Ethers-buliding-blocks

Catalyst-free ligin valorization by acetoacetylation. Structural elucidation by comparison with model compounds was written by Krall, Eric M.;Serum, Eric M.;Sibi, Mukund P.;Webster, Dean C.. And the article was included in Green Chemistry in 2018.HPLC of Formula: 3929-47-3 This article mentions the following:

Indulin AT Kraft lignin has been chem. modified without a catalyst by reaction with t-Bu acetoacetate. Elucidation and quantification of the modified lignin structure has been facilitated by employing a series of readily prepared model compounds which isolate three of the major hydroxyl containing moieties characteristic of lignin. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3HPLC of Formula: 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.HPLC of Formula: 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

N-(2-Benzoylphenyl)-L-tyrosine PPARγ Agonists. 2. Structure-Activity Relationship and Optimization of the Phenyl Alkyl Ether Moiety was written by Collins, Jon L.;Blanchard, Steven G.;Boswell, G. Evan;Charifson, Paul S.;Cobb, Jeff E.;Henke, Brad R.;Hull-Ryde, Emily A.;Kazmierski, Wieslaw M.;Lake, Debra H.;Leesnitzer, Lisa M.;Lehmann, Juergen;Lenhard, James M.;Orband-Miller, Lisa A.;Gray-Nunez, Yolanda;Parks, Derek J.;Plunkett, Kelli D.;Tong, Wei-Qin. And the article was included in Journal of Medicinal Chemistry in 1998.Application of 3929-47-3 This article mentions the following:

We previously reported the identification of (2S)-((2-benzoylphenyl)amino)-3-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl}propanoic acid (I) (PPARγ pK_i = 8.94, PPARγ pEC₅₀ = 9.47) as a potent and selective PPARγ agonist. We now report the expanded structure-activity relationship around the Ph alkyl ether moiety by pursuing both a classical medicinal chem. approach and a solid-phase chem. approach for analog synthesis. The solution-phase strategy focused on evaluating the effects of oxazole and Ph ring replacements of the 2-(5-methyl-2-phenyloxazol-4-yl)ethyl side chain of I with several replacements providing potent and selective PPARγ agonists with improved aqueous solubility Specifically, replacement of the Ph ring of the phenyloxazole moiety with a 4-pyridyl group to give (2S)-((2-benzoylphenyl)amino)-3-{4-[2-(5-methyl-2-pyridin-4-yloxazol-4-yl)ethoxy]phenyl}propionic acid (PPARγ pK_i = 8.85, PPARγ pEC₅₀ = 8.74) or a 4-methylpiperazine to give (2S)-((2-benzoylphenyl)amino)-3-(4-{2-[5-methyl-2-(4-methylpiperazin-1-yl)thiazol-4-yl]ethoxy}phenyl)propionic acid (PPARγ pK_i = 8.66, PPARγ pEC₅₀ = 8.89) provided two potent and selective PPARγ agonists with increased solubility in pH 7.4 phosphate buffer and simulated gastric fluid as compared to I. The second strategy took advantage of the speed and ease of parallel solid-phase analog synthesis to generate a more diverse set of Ph alkyl ethers which led to the identification of a number of novel, high-affinity PPARγ ligands (PPARγ pK_i‘s 6.98-8.03). The combined structure-activity data derived from the two strategies provide valuable insight on the requirements for PPARγ binding, functional activity, selectivity, and aqueous solubility In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Application of 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Application of 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Speciation Analysis and Thermodynamic Criteria of Solvated Ionic Liquids: Ionic Liquids or Superconcentrated Solutions? was written by Arai, Nana;Watanabe, Hikari;Nozaki, Erika;Seki, Shiro;Tsuzuki, Seiji;Ueno, Kazuhide;Dokko, Kaoru;Watanabe, Masayoshi;Kameda, Yasuo;Umebayashi, Yasuhiro. And the article was included in Journal of Physical Chemistry Letters in 2020.HPLC of Formula: 112-49-2 This article mentions the following:

Lithium-glyme solvate ionic liquids (Li-G SILs) and super-concentrated electrolyte solutions (SCESs) are expected as a promising electrolyte for the next generation lithium secondary batteries. The former consists of only the oligoether glyme solvated lithium ion and its counter anion and the latter contains no full solvated Li⁺ ion by the solvents due to the extremely high Li salt concentration Although both of them are similar with each other, it is still unclear that both should be room-temperature ionic liquids (RTILs). To reveal the distinct definition for them, speciation analyses were performed to the Li-G SIL and the aqueous SCES to evaluate the free solvent concentration in these solutions with a new Raman/IR spectral anal. technique called complementary least square anal. (CLSA). Furthermore, from a thermodn. point of views, we investigated the solvent activity/activity coefficient in the gas phase equilibrated with sample solutions and found they can be a good criterion for SILs. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2HPLC of Formula: 112-49-2).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.HPLC of Formula: 112-49-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cinnamonitrile Adjuvants Restore Susceptibility to β-Lactams against Methicillin-Resistant Staphylococcus aureus was written by Speri, Enrico;Kim, Choon;De Benedetti, Stefania;Qian, Yuanyuan;Lastochkin, Elena;Fishovitz, Jennifer;Fisher, Jed F.;Mobashery, Shahriar. And the article was included in ACS Medicinal Chemistry Letters in 2019.Recommanded Product: 3-Formyl-2-methoxyphenylboronic acid This article mentions the following:

β-Lactams are used routinely to treat Staphylococcus aureus infections. However, the emergence of methicillin-resistant S. aureus (MRSA) renders them clin. precarious. We describe a class of cinnamonitrile adjuvants that restore the activity of oxacillin (a penicillin member of the β-lactams) against MRSA. The lead adjuvants were tested against six important strains of MRSA, one vancomycin-intermediate S. aureus (VISA) strain, and one linezolid-resistant S. aureus strain. Five compounds out of 84 total compounds showed broad potentiation. At 8 μM (E)-3-(5-(3,4-dichlorobenzyl)-2-(trifluoromethoxy)phenyl)-2-(methylsulfonyl)acrylonitrile (26) potentiated oxacillin with a >4000-fold reduction of its MIC (from 256 to 0.06 mg·L^-1). This class of adjuvants holds promise for reversal of the resistance phenotype of MRSA. In the experiment, the researchers used many compounds, for example, 3-Formyl-2-methoxyphenylboronic acid (cas: 480424-49-5Recommanded Product: 3-Formyl-2-methoxyphenylboronic acid).

3-Formyl-2-methoxyphenylboronic acid (cas: 480424-49-5) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Recommanded Product: 3-Formyl-2-methoxyphenylboronic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

New crown compounds derived from 1,2-bis(2-hydroxybenzyl)benzene (II): bisaryl crowns was written by Lee, Woo Young;Jung, Jae Do;Park, Chang Hee;Sim, Wonbo. And the article was included in Bulletin of the Korean Chemical Society in 1990.Related Products of 60221-37-6 This article mentions the following:

The reaction of 1,2-(2-HOC₆H₄CH₂)₂C₆H₄ (I) in base with 4-MeC₆H₄SO₃CH₂(CH₂OCH₂)_nOR (R = tetrahydropyranyl; n = 0-3), deprotection of the bis-condensation product to give the diol, tosylation of the free hydroxyls of the diol, and condensation of the ditosylate in base with I afforded bisaryl corand II. Oxidation of the benzylic positions of II furnished novel aromatic corands containing carbonyl functions. In the experiment, the researchers used many compounds, for example, 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6Related Products of 60221-37-6).

2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Related Products of 60221-37-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Solvothermal Synthesis of CuFe₂O₄@rGO: Efficient Catalyst for C-O Cross Coupling and N-arylation Reaction under Ligand-Free Condition was written by Nakhate, Akhil V.;Yadav, Ganapati D.. And the article was included in ChemistrySelect in 2017.Category: ethers-buliding-blocks This article mentions the following:

The copper ferrite supported reduced graphene oxide (CuFe₂O₄@rGO) synthesis by solvothermal process has been reported. The prepared CuFe₂O₄@rGO catalyst was used for C-O and C-N cross coupling reactions. The activity of the catalyst was compared with com. Cu₂O, CuO and CuFe₂O₄ for C-O cross coupling of iodobenzene with phenol. The CuFe₂O₄@rGO was the best catalyst with 97% conversion towards iodobenzene at 100 °C under ligand free condition which is otherwise normally used. The virgin and five times reused CuFe₂O₄@rGO catalyst was characterized by XRD, SEM, FTIR, TEM, N2-adsorption desorption isotherm, XPS and TGA anal. The effect of solvent, nature of base, speed of agitation, mole ratio, catalyst loading and temperature were studied for phenol and iodobenzene reaction and its activity was further explored in N-arylation of indole with iodobenzene. The best conversion and yield were achieved at 100 °C at 1×10-3 g/cm³ catalyst loading. Notably, CuFe₂O₄@rGO was reusable without any loss of catalytic activity for five recycles. Reaction mechanism and kinetics are also presented. The overall process is novel and green. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Category: ethers-buliding-blocks).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Selective, Electrophilic Fluorinations Using N-Fluoro-o-benzenedisulfonimide was written by Davis, Franklin A.;Han, Wei;Murphy, Christopher K.. And the article was included in Journal of Organic Chemistry in 1995.Reference of 56619-93-3 This article mentions the following:

The synthesis of N-fluoro-o-benzenedisulfonimide (NFOBS) and its use as an electrophilic fluorinating reagent with nucleophilic substrates is described and compared with that of N-fluorobenzenesulfonimide (NFSi). NFOBS is prepared in three steps in 81% overall yield from com. available o-benzenedisulfonic acid and involves treatment of o-benzenedisulfonimide with dilute fluorine (10% F₂/N₂). Reaction of NFOBS with metal enolates, silyl enol ethers, and 1,3-dicarbonyl compounds affords the corresponding α-fluoro compounds in yields up to 95%, with good control of mono- and difluorination. Fluorination of ortho-metalated aromatic compounds was achieved in modest to good yields (10-80%). While the reactivities of NFOBS and NFSi are similar, better yields were observed with the former reagent in the fluorination of metal enolates, Grignard and lithium reagents, while NFSi gave better results with the ortho-lithiated aromatic substrates. The available evidence suggests an S_N2-type mechanism for the fluorination of nucleophilic substrates by these reagents. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Reference of 56619-93-3).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Reference of 56619-93-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Internalization of a peptide into multilamellar vesicles assisted by the formation of an α-oxo oxime bond was written by Richard, Antoine;Bourel-Bonnet, Line. And the article was included in Chemistry – A European Journal in 2005.Safety of 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol This article mentions the following:

As part of a drug-delivery project, we designed and synthesized a novel hydroxylamine cholesterol-based anchor to ensure the chemoselective ligation of recognition patterns onto multilamellar vesicles by oxime ligation. The entry of a glyoxylyl peptide into the vesicles was unexpectedly assisted by the formation of the α-oxo oxime bond. We studied extensively the kinetic and thermodn. aspects of this phenomenon. Briefly, for a glyoxylyl peptide, the speed and ability to enter the vesicle were dependent upon (1) the presence of a hydroxyl-amine anchor of the type Chol-E₃ONH₂, (2) the amount of peptide engaged in the ligation and (3) the flip-flop motion permitted by the different formulations, in which the presence of cholesterol seems to play an important role. In the experiment, the researchers used many compounds, for example, 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6Safety of 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol).

2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Safety of 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ignition-delay measurement for drop test with hypergolic propellants: Reactive fuels and hydrogen peroxide was written by Kang, Hongjae;Park, Seonghyeon;Park, Youngchul;Lee, Jongkwang. And the article was included in Combustion and Flame in 2020.Recommanded Product: 112-49-2 This article mentions the following:

Green hypergolic propellants have been extensively studied. In the present study, we attempted to improve the measurement technique for the ignition delay in hypergolic reactions by using a drop-test apparatus The evaluation method for the hypergolicity is important because an increase in the diversification of green hypergolic combinations is inevitable. Hydrogen peroxide (90 wt%) was used as an oxidizer, and six different reactive fuels were prepared Sodium borohydride was utilized as an ignition source for the fuels. Optical and acoustic sensors were employed to reliably measure the ignition delay. The proposed measurement technique used in this study accurately reflected the phys. phenomena of the hypergolic interactions. The tech. limitations in the conventional measurement technique using a high-speed camera were exptl. investigated. Liquid-phase reactions were dominant in the hypergolic reactions of the glyme-based reactive fuels. Gas-phase reactions significantly influenced the hypergolic reactions of most of the amine-based reactive fuels. The pyridine-based reactive fuel had a longer delay time for the gas-phase reaction process than the liquid-phase reaction process. Recognizing the rate-determining step of the hypergolic ignition is necessary for not only designing a rocket injector but also reducing combustion instability, e.g., reactive stream separation In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Recommanded Product: 112-49-2).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Recommanded Product: 112-49-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Access toward Fluorenone Derivatives through Solvent-Free Ruthenium Trichloride Mediated [2 + 2 + 2] Cycloadditions was written by Ye, Fei;Haddad, Mansour;Michelet, Veronique;Ratovelomanana-Vidal, Virginie. And the article was included in Organic Letters in 2016.SDS of cas: 16356-02-8 This article mentions the following:

An efficient and practical route for the preparation of highly substituted fluorenones and analogs via solvent-free ruthenium trichloride mediated [2 + 2 + 2] cycloaddition of α,ω-diynes and alkynes has been developed. This green chem. approach involves a solventless and atom-economical catalytic process to generate densely functionalized fluorenones and related derivatives of high synthetic utility. In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8SDS of cas: 16356-02-8).

1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.SDS of cas: 16356-02-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem