Ethers-buliding-blocks

Synthesis of 3,3-diarylpropionic acids using phosphoric acid as catalyst was written by Elsworth, J. F.;Lamchen, M.. And the article was included in Journal of the South African Chemical Institute in 1972.Recommanded Product: 3-(2,4-Dimethoxyphenyl)acrylic acid This article mentions the following:

Phenols and their Me ethers, in the presence of 85% H3PO4, readily add to the β-C atom of cinnamic acids bearing a MeO group in either the ortho or para positions on the phenyl group, to give high yields of 3,3-diarylpropionic acids. If an ortho HO group is present on the addend, the propionic acid can lactonize to yield a 4-aryldihydrocoumarin. The product from addition of 2,4-dimethoxycinnamic acid to anisole is capable reacting nucleophilically with more 2,4-dimethoxycinnamic acid to yield a bispropionic acid. A truxillic acid is obtained when 3,4-dimethoxycinnamic acid is either warmed with H3PO4 or shaken with m-xylene in the presence of H3PO4. The methoxycinnamic acid is initially protonated by H3PO4 and the derived quinonoid structure is susceptible to attack by nucleophiles. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Recommanded Product: 3-(2,4-Dimethoxyphenyl)acrylic acid).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Recommanded Product: 3-(2,4-Dimethoxyphenyl)acrylic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Visible Light- and Heat-promoted C-O Coupling Reaction of Phenols and Aryl Halides was written by Yang, Qing-Qing;Liu, Na;Yan, Jia-Ying;Ren, Zhi-Lin;Wang, Long. And the article was included in Asian Journal of Organic Chemistry in 2020.SDS of cas: 54916-28-8 This article mentions the following:

A visible light- and heat-promoted C-O coupling reaction of phenols and aryl halides was described to afford diaryl ethers in good to excellent yields without transition-metal, photocatalysts or ligands. Moreover, the reaction had good substrate universality, suitable for substituted phenol, naphthol and heterocyclic phenol derivatives Control experiments revealed that an electron donor-acceptor (EDA) complex formed from the association of an aryl halide and phenol anion. DFT calculation further confirmed the existence of the EDA complex. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8SDS of cas: 54916-28-8).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.SDS of cas: 54916-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Simulations of dielectric constants and viscosities of organic electrolytes by quantum mechanics and molecular dynamics was written by Yamaguchi, Toru;Yamada, Hidetaka;Fujiwara, Takayuki;Hori, Kenji. And the article was included in Journal of Molecular Liquids in 2020.Recommanded Product: 2,5,8,11-Tetraoxadodecane This article mentions the following:

Dielec. constants and viscosities are important phys. properties of organic electrolytes. Therefore, predicting these properties by practical computer simulations is valuable for developing new batteries. Here, a combination of quantum mech. calculations and mol. dynamics simulations was used to predict these properties for 17 electrolytes. The computed results were assembled using the Kirkwood-Onsager and the Green-Kubo relational equation to obtain the dielec. constants and viscosities, resp. In particular, Kirkwood’s g-factors were derived based on the method developed by Zhang et al. in 2016. The coefficients of determination (R²) for the dielec. constants and viscosities were calculated to be 0.9875 and 0.9230, resp. It was confirmed that both quantum mech. calculations for elec. properties and mol. dynamics simulations for macroscopic effects can well reproduce the abovementioned properties for a wide range of organic electrolytes. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Recommanded Product: 2,5,8,11-Tetraoxadodecane).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Recommanded Product: 2,5,8,11-Tetraoxadodecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Rhodium(III)-catalyzed synthesis of cinnolinium salts from azobenzenes and alkynes: application to the synthesis of indoles and cinnolines was written by Muralirajan, Krishnamoorthy;Cheng, Chien-Hong. And the article was included in Chemistry – A European Journal in 2013.Electric Literature of C6H10O2 This article mentions the following:

A rhodium-catalyzed C-H activation/annulation of azobenzenes with alkynes to give various substituted cinnolinium salts in good to excellent yields is reported. The reaction is compatible with a wide substrate scope and highly atom- and step-economic. The proposed mechanism is strongly supported by the isolation of a five-membered rhodacycle. This protocol has been successfully applied to the synthesis of indole, indoloindole, and cinnoline derivatives In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8Electric Literature of C6H10O2).

1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Electric Literature of C6H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A rapid Hg²⁺ sensor based on aza-15-crown-5 ether functionalized 1,8-naphthalimide was written by Hou, Chen;Urbanec, Alysha M.;Cao, Haishi. And the article was included in Tetrahedron Letters in 2011.HPLC of Formula: 66943-05-3 This article mentions the following:

A new 1,8-naphthalimide derivative bearing an aza-15-crown-5 macrocycle (I) was synthesized as a chemosensor for Hg²⁺ by a two-step reaction. The sensor shows selectivity to Hg²⁺ over 11 other metal cations in aqueous media. Upon addition of Hg²⁺, the fluorescence emission of the sensor at 537 nm is significantly quenched along with 22 nm blue-shift that makes this compound a useful sensor for Hg²⁺ measurement. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3HPLC of Formula: 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.HPLC of Formula: 66943-05-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A new modification of the Friedlander synthesis via ortho-dilithiated N-pivaloylanilines was written by Ubeda, J. Ignacio;Villacampa, Mercedes;Avendano, Carmen. And the article was included in Synlett in 1997.Safety of N-(3-Methoxyphenyl)pivalamide This article mentions the following:

Formylation of ortho-dilithiated N-pivaloylanilines followed by treatment with carbonyl compounds and KHMDS affords 3- or 2,3-substituted quinoline derivatives in a one-pot reaction. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Safety of N-(3-Methoxyphenyl)pivalamide).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Safety of N-(3-Methoxyphenyl)pivalamide

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Theoretical Infrared Spectra: Quantitative Similarity Measures and Force Fields was written by Henschel, Henning;Andersson, Alfred T.;Jespers, Willem;Mehdi Ghahremanpour, Mohammad;van der Spoel, David. And the article was included in Journal of Chemical Theory and Computation in 2020.Electric Literature of C8H18O4 This article mentions the following:

IR spectroscopy can provide significant insight into the structures and dynamics of mols. of all sizes. The information that is contained in the spectrum is, however, often not easily extracted without the aid of theor. calculations or simulations. We present here the calculation of the IR spectra of a database of 703 gas phase compounds with four different force fields (CGenFF, GAFF-BCC, GAFF-ESP, and OPLS) using normal-mode anal. Modern force fields increasingly use virtual sites to describe, e.g., lone-pair electrons or the σ-holes on halogen atoms. This requires some adaptation of code to perform normal-mode anal. of such compounds,the implementation of which into the GROMACS software is briefly described as well. For the quant. comparison of the obtained spectra with exptl. reference data, we discuss the application of two different statistical correlation coefficients, Pearson and Spearman. The advantages and drawbacks of the different methods of comparison are discussed, and we find that both methods of comparison give the same overall picture, showing that present force field methods cannot match the performance of quantum chem. methods for the calculation of IR spectra. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Electric Literature of C8H18O4).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Electric Literature of C8H18O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Living and Alternating Cationic Copolymerization of o-Phthalaldehyde and Various Bulky Enol Ethers: Elucidation of the “Limit” of Polymerizable Monomers was written by Hayashi, Keisuke;Kanazawa, Arihiro;Aoshima, Sadahito. And the article was included in Macromolecules (Washington, DC, United States) in 2022.Reference of 111-77-3 This article mentions the following:

Cationic copolymerization of various bulky enol ethers, which have been difficult to homopolymerize and/or copolymerize, was shown to proceed when o-phthalaldehyde (OPA) was used as a comonomer. A series of enol ethers with various substituents on the β-carbon was synthesized from aliphatic aldehydes and alcs. The relationships between the structures of the enol ethers and the copolymerization behavior were systematically investigated. As a result, monomers with one or two Me and/or primary alkyl groups on the β-carbon were found to undergo alternating copolymerization with OPA. Moreover, living cationic copolymerization of enol ethers and OPA yielded alternating copolymers under appropriate polymerization conditions. To elucidate the limit of polymerizable monomers, the copolymerization of very bulky enol ethers such as β-t-butyl- or norbornenylidene-type monomers with OPA was also examined OPA was found to be copolymerizable even with such very bulky monomers, indicating that the unique reactivity of the OPA-derived propagating carbocation with small steric hindrance is the key factor for successful copolymerization In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Reference of 111-77-3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Reference of 111-77-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A convenient synthesis of β-amino acid was written by Basheeruddin, K.;Siddiqui, Amin A.;Khan, Naseem H.;Saleha, S.. And the article was included in Synthetic Communications in 1979.Category: ethers-buliding-blocks This article mentions the following:

RCH:CHCO₂H [I; R = Ph, (Z)-CO₂H, (E)-CO₂H, Bz, 2,4-(MeO)₂C₆H₃, 2-MeOC₆H₄, 4-MeOC₆H₄, 3,4-(CH₂O₂)C₆H₃, 4,3-(MeO)(HO)C₆H₃] were treated with NH₂OH to give RCH(NHOH)CH₂CO₂H (II), which were hydrogenated over Pd/C to give the corresponding DL-RCH(NH₂)CH₂CO₂H. I (R = p-O₂NC₆H₄) was treated with NH₂OH to give II (R = p-O₂NC₆H₄), which was hydrogenated over Pd/C to give DL–p-H₂NC₆H₄CH(NH₂)CH₂CO₂H. I (R = PhCH:CH) was converted to DL-PhCH(NH₂)CH₂CH(NH₂)CO₂H by the above reactions. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Category: ethers-buliding-blocks).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Photosynthetic Bioelectronic Sensors for Touch Perception, UV-Detection, and Nanopower Generation: Toward Self-Powered E-Skins was written by Ravi, Sai Kishore;Wu, Tingfeng;Udayagiri, Vishnu Saran;Vu, Xuan Minh;Wang, Yanan;Jones, Michael R.;Tan, Swee Ching. And the article was included in Advanced Materials (Weinheim, Germany) in 2018.Synthetic Route of C9H10O4 This article mentions the following:

Energy self-sufficiency is an inspirational design feature of biol. systems that fulfills sensory functions. Plants such as the “touch-me-not” and “Venus flytrap” not only sustain life by photosynthesis, but also execute specialized sensory responses to touch. Photosynthesis enables these organisms to sustainably harvest and expend energy, powering their sensory abilities. Photosynthesis therefore provides a promising model for self-powered sensory devices like electronic skins (e-skins). While the natural sensory abilities of human skin have been emulated in man-made materials for advanced prosthetics and soft-robotics, no previous e-skin has incorporated phototransduction and photosensory functions that could extend the sensory abilities of human skin. A proof-of-concept bioelectronic device integrated with natural photosynthetic pigment-proteins is presented that shows the ability to sense not only touch stimuli (down to 3000 Pa), but also low-intensity UV radiation (down to 0.01 mW cm^-2) and generate an elec. power of ≈260 nW cm^-2. The scalability of this device is demonstrated through the fabrication of flexible, multipixel, bioelectronic sensors capable of touch registration and tracking. The polysensory abilities, energy self-sufficiency, and addnl. nanopower generation exhibited by this bioelectronic system make it particularly promising for applications like smart e-skins and wearable sensors, where the photogenerated power can enable remote data transmission. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7Synthetic Route of C9H10O4).

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Synthetic Route of C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem