Ethers-buliding-blocks

Ionic transport and mechanical properties of slide-ring gel swollen with Mg-ion electrolytes was written by Nishino, Haruka;Liu, Chang;Kanehashi, Shinji;Mayumi, Koichi;Tominaga, Yoichi;Shimomura, Takeshi;Ito, Kohzo. And the article was included in Ionics in 2020.Reference of 112-49-2 This article mentions the following:

The authors applied a slide-ring (SR) gel to a Mg²⁺ ion gel electrolyte and clarified the elec. and mech. properties in order to achieve a Mg²⁺ ion gel electrolyte with both sufficient mech. strength and high ionic conductivity The SR gel is made from polyrotaxane, which has a structure that consists of cyclic mols., α-cyclodextrins (CDs), threaded by an axial polymer chain, polyethylene glycol (PEG), and crosslinked by divinyl sulfone. Pure glymes and tetraethylene glycol di-Me ether (tetraglyme: G4) dissolving Mg²⁺ ions had no ability to swell the SR gel, whereas diethylene glycol di-Me ether (diglyme: G2) and triethylene glycol di-Me ether (triglyme: G3) dissolving Mg²⁺ ions were able to swell the SR gel. The swelling behavior was strongly dependent on the interaction between Mg²⁺ ions complexed with glymes and ether oxygens of a PEG-based hydroxypropyl PR (HyPR) network. Upon tensile elongation, SR gel swollen with G3 solution dissolving Mg²⁺ ions could be extended by 300%, which indicated the unique property of high ductility. The ionic conductivity of SR gel swollen with G3 dissolving Mg²⁺ ions, which approx. satisfied a Vogel-Tamman-Fulcher (VTF) dependence, was 1.73 mS cm^-1 at room temperature, and the molar conductivity was 67% of that for a pristine G3 solution dissolving Mg²⁺ ions. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Reference of 112-49-2).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Reference of 112-49-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Antibacterial Activity and Mechanism of Coenzyme Q₀ Against Escherichia coli was written by Wang, Ruixia;Li, Jiahui;Qu, Geruo;Guo, Du;Yang, Yanpeng;Ma, Xiaoyu;Wang, Muxue;Xu, Yunfeng;Wang, Yutang;Xia, Xiaodong;Shi, Chao. And the article was included in Foodborne Pathogens and Disease in 2021.Application of 605-94-7 This article mentions the following:

Coenzyme Q₀ (CoQ₀) is a natural compound found in Antrodia cinnamomea, which has a variety of biol. activities. Here, the antibacterial activity and possible antibacterial mechanism of CoQ₀ against Escherichia coli were investigated. The antibacterial effect was evaluated by determining min. inhibitory concentration (MIC) and min. bactericidal concentration (MBC) values, and by assessing bacterial survival and the effect on the growth of E. coli after CoQ₀ treatment in Luria-Bertani (LB) broth. To reveal the antibacterial mechanism of CoQ₀, changes in intracellular ATP (ATP) concentration, membrane potential, and bacterial protein content, as well as effects on cell morphol. and membrane integrity, were investigated. Both the MICs and MBCs of CoQ₀ against E. coli were 0.1 mg/mL. After treatment of E. coli (6.5 log colony-forming units/mL) with 0.1 mg/mL of CoQ₀ in LB broth for 3 h, the number of viable cells dropped below the detection limit. In addition, CoQ₀ treatment resulted in the reduction in intracellular ATP concentration, cell membrane hyperpolarization, decreased bacterial protein concentrations, and damage to cell membrane integrity and cellular morphol. These results indicated that CoQ₀ has effective antibacterial activity against E. coli, suggesting potential applications in food industry safety. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7Application of 605-94-7).

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Application of 605-94-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

syn-Diastereoselective glycolate aldol addition reactions of an N(3)-(p-methoxyphenoxy)acetyloxazolidine-2-thione was written by Haynes, Craig S.;Goodman, Cassie A.;Bruce, Juandah;Genin, Sarah C.;Austermuehle, Brad J.;Leong, Victor L.;Leise, Austin R.;Larson, Robert;Hamaker, Christopher G.;Hitchcock, Shawn R.. And the article was included in Tetrahedron: Asymmetry in 2017.Application of 1877-75-4 This article mentions the following:

An N₃-(p-methoxyphenoxy)acetyloxazolidine-2-thione was synthesized and employed in glycolate asym. aldol addition reactions with aromatic and aliphatic aldehydes. It was determined that the titanium tetrachloride medicated aldol reaction afforded diastereoselectivities that ranged from 75:25 to 94:6 when the reaction was conducted at -78°. The absolute stereochem. of the aldol adducts was determined by ¹H NMR spectroscopy and X-ray crystallog. The ¹H NMR spectra of the aldol adducts contained a signal (the α-proton of the glycolate position of the aldol side chain) that was highly deshielded due to conformational restriction about the N(3)-(p-methoxyphenoxy)acetyl side chain and the oxazolidine-2-thione auxiliary. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Application of 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Application of 1877-75-4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Concise access to perimidines by palladium (II) complexes via acceptorless dehydrogenative coupling of alcohols was written by Clinton, Savarimuthu Selvan;Ramesh, Rengan;Malecki, Jan Grzegorz. And the article was included in Applied Organometallic Chemistry in 2022.Related Products of 105-13-5 This article mentions the following:

A facile protocol for the one-pot synthesis of 2,3-dihydro-1H-perimidines via dehydrogenative coupling of easily exploitable benzyl alcs. supported by new Pd(II) complexes has been reported. To accomplish the construction of perimidines, a new set of palladium(II) complexes [Pd(L)Cl (PPh₃)] encompassing biphenyl benzhydrazone ligands I has been reported as catalysts. Structural characterization by elemental anal., FT-IR, NMR (¹H and ¹³C), and mass spectral analyses confirmed the composition of synthesized complexes. The mol. structures of complexes I(R = H, OCH₃), were unequivocally resolved using single-crystal X-ray diffraction. It reveals that the complex espoused distorted square-planar geometry around Pd(II) ion chelated by azomethine nitrogen and imidolate oxygen of biphenyl benzhydrazone ligands with labile chloride and a triphenylphosphine. Further, the selective synthesis of a broad range of functionalized perimidines has been accomplished via ADC of a variety of alcs. with 1,8-diaminonaphthalene. The palladium complexes mediated catalytic synthesis offered good yields of perimidines up to 86% using only 0.5 mol% catalyst loading. A probable mechanism to the formation of perimidines was postulated from the results of control exptl. investigations. The environmentally compassionate, greener ADC protocol progresses via the generation of aldehyde intermediate and releases only water and hydrogen gas. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Related Products of 105-13-5).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Related Products of 105-13-5

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Host-guest complexation. 9. Macrocyclic polyethers and sulfides shaped by one rigid dinaphthyl unit and attached arms. Synthesis and survey of complexing abilities was written by Cram, Donald J.;Helgeson, Roger C.;Koga, Kenji;Kyba, Evan P.;Madan, Khorshed;Sousa, Lynn R.;Siegel, Merrell G.;Moreau, Patrice;Gokel, George W.. And the article was included in Journal of Organic Chemistry in 1978.Electric Literature of C11H16O3 This article mentions the following:

The synthesis and characterization of a stereoisomeric macrocyclic polyether, e.g., I (R, R² = H, CH₂OH, CH₂OCH₂CO₂Me, etc.; R¹ = H, Br, COMe, etc.) and polyether-polythioether hosts are described. The unshared electron pairs of the heteroatoms act as binding sites for metal or alkylammonium cations. Substituents attached at the 3,3′-positions of the 1,1′-binaphthyl unit converge on and provide addnl. shape to the space surrounding the central binding hole of the macro ring. Certain of these units terminate in functional groups that provide addnl. ligands for cationic guests, in some cases supplying counterions for the charge on the guests. Substituents attached at the 6,6′-positions of the 1,1′-binaphthyl unit diverge from the macro ring and its environment and can be used to manipulate solubility properties or to bind the hosts to solid supports. Substituents attached at the 3- or 4-positions of the 1,2-benzene units, when long enough and in the proper conformations, can curl to place addnl. binding sites on the edge of the macro ring. The maximum rotations and absolute configurations of some of the optically active hosts were determined Ring closures (6-65% yield) involved aryloxide- or arylsulfide-anion substitutions on appropriate alkyl ditosylates. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Electric Literature of C11H16O3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Electric Literature of C11H16O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Photochromic polyphosphazenes with spiropyran units was written by Allcock, Harry R.;Kim, Chulhee. And the article was included in Macromolecules in 1991.Name: 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol This article mentions the following:

Photochromic spiropyrans were linked to polyphosphazenes through O(CH₂CH₂O)_nO (n = 2, 3) spacers. The reversion of photogenerated merocyanine groups to spiropyran units in the solid state was much slower than in solution (increasing with increasing polarity for the latter). Solid-state reversion was slower for a polymer containing all spiropyran units than for one containing mixed substituents, presumably a steric effect. Reversion was slower for polymers with a diethyleneoxy spacer than with a triethyleneoxy unit. Reversions in THF and the solid state were modeled by a biexponential process. The overall phenomena were explained by the solvation or aggregation of the polymer chains in solution as well as by the existence of 2 different environments for the merocyanine units. In the experiment, the researchers used many compounds, for example, 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6Name: 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol).

2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Name: 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The antimicrobial activity of coenzyme Q₀ against planktonic and biofilm forms of Cronobacter sakazakii was written by Guo, Du;Wang, Shuo;Li, Jiahui;Bai, Fangting;Yang, Yanpeng;Xu, Yunfeng;Liang, Sen;Xia, Xiaodong;Wang, Xin;Shi, Chao. And the article was included in Food Microbiology in 2020.Safety of 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione This article mentions the following:

Coenzyme Q₀ (CoQ₀) has demonstrated antitumor, anti-inflammatory, and anti-angiogenic activities. Cronobacter sakazakii is an opportunistic foodborne pathogen associated with high mortality in neonates. In this study, the antimicrobial activity and possible antimicrobial mechanism of CoQ₀ against C. sakazakii were investigated. Moreover, the inactivation effect of CoQ₀ on C. sakazakii in biofilms was also evaluated. The min. inhibitory concentration (MIC) of CoQ₀ against C. sakazakii strains ranged from 0.1 to 0.2 mg/mL. Treatment caused cell membrane dysfunction, as evidenced by cell membrane hyperpolarization, decreased intracellular ATP concentration and cell membrane integrity, and changes in cellular morphol. CoQ₀ combined with mild heat treatment (45, 50, or 55°C) decreased the number of viable non-desiccated and desiccated C. sakazakii cells in a time- and dose-dependent manner in reconstituted infant milk. Furthermore, CoQ₀ showed effective inactivation activity against C. sakazakii in biofilms on stainless steel, reducing the number of viable cells and damaging the structure of the biofilm. These findings suggest that CoQ₀ has a strong inactivate effect on C. sakazakii and could be used in food production environments to effectively control C. sakazakii and reduce the number of illnesses associated with it. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7Safety of 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione).

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Safety of 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Total synthesis of the teicoplanin aglycon was written by Boger, Dale L.;Kim, Seong Heon;Miyazaki, Susumu;Strittmatter, Harald;Weng, Jian-Hui;Mori, Yoshiki;Rogel, Olivier;Castle, Steven L.;McAtee, J. Jeffrey. And the article was included in Journal of the American Chemical Society in 2000.Related Products of 57179-35-8 This article mentions the following:

Teicoplanin is a complex of five antibiotics isolated from Actinoplanes teichomyceticus that are related to vancomycin. The first total synthesis of the teicoplanin aglycon (I) is described. Key elements of the approach include sequential DE and FG ring system introductions onto the common vancomycin/teicoplanin ABCD ring system providing a late stage divergent total synthesis of the two classes of glycopeptide antibiotics. The ring systems were introduced enlisting a nucleophilic aromatic substitution reaction of an o-fluoronitroarom. for macrocyclization and formation of the 16-membered DE diaryl ether and a macrolactamization of the N-terminus amide for closure of the 14-membered FG ring system. The teicoplanin aglycon was obtained in 48% yield identical in all respects with authentic material. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8Related Products of 57179-35-8).

3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Related Products of 57179-35-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Encapsulation effect on the in vitro bioaccessibility of sacha inchi oil (Plukenetia volubilis L.) by soft capsules composed of gelatin and cactus mucilage biopolymers was written by Otalora, Maria Carolina;Camelo, Robinson;Wilches-Torres, Andrea;Cardenas-Chaparro, Agobardo;Castano, Jovanny A. Gomez. And the article was included in Polymers (Basel, Switzerland) in 2020.Application of 111-77-3 This article mentions the following:

Sacha inchi (Plukenetia volubilis L.) seed oil is a rich source of polyunsaturated fatty acids (PUFAs) that are beneficial for human health, whose nutritional efficacy is limited because of its low water solubility and labile bioaccessibility (compositional integrity). In this work, the encapsulation effect, using blended softgels of gelatin (G) and cactus mucilage (CM) biopolymers, on the PUFAs’ bioaccessibility of P. volubilis seed oil was evaluated during in vitro simulated digestive processes (mouth, gastric, and intestinal). Gas chromatog.-mass spectrometry (GC-MS) and gas chromatog. with a flame ionization detector (GC-FID) were used for determining the chem. composition of P. volubilis seed oil both before and after in vitro digestion. The most abundant compounds in the undigested samples were α-linolenic, linoleic, and oleic acids with 59.23, 33.46, and 0.57 (g/100 g), resp. The bioaccessibility of α-linolenic, linoleic, and oleic acid was found to be 1.70%, 1.46%, and 35.8%, resp., along with the presence of some oxidation products. G/CM soft capsules are capable of limiting the in vitro bioaccessibility of PUFAs because of the low mucilage ratio in their matrix, which influences the enzymic hydrolysis of gelatin, thus increasing the release of the polyunsaturated content during the simulated digestion. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Application of 111-77-3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Application of 111-77-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Studies on the fat-soluble chemical constituents in stalk and leaf of fistular onion was written by Zhang, Geng;Zhou, Yinbo;Zhang, Changgong;Liu, Jingyou;Cheng, Lu. And the article was included in Zhongguo Yaoshi (Wuhan, China) in 2010.Category: ethers-buliding-blocks This article mentions the following:

The objective of this paper was to compare the difference of the chem. constituents between stalk and leaf of fistular onion. The stalk and leaf of fistular onion were extracted by supercritical CO₂ fluid resp., and then isolated by silica gel column chromatog. to obtain seven components with different polarities. Then four components of them were analyzed by GC-MS combined with computer database anal. The types of chem. constituents of stalk and leaf of fistular onion were basically similar, but there were more chem. materials in fistular onion stalk. The systematic research on the difference of the chem. constituents between stalk and leaf of fistular onion was significant for the development of them. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Category: ethers-buliding-blocks).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem