Ethers-buliding-blocks

Application of GC × GC coupled with TOF-MS for the trace analysis of chemical components and exploration the characteristic aroma profile of essential oils obtained from two tree peony species (Paeonia rockii and Paeonia ostii) was written by Wu, Yi;Li, LinZhu;Yuan, WeiQiong;Hu, JianZhong;Lv, ZhaoLin. And the article was included in European Food Research and Technology in 2021.Quality Control of 2-(2-Methoxyethoxy)ethanol This article mentions the following:

Tree peony essential oil (EO) is a critical material for flavor and function in the industrial fields of perfume, medicine and food. To conduct an overall anal. of different varieties of tree peony EOs, the composition, aroma characteristics and antioxidant activity of ZiBan and FengDan EOs were analyzed by two-dimensional gas chromatog. and time-of-flight mass spectrometry (GC × GC-TOF/MS) and the odor activity value (OAV). A total of 151 and 123 compounds were identified in ZiBan and FengDan EOs, resp., in which ZiBan EO was characterized by alc., alkane and acid, and FengDan EO was represented by aldehyde, alc. and terpene. Nevertheless, there were great differences in the content of coexisting substances in the two kinds of EOs. The aroma result indicated that the characteristic aroma and intensity of the two kinds of tree peony EOs were completely different; the aroma of ZiBan EO was mainly composed of fruity and floral aromas, whereas that of FengDan EO primarily consisted of fruity, fatty, grass and floral odors. The antioxidant activities of ZiBan EO was better than that of FengDan EO. The total antioxidant activities of ZiBan and FengDan EOs were found to be 0.020 mg Vc/mL EO and 0.003 mg Vc/mL EO, while the DPPH radical scavenging abilities of ZiBan and FengDan EOs were 24.77% and 21.60%, resp. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Quality Control of 2-(2-Methoxyethoxy)ethanol).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Quality Control of 2-(2-Methoxyethoxy)ethanol

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis of Indoles through Palladium-Catalyzed Three-Component Reaction of Aryl Iodides, Alkynes, and Diaziridinone was written by Zhou, Bo;Wu, Zhuo;Ma, Ding;Ji, Xiaoming;Zhang, Yanghui. And the article was included in Organic Letters in 2018.Product Details of 75581-11-2 This article mentions the following:

The three-component reaction of aryl iodides, alkynes, and diaziridinone is described. The reaction provides an innovative synthetic approach for indoles. The approach features high efficiency, broad substrate scope, and excellent regioselectivity. C,C-Palladacycles should act as the intermediates. The C,C-palladacycles are obtained from simple aryl halides and alkynes and then reacted with diaziridinone to afford indoles. In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2Product Details of 75581-11-2).

4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Product Details of 75581-11-2

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Thermo-Promoted Reactions of Anthranils with Carboxylic Acids, Amines, Phenols, and Malononitrile under Catalyst-Free Conditions was written by Jiang, Jing;Cai, Xin;Hu, Yanwei;Liu, Xuejun;Chen, Xiaodong;Wang, Shun-Yi;Zhang, Yinan;Zhang, Shilei. And the article was included in Journal of Organic Chemistry in 2019.Category: ethers-buliding-blocks This article mentions the following:

A convenient and atom-economical procedure for the thermo-promoted reactions of anthranil with different substrates was developed. The catalyst-free process affords various useful building blocks with good to moderate yields. This chem. enables several step- and cost-effective approaches for biol. interesting mols. and provides an efficient platform for the investigation of untapped reactions at high temperature In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Category: ethers-buliding-blocks).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Metal-free oxidative cross-dehydrogenative coupling of quinones with benzylic C(sp³)-H bonds was written by Dong, Yu;Yang, Jian;He, Shuai;Shi, Zhi-Chuan;Wang, Yu;Zhang, Xiao-Mei;Wang, Ji-Yu. And the article was included in RSC Advances in 2019.HPLC of Formula: 605-94-7 This article mentions the following:

A metal-free cross-dehydrogenative coupling of quinones with toluene derivatives has been established. A series of quinones were subjected to reaction with toluene derivatives in the presence of di-tertbutyl peroxide (DTBP) for direct synthesis of benzylquinones such as I [R = H, Me, c-hexyl, etc.; R¹ = R² = H, Me; Ar = Ph, 4-MeC₆H₄, 4-ClC₆H₄, etc.]. The method exhibited good functional group tolerance and desired products were obtained in moderate to good yields. Meanwhile, a radical pathway was proposed to describe the cross-dehydrogenative coupling of quinones with toluene derivatives In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7HPLC of Formula: 605-94-7).

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.HPLC of Formula: 605-94-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Quantitation of the contaminants in technical fenitrothion by reverse phase high-pressure liquid chromatography was written by Cochrane, William P.;Lanouette, Monique;Greenhalgh, Roy. And the article was included in Journal – Association of Official Analytical Chemists in 1979.Electric Literature of C8H9NO3 This article mentions the following:

Tech. grade samples of fenitrothion (I) [122-14-5] were analyzed by high-pressure liquid chromatog. on a reverse phase LiChrosorb RP-8 column, using 3 solvent systems and an UV detector set at 269 nm. All com. samples analyzed contained >94% I; in addn, 9 contaminants were identified and quantitated. Bisfenitrothion [4901-42-2] was the major contaminant, with average amounts of 2.46% from one manufacturer and 1.17% from another. The 2nd most abundant toxicant was S-Me fenitrothion [3344-14-7], which was present at an average level of 0.16-0.71%. The amount of fenitrooxon [2255-17-6] was ≤0.046%. Other contaminants quantitated include 2 demethyl fenitrothion [298-00-0] isomers, 3-methyl-4-nitrophenol [2581-34-2], 3-methyl-6-nitrophenol [700-38-9], 3-methyl-4-nitroanisole [5367-32-8], and bis-S-Me fenitrothion [55098-00-5]. The total amount of the constituents quantitated in 9 com. samples was 99.07%. By comparing the amounts of bis-fenitrothion and phenols present in tech. grade fenitrothion, it should be possible to identify the specific manufacturers of the various products. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Electric Literature of C8H9NO3).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Electric Literature of C8H9NO3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Copper-in-Charcoal (Cu/C) Promoted Diaryl Ether Formation was written by Lipshutz, Bruce H.;Unger, John B.;Taft, Benjamin R.. And the article was included in Organic Letters in 2007.Product Details of 54916-28-8 This article mentions the following:

Copper impregnated into charcoal efficiently catalyzes cross-couplings between aryl bromides and phenols to afford diaryl ethers, e.g., I, in good yields. The etherifications were conveniently promoted by microwave heating. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Product Details of 54916-28-8).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Product Details of 54916-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Transetherification reaction of aromatic-aliphatic ethers. II. Influence of the presence of a nitro group in an aromatic nucleus was written by Galmarini, Oscar L.;Deulofeu, Venancio. And the article was included in Anales de la Asociacion Quimica Argentina (1921-2001) in 1957.Quality Control of 3-Methyl-4-nitroanisole This article mentions the following:

Ether groups undergo nucleophilic displacement in an aromatic nucleus if there is a nitro group in a para position. 5-Methoxy-2-nitrotoluene is partially converted by boiling with NaOEt in EtOH 12 hrs. to 5-ethoxy-2-nitrotoluene (I), but I is unaffected on boiling with NaOMe in MeOH. 4-Methoxy-2-nitrotoluene is not affected by aqueous KOH or NaOEt. Similarly 4,5-dimethoxy-2-nitrotoluene (II) is converted to 5-ethoxy-4-methoxy-2-nitrotoluene (III). Oliverio (Boll. sedute accad. Gioenia sci. nat. Catania [3] 1937) gave the product as 4,5-diethoxy-2-nitrotoluene (IV). IV is partially converted to 4-ethoxy-5-methoxy-2-nitrotoluene (V) and III and V are partially interconverted by NaOEt. The mixtures of toluene ethers could not be separated, but were oxidized to the corresponding benzoic acids which were separated by paper chromatography using 8:1:1 iso-PrOH-NH₄OH-H₂O. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Quality Control of 3-Methyl-4-nitroanisole).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Quality Control of 3-Methyl-4-nitroanisole

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tandem oxidative amidation of benzylic alcohols by copper(II) supported on metformin-graphitic carbon nitride nanosheets as an efficient catalyst was written by Ghafuri, Hossein;Ghafori Gorab, Mostafa;Dogari, Haniyeh. And the article was included in Scientific Reports in 2022.SDS of cas: 105-13-5 This article mentions the following:

In this research, an efficient heterogeneous catalyst based on graphitic carbon nitride nanosheets (CN) was reported. The CN was functionalized by 1,3-dibromopropane as a linker (CN-Pr-Br) and subsequently modified with metformin (CN-Pr-Met). Furthermore, the copper(II) was coordinated on modified CN (CN-Pr-Met-Cu(II)) and during this process, 7.94% copper(II) was loaded into the catalyst structure. The synthesized catalyst was evaluated by various techniques including fourier-transform IR spectroscopy (FT-IR), energy dispersive X-ray spectroscopy (EDS), field emission SEM (FE-SEM), thermogravimetric anal. (TGA), X-ray diffraction (XRD), and inductively coupled plasma at. emission spectroscopy (ICP-OES). CN-Pr-Met-Cu(II) was used as a catalyst in the synthesis of amides via the oxidation of benzyl alcs. The conditions of this reaction were optimized in terms of temperature, time, amount of catalyst, type of base, oxidant, and solvent. Moreover, a variety of amides with an efficiency of 75-95% were synthesized. The reaction was carried out in the presence of benzyl alcs., amine hydrochloride salts, tert-Bu hydroperoxide (TBHP), CaCO₃, and CN-Pr-Met-Cu(II) at 80°C of acetonitrile solvent. The synthesized catalyst can be easily separated from the reaction medium and reused for 7 consecutive runs without a significant reduction in reaction efficiency. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5SDS of cas: 105-13-5).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.SDS of cas: 105-13-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and fluorescent properties of aza-crown ether tethered BODIPY fluorophores was written by Yang, Lijing;Liao, De-Jhong;Wu, An-tai;Yan, Hongbin. And the article was included in Tetrahedron Letters in 2017.HPLC of Formula: 66943-05-3 This article mentions the following:

Five BODIPY analogs modified at the meso-position were synthesized through a Mannich-type reaction. Among these derivatives, aza-12-crown-4 analog 3c was found to show Cu²⁺-specific behavior in UV/vis and fluorescent spectra, leading to blue shifts in absorption and effective fluorescent quenching in the presence of Cu²⁺. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3HPLC of Formula: 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.HPLC of Formula: 66943-05-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and Structure-Activity Relationships of Novel 8a-Aza-8a-homoerythromycin A Ketolides was written by Pavlovic, Drazen;Mutak, Stjepan. And the article was included in Journal of Medicinal Chemistry in 2010.HPLC of Formula: 1132-95-2 This article mentions the following:

A series of novel 6-O-substituted 8a-aza-8a-homoerythromycin A ketolides was synthesized and evaluated for in vitro antibacterial activity. Key strategic elements of the synthesis include the base-induced E-Z isomerization of 3-O-descladinosyl-6-O-allylerythromycin A 9(E)-oxime followed by ring-expanding reaction of the resulting 9(Z)-oxime via Beckmann rearrangement. The ketolides showed potent activity against a variety of erythromycin-susceptible and macrolide-lincosamide-streptogramin B (MLS_B) resistant Gram-pos. and fastidious Gram-neg. pathogens. The best compounds in this series overcome all types of resistance in relevant clin. Gram-pos. pathogens and display in vitro activity comparable to telithromycin and cethromycin. In the experiment, the researchers used many compounds, for example, 1,1-Diisopropoxycyclohexane (cas: 1132-95-2HPLC of Formula: 1132-95-2).

1,1-Diisopropoxycyclohexane (cas: 1132-95-2) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.HPLC of Formula: 1132-95-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem