Category: ethers-buliding-blocks

New triazolothiadiazole and triazolothiadiazine derivatives as kinesin Eg5 and HIV inhibitors: Synthesis, QSAR and modeling studies was written by Khan, Imtiaz;Hameed, Shahid;Al-Masoudi, Najim A.;Abdul-Reda, Nabeel A.;Simpson, Jim. And the article was included in Zeitschrift fuer Naturforschung, B: A Journal of Chemical Sciences in 2015.Name: 2-(4-Methoxyphenoxy)acetic acid This article mentions the following:

A new series of fused 1,2,4-triazoles, namely [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles I (R¹ = 2-F-4-Cl-C₆H₃, furan-3-yl, pyrrol-2-yl, etc.) and II (R² = 2-OH, 2-CH₃, 4-F, etc.) as well as [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines III (R³ = 4-H₃COC₆H₄, 4-FC₆H₄, biphen-4-yl, naphthalen-1-yl, etc.) were synthesized by the condensation of 4-amino-5-(furan-2-yl)-4H-1,2,4-triazole-3-thiol with substituted aromatic acids R¹CO₂H, substituted phenoxyacetic acids R²OCH₂CO₂H, and phenacyl bromides R³C(:O)CH₂Br, resp. The structures of the newly synthesized compounds were established using spectroscopic anal., while that of I (R¹ = 4-FC₆H₄CH₂) was confirmed independently by a single-crystal X-ray structure determination The compounds were evaluated for their antiviral activity against the replication of HIV-1 and HIV-2 in MT-4 cells using an MTT assay. In a docking study, II (R² = 4-OH) interacted with several amino acids in the reverse transcriptase (RT) binding site of HIV-1. Some new analogs were selected for evaluation of their Eg5 inhibitory activity using an in vitro malachite green ATPase assay, the QSAR of these new analogs was studied as well. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Name: 2-(4-Methoxyphenoxy)acetic acid).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Name: 2-(4-Methoxyphenoxy)acetic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Dependence of Linker Length and Composition on Ionic Conductivity and Lithium Deposition in Single-Ion Conducting Network Polymers was written by Aubrey, Michael L.;Axelson, Jordan C.;Engler, Kaitlyn E.;Long, Jeffrey R.. And the article was included in Macromolecules (Washington, DC, United States) in 2021.Application In Synthesis of 2,5,8,11-Tetraoxadodecane This article mentions the following:

Single-ion conducting electrolytes stand as promising alternatives to state-of-the-art electrolytes in lithium batteries, although a single-ion conducting material with high Li⁺ conductivity, stability in contact with lithium, and suitable mech. properties has been slow to emerge. Here, we describe the synthesis of a series of single-ion conducting network polymers from the reaction of tetrakis(4-(chloromethyl)-2,3,5,6-tetrafluorophenyl)borate with oligoethylene glycoxide linkers Li₂O[(CH₂CH₂)O]_n (n = 1, 2, 3, 9, and 22). Polymers with the longest linkers (n = 9 and 22; ANP-9 and ANP-10, resp.) form materials with conductivities of ~10^-6 S cm^-1 at 100°C. With the addition of 65 wt % propylene carbonate (PC), all the network polymers in the series exhibit high conductivities at ambient temperatures, with the n = 1 material (ANP-6) achieving a bulk ionic conductivity of 2.5 × 10^-4 S cm^-1 at 25°C. More conductive single-ion conducting gels could be prepared by using the less coordinating pentanediol dilithium salt as a linker (ANP-11; σ = 3.5 × 10^-4 S cm^-1 at 25°C), although this material exhibited a surprisingly high interfacial resistance in contact with a lithium electrode. In contrast, the gel formed with ANP-6 is notably stable in contact with metallic lithium electrodes, displays a lithium-ion transference number of unity, and boasts a wide electrochem. stability window of greater than 4.5 V. Temperature-dependent ac impedance anal. reveals that the ionic conductivity of this material-and likely the other gels in the series-matches closely to a Vogel-Tamman-Fulcher temperature model. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Application In Synthesis of 2,5,8,11-Tetraoxadodecane).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Application In Synthesis of 2,5,8,11-Tetraoxadodecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hydrogen peroxide oxidative desulfurization of model diesel fuel mixtures in the presence of crown ethers and transition metal peroxo complexes was written by Rakhmanov, E. V.;Jinyuan, Dan;Fedorova, O. A.;Tarakanova, A. V.;Anisimov, A. V.. And the article was included in Petroleum Chemistry in 2011.Name: 1,4,7,10-Tetraoxa-13-azacyclopentadecane This article mentions the following:

The catalytic ability of crown ethers and their complexes with transition metal cations in the desulfurization reaction of mixtures that simulate diesel fuel has been investigated. It has been found that the use of monoaza-15-crown-5-ethers with an admixture of NbCl₅ resulted in a fourfold decrease of the total sulfur content, thereby indicating partial oxidation of benzothiophenes and dibenzothiophenes. The complexation of azacrown ethers with NbCl₅ has been studied by ¹H NMR spectroscopy. A moderate efficiency of adsorption purification procedure using silica and alumina for both initial and oxidized model mixtures has been revealed. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Name: 1,4,7,10-Tetraoxa-13-azacyclopentadecane).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Name: 1,4,7,10-Tetraoxa-13-azacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis, complexation, and fluorescence behavior of 3,4-dimethylthieno[2,3-b]thiophene carrying two monoaza-15-crown-5 ether groups was written by Wu, Yong-Xiang;Cao, Jing;Deng, Hai-Yan;Feng, Jun-Xiang. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2011.COA of Formula: C10H21NO4 This article mentions the following:

A novel fluoroionophore I based on 3,4-dimethylthieno[2,3-b]thiophene bearing two monoaza-15-crown-5 ethers at the 3- and 4-positions was prepared UV-vis and fluorescence responses of compound I upon the addition of alkali and alk. earth metal cations were evaluated in acetonitrile solution Receptor I showed a unique response for Ba²⁺ due to the formation of an intramol. sandwich complex. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3COA of Formula: C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).COA of Formula: C10H21NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and herbicidal activity of N-(4-chloro-2-fluoro-5-substituted phenyl)isoindole-1,3-dione derivatives was written by Zhang, Hao;Li, Qibo;Liu, Kechang;Liu, Ruiquan;Li, Qingyang;Wang, Qingmin;Liu, Shangzhong. And the article was included in Youji Huaxue in 2015.Related Products of 1877-75-4 This article mentions the following:

In order to find new herbicidal leading compounds, a series of N-(4-chloro-2-fluoro-5-substituted phenyl)isoindole-1,3-dione derivatives were designed and synthesized via the strategy of linking active sub-structures which are chlorophthalim and phenoxy carboxylic ester. The target compounds were synthesized from starting material 2-chloro-4-fluoro-5-nitrophenol in four steps, and their structures were confirmed by ¹H NMR, ¹³C NMR and HRMS. The preliminary bioassay results indicated that most compounds exhibited excellent herbicidal activities at 1,500 g/ha in both pre- and post-emergence treatments against Abutilon theophrasti and Amaranthus retroflexus. On the basis of advanced screening tests, compound 6d exhibited 100% inhibitory effect against Abutilon theophrasti and Amaranthus retroflexus at 750 g/ha, compounds 7a and 7i were much more effective against Abutilon theophrasti than com. acifluorfen with 80%-86% inhibitory activity at 22.5 g/ha. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Related Products of 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Related Products of 1877-75-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Stereoselective synthesis of 3,4-trans-disubstituted γ-lactams by cerium(IV) ammonium nitrate mediated radical cyclization of cinnamamides was written by Nair, Vijay;Mohanan, Kishor;Suja, Tachapully D.;Biju, Akkattu T.. And the article was included in Synthesis in 2007.Safety of 3-(2,4-Dimethoxyphenyl)acrylic acid This article mentions the following:

A facile synthesis of 3,4-trans-disubstituted γ-lactams, e.g., I, was developed, consisting of the radical cyclization of cinnamamides mediated by cerium(IV) ammonium nitrate. The single-electron-transfer reaction of the methoxystyrenyl moiety mediated by cerium(IV) ammonium nitrate gives rise to a cation radical, whose cyclization followed by reaction with oxygen and methanol generates 3,4-trans-disubstituted γ-lactams. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Safety of 3-(2,4-Dimethoxyphenyl)acrylic acid).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Safety of 3-(2,4-Dimethoxyphenyl)acrylic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Fenitrothion and 3-methyl-4-nitrophenol degradation by two bacteria in natural waters under laboratory conditions was written by Alonso, Jose L.;Sabater, Consuelo;Ibanez, Maria J.;Amoros, Inmaculada;Botella, Maria S.;Carrasco, Jose. And the article was included in Journal of Environmental Science and Health, Part A: Environmental Science and Engineering & Toxic and Hazardous Substance Control in 1997.Related Products of 5367-32-8 This article mentions the following:

The ability of 2 bacterial strains, Flavobacterium strain ATCC 27551, and Arthrobacter aurescens strain TW17, to degrade fenitrothion and the product of its hydrolysis, 3-methyl-4-nitrophenol (MNP), in natural water under laboratory conditions was studied. Fenitrothion was degraded by Flavobacterium whereas MNP was not. In comparison, MNP was metabolized by A. aurescens and fenitrothion was not. Natural microbial populations did not decompose fenitrothion and MNP; however Flavobacterium and A. aurescens degraded these compounds in the presence of the natural microbial population. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Related Products of 5367-32-8).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Related Products of 5367-32-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Rhodium-catalyzed asymmetric synthesis of 1,1-disubstituted 1,3-dihydrobenzo[c]furans from prochiral triynes and internal alkynes was written by Ye, Fei;Haddad, Mansour;Ratovelomanana-Vidal, Virginie;Michelet, Veronique. And the article was included in Catalysis Communications in 2018.Recommanded Product: 16356-02-8 This article mentions the following:

The cationic rhodium/BINAP system was found to be an efficient catalytic system for the [2+2+2] cycloaddition of prochiral triynes with internal alkynes. The optimization of the catalytic system allowed the construction of 1,1-disubstituted 1,3-dihydrobenzo[c]furans I [R¹ = Me, n-Pr, t-Bu, Ph; R² = n-Bu, Ph; R³ = Me, SiMe₃; R⁴ = CH₂OMe, CH₂OAc, CH₂OC(O)t-Bu, CH₂CO₂Me, CH₂OC(O)Ph] containing a quaternary carbon stereogenic centers in fair yields and moderate enantiomeric excesses. In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8Recommanded Product: 16356-02-8).

1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Recommanded Product: 16356-02-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Covalently decorated crown ethers on magnetic graphene oxides as bi-functional adsorbents with tailorable ion recognition properties for selective metal ion capture in water was written by Nisola, Grace M.;Parohinog, Khino J.;Cho, Min Kyung;Burnea, Francis Kirby B.;Lee, Jin Yong;Seo, Jeong Gil;Lee, Seong-Poong;Chung, Wook-Jin. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2020.Recommanded Product: 1,4,7,10-Tetraoxa-13-azacyclopentadecane This article mentions the following:

Metal ions (Mⁿ⁺) in water are considered as environmental pollutants, as industrial impurities or as potential secondary sources for valuable metals. Increasing generation of complex feed streams has raised the need for more specialized adsorbents that could preferentially capture the target Mⁿ⁺. While graphene oxide (GO) is an effective adsorbent, its indiscriminate sequestration neg. affects its selectivity. To meet the growing demand for more Mⁿ⁺-selective materials, GO adsorbents with dual features of ion recognition and magnetic responsiveness were developed. The bi-functional GOs were fabricated by in-situ nucleation of Fe₃O₄ nanoclusters on GO oxygenous groups and by direct grafting of ethynylbenzene linkers on its backbone, which served as tethering sites for the macrocyclic crown ether (CEs) ligands with tunable Mⁿ⁺ affinities (i.e. CE@Fe₃O₄-rGO). As proof-of-concept, 12CE4@Fe₃O₄-rGO was proven highly selective for Li⁺ capture, achieving α = 367-14,513 against Na⁺, K⁺, Mg²⁺, Ca²⁺ in seawater. Its Langmuir-type Li⁺ adsorption achieved nearly âˆ?00% 12CE4 utilization (1.03 mmol g^-1 CE loading). Its pseudo-second uptake rate demonstrated its rapid Li⁺ capture. 12CE4@Fe₃O₄-rGO is water-dispersible, magnetically retrievable, and recyclable with consistent Li⁺ uptake performance. By replacing the CEs with aza15CE5, aza18CE6 and dibenzo-24CE8, three more types of CE@Fe₃O₄-rGOs (1.24-1.71 mmol CE g^-1) were successfully synthesized with varying affinities towards heavy metals, radionuclides and alkali metal ions. These findings highlight the versatility of the proposed technique in producing a wide selection of CE@Fe₃O₄-rGOs which can be used for selective Mⁿ⁺ capture in various application for water decontamination, salts removal, and resource recovery. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Recommanded Product: 1,4,7,10-Tetraoxa-13-azacyclopentadecane).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Recommanded Product: 1,4,7,10-Tetraoxa-13-azacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

All-Solid-State Vertical Three-Terminal N-Type Organic Synaptic Devices for Neuromorphic Computing was written by Xie, Zhichao;Zhuge, Chenyu;Zhao, Yanfei;Xiao, Wei;Fu, Yujun;Yang, Dongliang;Zhang, Shunpeng;Li, Yingtao;Wang, Qi;Wang, Yazhou;Yue, Wan;McCulloch, Iain;He, Deyan. And the article was included in Advanced Functional Materials in 2022.Category: ethers-buliding-blocks This article mentions the following:

Artificial synaptic devices are the basic composition units for neuromorphic computing processors that realize massive parallel computing. However, the n-type organic transistors have failed to achieve good performance as an artificial synaptic device for neuromorphic computing until now. Here, a vertical three-terminal n-type organic artificial synapse (TNOAS) using a lithium ion-based organic dielec. and the n-type donor-acceptor (D-A) conjugated polymer-naphthalene-1,4,5,8-tetracarboxylic-diimide-thiophene-vinyl-thiophene (NDI-gTVT) as the channel is proposed. The TNOAS achieves nonvolatile conductance modulation with high c.d. operation (�0 KA cm^-2) at low voltage and mimics the basic functions of biol. synapses, such as long-term synaptic plasticity and paired-pulse facilitation. The min. energy consumption of a response event triggered by a single action potential is 6.16 pJ, which can be comparable with p-type counterparts. Moreover, simulation using handwritten digital datasets exhibit a high recognition accuracy of 94%. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Category: ethers-buliding-blocks).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem