Related Products of 37466-89-0,Some common heterocyclic compound, 37466-89-0, name is 3-Methoxybenzene-1,2-diamine, molecular formula is C7H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 2-methoxy-6-nitroaniline (1 g, 5.95 mmol), 10% palladium carbon (300 mg) and methanol (25 ml) was stirred in a hydrogen atmosphere for 4 hours. The reaction vessel was purged with nitrogen and a catalyst was removed by filtration. To the reaction mixture, carbon disulfide (15 ml) was added and the mixture was stirred at room temperature overnight. Triethylamine (1 ml) was added to the reaction mixture, which was stirred at 50 C. for 3 hours. After the reaction mixture was concentrated, methanol (2 ml) and diethyl ether (20 ml) were added to the residue. The generated solid was collected by filtration to obtain the title compound (950 mg, yield: 88.6%) as a light orange solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Methoxybenzene-1,2-diamine, its application will become more common.
Reference:
Patent; Eisai Co., Ltd.; US2007/10542; (2007); A1;,
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