Category: 6972-61-8

Antipyretic activity of cinnamyl derivatives and related compounds in influenza virus-infected mice was written by Kurokawa, Masahiko;Kumeda, Cristina A.;Yamamura, Jun-ichi;Kamiyama, Tomoko;Shiraki, Kimiyasu. And the article was included in European Journal of Pharmacology in 1998.COA of Formula: C11H12O4 This article mentions the following:

Kakkon-to is composed of seven medicinal herbs and exhibited novel antipyretic activity by suppressing interleukin-1α production responsive to interferon in a murine intranasal influenza virus infection model. Using this model, antipyretic compounds with such novel biol. activities were characterized from the herbs. The organic solvent-extractable fractions of Cinnamomum cassia among the herbs showed antipyretic activity. The authors selected six antipyretic compounds from 48 cinnamyl derivatives and related compounds that may be mainly involved in the fractions. Their antipyretic activity was significantly correlated with interleukin-1α regulatory activity. Four of them suppressed interleukin-1α production to a basal level and showed different mode of antipyretic action from that of aspirin in interleukin-1α-injected mice. Structure-bioactivity relation of the four suggested that an ester bond played an important role for both antipyretic and interleukin-1α regulatory activities. These compounds may be useful in analyzing interleukin-1α-producing cells in fever production and the mechanism of defervescence by suppressing interferon-induced interleukin-1α production In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8COA of Formula: C11H12O4).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.COA of Formula: C11H12O4

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Ether | (C2H5)2O – PubChem

Identification and analysis of free and O-glycoside-bound volatile components in wild Rosa roxburghii juice was written by Zhou, Zhi;Wang, Xing-ping;Luo, Zu-you;Fan, Gang;Tian, Cheng;Tang, Qiao-yu;Pan, Si-yi. And the article was included in Shipin Kexue (Beijing, China) in 2012.Reference of 6972-61-8 This article mentions the following:

Wild Rosa roxburghii juice from Xuan En, E’ Zhou was extracted by headspace solid-phase microextraction (HS-SPME) to obtain free volatile components, and adsorbed with Amberlite XAD-2 column and hydrolyzed with β-glucosidase to release O-glycoside-bound volatile components. Both volatile compounds were analyzed by gas chromatog.-mass spectroscopy (GC-MS). The results indicated that there was a significant difference observed in the composition and contents of free volatile components and O-glycoside-bound volatile components. In total 38 free volatile compounds and 38 O-glycoside-bound volatile compounds were identified. The major free volatile compounds were (+)-limonene, leaf alc., Et butyrate, hexanol, styrene, Et isovalerate, 2,4-di-tert-butylphenol, γ-terpinene, β-myrcene, β-ocimene, 3-hexenyl butyrate, linalool, octanoic acid, Et caprylate and (-)-dipentene. Meanwhile, the major O-glycoside-bound volatile compounds were 4-hydroxycinnamic acid, 4’5′-dimethyl-2′-hydroxyacetophenone, octanoic acid, cinnamic acid, 2,4-di-tert-butylphenol, 3,4-dimethoxycinnamic acid, benzyl alc., hexanoic acid, 3,4,5-trimethoxyphenol, leaf alc. and 4-hydroxy-3-methoxycinnamic acid. In addition, 33 compounds were found only in the O-glycoside-bound volatile components, which were benzyl alc., phenylethyl alc., neroli, cinnamic acid, vanillic acid, 3-hydroxybutyric acid Et ester, eugenol, and so on. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Reference of 6972-61-8).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Reference of 6972-61-8

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Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor was written by Polepally, Prabhakar R.;Huben, Krzysztof;Vardy, Eyal;Setola, Vincent;Mosier, Philip D.;Roth, Bryan L.;Zjawiony, Jordan K.. And the article was included in European Journal of Medicinal Chemistry in 2014.Synthetic Route of C11H12O4 This article mentions the following:

The neoclerodane diterpenoid salvinorin A is a major secondary metabolite isolated from the psychoactive plant Salvia divinorum. Salvinorin A has been shown to have high affinity and selectivity for the κ-opioid receptor (KOR). To study the ligand-receptor interactions that occur between salvinorin A and the KOR, a new series of salvinorin A derivatives bearing potentially reactive Michael acceptor functional groups at C-2 was synthesized and used to probe the salvinorin A binding site. The κ-, δ-, and μ-opioid receptor (KOR, DOR and MOR, resp.) binding affinities and KOR efficacies were measured for the new compounds Although none showed wash-resistant irreversible binding, most of them showed high affinity for the KOR, and some exhibited dual affinity to KOR and MOR. Mol. modeling techniques based on the recently-determined crystal structure of the KOR combined with results from mutagenesis studies, competitive binding, functional assays and structure-activity relationships, and previous salvinorin A-KOR interaction models were used to identify putative interaction modes of the new compounds with the KOR and MOR. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Synthetic Route of C11H12O4).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Synthetic Route of C11H12O4

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Biological synthesis and anti-inflammatory activity of arylalkylamine was written by Song, Min Kyung;Lee, Su Jin;Kang, Yoon Young;Lee, Youngshim;Mok, Hyejung;Ahn, Joong-Hoon. And the article was included in Applied Biological Chemistry in 2017.Product Details of 6972-61-8 This article mentions the following:

Hydroxycinnamic acid amides (HCAAs) are natural compounds with antifungal, anticancer, and anti-inflammatory activities. Extraction from plants and chem. synthesis have been the major approaches to obtain these compounds We used a biol. method to synthesize HCAA derivatives (arylalkylamines). Two genes, SHT encoding serotonin N-hydroxycinnamoyl transferase and 4CL encoding 4-coumaroyl-CoA ligase, were introduced into Escherichia coli. Using this E. coli transformant as a biocatalyst, 24 arylalkylamines were synthesized. The anti-inflammatory activities of five synthesized compounds, including N-p-coumaroyl phenethylamine, N-caffeoyl phenethylamine, N-p-coumaroyl 3-phenylpropylamine, N-p-coumaroyl 4-phenylbutylamine, and N-p-coumaroyl 4-methoxyphenethylamine, were measured. Among them, N-p-coumaroyl 4-phenylbutylamine showed the best anti-inflammatory activity. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Product Details of 6972-61-8).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Product Details of 6972-61-8

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Quantitative structure-activity relationship (QSAR) studies on the inhibition of porcine pancreatic amylase by cinnamic acid derivatives was written by Ramanan, P. N.;Kutty, A. V. Moiden;Rao, M. N. A.. And the article was included in Indian Journal of Biochemistry & Biophysics in 1987.Recommanded Product: 6972-61-8 This article mentions the following:

The inhibition of porcine pancreatic α-amylase by cinnamic acid derivatives with various substitutions on the Ph ring was studied. Quant. correlation by regression anal. showed that hydrophobicity of the substituents was important for the inhibitory activity. Ionization studies showed that all of the compounds were present in highly ionized form at pH 7.4. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Recommanded Product: 6972-61-8).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Recommanded Product: 6972-61-8

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Synthesis of 3,3-diarylpropionic acids using phosphoric acid as catalyst was written by Elsworth, J. F.;Lamchen, M.. And the article was included in Journal of the South African Chemical Institute in 1972.Recommanded Product: 3-(2,4-Dimethoxyphenyl)acrylic acid This article mentions the following:

Phenols and their Me ethers, in the presence of 85% H3PO4, readily add to the β-C atom of cinnamic acids bearing a MeO group in either the ortho or para positions on the phenyl group, to give high yields of 3,3-diarylpropionic acids. If an ortho HO group is present on the addend, the propionic acid can lactonize to yield a 4-aryldihydrocoumarin. The product from addition of 2,4-dimethoxycinnamic acid to anisole is capable reacting nucleophilically with more 2,4-dimethoxycinnamic acid to yield a bispropionic acid. A truxillic acid is obtained when 3,4-dimethoxycinnamic acid is either warmed with H3PO4 or shaken with m-xylene in the presence of H3PO4. The methoxycinnamic acid is initially protonated by H3PO4 and the derived quinonoid structure is susceptible to attack by nucleophiles. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Recommanded Product: 3-(2,4-Dimethoxyphenyl)acrylic acid).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Recommanded Product: 3-(2,4-Dimethoxyphenyl)acrylic acid

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A convenient synthesis of β-amino acid was written by Basheeruddin, K.;Siddiqui, Amin A.;Khan, Naseem H.;Saleha, S.. And the article was included in Synthetic Communications in 1979.Category: ethers-buliding-blocks This article mentions the following:

RCH:CHCO₂H [I; R = Ph, (Z)-CO₂H, (E)-CO₂H, Bz, 2,4-(MeO)₂C₆H₃, 2-MeOC₆H₄, 4-MeOC₆H₄, 3,4-(CH₂O₂)C₆H₃, 4,3-(MeO)(HO)C₆H₃] were treated with NH₂OH to give RCH(NHOH)CH₂CO₂H (II), which were hydrogenated over Pd/C to give the corresponding DL-RCH(NH₂)CH₂CO₂H. I (R = p-O₂NC₆H₄) was treated with NH₂OH to give II (R = p-O₂NC₆H₄), which was hydrogenated over Pd/C to give DL–p-H₂NC₆H₄CH(NH₂)CH₂CO₂H. I (R = PhCH:CH) was converted to DL-PhCH(NH₂)CH₂CH(NH₂)CO₂H by the above reactions. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Category: ethers-buliding-blocks).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Category: ethers-buliding-blocks

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Ether | (C2H5)2O – PubChem

Hypocholesterolemic and choleretic effects of three dimethoxycinnamic acids in relation to 2,4,5-trimethoxycinnamic acid in rats fed with a high-cholesterol/cholate diet was written by Serna, Manuel;Wong-Baeza, Carlos;Santiago-Hernandez, Juan-Carlos;Baeza, Isabel;Wong, Carlos. And the article was included in Pharmacological Reports in 2015.Application of 6972-61-8 This article mentions the following:

2,4,5-Trimethoxycinnamic acid (2,4,5-TMC) is the major and non-toxic metabolite of α-asarone, which retains hypocholesterolemic and choleretic activities. We compared the activities of 2,4,5-TMC with those of 2,4-dimethoxycinnamic acid (2,4-DMC), 3,4-DMC and 3,5-DMC, to understand the role of the methoxyls on carbons 2, 4 and 5 on the pharmacol. properties of these compounds The methoxycinnamic acids were administered to high-cholesterol/cholate-fed rats. We measured bile flow, and quantified bile acids, phospholipids and cholesterol in bile, and cholesterol and cholesterol-lipoproteins in serum. The inhibition of HMG-CoA reductase by the methoxycinnamic acids was evaluated in vitro. The four methoxycinnamic acids decreased serum cholesterol, without affecting the concentration of HDL-cholesterol. 2,4,5-TMC produced the highest decrease in LDL-cholesterol, 73.5%, which exceeds the range of statins (20-40%), and produced the highest inhibition of the activity of HMG-CoA reductase. 3,4-DMC produced the highest increase in bile flow, bile acids and phospholipids concentrations, and reduction in bile cholesterol, which led to a decrease in the biliary cholesterol saturation index.2,4,5-TMC (which has three methoxyls) had the highest hypocholesterolemic activity, while 3,4-DMC, which lacks the methoxyl in carbon 2 but conserves the two other methoxyls in an adjacent position, had the highest choleretic activity and a probable cholelitholytic activity. In methoxycinnamic acids with two methoxyls in non-adjacent positions (2,4-DMC and 3,5-DMC), the hypocholesterolemic and choleretic activities were not as evident. 2,4,5-TMC and 3,4-DMC, which did not cause liver damage during the treatment period, should be further explored as a hypocholesterolemic and choleretic compounds in humans. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Application of 6972-61-8).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Application of 6972-61-8

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Ether – Wikipedia,
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