On May 14, 2020, Konradi, Andrei W.; Lin, Tracy Tzu-Ling Tang published a patent.Safety of (S)-1-Methoxypropan-2-amine hydrochloride The title of the patent was Preparation of substituted naphthalene-2-carboxamide derivatives useful for treatment of cancer. And the patent contained the following:
Provided herein are compounds of formula I and pharmaceutical compositions comprising said compounds that are useful for treating cancers specifically cancers that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD. Compounds of formula I [wherein X1 and X2 independently = N, NRx, C(=O), or CRx; X3, and X4 independently = N, NRx, C(=O), or CRx, with proviso; each Rx independently = H, halo, nitro, oxo, thioxo, (un)substituted C1-6 alkyl, (un)substituted (hetero)aryl, etc.; R1 = (un)substituted C1-6 alkyl, (un)substituted C1-6 haloalkyl, (un)substituted C3-10 cycloalkyl, etc.; each R2 independently = N3, CN, (un)substituted (hetero)aryl, etc.; n = 0, 1, 2, 3, or 4; each dashed line independently = single or double bond] or pharmaceutically acceptable salts or solvates thereof, are claimed and exemplified. Example compound II was synthesized from a multistep preparation starting from the bromination of 2-naphthylcarboxylic acid (preparation given). Exemplified I were evaluated in a YAP reporter assay from which II demonstrated an IC50 of ≤0.100μM against firefly luciferase activity. The experimental process involved the reaction of (S)-1-Methoxypropan-2-amine hydrochloride(cas: 1162054-86-5).Safety of (S)-1-Methoxypropan-2-amine hydrochloride
The Article related to naphthalene carboxamide derivative preparation cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Safety of (S)-1-Methoxypropan-2-amine hydrochloride
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