Ethers-buliding-blocks

Synthesis and biological activity of 1,3,4-thiadiazole compounds containing ferrocenyl moiety was written by Gou, Xiao-feng;Li, Yuan;Chen, Bang;Gao, Xue-xiang. And the article was included in Huaxue Shiji in 2013.SDS of cas: 1877-75-4 This article mentions the following:

A series of novel N-(ferrocenyl-methyl)-5-alkyl/aryl-1, 3, 4-thiadiazol-2-amines were synthesized by the condensation of ferrocenecarboxaldehyde with 2-amino-5-alkyl/aryl-1, 3, 4-thiadiazoles in presence of silica gel and then reduction by potassium borohydride. All products were characterized by IR, ¹HNMR, and ESI/MS. Further, all synthesized compounds were screened for their auxin activity. Most of the compounds showed potent activity. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4SDS of cas: 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.SDS of cas: 1877-75-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and crystal structure of new bis(azacrown ethers) on the basis of 1,2-bis(2,2,2-trichloro-1-isocyanatoethoxy)benzene was written by Luk’yanenko, Nickolay G.;Pastushok, Viktor N.;Lyapunov, Alexander Yu.;Onys’ko, Pyotr P.;Sinitsa, Anatoliy D.;Povolotskiy, Mark I.;Zubatyuk, Roman I.;Shiskhin, Oleg V.. And the article was included in Makrogeterotsikly in 2009.Computed Properties of C10H21NO4 This article mentions the following:

Synthesis, properties and X-Ray anal. of the new bis(azacrown ethers), containing bridging urea fragments are reported here. These substances have in their mol. structure both centers of anion linking (proton donating NH groups) and centers of cation linking (crown ether units) and thus may be considered as potential ion-pair receptors. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Computed Properties of C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Computed Properties of C10H21NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Selective oxidation of 5-hydroxymethylfurfural into 2,5-diformylfuran by TEMPO-assisted magnetic Fe₃O₄@SiO₂@mSiO₂-NH₂-Cu(II) catalytic system was written by Pan, Pan;Li, Mingming;Liu, Yuxin;Feng, Yisi;Li, Xinglong. And the article was included in Molecular Catalysis in 2022.Recommanded Product: 105-13-5 This article mentions the following:

2,5-Diformylfuran (DFF) is a multifunctional intermediate, which can be used in drugs, functional polymers, fluorescent materials and surfactants. In this paper, a TEMPO-assisted magnetic Fe₃O₄@SiO₂@mSiO₂-NH₂-Cu(II) catalytic system was developed for the selective oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-diformylfuran. The structure of Fe₃O₄@SiO₂@mSiO₂-NH₂-Cu(II) was double-layer shell-core spherical structure with uniform ordered mesoporous on the surface, amino groups and Cu were evenly distributed in the outer mesoporous. The catalyst was characterized by FT-IR, TEM, EDS, SEM, x-ray diffraction, BET and VSM. The effects of reaction conditions were studied in detail. The conversion of HMF was 98.9% and the highest DFF yield was 92.4% under atm. oxygen in toluene solvent. The catalytic activity did not decrease significantly after 5 cycles. The catalytic system had good substrate adaptability for benzyl alcs. and aromatic alcs. with satisfactory yield of corresponding aldehydes (91.3-100%). A possible reaction mechanism was also proposed and found that bis(μ-hydroxy) double copper (II) may be the active reactant in oxidation reaction. The system provides a promising industrialized preparation method for DFF. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Recommanded Product: 105-13-5).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Recommanded Product: 105-13-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A decarboxylative approach for regioselective hydroarylation of alkynes was written by Zhang, Jing;Shrestha, Ruja;Hartwig, John F.;Zhao, Pinjing. And the article was included in Nature Chemistry in 2016.Safety of 1,4-Dimethoxy-2-butyne This article mentions the following:

Regioselective activation of aromatic C-H bonds is a long-standing challenge for arene functionalization reactions such as the hydroarylation of alkynes. One possible solution is to employ a removable directing group that activates one of several aromatic C-H bonds. Here the authors report a new catalytic method for regioselective alkyne hydroarylation with benzoic acid derivatives during which the carboxylate functionality directs the alkyne to the ortho-C-H bond with elimination in situ to form a vinylarene product. The decarboxylation stage of this tandem sequence is envisioned to proceed with the assistance of an ortho-alkenyl moiety, which is formed by the initial alkyne coupling. This ruthenium-catalyzed decarboxylative alkyne hydroarylation eliminates the common need for pre-existing ortho-substitution on benzoic acids for substrate activation, proceeds under redox-neutral and relatively mild conditions, and tolerates a broad range of synthetically useful aromatic functionality. Thus, it significantly increases the synthetic utility of benzoic acids as easily accessible aromatic building blocks. In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8Safety of 1,4-Dimethoxy-2-butyne).

1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Safety of 1,4-Dimethoxy-2-butyne

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Phosphorus-nitrogen compounds: Part 61. The novel sodium complexes of monoferrocenylspirocyclotriphosphaza-crown ethers was written by Uzunalioglu, Nese;Asmafiliz, Nuran;Kilic, Zeynel;Hokelek, Tuncer. And the article was included in Inorganica Chimica Acta in 2022.Application of 66943-05-3 This article mentions the following:

Condensation reactions of hexachlorocyclotriphosphazene, N₃P₃Cl₆ (HCCP, trimer) and four different diamines (1–4) yielded tetrachloromono (5, 7 and 8) and bisferrocenyl (6) spirocyclotriphosphazenes. Reactions of 5, 7 and 8 with two equimolar amounts of 1-aza-15-crown-5 ether (L) produced new monoferrocenylspirocyclotriphosphazabis(crown ethers) (9, 10 and 12) in THF, resp. The only monoferrocenylspirocyclotriphosphazatris(crown ether) (13) was obtained from the reaction of 8 with three equimolar amounts of L. However, reactions of 7 and 8 with four equimolar amounts of L gave monoferrocenylspirocyclotriphosphaza-tetrakis(crown ethers) 11 and 14. In addition, the complexation reactions of ditopic phosphaza-crown ethers (9, 10 and 11) with NaClO₄ yielded novel mononuclear sandwich-type sodium complexes (9a, 10a and 11a). Tri- and tetranuclear complexes (13a and 14a) were obtained as a result of the complexation reactions of tri- and tetratopic phosphaza-crown ethers (13 and 14) with NaClO₄. Characterizations of phosphaza-crown ethers and complexes were performed using elemental anal., mass spectrometry, FTIR, and ¹H, ¹³C and ³¹P NMR techniques. Ditopic phosphazenes (9, 10 and 12) and complexes (9a, 10a and 11a) have a stereogenic P center. While the tritopic ligand (13) and complex (13a) have two stereogenic P centers. They are expected to be in racemic mixtures In addition, crystal structures of phosphazenes 6 and 9 were elucidated using x-ray crystallog. The absolute configurations of the enantiomers of 9 were determined as R and S. Furthermore, intermol. interactions in crystal structures of 6 and 9 were determined by Hirshfeld surface (HS) anal. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Application of 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Application of 66943-05-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Enantioselective iridium-catalyzed carbonyl isoprenylation via alcohol-mediated hydrogen transfer was written by Xiang, Ming;Luo, Guoshun;Wang, Yuankai;Krische, Michael J.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.COA of Formula: C7H9NO2 This article mentions the following:

Highly enantioselective iridium catalyzed carbonyl (2-vinyl)allylation or “isoprenylation” was developed for the synthesis of methylenealkenols I [R = cyclopropyl, 2-FC₆H₄, 2-thienyl, etc.] via hydrogen auto-transfer or 2-propanol-mediated reductive coupling of primary alcs. or aldehydes, resp. with tert-butyl-2-methylenebut-3-enyl carbonate. Using this method, asym. total syntheses of the terpenoid natural products, (+)-ipsenol and (+)-ipsdienol were also achieved. In the experiment, the researchers used many compounds, for example, (6-Methoxypyridin-2-yl)methanol (cas: 63071-12-5COA of Formula: C7H9NO2).

(6-Methoxypyridin-2-yl)methanol (cas: 63071-12-5) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.COA of Formula: C7H9NO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Studies on mixed trialkyltin derivatives. VII. Studies of [(phenyldimethylsilyl)methyl]dicyclohexyltin carboxylates was written by Xie, Qing-lan;Sha, Yin-lin;Yang, Zhi-qiang. And the article was included in Chemical Research in Chinese Universities in 1995.Reference of 1877-75-4 This article mentions the following:

Seventeen derivatives of mixed trialkyltin carboxylates (PhMe₂SiCH₂)Cy₂SnO₂CR were synthesized from ((PhMe₂SiCH₂)Cy₂Sn)₂O and RCO₂H. The results of IR, NMR (¹H, ¹³C, ¹¹⁹Sn) and MS showed that this kind of compounds is four-coordinated and that there are two good linear relations between the δ ¹¹⁹Sn and Hammett constants of para-substituent of the corresponding aryloxyacetates and arylcarboxylates. These compounds have a good acaricidal activity in the preliminary bioassay tests. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Reference of 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Reference of 1877-75-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bifunctional Cinchona Alkaloid Thiourea Catalyzed Highly Efficient, Enantioselective Aza-Henry Reaction of Cyclic Trifluoromethyl Ketimines: Synthesis of Anti-HIV Drug DPC 083 was written by Xie, Hexin;Zhang, Yinan;Zhang, Shilei;Chen, Xiaobei;Wang, Wei. And the article was included in Angewandte Chemie, International Edition in 2011.Reference of 56619-93-3 This article mentions the following:

A novel highly efficient bifunctional cinchona alkaloid thiourea catalyzed enantioselective aza-Henry reaction of trifluoromethylquinazolinones with nitromethanes is reported. The reaction provides enantioenriched trifluoromethyl nitromethyl dihydroquinazolinones in good yields and enantioselectivities. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Reference of 56619-93-3).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Reference of 56619-93-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Photochemical Cleavage and Release of Para-Substituted Phenols from α-Keto Amides was written by Ma, Chicheng;Chen, Yugang;Steinmetz, Mark G.. And the article was included in Journal of Organic Chemistry in 2006.Product Details of 1877-75-4 This article mentions the following:

In aqueous media α-keto amides 4-YC₆H₄OCH₂COCON(R)CH(R’)CH₃ (5a, R = Et, R’ = H; 5b, R = ⁱPr, R’ = Me) with para-substituted phenolic substituents (Y = CN, CF₃, H) undergo photocleavage and release of 4-YC₆H₄OH with formation of 5-methyleneoxazolidin-4-ones 7a,b. For both 5a,b quantum yields range from 0.2 to 0.3. The proposed mechanism involves transfer of hydrogen from an N-alkyl group to the keto oxygen to produce zwitterionic intermediates 8a–c that eliminate the para-substituted phenolate leaving groups. The resultant iminium ions H₂C:C(OH)CON⁺(R):C(R’)CH₃ 9a,b cyclize intramolecularly to give 7a,b. The quantum yields for photoelimination decrease in CH₃CN, CH₂Cl₂, or C₆H₆ due to competing cyclization of 8a,b to give oxazolidin-4-one products which retain the leaving group 4-YC₆H₄O^– (Y = H, CN). A greater tendency to undergo cyclization in nonaqueous media is observed for the N,N-di-Et amides 5a than the N,N-diisopropyl amides 5b. With para electron releasing groups Y = CH₃ and OCH₃ quantum yields for photoelimination significantly decrease and 1,3-photorearrangement of the phenolic group is observed The 1,3-rearrangement involves excited state ArO-C bond homolysis to give para-substituted phenoxyl radicals, which can be observed directly in laser flash photolysis experiments In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Product Details of 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Product Details of 1877-75-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

GC/MS, HPLC and FAB mass spectrometric analysis of organic micropollutants in Barcelona’s water supply was written by Rivera, Josep;Ventura Josep;Caixach, Josep;De Torres, Mariona;Figueras, Albert. And the article was included in International Journal of Environmental Analytical Chemistry in 1987.Application In Synthesis of 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol This article mentions the following:

Water samples from the Llobregat River entering 2 water work plants, Barcelona tap water, and waste dumping samples taken along the river course were analyzed for trace organic contaminants by different procedures, liquid-liquid extraction, adsorption on granular activated C followed by gas chromatog./mass spectrometry (GC/MS). Ether-insoluble organic fractions were analyzed and fractionated by HPLC with diode-array detection, followed by fast-atom bombardment (FAB) and fast-atom bombardment-collision induced dissociation-MIKES characterization. The results, after 2 yrs of monitoring, proved that surfactants, plasticizers, ethylene glycol derivatives, phosphates, hydrocarbons, and other miscellaneous compounds are considered chronic pollutants of the Llobregat River. Some of the compounds identified by GC/MS and FAB mass spectrometry have not been previously reported to occur in water. In the experiment, the researchers used many compounds, for example, 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol (cas: 20324-33-8Application In Synthesis of 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol).

1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol (cas: 20324-33-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Application In Synthesis of 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem