Category: 81616-80-0

On November 19, 1992, Achard, Daniel; Moutonnier, Claude; Peyronel, Jean Francois; Tabart, Michel; Truchon, Alain published a patent.Product Details of 81616-80-0 The title of the patent was Preparation of thiopyranopyrrole derivatives as substance P antagonists. And the patent contained the following:

The preparation of perhydrothiopyranopyrroles and oxide derivatives I [Z = O, NH; R1 = (un)substituted Ph, cyclohexadienyl, naphthyl, heterocyclyl; R2 = H, halo, alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxy, alkylthio, acyloxy, carboxy, alkoxycarbonyl, benzyloxycarbonyl, amino, acylamino; n = 0-2], stereoisomers and their mixtures, and salts is claimed. The compounds are particularly interesting as substance P antagonists. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Product Details of 81616-80-0

The Article related to thiopyranopyrrole perhydro preparation antagonist substance p, perhydrothiopyranopyrrole preparation antagonist substance p, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Product Details of 81616-80-0

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Ether – Wikipedia,
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On June 30, 1996, Mutti, S.; Daubie, C.; Decalogne, F.; Fournier, R.; Montuori, O.; Rossi, P. published an article.Safety of (S)-2-(2-Methoxyphenyl)propanoic acid The title of the article was A convenient synthesis of (S)-(+)-2-(2-methoxyphenyl)propanoic acid. And the article contained the following:

A short, convenient and large scale synthesis of (S)-(+)-2-(2-methoxyphenyl)propanoic acid, involving a resolution of the corresponding racemic acid with quinine, is reported. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Safety of (S)-2-(2-Methoxyphenyl)propanoic acid

The Article related to propanoic acid methoxyphenyl preparation, methoxyphenylpropanoic acid preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Safety of (S)-2-(2-Methoxyphenyl)propanoic acid

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Ether – Wikipedia,
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On September 29, 1992, Senanayake, Chris H.; Bill, Timothy J.; Larsen, Robert D.; Leazer, John; Reider, Paul J. published an article.Name: (S)-2-(2-Methoxyphenyl)propanoic acid The title of the article was Rabbit liver esterase-mediated enantioselective synthesis of 2-arylpropanoic acids. And the article contained the following:

A novel enzymic resolution of o-substituted 2-arylpropanoic acids I (R = H, iodo, Me, OMe) using rabbit liver esterase is described. The (R)-enantiomer is obtained by enzymic hydrolysis of the Et ester whereas the (S)-enantiomer is obtained by enzyme mediated enantioselective transesterification of allyl propionates to their corresponding Me esters. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Name: (S)-2-(2-Methoxyphenyl)propanoic acid

The Article related to arylpropanoic acid resolution enzymic, arylpropionate allyl transesterification esterase mediated, hydrolysis arylpropionate esterase mediated, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Name: (S)-2-(2-Methoxyphenyl)propanoic acid

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Ether – Wikipedia,
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On January 31, 1992, Fadel, Antoine published an article.Application In Synthesis of (S)-2-(2-Methoxyphenyl)propanoic acid The title of the article was Optically active arylpropionic acids from the stereoselective alkylation of chiral imide enolates. And the article contained the following:

The chiral imides (3-arylacetyl-4-isopropyl/benzyl-2-oxazolidinones I (R = Q, R1 = H, R3 = CHMe2, CH2 Ph), II (R = Q, R1 = H, R2 = 4-CHEtMe, 2,3-4-MeO, R3 = CHMe2), and III (R = Q, R1 = H, R3 = CHMe2) were alkylated via their imide enolates with Me iodide; subsequent removal of the chiral auxiliary provided readily, with high stereoselectivity, the (S)-2-arylpropionic acids I, II, and III (R = OH), in good yield. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Application In Synthesis of (S)-2-(2-Methoxyphenyl)propanoic acid

The Article related to arylacetyloxazolidinone preparation stereoselective alkylation, stereoselective methylation arylacetyloxazolidinone, arylpropionic acid optically active, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Application In Synthesis of (S)-2-(2-Methoxyphenyl)propanoic acid

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On April 15, 2022, Yu, Jianfei; Zhu, Haowei; Zhang, Xumu; Chen, Gen-Qiang published an article.Computed Properties of 81616-80-0 The title of the article was Development of C2-Symmetric Chiral Diphosphine Ligands for Highly Enantioselective Hydrogenation Assisted by Ion Pairing. And the article contained the following:

A new series of C2-sym. chiral ferrocene-based diphosphino-ethane ligands termed as f-DPE, I (R = Ph, Me CH2Ph, 2-MeOC6H4, 3-MeOC6H4, 4-MeOC6H4) were developed. Assisted by the ion pairing interaction with the ligand, a wide scope of 2-substituted acrylic acids was hydrogenated to obtain chiral propanoic acids. with high yields and enantioselectivities. The well-known anti-inflammatory drugs ibuprofen, naproxen, and flurbiprofen could be synthesized efficiently. In addition, the synthetic utilities of the current method were demonstrated by gram-scale experiments The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Computed Properties of 81616-80-0

The Article related to propanoic acid preparation enantioselective, acrylic acid hydrogenation chiral diphosphine ferrocene catalyst, sym chiral ferrocene diphosphinoethane ligand preparation catalyst and other aspects.Computed Properties of 81616-80-0

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Ether – Wikipedia,
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On June 6, 1996, Achard, Daniel; Peyronel, Jean-Francois; Tabart, Michel published a patent.Formula: C10H12O3 The title of the patent was Perhydroisoindole derivatives as antagonists of substance p. And the patent contained the following:

New perhydroinsoindoles having the general formula I wherein R1 is optionally substituted Ph or is cyclohexadienyl, naphthyl, indenyl or mono or polycyclic heterocyclyl, saturated or unsaturated 5 to 9C and optionally substituted, R2 is H or halogen, OH, alkyl, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkyloxy, alkylthio, acyloxy, carboxy, alkyloxycarbonyl, dialkylaminoalcyloxycarbonyl, benzyloxycarbonyl, amino or acylamino, R3 is Ph optionally substituted in position -2 by a radical alkyl or alkyloxy 1 or 2C or by OH or F, or disubstituted by CF3, and R4 is an alkyl radical containing 1 or 2C substituted by halogen or CN, N3 or -NHCN, and the radicals R which are similar or different represent H, alkyl or Ph, in their isomer forms having the structure II or mixtures thereof, optionally their salts when they exist and preparation thereof. The new derivatives of the invention are particularly useful as antagonists of substance P. The derivative II (R = H, R1 = Me, R2 = R3 = 2-MeOC6H4, R4 = CH2OH) was prepared via acylation of (卤)-III with (S)-(2-MeOC6H4)CHMeCO2H in CH2Cl2 containing hydroxybenzotriazole hydrate and EtN:C:N(CH2)3NMe2. The antiinflammatory activity of several II were tested with a DE50 mg/kg p.o. range of 0.004-1. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Formula: C10H12O3

The Article related to substance p antagonist preparation, perhydroisoindole derivative preparation bioactivity, isoindole perhydro derivative preparation bioactivity, nk2 receptor antagonist preparation and other aspects.Formula: C10H12O3

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Ether – Wikipedia,
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On May 6, 2016, Li, Jing; Shen, Jiefeng; Xia, Chao; Wang, Yanzhao; Liu, Delong; Zhang, Wanbin published an article.Recommanded Product: 81616-80-0 The title of the article was Asymmetric Hydrogenation of 伪-Substituted Acrylic Acids Catalyzed by a Ruthenocenyl Phosphino-oxazoline-Ruthenium Complex. And the article contained the following:

Asym. hydrogenation of various 伪-substituted acrylic acids was carried out using RuPHOX-Ru as a chiral catalyst under 5 bar H2, affording the corresponding chiral 伪-substituted propanoic acids in up to 99% yield and 99.9% ee. The reaction could be performed on a gram-scale with a relatively low catalyst loading (up to 5000 S/C), and the resulting product (97%, 99.3% ee) can be used as a key intermediate to construct bioactive chiral mols. The asym. protocol was successfully applied to an asym. synthesis of dihydroartemisinic acid, a key intermediate required for the industrial synthesis of the antimalarial drug artemisinin. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Recommanded Product: 81616-80-0

The Article related to chiral propanoic acid preparation, asym hydrogenation acrylic acid ruthenocenyl phosphino oxazoline complex catalyst, dihydroartemisinic acid synthon synthesis antimalarial drug artemisinin and other aspects.Recommanded Product: 81616-80-0

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Mandrelli, Francesca; Blond, Aurelie; James, Thomas; Kim, Hyejin; List, Benjamin published an article in 2019, the title of the article was Deracemizing α-Branched Carboxylic Acids by Catalytic Asymmetric Protonation of Bis-Silyl Ketene Acetals with Water or Methanol.Electric Literature of 81616-80-0 And the article contains the following content:

We report a highly enantioselective catalytic protonation of bis-silyl ketene acetals. Our method delivers α-branched carboxylic acids, including nonsteroidal anti-inflammatory arylpropionic acids such as Ibuprofen, in high enantiomeric purity and high yields. The process can be incorporated in an overall deracemization of α-branched carboxylic acids, involving a double deprotonation and silylation followed by the catalytic asym. protonation. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Electric Literature of 81616-80-0

The Article related to alpha branched carboxylic acid catalytic asym protonation deracemization, enantioselective catalytic protonation bissilyl ketene acetal, brønsted acids, bis-silyl ketene acetals, deracemization, deuteration, disulfonimide, protonation and other aspects.Electric Literature of 81616-80-0

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Ether – Wikipedia,
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On May 29, 1991, Dubroeucq, Marie Christine; Moutonnier, Claude; Peyronel, Jean Francois; Tabart, Michel; Truchon, Alain published a patent.Application In Synthesis of (S)-2-(2-Methoxyphenyl)propanoic acid The title of the patent was Preparation of 2-(phenylacetyl)-7,7-diphenylperhydroisoindol-4-ones and analogs as substance P antagonists. And the patent contained the following:

Title compounds [I; R = H; RR = bond; R4 = Ph, halophenyl, tolyl; R5 = C(:X)CHR1R2; R1 = (un)substituted Ph, alkyl, alkoxy, etc.; R2 = H, halo, OH, alkyl, etc.; X = O, S, NR3; R3 = H, dialkylamino, (un)substituted alkyl] were prepared Thus, 4,4-diphenyl-2-cyclohexenone was cyclocondensed with PhCH2N(CH2OBu)CH2SiMe3 to give, after debenzylation and optical resolution, (3aR, 7aR)-I (R = H, R4 = Ph) (II; R5 = H) which was condensed with 2-(Me2N)C6H4CH2CO2H to give II [R5 = COCH2C6H4(NMe2)-2]. The latter gave 80% inhibition of behavioral effects induced by substance P at 10 mg/kg s.c. I drug formulations were prepared The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Application In Synthesis of (S)-2-(2-Methoxyphenyl)propanoic acid

The Article related to isoindolone acyldiphenylperhydro substance p antagonist, analgesic acyldiphenylperhydroisoindolone preparation, antiinflammatory acyldiphenylperhydroisoindolone preparation, antiallergic acyldiphenylperhydroisoindolone preparation, nervous system agent acyldiphenylperhydroisoindolone preparation and other aspects.Application In Synthesis of (S)-2-(2-Methoxyphenyl)propanoic acid

Referemce:
Ether – Wikipedia,
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