Category: 4637-24-5

Ao, Mingtao; Zhang, Jianyu; Qian, Yuqing; Li, Boqun; Wang, Xiumei; Chen, Jun; Zhang, Yuxiang; Cao, Yin; Qiu, Yingkun; Xu, Yang; Wu, Zhen; Fang, Meijuan published an article in 2022. The article was titled 《Design and synthesis of adamantyl-substituted flavonoid derivatives as anti-inflammatory Nur77 modulators: Compound B7 targets Nur77 and improves LPS-induced inflammation in vitro and in vivo》, and you may find the article in Bioorganic Chemistry.Synthetic Route of C5H13NO2 The information in the text is summarized as follows:

In continuing our study on discovering new Nur77-targeting anti-inflammatory agents with natural skeletons, we combined adamantyl group and hydroxamic acid moiety with flavonoid nucleus, synthesized three series of flavonoid derivatives with a similar structure like CD437, and evaluated their activities against LPS-induced inflammation. Compound B7 was found to be an excellent Nur77 binder (Kd = 3.55 x 10-7 M) and a potent inhibitor of inflammation, which significantly decreased the production of cytokines in vitro, such as NO, IL-6, IL-1β, and TNF-α, at concentrations of 1.25, 2.5, and 5 μM. Mechanistically, B7 modulated the colocalization of Nur77 at mitochondria and inhibited the lipopolysaccharides (LPS)-induced inflammation via the blockade of NF-κB activation in a Nur77-dependent manner. Addnl., B7 showed in vivo anti-inflammatory activity in the LPS-induced mice model of acute lung injury (ALI). These data suggest that the Nur77-targeting flavonoid derivatives can be particularly useful for further pharmaceutical development for the treatment of inflammatory diseases such as ALI. In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Synthetic Route of C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Synthetic Route of C5H13NO2

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《Derivatization of Perfluorocarboxylic Acids with N,N-Dimethylformamide Dimethylacetal Prior to GC-MS Analysis》 was published in Chromatographia in 2020. These research results belong to Strozynska, Monika; Schuhen, Katrin. Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal The article mentions the following:

A simple derivatization reaction with N,N-dimethylformamide di-Me acetal (DMF-DMA) was developed for the anal. of perfluorocarboxylic acids (PFCA, C4-C12) in solid samples by gas chromatog.-mass spectrometry (GC-MS). After extraction with Me tert-Bu ether (MTBE), the samples are mixed with derivatizing agent and injected into GC. The derivatization reaction takes place in injection block forming corresponding N,N,N’,N’-tetramethyl diamines. The method provides excellent separation of nine PFCA (C4-C12) in 15 min and is characterized by good precision (maximum RSD = 6.21% for 10 ng/mL, n = 6), linearity and detection limits in the range of 0.15-0.38 ng/mL. The main aim of the study was to develop a quick and easy GC-MS screening for PFCA. The method was successfully applied for sewage sludge, textiles and dental flosses. To confirm the laboratory evaluation, two samples were measured by an external laboratory using LC-MS/MS and showed comparable results. The proposed method is very promising, taking into account its simplicity, mild conditions and application of cost-effective GC-MS system. Addnl., a comparison with two other derivatization methods for PFCA: reaction with N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) and benzyl bromide is presented. After reading the article, we found that the author used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal

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HPLC of Formula: 4637-24-5In 2019 ,《Scalable Sonochemical Synthetic Strategy for Pyrazolo[1,5-a]pyridine Derivatives: First Catalyst-Free Concerted [3 + 2] Cycloaddition of Alkyne and Alkene Derivatives to 2-Imino-1H-pyridin-1-amines》 was published in ACS Omega. The article was written by Ibrahim, Hamada Mohamed; Behbehani, Haider; Mostafa, Noha S.. The article contains the following contents:

A highly efficient and convenient one-pot sonochem. synthetic strategy has been sophisticated for synthesizing a novel class of polysubstituted pyrazolo[1,5-a]pyridines via [3 + 2] cycloaddition of dialkyl acetylenedicarboxylates, Et propiolate, and alkenes to 2-imino-1H-pyridin-1-amines under catalyst-free conditions. A series of uniquely substituted pyrazolo[1,5-a]pyridines has been synthesized with a very good to excellent yield, and the mechanistic pathway that involves a [3 + 2] annulation process was also proposed. In this study, several spectroscopic tools of analyses were employed for structure elucidation, and the X-ray single-crystal technique was utilized to confirm the proposed mechanism and the regioselectivity.N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5HPLC of Formula: 4637-24-5) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.HPLC of Formula: 4637-24-5

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Synthetic Route of C5H13NO2In 2020 ,《New facile method for synthesis of 5-[(dimethylamino)methylene]pyrimidine-2,4,6-trione as potential template for barbiturate drugs》 appeared in Pharma Chemica. The author of the article were Sarhan, Alaadin E.. The article conveys some information:

New eco-friendly rapid synthesis of 5-[(dimethylamino)methylene]pyrimidine-2,4,6-trione was achieved by new method with efficient yield as potential template in synthesis of many biol. important organic compounds In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Synthetic Route of C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Synthetic Route of C5H13NO2

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Application of 4637-24-5In 2021 ,《Photophysical and crystallographic study of three integrated pyrazolo[1,5-a]pyrimidine-triphenylamine systems》 appeared in Dyes and Pigments. The author of the article were Tigreros, Alexis; Macias, Mario; Portilla, Jaime. The article conveys some information:

Three new intramol. charge transfer (ICT) fluorophores having triphenylamine and pyrazolo[1,5-a]pyrimidine moieties 4a-c were synthesized, and their structures were solved by X-ray crystallog. (XRC). Compounds 4a, 4b and 4c crystallize in the tetragonal P42/n, triclinic P-1 and monoclinic P21/c space groups with calculated CE-B3LYP structural energies of -104.3, -125.6 and -123.8 kJ/mol, resp. Substituents effect on mol. and photophys. properties of 4a-c was studied in both solution and solid-state through fluorescence, UV-vis, XRC, and computational methods. The 2-Ph (4b) and 2-anisyl (2c) derivatives showed better absorption coefficient (4b, ε = 76400 → 119600 M-1cm-1 and 4c, ε = 66200 → 89200 M-1cm-1) than 4a (2-Me, ε = 9933 → 21667 M-1cm-1), while the relative quantum yield (φ) in solvents of diverse polarity is as high as φ = 0.98 for 4a, φ = 0.86 for 4b and φ = 0.83 for 4c. For these dyes, Lippert-Mataga correlation were used to estimate the difference between the excited and ground state dipole moments (Δμ), being 4b the one that suffer the bigger changes with a Δμ of 26.9 D. Probe 4c is found to be useful as a fluorescent indicators for the qual. sensing of water content in organic solvents. The solid-state emission data reveal that the antiparallel mol. packing of the crystal structure for 4a-c, with energy framework diagrams influenced mainly by dispersion forces, could disturbs the photophys. properties by changing the donor-acceptor intramol. coupling. Therefore, the combination of these XRC and photophys. results may constitute in a key input for designing applications in material science. The experimental part of the paper was very detailed, including the reaction process of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Application of 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Application of 4637-24-5

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Ether – Wikipedia,
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Category: ethers-buliding-blocksIn 2020 ,《Synthesis of 4,4-Disubstituted 1,2-Thiazinane-5-one 1,1-Dioxides via the CSIC[#] Reaction Strategy》 was published in ChemistrySelect. The article was written by Dyachenko, Maksim S.; Kochetkov, Artem O.; Dobrydnev, Alexey V.; Milokhov, Demyd S.; Shishkina, Svitlana V.; Konovalova, Irina S.; Omelchenko, Irina V.; Volovenko, Yulian M.. The article contains the following contents:

A series of sp3-enriched 2,2-disubstituted 1,2-thiazinane-5-one 1,1-dioxides (including spirocyclic derivatives) I (R1 = R2 = Me, Et, -(CH2)4-, -(CH2)5-, etc.), II (R1 = R2 = Me; R3 = NH2, Me, phenyl) and III (R1 = R2 = Me) has been synthesized through the CSIC [Carbanion mediated Sulfonate (Sulfonamido) Intramol. Cyclization] reaction strategy. In particular, 2,2-disubstituted alkyl 3-aminopropanoates C(R1)(R2)(CO2R4)CH2NH3+Cl- (R4 = Me, Et) were subsequently sulfonylated with mesyl chloride followed by alkylation with Me iodide to give the key precursor 2,2-disubstituted Me 3-(methylsulfonamido)propanoates C(R1)(R2)(CO2R4)CH2N(Me)SO2Me. The latter were treated with sodium hydride and underwent the intramol. sulfa-Dieckmann cyclization yielding the target 4,4-disubstituted 1,2-thiazinane-5-one 1,1-dioxides (so-called β-keto-δ-sultams) I. The structure of the target compounds was confirmed by an X-ray diffraction study. The results came from multiple reactions, including the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Category: ethers-buliding-blocks)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Category: ethers-buliding-blocks

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In 2019,European Polymer Journal included an article by Zupanc, Anze; Kotnik, Tomaz; Stanfel, Ursa; Brodnik Zugelj, Helena; Kristl, Anja; Rucigaj, Ales; Matoh, Lev; Pahovnik, David; Groselj, Uros; Opatz, Till; Pozgan, Franc; Stefane, Bogdan; Zagar, Ema; Svete, Jurij. Related Products of 4637-24-5. The article was titled 《Chemical recycling of polyenaminones by transamination reaction via amino-enaminone polymerization/depolymerization》. The information in the text is summarized as follows:

Novel oligo- and polyenaminones with Mw-3000 Da were prepared in excellent yields by amino-enaminone ‘click’ polymerization of 1,3- and 1,4-bis[3-(dimethylamino)acryloyl]arenes with 1,3- and 1,4-phenylenediamine. The obtained oligomers and polymers were depolymerized quant. to the starting bis-enaminones and diamines by treatment with excess dimethylamine in ethanol at 50°C. This simple polymerization/depolymerization method allows for a closed-loop recycling of polyenaminone-based materials. UV light absorbance at wavelengths below 470 nm indicates promising optical properties of these polymers. After reading the article, we found that the author used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Related Products of 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Related Products of 4637-24-5

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Ether – Wikipedia,
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In 2019,Methods and Protocols included an article by Martins, Ines S.; Coelho, Jaime A. S.. Application In Synthesis of N,N-Dimethylformamide Dimethyl Acetal. The article was titled 《Solvent-free synthesis of 2,5-bis((dimethylamino)methylene)cyclopentanone》. The information in the text is summarized as follows:

The important feature in synthesis of ketocyanine dyes precursor 2,5-bis((dimethylamino)methylene)cyclopentanone I through organocatalyzed condensation of cyclopentanone and N,N-dimethylformamide di-Me acetal was removal of methanol produced during the reaction. By studying reaction profile, in particular selectivity for formation of mono- and bis-condensation products, a high yield of desired product could be obtained through an operationally simple and solvent-free protocol.N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Application In Synthesis of N,N-Dimethylformamide Dimethyl Acetal) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Application In Synthesis of N,N-Dimethylformamide Dimethyl Acetal

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Ether – Wikipedia,
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In 2019,Bioorganic Chemistry included an article by Eldehna, Wagdy M.; Abo-Ashour, Mahmoud F.; Berrino, Emanuela; Vullo, Daniela; Ghabbour, Hazem A.; Al-Rashood, Sara T.; Hassan, Ghada S.; Alkahtani, Hamad M.; Almehizia, Abdulrahman A.; Alharbi, Amal; Abdel-Aziz, Hatem A.; Supuran, Claudiu T.. Name: N,N-Dimethylformamide Dimethyl Acetal. The article was titled 《SLC-0111 enaminone analogs, 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX》. The information in the text is summarized as follows:

SLC-0111, an ureido substituted benzenesulfonamide, is a selective carbonic anhydrase (CA, EC 4.2.1.1) IX inhibitor that is currently in Phase I/II clin. trials for the treatment of advanced hypoxic tumors complicated with metastases. Herein we report the synthesis of two series of 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides 5a-i and 6a-j as SLC-0111 enaminone congeners. The prepared enaminones were in vitro investigated as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA I, II, IV and IX, using a stopped-flow CO2 hydrase assay. All these isoforms were inhibited by the enaminones reported here in variable degrees. The target tumor-associated isoform hCA IX was undeniably the most affected one (KIs: 0.21-7.1 nM), with 6- to 21-fold enhanced activity than SLC-0111 (KI = 45 nM). All the prepared enaminones displayed interesting selectivity towards hCA IX over hCA I (SI: 32 – >35714), hCA II (SI: 2 – 1689) and hCA IV (SI: 11 – >45454). Of particular interest, bioisosteric replacement of Ph tail with the bulkier 2-naphthyl tail, sulfonamide 6h, achieved the higher II/IX selectivity herein reported with SI of 1689. After reading the article, we found that the author used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Name: N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Name: N,N-Dimethylformamide Dimethyl Acetal

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Hirata, Shuichi; Osako, Takao; Uozumi, Yasuhiro published their research in Helvetica Chimica Acta in 2021. The article was titled 《Palladium-Catalyzed Aminocarbonylation of Aryl Halides with N,N-Dialkylformamide Acetals》.Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal The article contains the following contents:

Herein, a protocol for the palladium-catalyzed aminocarbonylation of aryl halides using less-toxic formamide acetals as bench-stable aminocarbonyl sources under neutral conditions has been developed. Various aryl (including heteroaryl) halides reacted with N,N-dialkylformamide acetals in the presence of a catalytic amount of tris(dibenzylideneacetone)dipalladium(0)-chloroform adduct and xantphos to give the corresponding aromatic carboxamides at 90-140°C without any activating agents or bases in up to quant. chem. yield. This protocol was applied to aryl bromides, aryl iodides and a triflate, as well as to relatively less-reactive aryl chlorides. A wide range of functionalities on the aromatic ring of the substrates was tolerated under the aminocarbonylation conditions. The catalytic aminocarbonylation was used to prepare the insect repellent N,N-diethyl-3-methylbenzamide as well as a synthetic intermediate of the dihydrofolate reductase inhibitor triazinate. The experimental process involved the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem