Category: 52244-70-9

Harwood, Laurence M.; Robertson, Jeremy published the artcile< Preparation of cyclic ethers via oxidative cyclization of 2-(4-hydroxyalkyl)- and 2-(5-hydroxyalkyl)furans with DDQ>, Application In Synthesis of 52244-70-9, the main research area is hydroxyalkylfuran oxidative cyclization; ether cyclic; furyltetrahydrofuran.

Reaction of hydroxyalkylfurans I [n = 2, R = H, R1 = H, C(:CH2)COMe, 5-methyl-2-furyl; n = 2, RR1 = O; n = 3, R = H, R1 = 5-methyl-2-furyl] with DDQ gave cyclic ethers II under neutral conditions. Aromatic analogs do not give useful yields of desired products.

Tetrahedron Letters published new progress about Cyclic ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Application In Synthesis of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Shang, Gao; Liu, Duan; Allen, Scott E.; Yang, Qin; Zhang, Xumu published the artcile< Asymmetric hydrogenation of α-primary and secondary amino ketones: efficient asymmetric syntheses of (-)-arbutamine and (-)-denopamine>, Product Details of C11H16O2, the main research area is asym hydrogenation amino ketone rhodium catalyst; alc amino chiral preparation rhodium catalyst.

Two β-receptor agonists (-)-denopamine (I) and (-)-arbutamine (II) were prepared in good yields and enantioselectivities by asym. hydrogenation of unprotected amino ketones for the first time by using Rh catalysts bearing electron-donating phosphine ligands. A series of α-primary and secondary amino ketones, e.g. ArCOCH2NHR (Ar = Ph, 2-MeOC6H4, 2-naphthyl, R = Me; Ar = Ph, R = Et), were synthesized and hydrogenated to produce various 1,2-amino alcs., e.g. ArCH(OH)CH2NHR, in good yields and with good enantioselectivities. This Rh electron-donating phosphine-catalyzed asym. hydrogenation rep- resents one of the most promising and convenient approaches towards the asym. synthesis of chiral amino alcs.

Chemistry – A European Journal published new progress about Amines, keto Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Product Details of C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Shang, Gao; Liu, Duan; Allen, Scott E.; Yang, Qin; Zhang, Xumu published the artcile< Asymmetric hydrogenation of α-primary and secondary amino ketones: efficient asymmetric syntheses of (-)-arbutamine and (-)-denopamine>, Product Details of C11H16O2, the main research area is asym hydrogenation amino ketone rhodium catalyst; alc amino chiral preparation rhodium catalyst.

Two β-receptor agonists (-)-denopamine (I) and (-)-arbutamine (II) were prepared in good yields and enantioselectivities by asym. hydrogenation of unprotected amino ketones for the first time by using Rh catalysts bearing electron-donating phosphine ligands. A series of α-primary and secondary amino ketones, e.g. ArCOCH2NHR (Ar = Ph, 2-MeOC6H4, 2-naphthyl, R = Me; Ar = Ph, R = Et), were synthesized and hydrogenated to produce various 1,2-amino alcs., e.g. ArCH(OH)CH2NHR, in good yields and with good enantioselectivities. This Rh electron-donating phosphine-catalyzed asym. hydrogenation rep- resents one of the most promising and convenient approaches towards the asym. synthesis of chiral amino alcs.

Chemistry – A European Journal published new progress about Amines, keto Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Product Details of C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Harwood, Laurence M.; Robertson, Jeremy published the artcile< Preparation of cyclic ethers via oxidative cyclization of 2-(4-hydroxyalkyl)- and 2-(5-hydroxyalkyl)furans with DDQ>, Application In Synthesis of 52244-70-9, the main research area is hydroxyalkylfuran oxidative cyclization; ether cyclic; furyltetrahydrofuran.

Reaction of hydroxyalkylfurans I [n = 2, R = H, R1 = H, C(:CH2)COMe, 5-methyl-2-furyl; n = 2, RR1 = O; n = 3, R = H, R1 = 5-methyl-2-furyl] with DDQ gave cyclic ethers II under neutral conditions. Aromatic analogs do not give useful yields of desired products.

Tetrahedron Letters published new progress about Cyclic ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Application In Synthesis of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Apelt, Joachim; Ligneau, Xavier; Pertz, Heinz H.; Arrang, Jean-Michel; Ganellin, C. Robin; Schwartz, Jean-Charles; Schunack, Walter; Stark, Holger published the artcile< Development of a New Class of Nonimidazole Histamine H3 Receptor Ligands with Combined Inhibitory Histamine N-Methyltransferase Activity>, COA of Formula: C11H16O2, the main research area is piperidinoalkanamine derivative preparation histamine receptor methyltransferase.

In search of novel ways to enhance histaminergic neurotransmission in the central nervous system, a new class of nonimidazole histamine H3 receptor ligands were developed that simultaneously possess strong inhibitory activity on the main histamine metabolizing enzyme, histamine N-methyltransferase (HMT). The novel compounds contain an aminoquinoline moiety, which is an important structural feature for HMT inhibitory activity, connected by different spacers to a piperidino group (for H3 receptor antagonism). Variation of the spacer structure provides two different series of compounds One series, having only an alkylene spacer between the basic centers, led to highly potent HMT inhibitors with moderate to high affinity at human histamine H3 receptors. The second series possesses a p-phenoxypropyl spacer, which may be extended by another alkylene chain. This latter series also showed strong inhibitory activity on HMT, and in most cases, the H3 receptor affinity even surpassed that of the first series. One of the most potent compounds with this dual mode of action is 4-(4-(3-piperidinopropoxy)phenylamino)quinoline (hH3, Ki = 0.09 nM; HMT, IC50 = 51 nM). This class of compounds showed high antagonist potency and good H3 receptor selectivity in functional assays in guinea pig on H1, H2, and H3 receptors. Because of low or missing in vivo activity of two selected compounds, the proof of concept of these valuable pharmacol. tools for the supposed superior overall enhancing effect on histaminergic neurotransmission failed to appear hitherto.

Journal of Medicinal Chemistry published new progress about Drug screening. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, COA of Formula: C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adams, Theodore C.; Combs, Donald W.; Daves, G. Doyle Jr.; Hauser, Frank M. published the artcile< 7-Amino-5-(methylamino)heptanoic acid: a potential putrescine hapten>, Electric Literature of 52244-70-9, the main research area is heptanoic acid amino aminomethyl; aminoheptanoic acid aminomethyl.

H2N(CH2)2CH(CH2NH2)(CH2)3CO2H was prepared in three steps from R(CH2)3CHO (R = C6H4OMe-4, CH:CH2, CCH) by condensation with NCCH2CO2Et and KCN to form R(CH2)3CH(CN)CH2CN. Oxidation of the latent carboxyl substituent R and catalytic reduction of the succinonitrile groups completed the synthesis.

Journal of Organic Chemistry published new progress about 52244-70-9. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Electric Literature of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhao, Xiaoyong; Poon, Zhiyong; Engler, Amanda C.; Bonner, Daniel K.; Hammond, Paula T. published the artcile< Enhanced Stability of Polymeric Micelles Based on Postfunctionalized Poly(ethylene glycol)-b-poly(γ-propargyl L-glutamate): The Substituent Effect>, Quality Control of 52244-70-9, the main research area is block copolymer polymeric micelle polyethylene glycol propargyl glutamate stability.

One of the major obstacles that delay the clin. translation of polymeric micelle drug delivery systems is whether these self-assembled micelles can retain their integrity in blood following i.v. injection. The objective of this study was to evaluate the impact of core functionalization on the thermodn. and kinetic stability of polymeric micelles. The combination of ring-opening polymerization of N-carboxyanhydride (NCA) with highly efficient “”click”” coupling has enabled easy and quick access to a family of poly(ethylene glycol)-block-poly(γ-R-glutamate)s with exactly the same block lengths, for which the substituent “”R”” is tuned. The structures of these copolymers were carefully characterized by 1H NMR, FT-IR, and GPC. When pyrene is used as the fluorescence probe, the critical micelle concentrations (CMCs) of these polymers were found to be in the range of 10-7-10-6 M, which indicates good thermodn. stability for the self-assembled micelles. The incorporation of polar side groups in the micelle core leads to high CMC values; however, micelles prepared from these copolymers are kinetically more stable in the presence of serum and upon SDS disturbance. It was also observed that these polymers could effectively encapsulate paclitaxel (PTX) as a model anticancer drug, and the micelles possessing better kinetic stability showed better suppression of the initial “”burst”” release and exhibited more sustained release of PTX. These PTX-loaded micelles exerted comparable cytotoxicity against HeLa cells as the clin. approved Cremophor PTX formulation, while the block copolymers showed much lower toxicity compared to the cremophor-ethanol mixture The present work demonstrated that the PEG-b-PPLG can be a uniform block copolymer platform toward development of polymeric micelle delivery systems for different drugs through the facile modification of the PPLG block.

Biomacromolecules published new progress about Blood. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Quality Control of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Mohamed, Salah E. N.; Whiting, Donald A. published the artcile< Synthesis of meta,meta-bridged biaryls [7,0-metacyclophanes] via aryl-aryl coupling: factors affecting the cyclization>, Name: 4-(4-Methoxyphenyl)-1-butanol, the main research area is iodoarylheptane cyclization; metacycloptane.

Isoxazoline I and 3,4-I(MeO)C6H3(CH2)4CH(OAc)(CH2)2C6H3(OMe)I-4,3 were prepared; on treatment with (Ph3P)4Ni in DMF at 55-65° for 48 h these compounds cyclized to the [7.0]metacyclophanes II and III, resp., in 31 and 49% yield, resp. The analog 3,4-I(MeO)C6H3(CH2)4SO2(CH2)3C6H3(OMe)I-4,3 was also prepared; it failed to cyclize. Steric effects at the coupling site are more important than torsional strain in the products in determination of the product yield.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Cyclocondensation reaction, intramolecular. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Name: 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zha, Gao-Feng; Fang, Wan-Yin; Li, You-Gui; Leng, Jing; Chen, Xing; Qin, Hua-Li published the artcile< SO2F2-Mediated Oxidative Dehydrogenation and Dehydration of Alcohols to Alkynes>, Quality Control of 52244-70-9, the main research area is alkyne chemoselective preparation; phenyltriazole phenylacetylene preparation; sulfuryl fluoride DMSO mediated oxidative dehydrogenation elimination alc; beta hydroxy amide secondary alc oxidative elimination sulfuryl fluoride; sequential oxidative elimination primary alc azide alkyne cycloaddition azidobenzene; oxidative elimination primary alc Sonogashira coupling iodobenzene.

Terminal and internal alkynes were prepared directly from primary alcs. and secondary alcs. and β-hydroxyamides by oxidative dehydrogenation and dehydration using sulfuryl fluoride as the leaving group source and DMSO as oxidant; the method does not require transition metal reagents or catalysts. The method was used in one-pot preparations of phenyltriazoles and phenylacetylenes using the oxidative dehydrogenation/elimination reaction in sequence with azide-alkyne cycloaddition with Ph azide and Sonogashira coupling with iodobenzene.

Journal of the American Chemical Society published new progress about Alkynes, aryl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Quality Control of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

King, Frank D.; Aliev, Abil E.; Caddick, Stephen; Tocher, D. A. published the artcile< A novel synthesis of (di)-benzazocinones via an endocyclic N-acyliminium ion cyclization>, Category: ethers-buliding-blocks, the main research area is benzazocinone preparation; acyliminium cyclization.

The triflic acid-mediated endocyclic N-acyliminium ion cyclization provides a facile synthesis of (di)-benzazocinones, e.g. I (R = H, 14-Cl, 15-Br, etc.). On reduction of the 10-Ph derivative, an unusually nonpolar tertiary alkylamine II was obtained.

Organic & Biomolecular Chemistry published new progress about Cyclization. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem