Category: 54149-17-6

Related Products of 54149-17-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54149-17-6, name is 1-Bromo-2-(2-methoxyethoxy)ethane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: DBU (4.5mmol) and 1-bromo-2-methoxyethane or 1-(2?-methoxyethoxy)-2-bromoethane were added to a solution of a triterpenic acid 1, 2, 3, 4 (2.2mmol) in the mixture of CH2Cl2 (6mL) and MeCN (2mL). The reaction mixture was stirred for 2 days at room temperature. The work-up (A), column chromatography on silica gel, and crystallization afforded final products 1a – 3a and 1b – 3b.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-(2-methoxyethoxy)ethane, other downstream synthetic routes, hurry up and to see.

Related Products of 54149-17-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 54149-17-6 name is 1-Bromo-2-(2-methoxyethoxy)ethane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Under a nitrogen atmosphere, 2.00 g of the compound represented by the formula (C-7-1) and 20 mL of N,N-dimethylformamide were placed in a reaction vessel.While ice-cooling, 1.49 g of tertiary potassium butoxide was added, and the mixture was stirred at room temperature for 1 hour.While cooling with ice, a solution obtained by dissolving 2.44 g of the compound represented by the formula (C-7-2) in 3 mL of N,N-dimethylformamide was added dropwise.After stirring at room temperature for 5 hours, it was diluted with 100 mL of dichloromethane and poured into water.The organic layer was washed with brine and dried over sodium sulfate, and the solvent was evaporated.By subjecting column chromatography (alumina, dichloromethane) and recrystallization (dichloromethane/hexane), 3.04 g of the compound of formula (C-7) was obtained.The yield of the compound represented by the formula (C-7-1) was 94%.The reaction solution after the reaction showed a light coloration.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-2-(2-methoxyethoxy)ethane, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 54149-17-6, name is 1-Bromo-2-(2-methoxyethoxy)ethane, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 54149-17-6

To a vial containing ethyl 1H-indazoie-3-carboxyiate (150 mg, 0.789 inmol) in C1-I3CN (3 mL), were added I -bromo-2-(2-methoxyethoxy)etharie (217 mg, 1.183 mniol) and Cs?C03 (385 mg, 1.183 mrnol). The vial was sealed and the mixture was stirred at 80C overnight. Afterwards, water was added, extracted with EtOAc, washed organic layer with 10% LiCI, brine, concentrated and the residue was purified by normal phase chromatography with the second peak to elute off column being the desired product (105mg, 40.5%). MS (ESI) m/?: 293.2 (M±HY?. ?H NMR (400MHz, CDCI3) 5 8.20 (dt, J::r8.2,1.0 Hz, IH), 7.63- 7.57(m, 1H), 7.42 (ddd, J=8.4, 7.0, 1.1 Hz, IH), 7.30 (ddd, J=8.1,7.0, 0.9 Hz, 1H), 4.67 (t, J=5.6 Hz, 2H), 4.53 (q, J:::73 Hz, 21-1), 3.97 (t, J:::57 Hz. 21-1),3.56 – 3.48 (rn, 2H). 343 – 337 (m, 2H), 3.28 (s, 31:1), 1.48 (t, J:::7.2 Hz,3H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 54149-17-6.

Adding a certain compound to certain chemical reactions, such as: 54149-17-6, name is 1-Bromo-2-(2-methoxyethoxy)ethane, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 54149-17-6, HPLC of Formula: C5H11BrO2

The product from step (ii) above (1 g, 4.36 mmol) was dissolved in dry DMF (10 mL) under nitrogen and NaH (0.2 g, 5.00 mmol) added. Stirred for 10 minutes, then 1-bromo-2-(2-methoxyethoxy)ethane (0.75 ml, 5.57 mmol) and NaI (0.065 g, 0.436 mmol) added and stirred at rt for 2.5 h. The mixture was charged again with NaH (0.2 g, 5.00 mmol) and 1-bromo-2-(2-methoxyethoxy)ethane (0.75 ml, 5.57 mmol), stirred for a further 1 h then partitioned between NH4Cl solution (200 mL) and ethyl acetate (100 mL). The organic layer was separated and washed with 20% NaCl soln. (200 mL). The organic layer was separated, dried (MgSO4), filtered and solvent evaporated. The crude product was purified by chromatography on silica gel (80 g column, 30% EtOAc:isohexane to 50%) to afford the sub-title compound (1 g) as a clear yellow oil. 1H NMR (400 MHz, CDCl3) delta 7.80 (t, 1H), 7.53 (t, 1H), 7.18 (dd, 1H), 3.89 (s, 3H), 3.75 (t, 2H), 3.71-3.63 (m, 6H), 3.59-3.53 (m, 2H), 3.40 (s, 3H), 3.22 (t, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-(2-methoxyethoxy)ethane, other downstream synthetic routes, hurry up and to see.

Electric Literature of 54149-17-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54149-17-6, name is 1-Bromo-2-(2-methoxyethoxy)ethane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 66 Preparation of (4bR,8aR,9R)-N-(3-(2-(2-methoxyethoxy)ethoxy)pyridin-4-yl)-ll- methyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthren-3-amine (66), hydrochloride salt Step 1. Synthesis of 4-chloro-3-(2-(2-methoxyethoxy)ethoxy)pyridine, A mixture of 4-chloropyridin-3-ol (100 mg, 0.772 mmol), l-bromo-2-(2- methoxyethoxy)ethane (141 mg, 0.772 mmol) and CS2CO3 (503 mg, 1.544 mmol) in dimethylacetamide (5 mL) was irradiated in a microwave at 120 C for two hours. The reaction mixture was cooled to room temperature and poured into 20 mL of water. The aqueous solution was extracted with ethyl acetate 3×20 mL. The organic layer was combined, was washed with brine (50 mL), was dried over anhydrous sodium sulfate, was filtered and was concentrated. The crude product was purified via flash column chromatography on silica gel to afford 4-chloro-3-(2-(2-methoxyethoxy)ethoxy pyridine (87.4 mg, 48.9%). MS (EI) for C10H14CINO3: 232.0 (MH+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-(2-methoxyethoxy)ethane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NEKTAR THERAPEUTICS; ANAND, Neel; AURRECOECHEA, Natalia; CHENG, Lin; DENG, Bo-liang; O’MAHONY, Donogh; MU, Yongqi; KROGH-JESPERSEN, Erik; (215 pag.)WO2016/182840; (2016); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 54149-17-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 54149-17-6, name is 1-Bromo-2-(2-methoxyethoxy)ethane, This compound has unique chemical properties. The synthetic route is as follows.

Example 9 Synthesis of 2,7-Dibromo-9,9-bis(3,6-dioxaheptyl)-fluorene Benzyltriethylammonium chloride (3.19 g, 14 mmole, 0.077 eq) and 2,7-dibromofluorene (59 g, 182 mmole, 1 eq) were suspended in 178 mL DMSO. 50% aqeous NaOH (80 mL) was added. 1-Bromo-2-(2-methoxyethoxy)ethane (80 g, 437 mmole, 2.4 eq) was then added in small portions. The reaction was stirred at room temperature for 2 hours before it was stopped and the aqueous layer was extracted with ether. The combined ether layers were washed with water five times and dried over Na2SO4. The organic layer was filtered, evaporated to dryness, and the residual was flash chromatographed on a silica-gel column to give 73 g of the pure compound in a yield of 86%.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-2-(2-methoxyethoxy)ethane. I believe this compound will play a more active role in future production and life.

Reference:
Patent; 3M Innovative Properties Company; US7094902; (2006); B2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 54149-17-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 54149-17-6 as follows.

To a solution of m-toluidine (lOg, 9.3mmol) in DMF (lOmL), 1-bromo-2-(2- methoxyethoxy)ethane (0.85g, 4.6mmol) and diisopropylamine (1.2g, 0.93mmol) was added. The mixture was heated to 100C for 4h. The mixture was diluted with ethyl acetate and water, and the layers were separated. The organic layer was dried over anhydrous sodium sulfate and filtered. The filtrate was then concentrated. The residue was purified by column chromatography (silica, heptane/ethyl acetate) to afford the desired product (650mg, 66%) as an oil. ?H NMR (300 MHz, CDC13) oe 7.07 (t, J 7.5, 1H), 6.56 (d, J 7.5, 1H), 6.52 – 6.45 (m, 2H), 3.71 (t, J= 5.3, 2H), 3.67 – 3.62 (m, 2H), 3.60 – 3.52 (m, 2H), 3.31 (t, J= 5.3, 2H), 2.28 (s, 3H); ESI MS m/z 210 [M + Hj.

According to the analysis of related databases, 54149-17-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PROMEGA CORPORATION; DUELLMAN, Sarah; ROBERS, Matthew, B.; WALKER, Joel, R.; ZHOU, Wenhui; ZIMPRICH, Chad; (230 pag.)WO2016/210294; (2016); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 54149-17-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54149-17-6, name is 1-Bromo-2-(2-methoxyethoxy)ethane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Preparation of 1-[2-(2-methoxy-ethoxy)-ethyl]-5-nitro-1,2-dihydro-indazol-3-one A mixture of 5-nitro-1,2-dihydro-indazol-3-one (399 mg, 2.22 mmol), 1-bromo-2-(2-methoxy-ethoxy)-ethane (454 muL, 3.34 mmol), potassium iodide (370 mg, 2.22 mmol) and 1N sodium hydroxide solution (6.7 mL, 6.7 mmol) in 2 ml dioxane was stirred at 60 C. overnight. The reaction mixture was then cooled, poured into 50 mL H2O and 300 L 10N NaOH was added. The aqueous layer was extracted with CH2Cl2 and then acidified to ~pH 2 with 6N aqueous HCl. The aqueous layer was extracted with ethyl acetate. The combined organic layer dried over MgSO4, filtered and evaporated. The residue was purified by flash chromatography to afford the product 1-[2-(2-methoxy-ethoxy)-ethyl]-5-nitro-1,2-dihydro-indazol-3-one (380 mg, 61%). ES-MS calcd for C12H15N3O5 (m/e) 281.26, obsd 282.17 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-(2-methoxyethoxy)ethane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bolin, David Robert; Cai, Jianping; Goodnow, JR., Robert Alan; US2009/163546; (2009); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 54149-17-6, name is 1-Bromo-2-(2-methoxyethoxy)ethane, A new synthetic method of this compound is introduced below., COA of Formula: C5H11BrO2

0.058 mmol of hydroxystyrene was put into a 500 ml round-bottom flask, 50 ml of acetonitrile was added thereto to dissolve the hydroxystyrene, and then 0.07 1 mol ofpotassium t-butoxide was added dropwise to the flask, and the resulting solution was refluxed for 1 hout Subsequently, 0.076 mol of 1 -bromo-2-(2-methoxyethoxy)ethane was slowly added dropwise to the resultant and then refluxed in a nitrogen atmosphere for 6 hours to allow a reaction to occur therebetween. Afier the reaction was completed, the reaction product was neutralized with an aqueous hydrochloric acid solution, and then an organic layer was extracted with ethyl acetate/a saturated aqueous solution of a base, and the organic layer was dried with anhydrous magnesium sulfate and filtered to remove any remaining moisture. Thereafter, the solvent was removed under reduced pressure and, as a result, 10 g (96%) of a title compound represented by Formula (ii) below was obtained as a pale brown liquid. ?H NMR spectroscopic data of the purified 1 -(2-(2-methoxyethoxy)ethoxy)-4-vinylbenzene (ii) is as follows:

The synthetic route of 54149-17-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LG Chem, Ltd.; Kim, Min Soo; Choi, Won Mun; Joe, Dae June; (13 pag.)US2018/244819; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 54149-17-6, name is 1-Bromo-2-(2-methoxyethoxy)ethane, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 54149-17-6, category: ethers-buliding-blocks

Aniline (1.61g, 17.3mmol), potassium carbonate (9.56g, 69.2mmol), potassium iodide (1.43g,8.65mmol) and 1bromo2(2methoxyethoxy)ethane (9 .50g, was suspended 51.9 mmol) in dry DMF (5.0mL), it washeated at 80 C 24 hours. After allowed to cool to room temperature, ethyl acetate (200 mL) was added and the aqueouswas washed successively with saturated brine. The organic phase was dried over anhydrous magnesium sulfate, and thefiltrate was concentrated under reduced pressure. Crude was purified by silica gel column chromatography to give 4.27g ofcompound 14 as a colorless oily substance. 83% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-2-(2-methoxyethoxy)ethane, and friends who are interested can also refer to it.

Reference:
Patent; Kyushu University; Shinkai, Seiji; Noguchi, Takao; (37 pag.)JP2016/196447; (2016); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem