Category: ethers-buliding-blocks

Self-assembly of Amphiphilic Porphyrins To Construct Nanoparticles for Highly Efficient Photodynamic Therapy was written by Jiang, Meiyu;Wu, Jiasheng;Liu, Weimin;Ren, Haohui;Zhang, Wenjun;Lee, Chun-Sing;Wang, Pengfei. And the article was included in Chemistry – A European Journal in 2021.HPLC of Formula: 111-77-3 This article mentions the following:

Hydrophobic photosensitizers greatly affect cell permeability and enrichment in tumors, but they cannot be used directly for clin. applications because they always aggregate in water, preventing their circulation in the blood and accumulation in tumor cells. As a result, amphiphilic photosensitizers are highly desirable. Although nanomaterial-based photosensitizers can solve water solubility, they have the disadvantages of complicated operation, poor reproducibility, low drug loading, and poor stability. In this work, an efficient synthesis strategy is proposed that converts small mols. into nanoparticles in 100% aqueous solution by mol. assembly without the addition of any foreign species. Three photosensitizers with triphenylphosphine units and ethylene glycol chains of different lengths, TPP-PPh₃, TPP-PPh₃-2PEG and TPP-PPh₃-4PEG, were synthesized to improve amphiphilicity. Of the three photosensitizers, TPP-PPh₃-4PEG is the most efficient (singlet oxygen yield: 0.89) for tumor photodynamic therapy not only because of its definite constituent, but also because its amphiphilic structure allows it to self-assemble in water. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3HPLC of Formula: 111-77-3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.HPLC of Formula: 111-77-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Linked Rotaxane Structure Restricts Local Molecular Motions in Solution to Enhance Fluorescence Properties of Tetraphenylethylene was written by Miyagishi, Hiromichi V.;Masai, Hiroshi;Terao, Jun. And the article was included in Chemistry – A European Journal in 2022.Electric Literature of C5H12O3 This article mentions the following:

The restriction of local mol. motions is critical for improving the fluorescence quantum yields (FQYs) and the photostability of fluorescent dyes. Herein, we report a supramol. approach to enhance the performance of fluorescent dyes by incorporating a linked rotaxane structure with permethylated α-cyclodextrins. Tetraphenylethylene (TPE) derivatives generally exhibit low FQYs in solution due to the mol. motions in the excited state. We show that TPE with linked rotaxane structures on two sides displays up to 15-fold higher FQYs. Detailed investigations with variable temperature ¹H NMR, UV-Vis, and photoluminescence spectroscopy revealed that the linked rotaxane structure rigidifies the TPE moiety and thus suppresses the local mol. motions and non-radiative decay. Moreover, the linked rotaxane structure enhances the FQY of the dye in various solvents, including aqueous solutions, and improves the photostability through the inhibition of local mol. motions in the excited TPE. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Electric Literature of C5H12O3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Electric Literature of C5H12O3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Microbiological enantioselective synthesis of (S) and (R) 4-(p-anisyloxy)-3-hydroxybutyrates as new chiral building blocks for the synthesis of β-lactam antibiotics was written by Banfi, Luca;Cascio, Giuseppe;Ghiron, Chiara;Guanti, Giuseppe;Manghisi, Elso;Narisano, Enrica;Riva, Renata. And the article was included in Tetrahedron in 1994.Formula: C9H10O4 This article mentions the following:

Both enantiomers of 4-(p-anisyloxy)-3-hydroxybutanoates 4-MeOC₆H₄OCH₂CH(OH)CH₂CO₂R (R = Et, CH₂Ph) have been prepared in high e.e. by reduction of the corresponding β-keto esters or β-keto carboxylates with immobilized fermenting baker’s yeast. The utility of these new chiral building blocks in the synthesis of pharmacol. important β-lactam antibiotics has been demonstrated. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Formula: C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Formula: C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N’-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction was written by Lee, Sumi;Abed, Dhulfiqar Ali;Nguyen, Mai-Uyen;Verzi, Michael P.;Hu, Longqin. And the article was included in European Journal of Medicinal Chemistry in 2022.Recommanded Product: (4-Methoxyphenyl)methanol This article mentions the following:

A series of 1,4-bis(arylsulfonamido)benzenes I [R = 4-Me, 4-MeO, 4-F, etc.; R¹ = carboxymethyl, 1H-1,2,3,4-tetrazol-5-ylmethyl, 1-carboxyethyl; R² = Ph, piperidin-1-yl, phenoxy, etc.; R³ = H, MeO, (4-fluorophenyl)methoxy; R⁴ = H, MeO] or naphthalene-N,N’-diacetic acid II with varying substituents at C-2 position of the benzene or naphthalene core were designed and synthesized. Among them, compound II with 2-(4-fluorobenzyloxy) group was the most potent direct inhibitor of Keap1-Nrf2 PPI with an IC₅₀ of 64.5 nM in the fluorescent polarization (FP) assay and 14.2 nM in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. Moreover, cell-based biol. assay showed that compound II significantly increased the mRNA levels of Nrf2 downstream genes, GSTM3, HMOX2 and NQO1, through Nrf2 activation. The discovery of the new scaffolds possessing diverse O-linked fragments at the C2 position offers opportunities to further modify the chem. structures of Keap1-Nrf2 PPI inhibitors to improve their pharmacokinetic, efficacy and safety profiles. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Recommanded Product: (4-Methoxyphenyl)methanol).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Recommanded Product: (4-Methoxyphenyl)methanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electrochemical PINOylation of Methylarenes: Improving the Scope and Utility of Benzylic Oxidation through Mediated Electrolysis was written by Hoque, Asmaul Md;Twilton, Jack;Zhu, Jieru;Graaf, Matthew D.;Harper, Kaid C.;Tuca, Emilian;DiLabio, Gino A.;Stahl, Shannon S.. And the article was included in Journal of the American Chemical Society in 2022.Category: ethers-buliding-blocks This article mentions the following:

A mediated electrosynthetic method has been developed for selective benzylic oxidation of methylarenes RCH₃ (R = Ph, 4-chlorophenyl, pyridin-3-yl, 1,3-thiazol-2-yl, etc.). Phthalimide-N-oxyl (PINO) radical generated by proton-coupled electrochem. oxidation of N-hydroxypthalimide serves as a hydrogen atom-transfer (HAT) mediator and as a radical trap for the benzylic radicals generated in situ. This mediated electrolysis method operates at much lower anode potentials relative to direct electrolysis methods for benzylic oxidation initiated by single-electron transfer (SET). A direct comparison of SET and mediated-HAT electrolysis methods with a common set of substrates shows that the HAT reaction exhibits a significantly improved substrate scope and functional group compatibility. The PINOylated products I and II are readily converted into the corresponding benzylic alc. RCH₂OH or benzaldehyde derivatives RCHO under photochem. conditions, and the synthetic utility of this method is highlighted by the late-stage functionalization of the non-steroidal anti-inflammatory drug celecoxib. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Category: ethers-buliding-blocks).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Exploiting Alkylquinone Tautomerization: Amine Benzylation was written by Mori-Quiroz, Luis M.;Clift, Michael D.. And the article was included in Organic Letters in 2016.Related Products of 605-94-7 This article mentions the following:

A general protocol for the synthesis of benzylic amines via side-chain amination of alkylquinones is reported. The reactions are initiated by the tautomerization of an alkylquinone to the corresponding quinone methide, which is subsequently trapped in situ by an amine nucleophile. This process is promoted by tertiary amines in protic solvents under mild conditions and is compatible with many functional groups. 1,2- and 1,4-benzoquinones, as well as naphthoquinones, participate in this reaction using a wide range of primary and secondary amines/anilines. The synthetic utility of this transformation is also explored. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7Related Products of 605-94-7).

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Related Products of 605-94-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Computationally Guided Molecular Design to Minimize the LE/CT Gap in D-π-A Fluorinated Triarylboranes for Efficient TADF via D and π-Bridge Tuning was written by Narsaria, Ayush K.;Rauch, Florian;Krebs, Johannes;Endres, Peter;Friedrich, Alexandra;Krummenacher, Ivo;Braunschweig, Holger;Finze, Maik;Nitsch, Joern;Bickelhaupt, F. Matthias;Marder, Todd B.. And the article was included in Advanced Functional Materials in 2020.HPLC of Formula: 365564-07-4 This article mentions the following:

In this combined exptl. and theor. study, a computational protocol is reported to predict the excited states in D-π-A compounds containing the B(^FXyl)₂ (^FXyl = 2,6-bis(trifluoromethyl)phenyl) acceptor group for the design of new thermally activated delayed fluorescence (TADF) emitters. To this end, the effect of different donor and π-bridge moieties on the energy gaps between local and charge-transfer singlet and triplet states is examined To prove this computationally aided design concept, the D-π-B(^FXyl)₂ compounds 1–5 were synthesized and fully characterized. The photophys. properties of these compounds in various solvents, polymeric film, and in a frozen matrix were investigated in detail and show excellent agreement with the computationally obtained data. Furthermore, a simple structure-property relationship is presented on the basis of the mol. fragment orbitals of the donor and the π-bridge, which minimize the relevant singlet-triplet gaps to achieve efficient TADF emitters. In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4HPLC of Formula: 365564-07-4).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).HPLC of Formula: 365564-07-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Model compound studies of thermal reversion chemistry was written by Chong, J. M.;Nanayakkara, N. P. D.;Whiting, P.. And the article was included in Journal of Pulp and Paper Science in 1991.Name: 3-(3,4-Dimethoxyphenyl)propan-1-ol This article mentions the following:

The effect of heating a series of lignin model compounds absorbed onto stone groundwood pulp (SGW) was investigated. Pads with compounds containing a 3-methoxy-4-hydrobenzene unit were darkened considerably with those with the corresponding 3,4-dimethoxy compounds darkened only slightly. Prior chelation of the SGW or heating under an argon atm. decreased the amount of reversion. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Name: 3-(3,4-Dimethoxyphenyl)propan-1-ol).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Name: 3-(3,4-Dimethoxyphenyl)propan-1-ol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and luminescence properties of pyrazolone derivatives and their terbium complexes was written by Xiao, Haihua;Jiang, Xi;Li, Dong;Wu, Limin;Zhang, Wu;Guo, Dongcai. And the article was included in Luminescence in 2015.Category: ethers-buliding-blocks This article mentions the following:

Seven novel pyrazolone derivatives were synthesized and characterized by ¹H NMR and ¹³C NMR spectra, mass spectra, IR spectra and elemental anal. Their Tb complexes were prepared and characterized by elemental anal., EDTA titrimetric anal., UV/visible spectra, IR spectra and molar conductivity, as well as thermal anal. The fluorescence properties and fluorescence quantum yields of the complexes were studied at room temperature Pyrazolone derivatives had good energy-transfer efficiency for the Tb ion. All the Tb complexes emitted green fluorescence characteristic of Tb ions, possessed strong fluorescence intensity, and showed relatively high fluorescence quantum yields. Cyclic voltammograms of the Tb complexes were studied and the HOMO and lowest occupied MO (LUMO) energy levels of these complexes were estimated Copyright © 2014 John Wiley and Sons, Ltd. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Category: ethers-buliding-blocks).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

New methods to remove volatile organic compounds from post-consumer plastic waste was written by Cabanes, A.;Fullana, A.. And the article was included in Science of the Total Environment in 2021.SDS of cas: 111-77-3 This article mentions the following:

While the annual European demand for polyolefins is 25 million tonnes, only 3 million tonnes of recycled polyolefins find their place in the market, despite collecting 15 million tonnes of post-consumer polyolefins every year. Brand owners of care products are showing their interest in using post-consumer recycled plastics for their packaging. However, there is a general concern in using these materials, as recycled polymers can contain unwanted substances that may expose the consumer to health risks or make the packaging unattractive. Accordingly, the presence of these contaminants narrows the market opportunity of recycled plastics to applications with low-quality requirements and in which the product is not in direct contact with the consumer. Though mech. recycling is the most widespread solution presents limitations in terms of decontamination, as only superficial substances are removed. Thereby, the volatile organic compounds (VOCs) migrated to the polymer matrix remain inside. Consequently, there is a need to find a solution to purify recycled plastics and increase their market share. This study focuses on removing VOCs from post-consumer recycled HDPE through two innovative methods applied for the first time in this field, steam stripping and polyethylene glycol (PEG) extraction The methodol. implemented to analyze the volatile organic compounds in HDPE was HS-SPME-GC/MS. Both methods showed a decrease above 70% in the VOCs content compared to extrusion-degassing. Moreover, these were compared to hot air stripping, a new technol. developed at an industrial scale for the removal of VOCs. As a result, steam stripping improved efficiency in reducing the overall VOCs compared to hot air stripping. The PEG extraction method lowered the volatile polar compounds further than using hot air stripping. Addnl., none of these technologies modified the HDPE melting flow index. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3SDS of cas: 111-77-3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.SDS of cas: 111-77-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem