Category: 41365-75-7

Electric Literature of 41365-75-7,Some common heterocyclic compound, 41365-75-7, name is 1-Amino-3,3-diethoxypropane, molecular formula is C7H17NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of intermediate I-05a (300 mg, 748 mumol) and 3,3-diethoxypropan-1-amine (R-04a, 110 mg, 748 mumol) in 1,4-dioxane (10 mL), was added Pd(dba)2 (43 mg, 74 mumol), BINAP (47 mg, 75 mumol) and Cs2CO3 (487 mg, 1 .50 mmol) in one portion at 25C under N2. The mixture was stirred at 25C for 10 minutes and then heated to 110C and stirred for 12 hours. Then, the mixture was concentrated in vacuum and the residue was purified by prep-TLC to afford intermediate I-11a (250 mg, 65%) as yellow solid. ESI-MS (M+1): 512.3 calc. for C29H41N3O5: 511.3.

The synthetic route of 41365-75-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FUNDACION PARA LA INVESTIGACION MEDICA APLICADA; AGUIRRE ENA, Xabier; OYARZABAL SANTAMARINA, Julen; PROSPER CARDOSO, Felipe; RABAL GRACIA, Maria Obdulia; SAN JOSE ENERIZ, Edurne; SANCHEZ ARIAS, Juan Antonio; (92 pag.)WO2017/85053; (2017); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 41365-75-7,Some common heterocyclic compound, 41365-75-7, name is 1-Amino-3,3-diethoxypropane, molecular formula is C7H17NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of (S*)-3-methyl-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxylic acid (100 mg, 0.321 mmol) in DMF (1 ml.) was added sequentially HATU (183 mg, 0.482 mmol) and DIPEA (0.140 ml_, 0.803 mmol). The reaction was stirred for 1 min then 3,3-diethoxypropan-l-amine (0.057 ml_, 0.35 mmol) was added. The reaction was stirred for 1 h. Sat. LiCI (aq) and EtOAc were added and the layers separated. The aqueous layer was extracted with further EtOAc and the organic layers were combined, back extracted with sat. LiCI (aq) and water and filtered through a cartridge fitted with a hydrophobic frit. The filtrate was evaporated in vacuo to give a dark oil. This oil was purified using silica gel column chromatography eluting with a gradient of 60-100% EtOAc : cyclohexane and the appropriate fractions collected and concentrated in vacuoto afford (S*)-N5-(3,3-diethoxypropyl)-N5′,3-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide (141 mg, 0.320 mmol, 100 % yield) as a yellow solid LCMS (method Formic): Retention time 1.08, [M+H]” = poor ionisation

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Amino-3,3-diethoxypropane, its application will become more common.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen John; DEMONT, Emmanuel Hubert; HARRISON, Lee Andrew; LUCAS, Simon Christopher Cranko; PRESTON, Alexander G; SEAL, Jonathan Thomas; WALL, Ian David; WATSON, Robert J; WOOLVEN, James Michael; (89 pag.)WO2019/68782; (2019); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem