Category: 81616-80-0

On January 17, 1997, Commercon, Alain; Lebrun, Alain; Mailliet, Patrick; Peyronel, Jean Francois; Sounigo, Fabienne; Truchon, Alain; Zucco, Martine; Cheve, Michel published a patent.SDS of cas: 81616-80-0 The title of the patent was New benzisoindole derivatives as inhibitors of farnesyl transferase, their preparation, and pharmaceutical compositions containing them.. And the patent contained the following:

Title compounds I [R = (un)substituted (CH2)mX1(CH2)nZ; X1 = bond, O, S; m = 0-1; n = 0-2; Z = CO2H, alkoxycarbonyl, (un)substituted carbamoyl, etc.; R1, R2 = H, halo, alkyl, (un)substituted alkoxy; or R1R2 form (un)saturated heterocycle; or R2 forms dimer via disulfide bridge; R3 = H, halo, alkyl, alkenyl, alkoxy, alkylthio; X = O, S, NH, CO, CH2, CH2CH2, alkylene, 1,1-cycloalkanediyl; Y = O, S], in racemic form or as optical isomers, are claimed. The compounds are inhibitors of farnesyl transferase, and show marked antitumor and antileukemic properties. For example, cis-3,6-diphenyl-1,4-cyclohexadienecarboxylic acid Me ester (preparation given) reacted with PhCH2N(CH2OBu)(CH2SiMe3) in refluxing CF3CO2H to give the intermediate hexahydroisoindole derivative II.HCl, which was further cyclized by CF3SO3H at 5-20�to give the benz[f]isoindole intermediate III. This was then converted in 3 steps to title compound IV. In an assay for inhibition of farnesyl transferase, IV had an IC50 of 0.31 渭M. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).SDS of cas: 81616-80-0

The Article related to benzisoindole preparation farnesyl transferase inhibitor antitumor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.SDS of cas: 81616-80-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 18, 2001, Li, Zuyi; Wu, Zhongliu published a patent.Quality Control of (S)-2-(2-Methoxyphenyl)propanoic acid The title of the patent was Rhodococcus sp. d12 and its culture method and application. And the patent contained the following:

The Rhodococcus sp.D12 (CGMCC Number0497) is prepared by culturing in culture medium at 15-40° for 1-3 d, culturing again in culture liquid at 15-40° for 1-3 d, washing with physiol. saline, and centrifugating or filtering. The culture medium comprises C source 0-20, N source 1-15, 0.5-5 g L-1 phosphate buffer 0-10, NaCl 0-1, microelement 0-5, and agar 10-40 g L-1, and its pH is 3-8. The culture liquid is composed of C source 0-20, N source 1-15, 0.5-5 g L-1 phosphate buffer 0-10, NaCl 0-1, microelement 0-5, and inducer 0.2-10 g L-1, and its pH is 3-8. The C source is selected from glucose, sucrose, fructose, maltose, lactose, xylose, soluble starch, ethanol, Na succinate, mannitol, and soluble dextrin. The N source is selected from yeast extract, beef extract, soya extract, peptone, L-Glu, (NH4)2SO4, NH4Cl, or NH4NO3. The inducer is benzamide, urea, acetonitrile, methacrylonitrile, methacrylamide, isobutyric acid, butyronitrile, acrylamide, formamide, or propionic acid. The microelement is Zn, Mn, Co, Ni, Mg, Fe, Ca, Cu, or B. The Rhodococcus sp. D12 is used as hydrolytic catalyst of nitrile compounds The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Quality Control of (S)-2-(2-Methoxyphenyl)propanoic acid

The Article related to rhodococcus nitrile compound hydrolysis acid amide, Fermentation and Bioindustrial Chemistry: Pharmaceuticals (Including Nutrients) and other aspects.Quality Control of (S)-2-(2-Methoxyphenyl)propanoic acid

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On October 28, 1993, Achard, Daniel; Grisoni, Serge; Malleron, Jean Luc; Peyronel, Jean-francois; Tabart, Michel published a patent.Application In Synthesis of (S)-2-(2-Methoxyphenyl)propanoic acid The title of the patent was Perhydroisoindole derivatives as substance P antagonists and their preparation. And the patent contained the following:

Title compounds I [R = Ph optionally substituted with halogen or Me in position 2 or 3; R1 = (un)substituted Ph, cyclohexadienyl, naphthyl, indenyl, heterocyclyl; R2 = H, halo, OH, alkyl, aminoalkyl, CO2H, amino, etc.; R3 = Ph optionally substituted in position 2 by C1-2 alkyl or alkoxy; R4 = F, OH; R5 = H; or R4 = R5 = OH; or R4R5 = bond] and their stereoisomers, isomer mixtures, and salts, are claimed (40 synthetic examples). For example, N-acylation of [3a(S),4(S),7a(S)]-7,7-diphenyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol (prepared in 4 steps) with (S)-2-(MeO)C6H4CHMeCO2H (prepared in 3 steps) using EDCI in CH2Cl2 gave title compound II. The ED50 of II for inhibition of increased capillary permeability induced by septide (a substance P agonist) in guinea pigs was 0.04 mg/kg i.v. or 3.5 mg/kg p.o. II also countered hypotension and bronchoconstriction induced by substance P in guinea pigs. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Application In Synthesis of (S)-2-(2-Methoxyphenyl)propanoic acid

The Article related to perhydroisoindole preparation substance p antagonist, isoindole perhydro preparation substance p antagonist, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application In Synthesis of (S)-2-(2-Methoxyphenyl)propanoic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 9, 1995, Achard, Daniel; Grisoni, Serge; James-Surcouf, Evelyne; Malleron, Jean-Iuc; Morgat, Anne; Peyronel, Jean-Francois; Sabuco, Jean-Francois; Tabart, Michel published a patent.Related Products of 81616-80-0 The title of the patent was Preparation of N-acyl-4-hydroxyperhydroisoindoles as substance P antagonists. And the patent contained the following:

Title compounds [I; 1 of R = H, OH, (hydroxy)alkyl and the other = H, (hydroxy)alkyl, Ph; R1 = Ph, alkyl, alkoxy, etc.; R2 = H, halo, OH, alkyl,alkoxy, etc.; R3 = (un)substituted Ph; R4 = OH; R4 = F when R5,R15 = H or alkyl; 1 of R5,R15 = H, OH, alkyl and the other = H or alkyl; R4R5 = bond; R6 = H, OH, (hydroxy)alkyl] were prepared Thus, 5-methylcyclohex-2-en-1-one was cyclocondensed with PhCH2N(CH2OBu)CH2SiMe3 and the product condensed with BuLi-treated PhOMe to give, after deprotection and N-acylation by (S)-2-(MeO)C6H4CHMeCO2H, title compound (3aR*,4R*,6S*,7aS*)-II which had ED50 of 0.07mg/kg i.v. for inhibition of substance P-induced capillary permeability in monkeys. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Related Products of 81616-80-0

The Article related to acylhydroxyperhydroisoindole preparation substance p antagonist, isoindole acylhydroxyperhydro preparation substance p antagonist, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 81616-80-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On October 28, 1993, Achard, Daniel; Grisoni, Serge; Malleron, Jean Luc; Peyronel, Jean-francois; Tabart, Michel published a patent.Application In Synthesis of (S)-2-(2-Methoxyphenyl)propanoic acid The title of the patent was Perhydroisoindole derivatives as substance P antagonists and their preparation. And the patent contained the following:

Title compounds I [R = Ph optionally substituted with halogen or Me in position 2 or 3; R1 = (un)substituted Ph, cyclohexadienyl, naphthyl, indenyl, heterocyclyl; R2 = H, halo, OH, alkyl, aminoalkyl, CO2H, amino, etc.; R3 = Ph optionally substituted in position 2 by C1-2 alkyl or alkoxy; R4 = F, OH; R5 = H; or R4 = R5 = OH; or R4R5 = bond] and their stereoisomers, isomer mixtures, and salts, are claimed (40 synthetic examples). For example, N-acylation of [3a(S),4(S),7a(S)]-7,7-diphenyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol (prepared in 4 steps) with (S)-2-(MeO)C6H4CHMeCO2H (prepared in 3 steps) using EDCI in CH2Cl2 gave title compound II. The ED50 of II for inhibition of increased capillary permeability induced by septide (a substance P agonist) in guinea pigs was 0.04 mg/kg i.v. or 3.5 mg/kg p.o. II also countered hypotension and bronchoconstriction induced by substance P in guinea pigs. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Application In Synthesis of (S)-2-(2-Methoxyphenyl)propanoic acid

The Article related to perhydroisoindole preparation substance p antagonist, isoindole perhydro preparation substance p antagonist, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application In Synthesis of (S)-2-(2-Methoxyphenyl)propanoic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 9, 1995, Achard, Daniel; Grisoni, Serge; James-Surcouf, Evelyne; Malleron, Jean-Iuc; Morgat, Anne; Peyronel, Jean-Francois; Sabuco, Jean-Francois; Tabart, Michel published a patent.Related Products of 81616-80-0 The title of the patent was Preparation of N-acyl-4-hydroxyperhydroisoindoles as substance P antagonists. And the patent contained the following:

Title compounds [I; 1 of R = H, OH, (hydroxy)alkyl and the other = H, (hydroxy)alkyl, Ph; R1 = Ph, alkyl, alkoxy, etc.; R2 = H, halo, OH, alkyl,alkoxy, etc.; R3 = (un)substituted Ph; R4 = OH; R4 = F when R5,R15 = H or alkyl; 1 of R5,R15 = H, OH, alkyl and the other = H or alkyl; R4R5 = bond; R6 = H, OH, (hydroxy)alkyl] were prepared Thus, 5-methylcyclohex-2-en-1-one was cyclocondensed with PhCH2N(CH2OBu)CH2SiMe3 and the product condensed with BuLi-treated PhOMe to give, after deprotection and N-acylation by (S)-2-(MeO)C6H4CHMeCO2H, title compound (3aR*,4R*,6S*,7aS*)-II which had ED50 of 0.07mg/kg i.v. for inhibition of substance P-induced capillary permeability in monkeys. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Related Products of 81616-80-0

The Article related to acylhydroxyperhydroisoindole preparation substance p antagonist, isoindole acylhydroxyperhydro preparation substance p antagonist, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 81616-80-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On January 31, 1985, Matsumoto, Takashi; Imai, Sachihiko; Miuchi, Shigekazu; Sugibayashi, Hidenori published an article.Computed Properties of 81616-80-0 The title of the article was The total synthesis of (15R)- and (15S)-16-hydroxyferruginol. And the article contained the following:

(15R)- And (15S)-16-hydroxyferruginol (I; R = Me, R1 = H; R = H, R1 = Me; resp.) were totally synthesized via optical resolution of the phenylpropanoic acid II (R2 = H, R3 = CO2H), Wittig condensation of II (R2 = CH2PPh3Cl, R3 = CH2OMe) with (S)-(-)-α-cyclocitral, and cyclization. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Computed Properties of 81616-80-0

The Article related to hydroxyferruginol synthesis configuration, diterpene hydroxyferruginol, ferruginol hydroxy preparation absolute configuration, Terpenes and Terpenoids: Diterpenes (C20), Including Gibberellins, Retinoids, Quassinoids, and Tocopherols and other aspects.Computed Properties of 81616-80-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On December 21, 2001, Wu, Zhong-Liu; Li, Zu-Yi published an article.COA of Formula: C10H12O3 The title of the article was Enantioselective hydrolysis of various racemic α-substituted arylacetonitriles using Rhodococcus sp. CGMCC 0497. And the article contained the following:

The enantioselective hydrolysis of 17 racemic α-substituted arylacetonitriles by Rhodococcus sp. CGMCC 0497 is described. The corresponding (R)-amides and (S)-acids were obtained with excellent enantiomeric excess in most cases. The effect of steric and electronic factors on the outcome of the reactions are discussed here. The results prove that nitrile-converting enzymes are efficient tools for the synthesis of sterically unencumbered chiral α-arylpropionic acids and amides. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).COA of Formula: C10H12O3

The Article related to enantioselective hydrolysis arylacetonitrile rhodococcus, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.COA of Formula: C10H12O3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On August 3, 1995, Grisoni, Serge; Huon, Christian; Peyronel, Jean-Francois published an article.HPLC of Formula: 81616-80-0 The title of the article was 4,4-Diphenyl-7-perhydrothiapyrano[3,4-c]pyrrolone, a new series of substance P receptors antagonists. And the article contained the following:

The synthesis of 4,4-diphenyl-7-perhydrothiapyrano[3,4-c]pyrrolones, a new series of substance P antagonists with high affinity for rat and human NK1 receptors is described. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).HPLC of Formula: 81616-80-0

The Article related to diphenylperhydrothiapyranopyrrolone substance p receptor antagonists, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.HPLC of Formula: 81616-80-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 19, 1992, Achard, Daniel; Moutonnier, Claude; Peyronel, Jean Francois; Tabart, Michel; Truchon, Alain published a patent.Electric Literature of 81616-80-0 The title of the patent was Preparation and reactions of thiopyranopyrroles and oxide derivatives. And the patent contained the following:

Title compounds I [R = H, allyl, or CR1R2R3, where R1 and R2 are H, (un)substituted Ph (with halo, alkyl, alkyloxy, NO2), and R3 is defined as for R1 or R2 or alkyl or alkyloxyalkyl, where at least one R1-3 is (un)substituted Ph, and n = 0-2], and isomers, are prepared by N-deprotection of the appropriate perhydrothiopyranopyrrole. Salts, isomers, and mixtures of isomers of these compounds are claimed. The above compounds are reacted with alkanoic acids R4CHR5CO2H [e.g., (2-methoxyphenyl)acetic acid] or with an imide analog to give claimed compounds N-substituted I [R = C(:Z)CHR4R5, n = 0-2, Z = O or NH, R4 = (un)substituted Ph (with halo, amino, alkylamino, etc., R5 = H, halo, OH, alkyl, etc.]. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Electric Literature of 81616-80-0

The Article related to thiopyranopyrrole oxide perhydro preparation reaction, perhydrothiopyranopyrrole oxide preparation reaction, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Electric Literature of 81616-80-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem