Tag: 100-200

Quality Control of N,N-Dimethylformamide Dimethyl AcetalIn 2020 ,《Pyrazolo[1,5-a]pyrimidines-based fluorophores: a comprehensive theoretical-experimental study》 appeared in RSC Advances. The author of the article were Tigreros, Alexis; Aranzazu, Sandra-L.; Bravo, Nestor-F.; Zapata-Rivera, Jhon; Portilla, Jaime. The article conveys some information:

Fluorescent mols. are crucial tools for studying the dynamics of intracellular processes, chemosensors, and the progress of organic materials. In this study, a family of pyrazolo[1,5-a]pyrimidines (PPs) 4a-g has been identified as strategic compounds for optical applications due to several key characteristics such as their simpler and greener synthetic methodol. (RME: 40-53%) as compared to those of BODIPYS (RME: 1.31-17.9%), and their tunable photophys. properties (going from ε = 3320 M-1 cm-1 and φF = 0.01 to ε = 20 593 M-1 cm-1 and φF = 0.97), in which electron-donating groups (EDGs) at position 7 on the fused ring improve both the absorption and emission behaviors. The PPs bearing simple aryl groups such as 4a (4-Py), 4b (2,4-Cl2Ph), 4d (Ph) and 4e (4-MeOPh), allow good solid-state emission intensities (QYSS = 0.18 to 0.63) in these compounds and thus, solid-state emitters can be designed by proper structural selection. The properties and stability found in 4a-g are comparable to com. probes such as coumarin-153, prodan and rhodamine 6G. Ultimately, the electronic structure anal. based on DFT and TD-DFT calculations revealed that EDGs at position 7 on the fused ring favor large absorption/emission intensities as a result of the ICT to/from this ring; however, these intensities remain low with electron-withdrawing groups (EWGs), which is in line with the exptl. data and allows us to understand the optical properties of this fluorophore family. In the experimental materials used by the author, we found N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Quality Control of N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Quality Control of N,N-Dimethylformamide Dimethyl Acetal

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In 2022,Rather, Ishfaq Ahmad; Ali, Rashid published an article in ACS Omega. The title of the article was 《An Efficient and Versatile Deep Eutectic Solvent-Mediated Green Method for the Synthesis of Functionalized Coumarins》.Application of 150-19-6 The author mentioned the following in the article:

Herein, we report a green and efficient synthetic route for the construction of diverse functionalized coumarins in good-to-excellent yields (60-98%) via the Pechmann condensation. The optimized synthetic route involves a biodegradable, reusable, and inexpensive deep eutectic solvent (DES) of choline chloride and L-(+)-tartaric acid in a ratio of 1:2 at 110°C. Interestingly, phloroglucinol and Et acetoacetate, upon reaction, furnished the functionalized coumarin (I) in 98% yield within 10 min. On the other front, the same DES at relatively lower reaction temperature (90°C) was found to provide the bis-coumarins in decent yields (81-97%) within 20-45 min. Moreover, this particular method was found to be quite effective for large-scale coumarin synthesis without noteworthy reduction in the yields of the desired products. Noticeably, in this versatile approach, the DES plays a dual role as solvent as well as catalyst, and it was effectively recycled and reused four times with no significant drop-down in the yield of the product. After reading the article, we found that the author used m-Methoxyphenol(cas: 150-19-6Application of 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Application of 150-19-6

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Ether – Wikipedia,
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In 2022,Wu, Kai; Yang, Ke; Wang, Siyu; Yu, Jiajun; Chu, Chenyang; Luo, Bingbing; Zhang, Huiyan published an article in Bioresource Technology. The title of the article was 《The enrichment of sugars and phenols from fast pyrolysis of bamboo via ethanol-Fenton pretreatment》.Quality Control of m-Methoxyphenol The author mentioned the following in the article:

The high-purity compounds (e.g., sugars and phenols) are important raw materials and chems., which can be produced by biomass pyrolysis. However, the direct biomass pyrolysis produces complex compounds and thus inhibiting its large-scale utilization. To increase the yield and enrichment of sugars and phenols, a green coupling process based on ethanol-Fenton pretreatment combined with fast pyrolysis is firstly proposed. The bamboo was effectively separated into the ethanol-Fenton pretreated bamboo (EF-bamboo), lignin-rich fractions, and hemicellulose-degradation intermixts. with the massive removal of inorganic metals via this process. Compared with the fast pyrolysis of raw bamboo, the levoglucosan yield of EF-bamboo increased 5.4 times and the enrichment of sugars improved from 7.6% to 59.7%. Similarly, the yield of monophenols from lignin-rich fractions increased around 0.6 times and the enrichment of monophenols increased from 25.7% to 63.5%. This work provides a green and efficient route to produce high-yield and high-enrichment sugars and phenols. In the experiment, the researchers used many compounds, for example, m-Methoxyphenol(cas: 150-19-6Quality Control of m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneQuality Control of m-Methoxyphenol

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Safety of 1,4-Diethynyl-2,5-dimethoxybenzeneOn March 8, 2010, Wu, Xiang-Hua; Liang, Jin Hua; Xia, Jian-Long; Jin, Shan; Yu, Guang-Ao; Liu, Sheng Hua published an article in Organometallics. The article was 《Bimetallic Ruthenium Complexes: Synthesis, Characterization, and the Effect of Appending Long Carbon Chains to Their Bridges》. The article mentions the following:

A series of binuclear ruthenium complexes [RuCl(CO)(PMe3)3]2(μ-CH=CH-Ar-CH=CH) (Ar = C6H2(OR)2-2,5; R = CH3 (4a), nC4H9 (4b), nC6H13 (4c), nC8H17 (4d), nC10H21 (4e), nC12H25 (4f), nC14H29 (4g)), [RuCl(CO)(PMe3)3]2(μ-CH=CH-Ar--Ar-CH=CH) (Ar = C6H2(R)2-2,5; R = OCH3 (10a), OnC8H17 (10b), H (10c)), and [RuCl(CO)(PMe3)3]2(μ-CH=CH-Ar--Ar--Ar-CH=CH) (Ar = C6H2(R)2-2,5; R = OCH3 (13a), OnC8H17 (13b), H (13c)) have been synthesized. These complexes have been characterized by elemental anal., NMR, and UV/vis spectrophotometry. The structures of 4b and 4d have been determined by x-ray crystallog. Electrochem. studies have shown that long carbon chains attached to the bridges of the complexes facilitate the stability of mixed-valence bimetallic ruthenium complexes.1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Safety of 1,4-Diethynyl-2,5-dimethoxybenzene) was used in this study.

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Safety of 1,4-Diethynyl-2,5-dimethoxybenzene Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other.

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Ether – Wikipedia,
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《Synthesis, Characterization, and Substituent Effects of Binuclear Ruthenium Vinyl Complexes [RuCl(CO)(PMe3)3]2(μ-CH:CH-Ar-CH:CH)》 was written by Wu, Xiang Hua; Jin, Shan; Liang, Jin Hua; Li, Zi Yong; Yu, Guang-ao; Liu, Sheng Hua. Application In Synthesis of 1,4-Diethynyl-2,5-dimethoxybenzene And the article was included in Organometallics on April 27 ,2009. The article conveys some information:

Reactions of 1,4-diethenylbenzene derivatives with Ru(H)(Cl)(CO)(PPh3)2 followed by PMe3 to give binuclear Ru divinylbenzene complexes [RuCl(CO)(PMe3)3]2(μ-CH:CH-Ar-CH:CH) (Ar = C6H4 (6a), C6H3CH3 (6b), C6H3OCH3 (6c), C6H3F (6d), C6H3Cl (6e), C6H3Br (6f), C6H3CN (6g), C6H3NO2 (6h), C6H2Me2-2,5 (6i), C6H2(OCH3)2-2,5 (6j), C6H2(F)2-2,5 (6k), C6H2(CF3)2-2,5 (6l), and C6H3CF3 (6m)). The resp. products were characterized by elemental analyses, NMR spectrometry, and UV/visible spectrophotometry. The structures of 6h, 6i, and 6j were established by x-ray crystallog. Electrochem. studies revealed that intermetallic electron communication between the two Ru centers may be fine-tuned by modification of the bridging spacers, i.e., by introducing one or two substituent groups on the 1,4-diethenylphenylene bridge. Electron-releasing substituents facilitate electron communication between the two metal centers. In the experiment, the researchers used many compounds, for example, 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Application In Synthesis of 1,4-Diethynyl-2,5-dimethoxybenzene)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Application In Synthesis of 1,4-Diethynyl-2,5-dimethoxybenzene

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《Synthesis and antiplasmodial activity of 1,2,3-triazole-naphthoquinone conjugates》 was written by Oramas-Royo, Sandra; Lopez-Rojas, Priscila; Amesty, Angel; Gutierrez, David; Flores, Ninoska; Martin-Rodriguez, Patricia; Fernandez-Prrez, Leandro; Estevez-Braun, Ana. SDS of cas: 10365-98-7This research focused ontriazole naphthoquinones copper catalyzed cycloaddition mol docking Plasmodium malaria; 1,2,3-triazole-naphthoquinones; Plasmodium falciparum; copper-catalyzed cycloaddition; docking; malaria. The article conveys some information:

A series of 34 1,2,3-triazole-naphthoquinone conjugates were synthesized via copper-catalyzed cycloaddition (CuAAC). They were evaluated for their in vitro antimalarial activity against chloroquine-sensitive strains of Plasmodium falciparum and against three different tumor cell lines (SKBr-3, MCF-7, HEL). The most active antimalarial compounds showed a low antiproliferative activity. Simplified analogs were also obtained and some structure-activity relationships were outlined. The best activity was obtained by compounds 3s and 3j, having IC50 of 0.8 and 1.2 μM, resp. Mol. dockings were also carried on Plasmodium falciparum enzyme dihydroorotate dehydrogenase (PfDHODH) in order to rationalize the results. In the experimental materials used by the author, we found 3-Methoxyphenylboronic acid(cas: 10365-98-7SDS of cas: 10365-98-7)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.SDS of cas: 10365-98-7

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Ether – Wikipedia,
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Product Details of 60656-87-3In 2022 ,《Access to Sulfoxides under NHC/Photocatalysis via a Radical Pathway》 was published in Organic Letters. The article was written by Wang, Xuefeng; Tang, Yulian; Ye, Shengqing; Zhang, Jun; Kuang, Yunyan; Wu, Jie. The article contains the following contents:

A photocatalyzed transformation from sulfinic acids to sulfoxides under visible-light irradiation in the presence of N-heterocyclic carbene is established. Various alkyl groups from four-substituted Hantzsch esters or Meyer nitriles are smoothly converted to the corresponding sulfoxides through a radical coupling pathway in the presence of 1,1-carbonyldiimidazole. This method allows sulfoxide synthesis to refrain from relying on the oxidation of sulfides and provides an alternative route for the preparation of sulfoxides. In the experiment, the researchers used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Product Details of 60656-87-3)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Product Details of 60656-87-3

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Synthetic Route of C8H8O3In 2020 ,《Rhodium-Catalyzed Ring-Opening Hydroacylation of Alkylidenecyclopropanes with Chelating Aldehydes for the Synthesis of γ,δ-Unsaturated Ketones》 was published in Organic Letters. The article was written by Li, Hong-Shuang; Lu, Shi-Chao; Chang, Zhi-Xin; Hao, Liqiang; Li, Fu-Rong; Xia, Chengcai. The article contains the following contents:

The first intermol. ring-opening hydroacylation of alkylidenecyclopropanes with chelating aldehydes through a rhodium-catalyzed acrylamide-promoted protocol is reported. This highly efficient catalytic system enables the direct synthesis of a diverse range of linear γ,δ-unsaturated ketones. Good functional group compatibility is demonstrated for the completely atom-economical and remarkably selective proximal C-C bond cleavage process. Mechanistic studies reveal that the bidentate coordination of N,N-dimethylmethacrylamide (L1) to the acylrhodium intermediates might facilitate the cyclopropane ring fragmentation and isomerization. In the experimental materials used by the author, we found 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Synthetic Route of C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Synthetic Route of C8H8O3

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Ether – Wikipedia,
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Electric Literature of C5H13NO2In 2019 ,《Synthesis and antimicrobial evaluation of novel pyrazolopyrimidines incorporated with mono- and diphenylsulfonyl groups》 appeared in Molecules. The author of the article were Alsaedi, Amani M. R.; Farghaly, Thoraya. A.; Shaaban, Mohamed R.. The article conveys some information:

A novel series of pyrazolo[1,5-a]pyrimidine ring systems containing phenylsulfonyl moiety I (Ar = C6H5, 3-H3CC6H4, 2-ClC6H4, etc.) have been synthesized via the reaction of 2-(phenylsulfonyl)-1-(4-(phenylsulfonyl)phenyl)ethan-1-one, 2-benzenesulfonyl-1-(4-benzenesulfonyl-phenyl)-3-dimethylamino-propenone and 3-(dimethylamino)-1-(4-(phenylsulfonyl)phenyl)prop-2-en-1-one each with various substituted aminoazopyrazole derivatives in one pot reaction strategy. The proposed structure as well as the mechanism of their reactions were discussed and proved with all possible spectral data. The results of antimicrobial activities of the new sulfone derivatives revealed that several derivatives showed activity exceeding the activity of reference drug. Contrary to expectations, derivatives containing one sulfonyl group are more effective against all bacteria and fungi than those containing two sulfonyl groups. The experimental process involved the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Electric Literature of C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Electric Literature of C5H13NO2

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Ether – Wikipedia,
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In 2022,Hadsarung, Rungsima; Thongnest, Sanit; Oekchuae, Sittisak; Chaiyaveij, Duangduan; Boonsombat, Jutatip; Ruchirawat, Somsak published an article in Tetrahedron. The title of the article was 《Facile synthesis of 1-substituted 4-H phthalazine, a versatile scaffold for chemically diverse phthalazines》.SDS of cas: 673-22-3 The author mentioned the following in the article:

An improved synthetic strategy for 1-substituted 4-H phthalazines using a convenient, three-step reaction sequence under mild conditions is described. The protocol involves condensation of hydrazine hydrate with o-ketobenzaldehydes derived through the Pb(OAc)4 oxidation of the N-acylhydrazones of salicylaldehydes. This pathway is of high practical value since a wide variety of substituted acylhydrazides and salicylaldehydes, the substrates for N-acylhydrazones, are com. available. In addition, the three-step sequence could be scaled up without the need for intermediate purification affording a broad range of products in high yield. 1-Ph 4-H phthalazine was a versatile compound providing ready access to multiple phthalazine analogs, including the vasodilating agent MY5445.2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3SDS of cas: 673-22-3) was used in this study.

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.SDS of cas: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem