Category: ethers-buliding-blocks

4463-59-6, name is 1-(2-Bromoethoxy)-2-methoxybenzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C9H11BrO2

EXAMPLE 68 4-Benzyl-1-[2-(2-methoxyphenoxy)ethyl]piperidine STR105 From 1-(2-Bromoethoxy)-2-methoxybenzene (515 mg, 2.23 mmol) and 4-benzylpiperidine (785 mg, 4.48 mmol) there was obtained 560 mg (85%) of the amine as a yellowish oil. 1 H NMR (CDCl3): 1.27-1.40 (m, 2H), 1.47-1.58 (m, 1H), 1.62-1.66 (m,2H), 1.99-2.06 (m, 2H), 2.543 (d, 2H, J=7), 2.745 (t, 2H, J=6), 2.95-2.99 (m, 2H), 3.760 (s, 3H), 4.041 (t, 2H, J=6), 6.79-6.85 (m, 4H), 7.13-7.30 (m, 5H). The hydrochloride, mp 165-6 C.

The synthetic route of 4463-59-6 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 332-48-9 as follows. SDS of cas: 332-48-9

EXAMPLE 7Synthesis of 2-(2-(2-(4-fluorophenoxy)ethyl)-2/T-tetrazol-5-yl)-4-methyl-J/V-(pyridin-3-ylmethyl)thiazole-5-carboxamide and 2-(l-(2-(4-fluorophenoxy)ethyl)-l£-r-tetrazol-5-yl)-4-methyl-lambdaf-(pyridin-3-ylmethyl)thiazole-5-carboxamideTo a mixture of 4-methyl-lambdar-(pyridin-3-ylmethyl)-2-(2//-tetrazol-5-yl)thiazole-5- carboxamide (0.10 g, 0.33 mmol) and potassium carbonate (0.069 g, 0.50 mmol) in NJV- dimethylformamide (2 mL) was added l-(2-bromoethoxy)-4-fluorobenzene (0.08 mL, 0.37 mmol). The reaction mixture was stirred at ambient temperature for 17 hours, diluted with ethyl acetate (15 mL) and washed with brine (5 mL). The organic solution was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography (ethyl acetate). Compound 2-(l-(2-(4- fluorophenoxy)ethyl)-lH-tetrazol-5-yl)-4-methyl-lambdar-(pyridin-3-ylmethyl)thiazole-5- carboxamide was first eluted from the column and isolated as a white solid (0.010 g, 7%): 1H NMR (300 MHz, CDCl3) delta 8.61-8.55 (m, 2H), 7.77-7.68 (m, IH), 7.37-7.28 (m, IH), 7.03-6.88 (m, 2H), 6.86-6.74 (m, 2H), 6.49 (t, J= 5.8 Hz, IH), 5.06 (t,J= 5.3 Hz, 2H), 4.65 (d, J= 5.8 Hz, 2H), 4.55 (t, J= 5.3 Hz, 2H), 2.79 (s, 3H); MS (ES+) m/z 440.3 (M + 1 ). Compound 2-(2-(2-(4-fluorophenoxy)ethyl)-2H-tetrazol-5-yl)-4-methyl-N-(pyridin-3- ylmethyl)thiazole-5-carboxamide was second eluted from the column and isolated as a white solid (0.02 g, 14%): mp 137-138 0C (ethyl acetate); 1H NMR (300 MHz, CDCl3) delta 8.59 (br s, IH), 8.54 (br s, IH), 7.76-7.65 (m, IH), 7.35-7.26 (m, IH), 6.94-6.86 (m, 2H), 6.72-6.66 (m, 2H), 6.58 (t, J= 5.8 Hz, IH), 5.31 (t, J= 5.4 Hz, 2H), 4.64 (d, J= 5.8 Hz, 2H), 4.45 (t,J= 5.4 Hz, 2H), 2.72 (s, 3H); 13C NMR (75 MHz, CDCl3) delta 161.3, 160.2, 157.8, 157.2, 153.8, 153.7, 153.7, 149.2, 149.2, 135.8, 127.7, 116.2, 115.9, 115.8, 65.6, 53.0, 41.8, 17.5; MS (ES+) m/z 440.3 (M + 1).

According to the analysis of related databases, 332-48-9, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19500-02-8, name is 3-Methoxy-2-methylaniline, A new synthetic method of this compound is introduced below., Quality Control of 3-Methoxy-2-methylaniline

Part A. Preparation of N-tert-butoxycarbonyl-3-methoxy-2-methylaniline. A solution of 44.4 g (344 mmol) of 3-methoxy-2-methylaniline and 75 g (344 mmol) of di-tert-butyl dicarbonate in 400 mL of THF was heated to maintain reflux for 4 hours. After concentrating at reduced pressure, the residue was taken up in ethyl acetate, washed with 1N citric acid, water and dried (MgSO4). After removing the solvent at reduced pressure, the residue was crystallized from hexane to give 64.5 g (84percent yield) of N-tert-butoxycarbonyl-3-methoxy-2-methylaniline, mp, 56°-57° C. Analysis for C13 H19 NO3: Calculated: C, 65.80; H, 8.07; N, 5.90 Found: C, 63.32; H, 7.83; N, 5.56.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 41864-45-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41864-45-3, name is 4,5-Dimethoxy-2-methylaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The compound 71 (75 mg, 0.223 mmol) was dissolved in acetic acid (0.375 mL). 4,5-Dimethoxy-2-methylaniline (374 mg, 2.23 mmol) was added to the solution. The mixture was stirred at 100C for 3 hours. Water was added to the reaction mixture. The mixture was extracted with ethyl acetate. The organic layer was washed by brine, and dried over sodium sulfate. The solvent was evaporated under reduced pressure. The obtained residue was purified by silica-gel column chromatography (ethyl acetate-n-hexane) to give the compound 1-1264 (19.3 mg, yield 19%). 1H-NMR (DMSO-D6) delta: 1.92 (s, 3H), 3.68 (s, 3H), 3.74 (s, 3H), 5.31 (s, 2H), 6.74 (s, 1H), 6.81 (s, 1H), 7.36 (dd, J = 7.2 Hz, 2H), 9.05 (br, 1H).

The synthetic route of 4,5-Dimethoxy-2-methylaniline has been constantly updated, and we look forward to future research findings.

Synthetic Route of 588-96-5, These common heterocyclic compound, 588-96-5, name is p-Bromophenetole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference Example 3 2-(4-Ethoxybenzyl)phenol A Grignard reagent was prepared from 1-bromo-4-ethoxybenzene (1.5g), magnesium (0.19g), a catalytic amount of iodine and tetrahydrofuran (2mL) in the usual manner. To the obtained Grignard reagent solution was added dropwise a solution of 2-benzyloxybenzaldehyde (1.1g) in tetrahydrofuran (15mL), and the mixture was stirred at room temperature for 30 minutes. To the reaction mixture were added a saturated aqueous ammonium chloride solution (10mL) and water (20mL), and the mixture was extracted with ethyl acetate (100mL). The extract was washed with water (20mL) and brine (20mL), and dried over anhydrous sodium sulfate. Thereafter, the solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate = 5/1) to give a diphenylmethanol compound (1.7g). The obtained diphenylmethanol compound (1.7g) was dissolved in ethanol (25mL). To the solution were added concentrated hydrochloric acid (0.42mL) and a catalytic amount of 10% palladium-carbon powder, and the mixture was stirred under a hydrogen atmosphere at room temperature for 18 hours. The catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure. To the residue was added ethyl acetate (100mL), and the mixture was washed with a saturated aqueous sodium hydrogen carbonate solution (30mL) and brine (30mL). The organic layer was dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate = 8/1) to give 2-(4-ethoxybenzyl)phenol (0.85g). 1H-NMR (CDCl3) delta ppm: 1.39 (3H, t, J=7.1Hz), 3.93 (2H, s), 4.00 (2H, q, J=7.1Hz), 4.72 (1H, s), 6.75-6.85 (3H, m), 6.85-6.95 (1H, m), 7.05-7.20 (4H, m)

Statistics shows that p-Bromophenetole is playing an increasingly important role. we look forward to future research findings about 588-96-5.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 36449-75-9, name is 1-(2-Bromoethyl)-2-methoxybenzene, A new synthetic method of this compound is introduced below., Safety of 1-(2-Bromoethyl)-2-methoxybenzene

General procedure: General synthetic procedure for the final products.The appropriately substituted 4-phenethylpiperidine (6)(0.5 mmol) was dissolved in acetonitrile (5 mL) and K2CO3(0.75 mmol) and the appropriate phenethyl bromide (7) (0.5 mmol) added. The reaction mixture was refluxedfor 8 h.After completion of the reaction (monitored by TLC), the reaction mixture was cooled to ambient temperature and filtered through a Celite pad. The filtrate was concentrated under vacuum to obtain the desired crude product. The crude product was further purified by column chromatography (silica gel: 3-5% methanol in dichloromethane) to afford the corresponding 1,4-diphenethylpiperidine (8a-8y) in good yield (75-80 %), which was then converted to hydrochloride salt by treatment with 2M HCl in diethyl ether.Compounds12a-12dwere synthesized using the same procedure as above, except that an appropriately substituted 4-benzylpiperidine (11) was utilized in place of compound6.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 29578-83-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 29578-83-4, name is 1-Bromo-3-methoxy-5-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows.

To a vigorously stirred mixture of 1-Bromo-3-methoxy-5-methylbenzene (1 g, 4.97 mmol), Pyridine (3.22 ml_, 39.8 mmol) and Water (8 ml) was added in small portions KMnO 4 (3.14g, 19.89 mmol) at 105C. The mixture which turned to a black suspension was stirred 24 hours at 105C, then cooled down to RT and filtered over Hyflo. The black residue was washed several times with EtOAc. The filtrate was then diluted in EtAOc and washed with a 2M solution of HCI. The organic layer was dried over sodium sulfate, filtered and concentrated to afford the title compound (281 mg, 24% yield) as a white solid. MS: 229.1 [M+H]+, Rt (1 ) 1 .18 min.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-3-methoxy-5-methylbenzene. I believe this compound will play a more active role in future production and life.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 588-96-5 as follows. Recommanded Product: 588-96-5

Example 2.1(2-{4-[1 -(4-Ethoxy-phenyl)-piperidin-4-yl1-phenyl)-1 -methyl-ethyl Vacetamide3.0 mL Toluene/tert-butanol (5:1 ) are added to a mixture of 130 mg (0.50 mmol) N-[1 – methyl-2-(4-piperidin-4-yl-phenyl)-ethyl]-acetamide (VIII.1 ), 100 mg (0.50 mmol) 1 – bromo-4-ethoxy-benzene, 80 mg (0.83 mmol) sodium tert-butyrat, 20 mg (0.040 mmol) X-Phos and 10 mg (0.040 mmol) palladium(ll) acetate. The mixture is stirred for 10 min at 150C under microwave irradiation in a sealed tube. After that time, the mixture is poured into 1 mL 0.1 N HCl . 1 mL cone, ammonia is added and the mixture is extracted with ethyl acetate (3x). The combined organic layers are dried over sodium sulphate and the solvent is removed in vacuo. The residue is purified by column chromatography (silica gel; DCM/MeOH 19:1 ) to yield the desired product. C2 H32N2O2 (M = 380.5 g/mol), ESI-MS: 381 [M+H]+

According to the analysis of related databases, 588-96-5, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 2688-84-8, name is 2-Phenoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2688-84-8, HPLC of Formula: C12H11NO

In a dry 25 mL Schlenk reaction tube, 55.6 mg of 2-phenoxyaniline was added.71 mg of 4-methylstyrene, 38.4 mg of sulfur, 35 mg of potassium fluoride and 1.5 mL of dimethyl sulfoxide.Stir at 100 C for 24 hours under nitrogen.After completion of the reaction, the mixture was cooled to room temperature, and the insoluble material was removed by filtration, washed with water and ethyl acetate.Directly through the silica gel column (the ratio of ethyl acetate to petroleum ether is 1:50-1:3),The product was obtained in 88.0 mg, yield 92%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Phenoxyaniline, other downstream synthetic routes, hurry up and to see.

Reference of 1116-77-4, These common heterocyclic compound, 1116-77-4, name is 4,4-Diethoxy-N,N-dimethyl-1-butanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example-2: Preparation of Rizatriptan Benzoate:- l-(4-Hydrazinophenyl)methyl-l52:,4-triazole hydrochloride (7.0 kg.) in Cone. HCl (35.0 It.) is stirred for 30 min at 20-250C, to that water (140.0 It.) is added and stirred for another 30min at 20-250C. 4-(Dimethylamino) butanal diethylacetal (7.10 kg.) is added slowly at 20-250C and stirred for 60 min. The reaction mixture is hated to 70-750C and maintained for 60 min. After completion of reaction, cooled the mass to 3O0C, adjusted the pH to 6.0-6.5 and extracted with methylene chloride (2 x 35 It.). Aq.layer is separated and adjusted the pH to 10-11 and extracted with ethyl acetate (3 x 55 It.). Ethyl acetate is removed under vacuum and the residue is chromatographed on silica gel (55 kg.) and eluted with ethyl acetate (25 It.) followed by methanol (30 It.) to give Rizatriptan as residue. The obtained residue is dissolved in ethanol (15 It.) and pH is adjusted to 6.0- 6.5 with benzoic acid (1.8 kg.) in ethanol (3.5 It ) at 30-350C. The reaction mass is cooled to O0C and stirred for lhr. The product is centrifuged and washed with ethanol ( 3 It) to yield Rizatriptan benzoate (3.0 kg.) with purity >99.0%.

The synthetic route of 1116-77-4 has been constantly updated, and we look forward to future research findings.