Category: 91-16-7

Synthetic Route of 91-16-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 91-16-7, name is 1,2-Dimethoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

The cooled solution of veratrol (32 ml) and acetic acid (125 ml) was slowly added to a cooled solution of methanol (20 ml) and acetaldehyde (21 ml). The mixed solution was thoroughly stirred for 1 hour, then concentrated sulthric acid (95%, 125 ml) was added over 2 hours and reacted with stirring for 20 hours. Afier the reaction was completed, the reaction mixture was poured into ice water to terminate the reaction. The reaction mixture was filtered, washed with water and subjected to colunm chromatography using chloroform as a developing solution to obtain isolated 2,3,6,7-tetrakis(methoxy)-9, 1 0-dimethylanthracene (1)

The chemical industry reduces the impact on the environment during synthesis 1,2-Dimethoxybenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY; SUH, Donghack; CHOI, Kyounghwan; (106 pag.)US2019/31586; (2019); A1;,
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Synthetic Route of 91-16-7,Some common heterocyclic compound, 91-16-7, name is 1,2-Dimethoxybenzene, molecular formula is C8H10O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

That is,A 30 mL Schlenk tube was charged with 1,2-dimethoxybenzene (76 muL, 0.6 mmol)GO containing 50.66 w% of oxygen (100 mg)And boron trifluoride-ethyl ether complex (2.0 mL, 16.2 mmol) were charged,And reacted at 60 C. for 8 hours.Here, in GO,The amount of potassium permanganate to be used at the time of synthesis of GO is set to 5 times the amount of potassium permanganate used in Example 7 is used.After the reaction, the GO was crushed with ultrasonic waves, and the filtrate was suction filtered while washing with chloroform, the filtrate was separated with chloroform and water, the organic layer was filtered with folded folded paper and the solvent was distilled off under reduced pressure with an evaporator And dried under reduced pressure. The yield was 83%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,2-Dimethoxybenzene, its application will become more common.

Reference:
Patent; OKAYAMA UNIVERSITY; NISHINA, YUTA; MORIOKU, KUMIKA; (13 pag.)JP2017/31106; (2017); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 91-16-7, name is 1,2-Dimethoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 91-16-7, Recommanded Product: 91-16-7

General procedure: A mixture of aldehyde 2 (1.0 mmol), aromatic compound 1(2.0 mmol) and BAILs (0.2 mmol) was stirred at 40?C for the desired time. The reaction was monitored by thin layer chromatography(TLC). After the completion of the reaction, 1 ml of water was added into the reaction mixture, and the target compound was obtained though simple filtration. The pure ionic liquids got by drying the filtrate were reused for another cycle. Synthesis route is listed in Scheme 2.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Wang, Ailing; Zheng, Xueliang; Zhao, Zhuangzhi; Li, Changping; Cui, Yingna; Zheng, Xuefang; Yin, Jingmei; Yang, Guang; Applied Catalysis A: General; vol. 482; (2014); p. 198 – 204;,
Ether – Wikipedia,
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Electric Literature of 91-16-7, These common heterocyclic compound, 91-16-7, name is 1,2-Dimethoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A type B crystal of 2,3,6,7,10,11-hexahydroxytriphenylene monohydrate was synthesized according to the process described in Synthesis, 477, 1994 and JP-A-8-119894. Namely, 1,2-dimethoxybenzene (31.78 g, 0.23 moles) and anhydrous ferric chloride (120 g, 0.74 moles) were dissolved in 70% sulfuric acid, and the solution was reacted at 25C for 24 hours with stirring. After completion of the reaction, the solution was poured into ice water (500 g), and the precipitated crystal was collected by filtration. After the resultant crystal was washed with water (1 L), and then dried to give pale purple colored 2,3,6,7,10,11-hexamethoxytriphenylene (28.2 g, theoretical yield from 1,2-dimethoxybenzene: 90.1%) (the method of Synthesis, 477, 1994).

The synthetic route of 91-16-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Wako Pure Chemical Industries, Ltd.; EP2177495; (2010); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

91-16-7, name is 1,2-Dimethoxybenzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 1,2-Dimethoxybenzene

Preparation A 1,2-dibromo-4,5-dimethoxybenzene 16.16 g of 1,2-dimethoxybenzene (117 mmol) are stirred at 0 C. in CCl4 (120 mL). 13.2 mL of dibromine (2.2 eq; 257.4 mmol; 41.13 g) dissolved in CCl4 (25 mL) are added dropwise (30 min) whilst monitoring the temperature (0-5 C.) [Fit an outlet which bubbles into a solution of Na2CO3 in order to neutralise the hydrobromic acid which forms]. After stirring for 2 hours at 0 C., the reaction mixture is then poured onto a mixture of water+ice, and the organic phase is washed with aqueous 10% NaHSO3 solution and then with aqueous 10% NaOH solution. After evaporation and drying, 33.42 g of a white solid corresponding to the title product are obtained. Yield=97% m.p. 92-93 C. 1H NMR (CDCl3): delta=7.06 (s; 2H); 3.86 (s; 6H). 13C NMR (CDCl3): delta=148.8; 115.9; 114.7; 56.2.

The synthetic route of 91-16-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Les Laboratoires Servier; Vaysse-Ludot, Lucile; Le Flohic, Alexandre; Vaultier, Michel; Pucheault, Mathieu; Kaminski, Thomas; US8859763; (2014); B1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 91-16-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 91-16-7, name is 1,2-Dimethoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

The cooled solution of veratrol (32 ml) and acetic acid (125 ml) was slowly added to a cooled solution of methanol (20 ml) and acetaldehyde (21 ml). The mixed solution was thoroughly stirred for 1 hour, then concentrated sulthric acid (95%, 125 ml) was added over 2 hours and reacted with stirring for 20 hours. Afier the reaction was completed, the reaction mixture was poured into ice water to terminate the reaction. The reaction mixture was filtered, washed with water and subjected to colunm chromatography using chloroform as a developing solution to obtain isolated 2,3,6,7-tetrakis(methoxy)-9, 1 0-dimethylanthracene (1)

The chemical industry reduces the impact on the environment during synthesis 1,2-Dimethoxybenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY; SUH, Donghack; CHOI, Kyounghwan; (106 pag.)US2019/31586; (2019); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 91-16-7, name is 1,2-Dimethoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 91-16-7, category: ethers-buliding-blocks

A solution of 1,2-dimethoxybenzene (10 g, 72.4 mmol) in dichloromethane(50 ml) was added dropwise to a suspension of anhydrous FeCl3 (35.22 g, 217.2 mmol) in dichloromethane (100 ml) and concentrated sulphuric acid (0.5 ml). After complete addition (15 min), the reaction mixture was further stirred for 3 h at room temperature. 200 ml of methanol were then slowly added under vigorous stirring. The obtained mixture was further stirred for additional 30 min. And the precipitate was filtered off, washed with methanol (5 × 100 ml) and dried under reduced pressure to give a purple solid. Yield: 80%, 1HNMR (CDCl3) delta/ppm: 4.10 (s, 18H, OCH3), 7.80 (s, 6H, ArH).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Dimethoxybenzene, other downstream synthetic routes, hurry up and to see.

Application of 91-16-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 91-16-7 name is 1,2-Dimethoxybenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Under nitrogen atmosphere, to a suspension of 4-chlorobutyrylchloride (4.0 mL, 36.1 mmol), 1,2-dimethoxybenzene (23.1 mL,180.9 mmol) in dichloromethane (60 mL) was added portionwisealuminum chloride (5.8 g, 43.4 mmol) at 0 C. The resulting suspensionwas stirred for 3 h at 25 C. The reaction was quenched bypouring the reaction mixture into an ice/water mixture. Theresulting aqueous solution was extracted with dichloromethane(3), and the organic layer was washed with water and brine, driedwith Na2SO4, and concentrated in vacuo. The crude residue wasthen purified by chromatography on silica gel (gradient of EtOAc inpetroleum ether) to afford the title compound 26 as a pale yellowsolid. (Yield 7.9 g, 90%). Rf 0.4 (EtOAc/petroleum ether 1:4).1HNMR (300 MHz, CDCl3, d): 2.13e2.22 (m, 2H), 3.09 (t, 2H, J 6.9 Hz),3.63 (t, 2H, J 6.0 Hz), 3.89 (s, 3H), 3.91 (s, 3H), 6.85 (d, 1H,J 8.4 Hz), 7.49 (d, 1H, J 2.1 Hz), 7.57 (dd, 1H, J 8.4 Hz, J 1.8 Hz).13C NMR (75 MHz, CDCl3, d): 27.1, 34.8, 44.8, 56.0, 56.7, 110.0, 110.6,122.7, 130.0, 149.0, 153.3, 197.5. HRMS (ESI): m/z calcd forC12H16O3Cl [MH]: 243.0788; found 243.0787.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,2-Dimethoxybenzene, and friends who are interested can also refer to it.

Reference:
Article; Azzouz, Rabah; Peauger, Ludovic; Gembus, Vincent; ?in?a?, Mihaela-Liliana; Papamicael, Cyril; Levacher, Vincent; Sopkova-de Oliveira Santos, Jana; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 165 – 190;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem