Category: ethers-buliding-blocks

Synthetic Route of 15799-79-8, The chemical industry reduces the impact on the environment during synthesis 15799-79-8, name is 3-Methoxy-N,N-dimethylaniline, I believe this compound will play a more active role in future production and life.

[0109] (R)-3-(4-Nitro-phenyl)-3-(4-dimethylamino-2-methoxy-phenyl)-propionaldehyde (Table 1, entry 9): To a 2-dram vial equipped with a magnetic stir bar was added (2S,5S)-5-benzyl-2-tert-butyl-3-methylimidazolidin-4-one (24.6 mg, 0.100 mmol, 0.100 equiv), N,N-dimethyl-m-anisidine hydrochloride (18.8 mg, 0.100 mmol, 0.100 equiv), CH2Cl2 (1.00 ml), and N,N-dimethyl-m-anisidine (425 uL, 2.90 mmol, 2.90 equiv). The solution was cooled to -10o C. before p-nitro-cinnamaldehyde (177 mg, 1.00 mmol, 1.00 equiv) was added as a solid. After 48 h, the reaction mixture was subjected directly to silica gel chromatography. Gradient elution with 10-50% EtOAc in hexanes followed by concentration in vacuo afforded the product as a bright orange oil in 87% yield (285 mg, 0.867 mmol); 92% ee. IR (film) 2938, 2894, 2837, 2726, 1722, 1614, 1516, 1345, 1241, 1120, 1033, 980.1, 858.6, 814.9 cm-1; 1HNMR (300 MHz, CDCl3) ?9.74 (t, J=1.9 Hz, 1H, CHO), 8.12 (td, J=2.2, 9.3 Hz, 2H, ArH), 7.42 (td, J=1.5, 9.3 Hz, 2H, ArH), 6.97 (d, J=8.3 Hz, 1H, ArH), 6.30 (dd, J=2.5, 8.8 Hz, 1H, ArH), 6.24 (d, J=2.2 Hz, 1H, ArH), 4.98 (t, J=7.8 Hz, 1H, ArCH), 3.79 (s, 3H, OCH3), 3.21-3.09 (m, 2H, CH2CO), 2.96 (s, 6H, N(CH3)2); 13C NMR (75 MHz, CDCl3) ?201.2, 157.8, 152.3, 151.4, 146.5, 128.9, 128.6, 123.8, 118.0, 104.8, 96.4, 55.4, 48.4, 40.8, 38.2. HRMS (CI) exact mass calcd for (C18H20N2O4) requires m/z 328.1423, found m/z 328.1422. [?]D=0.58.1 (c=1.0, CHCl3). [0110] The enantiomeric ratio of the product was determnined by HPLC analysis of the corresponding alcohol (obtained by NaBH4 reduction of the aldehyde) using a Chiracel AD and AD guard column (10% ethanol/hexanes, 1 mL/min); R isomer tr=25.6 min, S isomer tr=29.5 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methoxy-N,N-dimethylaniline, other downstream synthetic routes, hurry up and to see.

Application of 13985-15-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13985-15-4 name is 2,3,6,7-Tetramethoxy-9,10-dimethylanthracene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

FIG. 17 shows schematically the methods by which the substituted precursor compounds were prepared. The tested products are labelled CMR 1 (R1-R4=-OCH3); CMR 4 (R1-R4=-CO2CH3); and CMR 6 (R1-R4?N-substituted cyclic imido).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,3,6,7-Tetramethoxy-9,10-dimethylanthracene, and friends who are interested can also refer to it.

Related Products of 10484-56-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10484-56-7 name is 2-Butoxynaphthalene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A flame dried Schlenk flask was charged with Bi(OTf)3 (13.1 mg,0.020 mmol), alkyl aryl ethers (0.40 mmol), alcohols or thiols (1.2 mmol) andCH2ClCH2Cl (0.20 mL), and then the resulting mixture was stirred at 110 C (or 130 C forthe synthesis of 1m) for 24 h. The solvent was removed under the reduced pressure, andthe residue was subjected to flash column chromatography on silica gel with hexane /AcOEt as eluents to afford the corresponding aryl ethers or aryl thioethers

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Butoxynaphthalene, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 2186-92-7, name is P-anisaldehyde dimethyl acetal, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2186-92-7, HPLC of Formula: C10H14O3

7-Anisaldehyde dimethylacetal (50 mL, 294 mmol, 1.14 equiv) was added to a suspension of a mixture of methyl a-D-glucopyranoside (50 g, 257 mmol) and D- camphorsulfonic acid (1.79 g, 7.72 mmol, 0.03 equiv) in DMF (250 mL). The reaction mixture was stirred at 60 C for 21 h. After cooling to rt, the solution was concentrated under reduced pressure. A saturated sodium bicarbonate aqueous solution (500 mL) was added to the residue and the resulting mixture was stirred for 1 h. The precipitate was filtered and washed with cold aqueous saturated sodium bicarbonate solution (500 mL) to provide methyl 4,6-O-(4-methoxy)benzylidene-a-D-galactopyranoside (78.5 g, 98%) as a colorless solid, mp: 192-194 C; 1H NMR (CD3OD, 600 MHz) delta = 7.40 (d, 2H, J = 8.4 Hz, CH of Ar), 6.88 (d, 2H, J = 8.4 Hz, CH of Ar), 5.51 (s, IH, ArCH), 4.71 (d, IH, J = 3.8 Hz, H- l), 4.18 (dd, IH, J = 8.1 Hz, 3.3 Hz, H-6?), 3.81-3.78 (m, IH, H-4), 3.78 (s, 3H, OCH3 of An), 3.74-3.68 (m, 2H, H-3, H-6P), 3.50 (dd, IH, J = 9.3 Hz, 3.8 Hz, H-2), 3.43-3.40 (m, IH, H-5), 3.42 (s, 3H, OCH3); 13C NMR (CD3OD, 125 MHz) delta = 161.6, 131.5, 128.8, 114.3, 103.0, 102.0, 82.9, 74.1, 72.0, 70.0, 63.9, 55.8, 55.7; HRMS (ESI) Calcd for Ci5H2107 [M+H]+: 313.1287

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Application of 866633-25-2, These common heterocyclic compound, 866633-25-2, name is 2-Bromo-4-fluoro-1-(trifluoromethoxy)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of the aryl bromide (from Step 2 above) (5g) in THF (25 mL) was added Isopropylmagnesium chloride (15 mL, 2.0M in THF) at room temperature. After stirring at the ambient for 2 h, B (OiPr)3 added to the reaction and stirred overnight. The reaction was quenched with IN HCl, stirred at room temperature for 30min and extracted with EtOAc. The residue obtained after removal of the solvent in vacuo, was dissolved in 10% KOH, extracted with ether. The aqueous phase was acidified with concentrated HCl and extracted with EtOAc. The organic layer was dried over Na2SO4 and concentrated to give the aryl boronic acid as a white solid. ¹H NMR (CDCl3) : 7.28-7.32 (m, 1H), 7.17-7.22 (m, 2H) MS (ESI): m/e 225 (M+1)+

Statistics shows that 2-Bromo-4-fluoro-1-(trifluoromethoxy)benzene is playing an increasingly important role. we look forward to future research findings about 866633-25-2.

Reference of 36397-23-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 36397-23-6, name is 3-(4-Methoxyphenyl)propan-1-amine, This compound has unique chemical properties. The synthetic route is as follows.

3-(4-Hydroxyphenyl)propylamine hydrobromide (14). Compound 14 was synthesised according to procedure B from 13 (2.5 g, 0.015 mol) in 75% yield as a light brown solid. 1H NMR (300 MHz, DMSO-d6) delta1.80 (m, 2H), 2.53 (m, 2H), 2.78 (m, 2H), 6.70 (d, 2H), 7.02 (d, 2H), 7.80 (br s, 4H).

The chemical industry reduces the impact on the environment during synthesis 3-(4-Methoxyphenyl)propan-1-amine. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1840-97-7, name is 2,4-Dibromo-1-(trifluoromethoxy)benzene, A new synthetic method of this compound is introduced below., Product Details of 1840-97-7

Add 1008 g of 2,4-dibromotrifluoromethoxybenzene, 5200 mL of DMF to the reaction vessel, and control the temperature to 150 C.Slowly add 774 g of cuprous cyanide solids with stirring.During the addition, the temperature should not exceed 155 C. After the addition, the reaction is stirred and the GC is traced until the reaction is over.After the reaction is completed, it is cooled, and the reaction product is poured into water to analyzeSolid, suction filtration,Extraction with 1,2-dichloroethane, followed by suction filtration, liquid separation, rotary evaporation, drying,Obtained a white powdery solid2,4-dicyanotrifluoromethoxybenzene 326 g,The yield was 49%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 50868-72-9, name is 5-Methoxy-2-methylaniline, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 50868-72-9

3-Fluoro-4-methyl-phenyl chloroformate A mixture of 5-methoxy-2-methyl aniline (5.0 g; 36 mmol), HCl (7.6 mL of a 12 M solution; 91 mmol) and H2O (11 mL) was heated at 60 C. for 15 min until complete dissolution had occurred. The reaction was cooled to 0 C. and an aqueous solution of NaNO2 (2.5 g; 36 mmol) was added dropwise (internal temperature <=7 C.). The reaction was stirred at 0 C. for 30 min and a 0 C. solution of HBF4 (5.3 mL of a 48% solution; 40 mmol) was added cautiously. The reaction was stirred at 0 C. for 20 min, and the resultant brown solid was filtered, washed with ice water (3*10 mL) and H2O (2*10 mL). The solid was dried under high vacuum for 20 h, then heated (heat gun) until evolution of BF3 (white fumes) had ceased. The resulting brown oil was partitioned between EtOAc and H2O. The organic phase was dried (Na2SO4), concentrated in vacuo and distilled by Kugelrohr to give 3-fluoro-4-methyl anisole (1.6 g; 31%) as a colorless oil. According to the analysis of related databases, 50868-72-9, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2186-92-7, name is P-anisaldehyde dimethyl acetal, A new synthetic method of this compound is introduced below., Quality Control of P-anisaldehyde dimethyl acetal

Step a); Methyl 4,6-0-(4-methoxybenzylidene)-alpha-D-glucopyranoside(4); A solution of methyl alpha-D-glucopyranoside (10 g, 51.5 mmol) in dimethylformamide (DMF, 50 ml) was added with a catalytic amount of camphorsulfonic acid (CSA) and anysaldehyde dimethylacetal (ADMA, 10 ml, 51.5 mmol) and the mixture was kept under magnetic stirring and low vacuum to remove the methanol formed during the condensation reaction. After 40 min the solvent was evaporated off. The residue was added with a NaHCO3 saturated solution and the resulting diphasic mixture was kept under vigorous stirring for one hour. The resulting precipitate was filtered and washed with an ice-cold bicarbonate solution (100 ml). The residue was triturated in hexane to afford compound 4 as a white solid (15 g, 94%). 4: Rf = 0,31 (EtOAc/MeOH/H2O 7:2:1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 14593-43-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14593-43-2 name is ((Allyloxy)methyl)benzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: (2) An ozone-oxygen mixture was bubbled through a solution of 10.00 mmol of ethers Ia or Ib in50 mL of MeOH at -78C until blue color appeared.The reaction mixture was purged with argon, 3.88 g(35.00 mmol) of NH2C(O)NHNH2 HCl. HCl was added at -50C. The mixture was stirred at ambient temperature for 24 h. The reaction mixture was evaporated, the residue was dissolved in 100 mL of CHCl3, washed with 2 (to pH ? 7), and dried with Na2SO4. After evaporation, ether I produced 1.86 g of a mixture of compounds II and IV in 40 : 60 ratio(according to GLC and NMR), column chromatography (Si2, PE, PE : MTBE = 5 : 1, 4 : 1) afforded0.74 g (42%) of ester IIa and 1.09 g (56%) of acetal IV.After evaporation, ether Ib produced 1.64 g of a mixture of compounds IIb and IVb in 25 : 75 ratio (according to GLC and NMR data), column chromatography (Si2, PE, PE : MTBE = 5 : 1, 4 : 1) gave 0.40 g (24%)of ester IIb and 1.15 g (63%) of acetal IVb.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, ((Allyloxy)methyl)benzene, and friends who are interested can also refer to it.