Oramas-Royo, Sandra’s team published research in Molecules in 2019 | CAS: 10365-98-7

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.SDS of cas: 10365-98-7

《Synthesis and antiplasmodial activity of 1,2,3-triazole-naphthoquinone conjugates》 was written by Oramas-Royo, Sandra; Lopez-Rojas, Priscila; Amesty, Angel; Gutierrez, David; Flores, Ninoska; Martin-Rodriguez, Patricia; Fernandez-Prrez, Leandro; Estevez-Braun, Ana. SDS of cas: 10365-98-7This research focused ontriazole naphthoquinones copper catalyzed cycloaddition mol docking Plasmodium malaria; 1,2,3-triazole-naphthoquinones; Plasmodium falciparum; copper-catalyzed cycloaddition; docking; malaria. The article conveys some information:

A series of 34 1,2,3-triazole-naphthoquinone conjugates were synthesized via copper-catalyzed cycloaddition (CuAAC). They were evaluated for their in vitro antimalarial activity against chloroquine-sensitive strains of Plasmodium falciparum and against three different tumor cell lines (SKBr-3, MCF-7, HEL). The most active antimalarial compounds showed a low antiproliferative activity. Simplified analogs were also obtained and some structure-activity relationships were outlined. The best activity was obtained by compounds 3s and 3j, having IC50 of 0.8 and 1.2 μM, resp. Mol. dockings were also carried on Plasmodium falciparum enzyme dihydroorotate dehydrogenase (PfDHODH) in order to rationalize the results. In the experimental materials used by the author, we found 3-Methoxyphenylboronic acid(cas: 10365-98-7SDS of cas: 10365-98-7)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.SDS of cas: 10365-98-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem