Tag: 100-200

On May 14, 2020, Konradi, Andrei W.; Lin, Tracy Tzu-Ling Tang published a patent.Safety of (S)-1-Methoxypropan-2-amine hydrochloride The title of the patent was Preparation of substituted naphthalene-2-carboxamide derivatives useful for treatment of cancer. And the patent contained the following:

Provided herein are compounds of formula I and pharmaceutical compositions comprising said compounds that are useful for treating cancers specifically cancers that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD. Compounds of formula I [wherein X1 and X2 independently = N, NRx, C(=O), or CRx; X3, and X4 independently = N, NRx, C(=O), or CRx, with proviso; each Rx independently = H, halo, nitro, oxo, thioxo, (un)substituted C1-6 alkyl, (un)substituted (hetero)aryl, etc.; R1 = (un)substituted C1-6 alkyl, (un)substituted C1-6 haloalkyl, (un)substituted C3-10 cycloalkyl, etc.; each R2 independently = N3, CN, (un)substituted (hetero)aryl, etc.; n = 0, 1, 2, 3, or 4; each dashed line independently = single or double bond] or pharmaceutically acceptable salts or solvates thereof, are claimed and exemplified. Example compound II was synthesized from a multistep preparation starting from the bromination of 2-naphthylcarboxylic acid (preparation given). Exemplified I were evaluated in a YAP reporter assay from which II demonstrated an IC50 of ≤0.100μM against firefly luciferase activity. The experimental process involved the reaction of (S)-1-Methoxypropan-2-amine hydrochloride(cas: 1162054-86-5).Safety of (S)-1-Methoxypropan-2-amine hydrochloride

The Article related to naphthalene carboxamide derivative preparation cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Safety of (S)-1-Methoxypropan-2-amine hydrochloride

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Ether | (C2H5)2O – PubChem

On September 30, 2021, Rawat, Vishal Kumar; Higashida, Kosuke; Sawamura, Masaya published an article.Computed Properties of 93-04-9 The title of the article was Nickel-Catalyzed Homocoupling of Aryl Ethers with Magnesium Anthracene Reductant. And the article contained the following:

Nickel-catalyzed reductive homocoupling of aryl ethers has been achieved with Mg(anthracene)(thf)3 as a readily available low-cost reductant. DFT calculations provided a rationale for the specific efficiency of the diorganomagnesium-type two-electron reducing agent. The calculations show that the dianionic anthracene-9,10-diyl ligand reduces the two aryl ether substrates, resulting in the homocoupling reaction through supply of electrons to the Ni-Mg bimetallic system to form organomagnesium nickel(0)-ate complexes, which cause two sequential C-O bond cleavage reactions. The calculations also showed cooperative actions of Lewis acidic magnesium atoms and electron-rich nickel atoms in the C-O cleavage reactions. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Computed Properties of 93-04-9

The Article related to aryl ether reductive homocoupling nickel catalyst magnesium anthracene reductant, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Computed Properties of 93-04-9

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Salamanca, Vanesa; Albeniz, Ana C. published an article in 2021, the title of the article was Faster palladium-catalyzed arylation of simple arenes in the presence of a methylketone: beneficial effect of an a priori interfering solvent in C-H activation.Electric Literature of 91-16-7 And the article contains the following content:

The arylation of arenes with no directing groups (non-chelate assisted) was carried out using the cooperating ligand [2,2′-bipyridin]-6(1H)-one (bipy-6-OH), the use of a moderately coordinating solvent allows a decrease of the amount of arene used. Moreover, for the least coordinating arenes, the co-solvent produced a significant accelerating effect by altering the concentration and relative stability of relevant metal species in the catalytic cycle as well as the catalyst resting state. t-Bu Me ketone (pinacolone) was one of the most effective co-solvents: Even if the ketone C-H bond cleaves easily, the final products were determined by the reductive elimination step (the product-forming step) so the target biaryl products were selectively observed The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Electric Literature of 91-16-7

The Article related to arene haloarene palladium catalyst regioselective arylation, biaryl preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Electric Literature of 91-16-7

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 27, 2013, Ye, Yingda; Sanford, Melanie S. published an article.Application of 321-28-8 The title of the article was Mild Copper-Mediated Fluorination of Aryl Stannanes and Aryl Trifluoroborates. And the article contained the following:

This communication describes a mild copper-mediated fluorination of aryl stannanes and aryl trifluoroborates with N-fluoro-2,4,6-trimethylpyridinium triflate. This protocol demonstrates broad substrate scope and functional group tolerance, and does not require the use of any noble metal additives. The reaction is proposed to proceed via an arylcopper(III) fluoride intermediate. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Application of 321-28-8

The Article related to copper catalyst fluorination aryl stannane trifluoroborate, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Application of 321-28-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bai, Chaolumen; Chao, Bao; Muschin, Tegshi; Bao, Agula; Baiyin, Menghe; Liu, Dan; Bao, Yong-Sheng published an article in 2021, the title of the article was Regiodivergent CDC reactions of aromatic aldehydes with unactivated arenes controlled by transient directing strategy.Category: ethers-buliding-blocks And the article contains the following content:

The regiodivergent catalytic dehydrogenative cross-coupling reactions at both sp2 and sp3 hybridized carbons of aromatic compounds are particularly challenging. Herein, the finding of transient directing group controlled regiodivergent C(sp3)-C(sp2) and C(sp2)-C(sp2) cross-coupling in the o-Me benzaldehyde frameworks 2-CH3RC6H3CHO (R = H, 6-Me, 4-Br, 4,6-(CH3)2, etc.) is reported. Catalyzed by palladium, using K2S2O8 or [F+] reagents as by-standing oxidants and unactivated arenes R1C6H5 (R1 = H, OEt, Me, Cl, etc.) as substrates/solvents, various benzyl benzaldehydes RC6H3CHO-2-CH2C6H4R1 or Ph benzaldehydes R-2-MeC6H2CHOC6H4R1 were prepared A mechanism study indicated that the regiospecificity is dominated by the [5,6]-fused palladacycle or [6,5]-fused palladacycle intermediates, which are generated from Pd-chelation with specified transient directing groups and further C-H activations. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Category: ethers-buliding-blocks

The Article related to benzylbenzaldehyde preparation regioselective, phenylbenzaldehyde preparation regioselective, arene aromatic aldehyde coupling reaction palladium catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Aldehydes and Derivatives, Including Sulfur Analogs and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On September 26, 2022, Sudhakaran, Swetha; Siddiki, S. M. A. Hakim; Kitiyanan, Boonyarach; Nomura, Kotohiro published an article.Application In Synthesis of 2-(2-(Vinyloxy)ethoxy)ethanol The title of the article was CaO Catalyzed Transesterification of Ethyl 10-Undecenoate as a Model Reaction for Efficient Conversion of Plant Oils and Their Application to Depolymerization of Aliphatic Polyesters. And the article contained the following:

Transesterification of Et 10-undecenoate (derived from castor oil) with cyclohexanemethanol over a CaO catalyst (prebaked at 300°C) gave undec-10-enoate exclusively (yield 92%, selectivity 95-98%) at 100°C, and the activity increased at 120°C with maintaining the high selectivity (97-98%). The transesterification with other alcs., especially primary alcs. (2-ethyl-1-butanol, 1-hexanol, 3-buten-1-ol, and 10-undecen-1-ol), afforded the corresponding esters with high selectivity, indicating the possibility for application of efficient conversion of plant oils to various fine chems. including the monomer for the synthesis of polyesters. Efficient acid-, base-free depolymerization of aliphatic polyesters, poly(ethylene adipate) and poly(butylene adipate), has been demonstrated in this catalysis by transesterification with ethanol and cyclohexanemethanol, affording corresponding adipates and ethylene glycol or butylene glycol exclusively: the reusability of a CaO catalyst has also been demonstrated. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Application In Synthesis of 2-(2-(Vinyloxy)ethoxy)ethanol

The Article related to cao transesterification ethyl undecenoate plant oil depolymerization polyester, Chemistry of Synthetic High Polymers: Polymerization Kinetics, Mechanisms, Thermodynamics, Catalysis, Catalysts and other aspects.Application In Synthesis of 2-(2-(Vinyloxy)ethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Lin, Yan; Stansbury, Jeffrey W. published an article in 2003, the title of the article was In situ characterization of hybrid polymerization by NIR.Recommanded Product: 929-37-3 And the article contains the following content:

The effect of water on cationic photopolymerization of vinyl ethers was studied by real time FT-NIR (Fourier transform near IR) spectroscopy. The following vinyl ethers were used: tri(ethylene glycol)methyl, bis(ethylene glycol), and Et. The photopolymerization of the vinyl ethers was followed in situ and the water absorbance and environment changes during polymerization were investigated. The formation of acetaldehyde and aldehydic end groups was confirmed and attributed to a water-driven chain transfer reaction. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Recommanded Product: 929-37-3

The Article related to vinyl ether photopolymerization water effect near ir spectroscopy, Chemistry of Synthetic High Polymers: Polymerization Kinetics, Mechanisms, Thermodynamics, Catalysis, Catalysts and other aspects.Recommanded Product: 929-37-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Liu, Jingjuan; Zhou, Yi; Xie, Zhen; Li, Yang; Liu, Yunpeng; Sun, Jie; Ma, Yanhang; Terasaki, Osamu; Chen, Long published an article in 2020, the title of the article was Conjugated Copper-Catecholate Framework Electrodes for Efficient Energy Storage.Application In Synthesis of 1,2-Dimethoxybenzene And the article contains the following content:

A conjugated copper(II) catecholate based metal-organic framework (namely Cu-DBC) was prepared using a D2-sym. redox-active ligand in a copper bis(dihydroxy) coordination geometry. The π-d conjugated framework exhibits typical semiconducting behavior with a high elec. conductivity of ca. 1.0 S m-1 at room temperature Benefiting from the good elec. conductivity and the excellent redox reversibility of both ligand and copper centers, Cu-DBC electrode features superior capacitor performances with gravimetric capacitance up to 479 F g-1 at a discharge rate of 0.2 A g-1. Moreover, the sym. solid-state supercapacitor of Cu-DBC exhibits high areal (879 mF cm-2) and volumetric (22 F cm-3) capacitances, as well as good rate capability. These metrics are superior to most reported MOF-based supercapacitors, demonstrating promising applications in energy-storage devices. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Application In Synthesis of 1,2-Dimethoxybenzene

The Article related to copper catecholate metal organic framework semiconductor supercapacitor electrode, catecholate, copper, metal-organic frameworks, semiconductors, supercapacitors, Electrochemical, Radiational, and Thermal Energy Technology: Energy-Conversion Devices and Their Components and other aspects.Application In Synthesis of 1,2-Dimethoxybenzene

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sousa, Karlisson Rodrigo de Almeida; Benatto, Leandro; Wouk, Luana; Roman, Lucimara Stolz; Koehler, Marlus published an article in 2020, the title of the article was Effects of non-halogenated solvent on the main properties of a solution-processed polymeric thin film for photovoltaic applications: a computational study.Category: ethers-buliding-blocks And the article contains the following content:

Organic photovoltaic (OPV) devices have reached high power conversion efficiencies, but they are usually processed using halogenated toxic solvents. Hence, before OPV devices can be mass-produced by industrial processing, it would be desirable to replace those solvents with eco-friendly ones. Theor. tools may be then a powerful ally in the search for those new solvents. In order to better understand the mechanisms behind the interaction between solvent and polymer, classical mol. dynamics (MD) calculations were used to produce a thin film of poly(4,8-bis[(2-ethylhexyl)oxy]benzo[1,2-b:4,5-b’]dithiophene-2,6-diyl-3-fluoro-2-[(2-ethylhexyl)carbonyl]thieno[3,4-b]thiophenediyl) (PTB7-Th), processed using two different solvents. PTB7-Th is widely applied as a donor material in OPVs. The first solvent is ortho-dichlorobenzene (o-DCB), which is a highly toxic solvent widely used in lab-scale studies. The second solvent is ortho-methylanisole (o-MA), which is an eco-friendly solvent for organic photovoltaic (OPV) manufacturing Here we use a solvent evaporation protocol to simulate the formation of the PTB7-Th film. We demonstrate that our theor. MD calculations were able to capture some differences in the macroscopic properties of thin films formed by o-DCB or o-MA evaporation We found that the interaction of the halogenated solvent with the polymer tends to break the bonds between the lateral thiophenediyl groups and the main chain. We show that those defects may create traps that can affect the charge transport and also can be responsible for a blue shift in the absorption spectrum. Using the Monte Carlo method, we also verified the influence of the resulting MD morphol. on the mobility of holes. Our theor. results showed good agreement with the exptl. measurements and both demonstrate that o-MA can be used to make polymer thin films without any loss of key properties for the device performance. The findings here highlight the importance of theor. results as a guide to the morphol. optimization of green processed polymeric films. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Category: ethers-buliding-blocks

The Article related to effect nonhalogenated solvent solution process polymeric film photovoltaic computation, organic photovoltaic polymer spin coating mol dynamic hole mobility, Electrochemical, Radiational, and Thermal Energy Technology: Energy-Conversion Devices and Their Components and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 30, 2020, Park, Sang Hyun; Jin, In Su; Ahn, Hyungju; Jung, Jae Woong published an article.HPLC of Formula: 578-58-5 The title of the article was Non-halogenated additive engineering for morphology optimization in environmental-friendly solvent processed non-fullerene organic solar cells. And the article contained the following:

In this work, efficient non-fullerene organic solar cells are demonstrated based on the environmentally-friendly solvent system. The blend films morphol. from the non-halogenated solvent exhibits more suitable phase separation as the non-halogenated additive is employed. In addition, the additive engineering induces the preferentially oriented self-assembly for the mols., which contributes to better exciton dissociation, enhanced carrier mobility, and balanced charge transport. All these benefits for the additive engineering achieve the power conversion efficiency of the environmentally-friendly solvent system processed non-fullerene organic solar cells up to 4.52% efficiency, which promises the non-halogenated solvent system for eco-friendly and sustainable organic solar cell technol. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).HPLC of Formula: 578-58-5

The Article related to nonfullerene organic solar cell morphol optimization nonhalogenated additive engineering, Electrochemical, Radiational, and Thermal Energy Technology: Energy-Conversion Devices and Their Components and other aspects.HPLC of Formula: 578-58-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem