Category: ethers-buliding-blocks

On February 29, 2020, Song, Song; Li, Xinyao; Wei, Jialiang; Wang, Weijin; Zhang, Yiqun; Ai, Lingsheng; Zhu, Yuchao; Shi, Xiaomeng; Zhang, Xiaohui; Jiao, Ning published an article.Safety of 2-Methoxynaphthalene The title of the article was DMSO-catalysed late-stage chlorination of (hetero)arenes. And the article contained the following:

A highly efficient aromatic chlorination of arenes such as 1-methyl-indazole, imidazo[1,2-a]pyrazine, phenylthiophene, anthracene, etc. that is catalyzed by DMSO with N-chlorosuccinimide as the chloro source is reported. The mild conditions, easy-availability and stability of the catalyst and reagents, as well as good functional-group tolerance, showed the approach to be a versatile protocol for the late-stage aromatic chlorination of complex natural products, e.g., papaverine, drugs, e.g., diclofenac and peptides, e.g., I. The multi-gram experiment and low-cost of N-chlorosuccinimide and DMSO show great potential for drug discovery and development in industrial applications. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Safety of 2-Methoxynaphthalene

The Article related to arene heteroarene chlorination dimethyl sulfoxide catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Safety of 2-Methoxynaphthalene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On May 4, 2001, Bravo, Anna; Dordi, Barbara; Fontana, Francesca; Minisci, Francesco published an article.Application of 53136-21-3 The title of the article was Oxidation of Organic Sulfides by Br2 and H2O2. Electrophilic and Free-Radical Processes. And the article contained the following:

The bromine-catalyzed oxidation of sulfides with hydrogen peroxide was studied. Diaryl sulfides do not react with hydrogen peroxide and a catalytic amount of bromine; the latter is consumed by electrophilic aromatic substitution and no further reaction occurs. Dibenzyl sulfide reacts with hydrogen peroxide and a catalytic amount of bromide leading mainly to dibenzyl sulfoxide and minor amounts of benzyl bromide, benzenemethanesulfonic acid, benzyl alc. and benzaldehyde. Benzyl bromide and benzenemethanesulfonic acid were obtained in almost quant. yield by using stoichiometric amounts of bromine in the absence of hydrogen peroxide. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Application of 53136-21-3

The Article related to sulfide oxidation bromine peroxide, sulfoxide preparation, General Organic Chemistry: Synthetic Methods and other aspects.Application of 53136-21-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On September 26, 2022, Yang, Tao; Li, Xiaoqian; Deng, Shuang; Qi, Xiaotian; Cong, Hengjiang; Cheng, Hong-Gang; Shi, Liangwei; Zhou, Qianghui; Zhuang, Lin published an article.Electric Literature of 578-58-5 The title of the article was From N-H Nitration to Controllable Aromatic Mononitration and Dinitration-The Discovery of a Versatile and Powerful N-Nitropyrazole Nitrating Reagent. And the article contained the following:

Herein,the identification of a powerful nitrating reagent, 5-methyl-1,3-dinitro-1H-pyrazole, from the N-nitro-type reagent library constructed using a practical N-H nitration method was reported. This nitrating reagent behaved as a controllable source of the nitronium ion, enabling mild and scalable nitration of a broad range of (hetero)arenes with good functional group tolerance. Of note, this nitration method was controlled by manipulating the reaction conditions to furnish mononitrated or dinitrated product selectively. The value of this method in medicinal chem. was well established by its efficient late-stage C-H nitration of complex biorelevant mols. D. functional theory (DFT) calculations and preliminary mechanistic studies reveal that the powerfulness and versatility of this nitrating reagent were due to the synergistic “nitro effect” and “methyl effect”. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Electric Literature of 578-58-5

The Article related to arene nitropyrazole nitration, nitroarene preparation, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 578-58-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On January 31, 2022, Fang, Jing; Li, Ting; Ma, Xiang; Sun, Jiuchang; Cai, Lei; Chen, Qi; Liao, Zhiwen; Meng, Lingkui; Zeng, Jing; Wan, Qian published an article.COA of Formula: C13H11BrS The title of the article was Discriminating non-ylidic carbon-sulfur bond cleavages of sulfonium ylides for alkylation and arylation reactions. And the article contained the following:

A sulfonium ylide participated alkylation and arylation under transition-metal free conditions was described. The disparate reaction pattern allowed the sep. activation of non-ylidic S-alkyl and S-aryl bond. Under acidic conditions, sulfonium ylides served as alkyl cation precursors which facilitated the alkylations. While under alk. conditions, cleavage of non-ylidic S-aryl bond produces O-arylated compounds efficiently. The robustness of the protocols were established by the excellent compatibility of wide variety of substrates including carbohydrates. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).COA of Formula: C13H11BrS

The Article related to sulfonium ylide preparation alkylation arylation, General Organic Chemistry: Synthetic Methods and other aspects.COA of Formula: C13H11BrS

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 30, 2022, Shiri, Pezhman; Amani, Ali Mohammad; Aboonajmi, Jasem published an article.COA of Formula: C13H11BrS The title of the article was Supported Cu(II)-Schiff base: novel heterogeneous catalyst with extremely high activity for eco-friendly, one-pot and multi-component C-S bond-forming reaction toward a wide range of thioethers as biologically active cores. And the article contained the following:

An effective and proficient process for the synthesis of a variety of thioethers via the one-step reaction of benzyl halides, aryl halides, and thiourea is presented. This strategy is a one-pot procedure to achieve a variety of thioethers without the requirement to thiols as starting compounds A range of thioethers containing electron donating/electron-withdrawing functional groups were obtained with good to excellent yields under mild conditions. Moreover, the nanocatalyst exhibited excellent recyclability for the reaction, making it more sustainable. One-pot and multi-component synthesis, high yields of final products, green reaction media, high activity of nanocatalyst, simple separation of the products and catalyst, and high regioselectivity are several highlights of this method. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).COA of Formula: C13H11BrS

The Article related to copper thioether heterogeneous catalyst bond forming reaction, cu(ii)-complex, c–s bond-forming reaction, green media, odorless intermediates, one pot, thioether, Placeholder for records without volume info and other aspects.COA of Formula: C13H11BrS

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhao, Meng; Li, Changjun; Shan, Xiaotao; Han, Huijing; Zhao, Qiuhua; Xie, Meiran; Chen, Jianzhuang; Liao, Xiaojuan published an article in 2021, the title of the article was A stretchable pillararene-containing supramolecular polymeric material with self-healing property.Application of 150-78-7 And the article contains the following content:

Constructing polymeric materials with stretchable and self-healing properties arise increasing interest in the field of tissue engineering, wearable electronics and soft actuators. Herein, a new type of supramol. crosslinker was constructed through host-guest interaction between pillar[5]arene functionalized acrylate and pyridinium functionalized acrylate, which could form supramol. polymeric material via photo-polymerization of Bu acrylate (BA). Such material exhibited excellent tensile properties, with maximum tensile strength of 3.4 MPa and strain of 3000%, resp. Moreover, this material can effectively dissipate energy with the energy absorption efficiency of 93%, which could be applied in the field of energy absorbing materials. In addition, the material showed self-healing property after cut and responded to competitive guest. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).Application of 150-78-7

The Article related to stretchable pillararene supramol polymeric material self healing property, host-guest chemistry, pillararene, supramolecular chemistry, supramolecular polymer, Placeholder for records without volume info and other aspects.Application of 150-78-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On December 31, 2009, Khodaei, Mohammad Mehdi; Bahrami, Kiumars; Tirandaz, Yeganeh published an article.COA of Formula: C13H11BrS The title of the article was POCl3 as a catalytic activator for H2O2 activation in selective sulfide oxidation. And the article contained the following:

Various types of sulfides are selectively oxidized to sulfoxides in excellent yields using 30% aqueous hydrogen peroxide as an oxidant in the presence of POCl3 in ethanol at 50°. It is noteworthy that functional groups remain unaffected and only the sulfur atom is selectively oxidized. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).COA of Formula: C13H11BrS

The Article related to sulfide selective oxidation hydrogen peroxide oxidant phosphoryl chloride catalyst, sulfoxide preparation, General Organic Chemistry: Synthetic Methods and other aspects.COA of Formula: C13H11BrS

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gui, Jingjing; Cai, Xin; Chen, Lingyun; Zhou, Yuxin; Zhu, Wenjing; Jiang, Yuanrui; Hu, Min; Chen, Xiaobei; Hu, Yanwei; Zhang, Shilei published an article in 2021, the title of the article was Facile and practical hydrodehalogenations of organic halides enabled by calcium hydride and palladium chloride.Safety of 2-Methoxynaphthalene And the article contains the following content:

Herein, a convenient hydrodehalogenation method was described by employing less-explored calcium hydride as the reductant. A wide range of organic halides such as aromatic bromides RBr (R = 4-(dimethylamino)phenyl, 4-aminonaphthalen-1-yl, quinolin-5-yl, etc.), aromatic chlorides R1Cl (R1 = naphthalen-1-yl, 3-carboxy-5-methoxyphenyl, 2-[2-(cyclohexa-1,5-dien-1-yl)ethenyl]phenyl, etc.), aromatic triflates R2Otf (R2 = 2-methylquinolin-8-yl, 2-nitrophenyl, 2-acetylnaphthalen-1-yl, etc.), 1-(2-(4-bromo/chlorobutoxy)phenyl)ethan-1-one were efficiently and selectively reduced to obtain the corresponding hydrocarbons e.g., Phenyl(pyrrolidin-1-yl)methanone. More importantly, monodehalogenation of trihalomethyl compounds R3CXY2 (R3 = benzenesulfonyl, 3-oxo-1-phenyl-3-(thiophen-3-yl)propyl, N-(naphthalen-1-yl)carbamoyl, etc.; X = Br, Cl; Y = Br, Cl, F) in THF could provide various useful dihalomethyl products R3CHY2. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Safety of 2-Methoxynaphthalene

The Article related to hydrocarbon preparation, aromatic halide hydrodehalogenation calcium hydride palladium chloride catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Safety of 2-Methoxynaphthalene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 20, 2022, Liu, Bin; Wang, Guanyu; Xu, Zhenhao; Wang, Menglin; Nie, Yangleiyu; Luo, Zhibin published an article.Reference of 2-Methoxynaphthalene The title of the article was Ionic liquid/boronic acid system enabled deuteration with D2O. And the article contained the following:

The development of transition-metal free systems for multi-sites deuteration is important for the preparation of deuterium-labeled drugs and intermediates e.g, d-agomelatine. The ionic liquid [bmim]PF6, which was able to promote highly efficient deuterodeborylation of boronic acids RB(OH)2 [R = thianthren-1-yl, 1-benzothiophen-2-yl, 4-formyl-2-methoxyphenyl, etc.] with D2O was reported. The ionic liquid/boronic acid system was successfully applied to the selective H/D exchange at various sp2/sp3 C-H positions. Moreover, unusual nucleophilic behaviors of nitrogen-containing heteroaromatics in ionic liquid were observed The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Reference of 2-Methoxynaphthalene

The Article related to deuterium compound preparation, boronic acid deuterium oxide deuterodeborylation ionic liquid catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Reference of 2-Methoxynaphthalene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On June 2, 2008, Khodaei, Mohammad Mehdi; Bahrami, Kiumars; Karimi, Ahmad published an article.Related Products of 53136-21-3 The title of the article was H2O2/Tf2O system. An efficient oxidizing reagent for selective oxidation of sulfanes. And the article contained the following:

A versatile procedure for the oxidation of sulfides to sulfoxides without any over-oxidation to sulfones was reported. It is noteworthy that the reaction tolerates oxidatively sensitive functional groups and that the sulfur atom is selectively oxidized. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Related Products of 53136-21-3

The Article related to sulfide selective oxidation hydrogen peroxide triflic anhydride oxidizing agent, sulfoxide preparation, General Organic Chemistry: Synthetic Methods and other aspects.Related Products of 53136-21-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem