Category: 622-86-6

Morgan, David L. published the artcileEnd-Quenching of TiCl4-Catalyzed Quasiliving Polyisobutylene with Alkoxybenzenes for Direct Chain End Functionalization, Product Details of C8H9ClO, the main research area is polyisobutylene alkoxybenzene end quenching.

Alkoxybenzenes were used to end-quench TiCl4-catalyzed quasiliving isobutylene polymerizations initiated from 2-chloro-2,2,4-trimethylpentane or 5-tert-butyl-1,3-di(1-chloro-1-methylethyl)benzene at -70 °C in 40/60 (volume/volume) hexane/methyl chloride. The alkoxybenzene/chain end molar ratios were in the range 2.5-4. Effective alkoxybenzene quenchers included those with simple alkyl groups, such as anisole and isopropoxybenzene, haloalkyl tethers, such as (3-bromopropoxy)benzene and (2-chloroethoxy)benzene, and even those with hydroxyl and amine functionality, such as 4-phenoxy-1-butanol and 6-phenoxyhexylamine. Alkylation was generally quant. and occurred exclusively in the para position; multiple alkylations on the same alkoxybenzene were not observed The alkylation reactions were tolerant of temperatures ranging from -70 to -30 °C and were unimpeded by the presence of endo- or exo-olefin termini. In situ cleavage of the ether linkage of anisole and isopropoxybenzene termini allowed single pot syntheses of phenol-terminated polyisobutylenes.

Macromolecules (Washington, DC, United States) published new progress about Polymerization. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Product Details of C8H9ClO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ali, Shoukath M. published the artcileEndoxifen is a new potent inhibitor of PKC: A potential therapeutic agent for bipolar disorder, Recommanded Product: (2-Chloroethoxy)benzene, the main research area is endoxifen preparation PKC inhibitor bipolar disorder.

Protein kinase C (PKC) plays a major role in regulation of both pre and postsynaptic neurotransmission. Excessive activation of PKC results in symptoms related to bipolar disorder. Tamoxifen, a widely used breast cancer drug is known to inhibit PKC and demonstrate antimanic properties in human. We describe herein the synthesis of endoxifen, a tamoxifen active metabolite and compared its PKC inhibitory activity with that of tamoxifen. Endoxifen exhibited fourfold higher potency compared to tamoxifen.

Bioorganic & Medicinal Chemistry Letters published new progress about Antipsychotics. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Recommanded Product: (2-Chloroethoxy)benzene.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Aranapakam, Venkatesan published the artcileSynthesis and Structure-Activity Relationship of N-Substituted 4-Arylsulfonylpiperidine-4-hydroxamic Acids as Novel, Orally Active Matrix Metalloproteinase Inhibitors for the Treatment of Osteoarthritis, Category: ethers-buliding-blocks, the main research area is arylsulfonylpiperidinehydroxamic acid preparation matrix metalloproteinase inhibitor structure activity.

A series of novel and orally active N-substituted 4-benzenesulfonylpiperidine-4-carboxylic acid hydroxyamide derivatives have been synthesized and their structure-activity relationships determined Among the several compounds synthesized, I turned out to be a potent, selective, and an orally active MMP inhibitor in the clin. relevant advanced rabbit osteoarthritis model. Pharmacokinetics and metabolism data are reported.

Journal of Medicinal Chemistry published new progress about Antiarthritics. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kawashima, Yutaka published the artcileStructure-activity studies of 3-benzoylpropionic acid derivatives suppressing adjuvant arthritis, Application In Synthesis of 622-86-6, the main research area is antiarthritic benzoylpropionate.

3-Benzoylpropionic acid derivatives possess an immunomodulative activity and suppress adjuvant arthritis. To understand how substituents affect the biol. activity, the quant. structure-activity relationships of 30 compounds were analyzed by the adaptive least-squares method. For the suppressing activity in rats, the electronic effects and the structural feature of the substituent on benzene ring were suggested to be important. To reinforce and confirm the correlation, 4 addnl. compounds of phenoxybutyric acid derivatives were synthesized and tested with the rat adjuvant-induced arthritis. These compounds were found to have potent suppressing activity.

Chemical & Pharmaceutical Bulletin published new progress about Antiarthritics. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Application In Synthesis of 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Childers, Wayne published the artcileNovel compounds that reverse the disease phenotype in Type 2 Gaucher disease patient-derived cells, Computed Properties of 622-86-6, the main research area is structure preparation compound reversing phenotype Gaucher disease; Diphenylethanono; Gaucher disease; Lysosomal storage disease; Neuronopathic; Phenotypic screening.

Gaucher disease (GD) results from inherited mutations in the lysosomal enzyme β-glucocerobrosidase (GCase). Currently available treatment options for Type 1 GD are not efficacious for treating neuronopathic Type 2 and 3 GD due to their inability to cross the blood-brain barrier. In an effort to identify small mols. which could be optimized for CNS penetration we identified tamoxifen from a high throughput phenotypic screen on Type 2 GD patient-derived fibroblasts which reversed the disease phenotype. Structure activity studies around this scaffold led to novel mols. that displayed improved potency, efficacy and reduced estrogenic/antiestrogenic activity compared to the original hits. Here we present the design, synthesis and structure activity relationships that led to the lead mol. Compound 31.

Bioorganic & Medicinal Chemistry Letters published new progress about Gaucher disease. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Computed Properties of 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Richter, Reinhard published the artcileDimethylformamide-catalyzed decarboxylation of alkyl chloroformates. A synthesis of primary alkyl chlorides, COA of Formula: C8H9ClO, the main research area is alkyl chloroformate decarboxylation DMF catalyst; chloride alkyl.

Chloroformates prepared from primary aliphatic alcs. readily decompose on heating with catalytic amounts of DMF, thereby giving CO2 and ∼90% alkyl chlorides RCl [R = Me(CH2)nCH2 (n = 5, 8, 10), Me(CH2)7CH:CH(CH2)7CH2, PhOCH2CH2, BuCHEtCH2], Cl2Z [Z = (CH2)10, cis- and trans-1,4-cyclohexanediyldimethylene, 1,4-CH2C6H4CH2, CH2CCCH2] and I. Reactions at 3-5° yield formimidate chlorides as labile intermediates which dissociate on heating into DMF and alkyl chlorides. Formimidates II (X = Cl, BF4) were prepared from trans-1,4-bis(hydroxymethyl)cyclohexane.

Journal of Organic Chemistry published new progress about Decarboxylation. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, COA of Formula: C8H9ClO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Felfoldi, K. published the artcileChemistry of 1,3-bifunctional compounds. XXIV. Preparation and pharmacology of cycloalkylaminopropyl trimethoxybenzoates, Application of (2-Chloroethoxy)benzene, the main research area is cycloalkylaminopropyl trimethoxybenzoate preparation pharmacol.

Nineteen title compounds I (R = CHMe2, CH2Ph, CH2CH2CHPh2, etc.; n = 1,2,3, or 4) were synthesized by reaction of aminoalcs. with 3,4,5-trimethoxybenzoyl chloride [4521-61-3] and were tested for various pharmacol. activities. I (R = CH2CH:CHPh, n = 1, ·HCl [41788-00-5] was the most active compound; it had significant vasodilatory activity in the isolated rat heart.

Acta Physica et Chemica published new progress about Bronchodilators. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Application of (2-Chloroethoxy)benzene.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Glennon, Richard A. published the artcileIdentification and exploitation of the σ-opiate pharmacophore, Formula: C8H9ClO, the main research area is alkylation reduction phenylpropylamine; amine alkylmethylphenylethyl sigma receptor; benzeneethanamine alkylmethyl psychotomimetic sigma receptor; benzomorphan receptor binding; phenylpropylamine alkyl psychotomimetic sigma receptor; reduction alkylation phenylpropylamine; psychotomimetic sigma receptor phenylpropylamine alkyl; sigma receptor psychotomimetic phenylpropylamine alkyl; structure activity phenylpropylamine benzomorphan.

Reductive alkylation of PhCH2CH(NH2)Me gave (R)- and (S)-RR1NCHMeCH2Ph [I; R = Et, Pr, Bu, CH2Ph, CHMePh, CH2CH2Ph, (CH2)3Ph, (CH2)4Ph, (CH2)5Ph, C:CHPh, CH2OPh, etc.; R1 = H, Me]. E.g., alkylation of (R)-PhCH2CH(NH2)Me with PhCH2CH2CHO gave (R)-PhCH2CH2CH2NHCHMeCH2Ph. I were tested for their affinity to σ-receptors and their psychotomimetic activity; the structure-activity relationship was discussed. The role of I as a component of a benzomorphan structure was studied; the presence of a 1-phenyl-2-aminopropane nucleus was sufficient for binding at the σ-site, provided that the terminal amine is not a tertiary amine.

Journal of Medicinal Chemistry published new progress about Psychotomimetics. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Formula: C8H9ClO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Horton, Martin N. published the artcileSynthesis of [D5-ethyl]-tamoxifen; a mechanistic probe of tamoxifen induced hepatic DNA adduct formation, Related Products of ethers-buliding-blocks, the main research area is tamoxifen deuterated.

Tamoxifen which incorporates a fully deuterated Et group, [D5-ethyl]-tamoxifen, has been synthesized in order to probe the mechanism of tamoxifen induced hepatic DNA adduct formation. The pentadeuteroethyl group was introduced into the tamoxifen structure by treatment of the ketone precursor 1-[4-(2-chloroethoxy)phenyl]-2-phenylethanone, as its sodium enolate, with [D5]-iodoethane.

Journal of Labelled Compounds and Radiopharmaceuticals published new progress about tamoxifen deuterated. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Related Products of ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Van Velzen, P. N. T. published the artcileIon structures and relaxation of vibrationally excited ions as studied by photodissociation, Quality Control of 622-86-6, the main research area is photodissociation spectra phenol hexene.

Photodissociation spectra of the m/2 94 ions from PhOH, PhOEt, bicyclo[2.2.2]oct-2-ene-5,7-dione, and 2-phenoxyethyl chloride were given. The spectra of the ions from the bicyclo compound and from 2-phenoxyethyl chloride were essentially different from those of the ions from PhOH and PhOEt. The two different spectra were ascribed to structures I and II, resp. The photodissociation spectra of 1-hexene is strongly pressure dependent suggesting the existence of an ion mixture

Lecture Notes in Chemistry published new progress about photodissociation spectra phenol hexene. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Quality Control of 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem