Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64115-88-4, name is 1-Bromo-2-(trifluoromethoxy)benzene, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1-Bromo-2-(trifluoromethoxy)benzene
a.9 3-Bromo-4-trifluoromethoxy-benzenesulfonyl chloride2.0 g of 1-bromo-2-(trifluoro-methoxy)benzene (8.3 mmol) were dissolved in 30 ml of dichloromethane. At 0-50C, 1.06 g of chlorosulfonic acid (9.13 mmol), dissolved in 3 ml of dichloromethane, were added dropwise. The reaction mixture was stirred for 30 min at room temperature. Additional 5.5 equivalents of chlorosulfonic in dichloromethane were added to drive the reaction to completion. Standard work-up was followed and silica gel chromatography with n-heptane- dichloromethane (6:4) as eluent gave 2.19 g of the title compound.1H-NMR (CDCI3, 400 MHz): delta [ppm] 8.3 (d, 1 H), 8.05 (dd, 1 H), 7.5 (dd, 1 H).
According to the analysis of related databases, 64115-88-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ABBOTT GMBH & CO. KG; WO2006/40176; (2006); A1;,
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