Category: ethers-buliding-blocks

Reference of 112970-44-2, A common heterocyclic compound, 112970-44-2, name is 2-Bromo-3-methoxyaniline, molecular formula is C7H8BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of Intermediate iSA (3.25 g, 16.09 mmol) and potassium 0-ethyl carbonodithioate (6.45 g, 40.2 mmol) in DMF (20 mL) was heated at 135 C under argon for 6.0 h. HPLC and LCMS indicated a completion of the reaction. The mixture was cooled to room temperature, diluted with 20 mL water, followed by addition of 30 mL 1.0 N HC1. The precipitate formed was collected by filtration, washed with water, dried under vacuum and then chased with toluene (3X) to yield Intermediate 15B (3.1 g, 15.71 mmol, 98 % yield) as a brown solid. It was used for the next step without further purification. ?H NMR (500MHz, DMSO-d6) 13.77 (br. s., 1H), 7.38 (t, J=8.1 Hz, 1H), 6.94 (t, J=8.1 Hz, 2H), 3.91 (s, 3H); LC-MS: method A, RT = 1.63 mm, MS (ESI) m/z:198.0(M+H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 150-78-7, name is 1,4-Dimethoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 150-78-7, COA of Formula: C8H10O2

General procedure: a glass tube was filled with Bi(OTf)3 (0.0328 g, 0.05 mmol), [BMIM]OTf (0.1 g), anisole (0.108 g, 1 mmol), and benzoyl chloride (0.281 g, 2 mmol) and reacted at 120 C for 30 min under microwave activation. After cooling, the mixture was extracted with Et2O (3 × 20 mL). The organic layer was decanted, washed with water (10 mL), aqueous NaHCO3 (2 × 20mL), brine (10 mL), and dried over MgSO4. The solvent was removed using a rotary evaporator. Conversion was determined by GC analysis using n-hexadecane as the internal standard. The isolated yield was determined after purification by flash chromatography (n-hexane, then 10 % EtOAc in n-hexane) to give 4-methoxybenzophenone (0.1993 g, 94 % yield). The purity and authenticity of the product were confirmed by GC-MS and 1H NMR spectroscopy. The same procedure was carried out under conventional heating method.

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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4179-19-5, name is 3,5-Dimethoxytoluene, A new synthetic method of this compound is introduced below., Product Details of 4179-19-5

Electrolysis experiments were performed on Vertex Potentiostat/Galvanostat. Both the working electrode and the counter electrode were made of platinum (1.5cm×1.5cm). Ag/Ag+ electrode (0.1mol/L AgNO3 in CH3CN) was employed as the reference electrode. The 0.1mol/L of NaBF4/CH3CN solution (15mL) with 1,3,5-trimethoxybenzene (1a, 0.5mmol, 84mg), 4-chlorothiophenol (2a, 0.6mmol, 86mg) and KI (0.05mmol, 8.3mg) was added into a 25mL undivided beaker and the resulting mixture was stirred at 60C. After completion of the reaction (analysed by GC or TLC), the resulting mixture was concentrated under reduced pressure and purified by column chromatography on 200-300 mesh silica gel using petroleum ether: ethyl acetate (50:1) as eluent to afford (4-chlorophenyl) (2,4,6-trimethoxyphenyl)sulfane (3aa) as a white solid in 90% yield.

The synthetic route of 4179-19-5 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10103-06-7, name is 2,3-Dimethoxynaphthalene, This compound has unique chemical properties. The synthetic route is as follows., category: ethers-buliding-blocks

A mixture of 2,3-dimethoxynaphthalene (1.1 g, 5.85 mmol) was dissolved in 17 mL of dry 1,2-dichloroethane, Acetyl chloride (0.5 mL, 7.0 mmol) was added and AlCl3 (2.1 g, 15.75 mmol) was added in portions at 0 C for 12 hours. 15 g of ice and 5 mL of concentrated hydrochloric acid were added, the organic phase was separated and the aqueous phase was extracted with dichloromethane The organic phase was dried over anhydrous sodium sulfate, concentrated by filtration and separated by flash chromatography on CH2Cl2 to give 6,7-dimethoxy-2-naphthoethanone in 83.6% yield.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 10103-06-7.

Adding a certain compound to certain chemical reactions, such as: 54149-17-6, name is 1-Bromo-2-(2-methoxyethoxy)ethane, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 54149-17-6, HPLC of Formula: C5H11BrO2

The product from step (ii) above (1 g, 4.36 mmol) was dissolved in dry DMF (10 mL) under nitrogen and NaH (0.2 g, 5.00 mmol) added. Stirred for 10 minutes, then 1-bromo-2-(2-methoxyethoxy)ethane (0.75 ml, 5.57 mmol) and NaI (0.065 g, 0.436 mmol) added and stirred at rt for 2.5 h. The mixture was charged again with NaH (0.2 g, 5.00 mmol) and 1-bromo-2-(2-methoxyethoxy)ethane (0.75 ml, 5.57 mmol), stirred for a further 1 h then partitioned between NH4Cl solution (200 mL) and ethyl acetate (100 mL). The organic layer was separated and washed with 20% NaCl soln. (200 mL). The organic layer was separated, dried (MgSO4), filtered and solvent evaporated. The crude product was purified by chromatography on silica gel (80 g column, 30% EtOAc:isohexane to 50%) to afford the sub-title compound (1 g) as a clear yellow oil. 1H NMR (400 MHz, CDCl3) delta 7.80 (t, 1H), 7.53 (t, 1H), 7.18 (dd, 1H), 3.89 (s, 3H), 3.75 (t, 2H), 3.71-3.63 (m, 6H), 3.59-3.53 (m, 2H), 3.40 (s, 3H), 3.22 (t, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-(2-methoxyethoxy)ethane, other downstream synthetic routes, hurry up and to see.

Related Products of 1535-73-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1535-73-5, name is 3-Trifluoromethoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 3- (trifluoromethoxy) aniline (110 mg, 0.624 mmol), pyridine (151 muL, 1.87 mmol) in N, N- dimethylacetamide (3 mL) was added phenyl chloroformate (83.0 muL, 0.625 mmol) with stirring under ice-cooling, and the mixture was stirred at room temperature for 1 hr. 4- [ (5- Methyl-5H-pyrrolo [3, 2-d]pyrimidin-4-yl) oxy] aniline (100 mg, 0.416 mmol) was added to the reaction mixture, and the mixture was stirred at 900C for 15 hr. The reaction mixture was diluted with water, and extracted with ethyl acetate (chi3) . The organic layer was washed with saturated brine, dried over EPO anhydrous magnesium sulfate, and filtrated. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane=10/90->100/0) and recrystallized from ethyl acetate-hexane to give the title compound (74.6 mg, 40%) as a white solid.1H-NMR (DMSO-de, 300 MHz-) delta 4.09 (3H, s) , 6.57 (IH, d, J = 3.0 Hz), 6.93 (IH, d, J = 8.4 Hz), 7.22 (2H, d, J = 8.8 Hz), 7.29(IH, d, J = 8.4 Hz), 7.38 (IH, t, J = 8.4 Hz), 7.51 (2H, d, J = 8.8 Hz), 7.69 (IH, s), 7.75 (IH, d, J = 3.0 Hz), 8.25 (IH, s), 8.83 (IH, s), 9.01 (IH, br s) .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Trifluoromethoxyaniline, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 39021-83-5, name is 1,4-Dimethoxy-2,3-dimethylbenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39021-83-5, Safety of 1,4-Dimethoxy-2,3-dimethylbenzene

Step 2 A solution of 1,4-dimethoxy-2,3-dimethyl-benzene (1 g) in dichloromethane was stirred and cooled in an ice-water bath, and TiCl4 (1.1 mL) was slowly added, followed by the addition of CHCl2OCH3 (0.58 g). The solution was stirred for another 15 min with ice-water bath, 30 min at RT, then 15 min at 35 C. Then the red solution was poured into ice and extract with dichloromethane. Workup and purification by chromatography (silicagel column, eluding with EtOAc/:hexane 1:4) gave 973 mg of 2,5-dimethoxy-3,4-dimethyl-benzaldehyde.

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Some common heterocyclic compound, 27060-75-9, name is 1-Bromo-4-methoxy-2-methylbenzene, molecular formula is C8H9BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 1-Bromo-4-methoxy-2-methylbenzene

General procedure: In a microwave tube were added a suspension of Pd(dba)2 (5mol%), tBu3PHBF4 (10mol%), NaOH (2eq), aryl bromide (1.2eq) and alpha-tetralone (1.0eq) in a mixture of degassed dioxane/water (4:1, v/v, 2-4mL) and heated under Ar and microwave irradiation (100W of initial power, 100C, 60min, infrared probe). Then, the mixture was allowed to cool to rt, diluted in AcOEt, washed with saturated NH4Cl solution, dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The crude material was purified by silica gel column with n-hexane:AcOEt (95:5) as solvent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 27060-75-9, its application will become more common.

These common heterocyclic compound, 1758-46-9, name is 2-Phenoxyethylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2-Phenoxyethylamine

Example s; 2-Isopropyl-4-[(2-phenoxyethyl)amino]-5-phenyIisothiazol-3(2.pound.f)-one 1,1-dioxide EPO A solution of 4-chloro-2~isopropyl-5-phenylisothiazol-3(2H)-one 1,1-dioxide (0.20Og, OJOOmmol), TEA (0.106g, 1.050mmol) and 2-phenoxyethylamine (0.144g, 1.050mmol) in MeCN (3mL) was heated at in a microwave reactor 120°C for 5 mins. The residue was 5 purified by silica gel column chromatography (Horizons Biotage) using a 65:35 mixture of heptane and EtOAc as eluant to give the title compound (0.262g, 97percent); 1H NMR (500 MHz, CDCl3): 87.57-7.54 (m, 2H), 7.49-7.45 (m, 3H), 7.32-7.27 (m, 2H), 7.02-6.97 (m, IH), 6.86- 6.83 (m, 2H), 5.71-5.66 (br m, IH), 4.46-4.39 (m, IH), 3.89 (t 2H), 3.27 (q 2H), 1.60 (d 6H); 13C NMR (125 MHz, CDCl3): delta 158.5, 158.2, 135.6, 131.7, 130.0, 129.8, 129.1, 125.1, 121.8, 10 114.7, 108.0, 65.8, 47.8, 43.6, 20.4; Mass Spectrum: M-H+ 387.

The synthetic route of 2-Phenoxyethylamine has been constantly updated, and we look forward to future research findings.

Application of 645-36-3, A common heterocyclic compound, 645-36-3, name is 2,2-Diethoxyethanamine, molecular formula is C6H15NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixed solution of a commercially available product of 2,2-diethoxyethan-1-amine (926 pL, 6.39 mmol), THF (10.0 mE) and acetic acid (1.00 mE) was added a commercially available product of 6-fluoropyridine-2-carb- aldehyde (800 mg, 6.39 mmol) at room temperature. The resultant mixture was stirred at room temperature for 25 minutes. Subsequently, sodium triacetoxyborohydride (2.71 g, 12.8 mmol) was added to the reaction mixture at room temperature and then stirred for 1 hour and 10 minutes. To the reaction mixture was added sodium hydrogen carbonate and water to terminate the reaction. The resultant solution was extracted with ethyl acetate. An organic layer was dried over anhydrous magnesium sulfate and then filtrated. The solvent was evaporated under a reduced pressure, and the resultant residue was purified by NH silica gel colunm chromatography (heptane:ethyl acetate=1 :1), and was then thrther purified by silica gel column chromatography (ethyl acetate_methanol=20: 1) to give the title compound (1.14 g, yield: 74%).?H-NMR Spectrum (400 MHz, CDC13) oe (ppm):1.22 (6H, t, J=7.2 Hz), 2.76 (2H, d, J=5.5 Hz), 3.50-3.61(2H, m), 3.65-3.76 (2H, m), 3.89 (2H, s), 4.64 (1H, t, J=5.5Hz), 6.80 (1H, dd, J=2.8 Hz, 8.2 Hz), 7.22 (1H, dd, J=2.4 Hz,7.3 Hz), 7.74 (1H, q, J=7.9 Hz)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.