.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; MERCK PATENT GMBH; SHERER, Brian A.; BRUGGER, Nadia; (546 pag.)WO2017/106607; (2017); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 37466-89-0, name is 3-Methoxybenzene-1,2-diamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37466-89-0, Computed Properties of C7H10N2O

Step 3: 3~but-3-en~l-yl-8-rnethoxyquinoxalin-2-ol; To a solution of 3-methoxybenzene-l ,2-diamine from step 2 (5.6 g, 40.5 mmol) inDCE (250 ml), ethyl 2-oxohex-5-enoate (9.50 g, 60.8 mmol) was added, and the mixture was stirred at 60C for 14 hours. An additional charge of ethyl 2-oxohex-5-enoate (1.45 g, 9.28 mmol) was added, and the mixture was heated for 24 hours. The reaction mixture was concentrated and filtered from CH2CI2 to remove a portion of the undesired regio-isomer as a tan solid. The filtrate was purified by column chromatography on S1O2 (gradient elution, 1-9% acetone/C?Cl2) to give the title compound as a tan solid (6.4 g, 68.6 %) after triturating with 10% Et20/hexane. LCMS (ES+) m/z 231.1 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methoxybenzene-1,2-diamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.R.L.; MCCAULEY, John, A.; LIVERTON, Nigel, J.; RUDD, Michael, T.; GILBERT, Kevin, F.; FERRARA, Marco; SUMMA, Vincenzo; CRESCENZI, Benedetta; WO2012/40040; (2012); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem