Electric Literature of 41365-75-7,Some common heterocyclic compound, 41365-75-7, name is 1-Amino-3,3-diethoxypropane, molecular formula is C7H17NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of intermediate I-05a (300 mg, 748 mumol) and 3,3-diethoxypropan-1-amine (R-04a, 110 mg, 748 mumol) in 1,4-dioxane (10 mL), was added Pd(dba)2 (43 mg, 74 mumol), BINAP (47 mg, 75 mumol) and Cs2CO3 (487 mg, 1 .50 mmol) in one portion at 25C under N2. The mixture was stirred at 25C for 10 minutes and then heated to 110C and stirred for 12 hours. Then, the mixture was concentrated in vacuum and the residue was purified by prep-TLC to afford intermediate I-11a (250 mg, 65%) as yellow solid. ESI-MS (M+1): 512.3 calc. for C29H41N3O5: 511.3.
The synthetic route of 41365-75-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FUNDACION PARA LA INVESTIGACION MEDICA APLICADA; AGUIRRE ENA, Xabier; OYARZABAL SANTAMARINA, Julen; PROSPER CARDOSO, Felipe; RABAL GRACIA, Maria Obdulia; SAN JOSE ENERIZ, Edurne; SANCHEZ ARIAS, Juan Antonio; (92 pag.)WO2017/85053; (2017); A1;,
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