Tag: 100-200

In 2019,European Polymer Journal included an article by Zupanc, Anze; Kotnik, Tomaz; Stanfel, Ursa; Brodnik Zugelj, Helena; Kristl, Anja; Rucigaj, Ales; Matoh, Lev; Pahovnik, David; Groselj, Uros; Opatz, Till; Pozgan, Franc; Stefane, Bogdan; Zagar, Ema; Svete, Jurij. Related Products of 4637-24-5. The article was titled 《Chemical recycling of polyenaminones by transamination reaction via amino-enaminone polymerization/depolymerization》. The information in the text is summarized as follows:

Novel oligo- and polyenaminones with Mw-3000 Da were prepared in excellent yields by amino-enaminone ‘click’ polymerization of 1,3- and 1,4-bis[3-(dimethylamino)acryloyl]arenes with 1,3- and 1,4-phenylenediamine. The obtained oligomers and polymers were depolymerized quant. to the starting bis-enaminones and diamines by treatment with excess dimethylamine in ethanol at 50°C. This simple polymerization/depolymerization method allows for a closed-loop recycling of polyenaminone-based materials. UV light absorbance at wavelengths below 470 nm indicates promising optical properties of these polymers. After reading the article, we found that the author used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Related Products of 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Related Products of 4637-24-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kim, Wan Shin; Shalit, Zachary A.; Nguyen, Sidney M.; Schoepke, Emmalie; Eastman, Alan; Burris, Thomas P.; Gaur, Arti B.; Micalizio, Glenn C. published their research in Nature Communications on December 31 ,2019. The article was titled 《A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ》.Name: (3-Methoxy-2-methylphenyl)methanol The article contains the following contents:

A concise asym. route to forging natural and unnatural (enantiomeric) C19 and C20 tetracyclic terpenoid skeletons (1S,13S,15R)/(1R,13R,15S)/(1S,13R,15S)/(1R,13S,15R)-I (R = H, Me) and (2S,13S,15R)/(2R,13R,15S)-II (R1 = H, Me) suitable to drive medicinal exploration was reported. While efforts have been focused on establishing the chem. science, early investigations reveal that the emerging chem. technol. can deliver compositions of matter that are potent and selective agonists of the estrogen receptor beta, and that are selectively cytotoxic in two different glioblastoma cell lines (U251 and U87). In the experiment, the researchers used many compounds, for example, (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Name: (3-Methoxy-2-methylphenyl)methanol)

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Name: (3-Methoxy-2-methylphenyl)methanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Category: ethers-buliding-blocksOn March 31, 2020, Albano, Gianluigi; Colli, Tony; Nucci, Luigi; Charaf, Rima; Biver, Tarita; Pucci, Andrea; Aronica, Laura Antonella published an article in Dyes and Pigments. The article was 《Synthesis of new bis[1-(thiophenyl)propynones] as potential organic dyes for colorless luminescent solar concentrators (LSCs)》. The article mentions the following:

New luminophores having different aryl nuclei and propynones moieties have been obtained via Sonogashira reactions. Their optical properties were evaluated and indicated that carbonyl groups are responsible for significant bathochromic effects and high Stokes shifts. The insertion of -OMe groups on the central benzene unit gives to the fluorophore high optical efficiency (7.7%) when homogeneously dispersed in a poly(cyclohexyl methacrylate) (PCMA) film and connected to a PV cell. In the experiment, the researchers used many compounds, for example, 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Category: ethers-buliding-blocks)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Category: ethers-buliding-blocks The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Computed Properties of C12H10O2On November 5, 2021 ,《Effects of side alkoxy groups on the arylacetylene unit on properties of Poly(silylene arylacetylene)s》 appeared in European Polymer Journal. The author of the article were Li, Jixian; Gong, Changjun; Lv, Shuaikang; Huang, Farong. The article conveys some information:

A series of poly(dimethylsilylene arylacetylene)s with different side alkoxy groups on the arylacetylene unit (named as PSA-(AO) resins), including methoxy (MO), ethoxy (EO), pentyloxy (PO), and decyloxy (DO), were synthesized from corresponding disubstituted diethynylbenzene and dichlorodimethylsilane. The processability, heat resistance and mech. properties, and the effects of side alkoxy groups were investigated. The results show the processability of PSA-(AO) resins is improved, while the flexural properties and heat resistance of the relative cured resins decrease with the increase in the length of side alkoxy groups. The flexural strength and degradation temperature of 5% weight loss for the cured PSA-(EO) resin with side ethoxy groups reach 20.8 MPa and 415°, resp. In the experiment, the researchers used 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Computed Properties of C12H10O2)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Computed Properties of C12H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Catalytic Ynone-Amidine Formal [4 + 2]-Cycloaddition for the Regioselective Synthesis of Tricyclic Azepines》 was written by Reddy, T. Prabhakar; Gujral, Jagjeet; Roy, Pritam; Ramachary, Dhevalapally B.. COA of Formula: C9H10O2This research focused onynone amidine calcium cycloaddition catalyst; azepine tricyclic stereoselective preparation. The article conveys some information:

A Ca(OTf)2- and self-promoted ynone-amidine atom-economic formal [4 + 2]-cycloaddition of various ynones with amidines is reported for the construction of highly functionalized tricyclic azepines. High reaction rate, ease of operation, and high product selectivity with wide substrate scope are the key advantages of the present annulation protocol. The experimental part of the paper was very detailed, including the reaction process of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3COA of Formula: C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).COA of Formula: C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《An efficient approach to access 1,1,2-triarylethanes enabled by the organo-photoredox-catalyzed decarboxylative addition reaction》 was written by Guo, Jing; Huang, Gong-Bin; Wu, Qiao-Lei; Xie, Ying; Weng, Jiang; Lu, Gui. Related Products of 135-02-4This research focused ontriarylethane diarylethylamine preparation green chem; carboxylic acid para quinone methide decarboxylative conjugate addition; photoredox organocatalyst. The article conveys some information:

An efficient protocol for the synthesis of 1,1,2-triarylethanes I (R1 is 4-OH-3,5-(t-Bu)2 and 4-OH-3,5-(i-Pr)2; R2 is H, 2-OMe, 4-CN, etc.; R3 is 2-Me, 3,4-(OMe)2, 4-Br, etc.) and 2,2-diarylethylamines II (R4 is NH(Boc); R5 is H, i-Pr, Bn, etc; R4R5 is (CH2)2N(Boc)(CH2)2 and (CH2)2O(CH2)2) with biol. and pharmacol. potential via organo-photoredox-catalyzed decarboxylative 1,6-conjugate addition of carboxylic acids to para-quinone methides has been developed. Different from the traditional transition-metal catalyzed multi-step synthetic strategy, this process involves a photoredox-promoted free radical pathway. A variety of structurally diverse products can be easily obtained under metal-free conditions in good to excellent yields (38 examples, up to 98% yield) in one step.2-Methoxybenzaldehyde(cas: 135-02-4Related Products of 135-02-4) was used in this study.

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Related Products of 135-02-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Category: ethers-buliding-blocksIn 2020 ,《Synthesis of 4,4-Disubstituted 1,2-Thiazinane-5-one 1,1-Dioxides via the CSIC[#] Reaction Strategy》 was published in ChemistrySelect. The article was written by Dyachenko, Maksim S.; Kochetkov, Artem O.; Dobrydnev, Alexey V.; Milokhov, Demyd S.; Shishkina, Svitlana V.; Konovalova, Irina S.; Omelchenko, Irina V.; Volovenko, Yulian M.. The article contains the following contents:

A series of sp3-enriched 2,2-disubstituted 1,2-thiazinane-5-one 1,1-dioxides (including spirocyclic derivatives) I (R1 = R2 = Me, Et, -(CH2)4-, -(CH2)5-, etc.), II (R1 = R2 = Me; R3 = NH2, Me, phenyl) and III (R1 = R2 = Me) has been synthesized through the CSIC [Carbanion mediated Sulfonate (Sulfonamido) Intramol. Cyclization] reaction strategy. In particular, 2,2-disubstituted alkyl 3-aminopropanoates C(R1)(R2)(CO2R4)CH2NH3+Cl- (R4 = Me, Et) were subsequently sulfonylated with mesyl chloride followed by alkylation with Me iodide to give the key precursor 2,2-disubstituted Me 3-(methylsulfonamido)propanoates C(R1)(R2)(CO2R4)CH2N(Me)SO2Me. The latter were treated with sodium hydride and underwent the intramol. sulfa-Dieckmann cyclization yielding the target 4,4-disubstituted 1,2-thiazinane-5-one 1,1-dioxides (so-called β-keto-δ-sultams) I. The structure of the target compounds was confirmed by an X-ray diffraction study. The results came from multiple reactions, including the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Category: ethers-buliding-blocks)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Category: ethers-buliding-blocksIn 2022 ,《Greener synthesis of pyranopyrazole derivatives catalyzed by CaO nanoparticles》 appeared in Rasayan Journal of Chemistry. The author of the article were Sangeeta; Singh, Har Lal; Chahar, Mamta; Sahal, Saloni; Khaturia, Sarita. The article conveys some information:

The development of a novel green synthetic protocol for the series of pyrano-pyrazole derivatives I (R = CN, COOEt; X = H, 4-Cl, 2-OH-4-OMe, 4-NO2, etc.) in a one-pot multi-component method using CaO nanoparticles as the heterogeneous catalyst was reported. The CaO nanoparticles were synthesized by a greener route using an economic and efficient alternative i.e. papaya leaf extract and exhibited excellent catalytic activity, and this plant-mediated synthesis of CaO nanoparticles is a very promising area of research. CaO nanoparticles can be efficiently used in the synthesis of pyrano-pyrazoles I and this catalytic approach can deliver the appropriate products in a rapid reaction time with a high yield (85-91%). The current protocol has various advantages, including a short reaction time, a high percent yield, a clean reaction, a simple separation technique, and a recoverable catalyst that retains its catalytic activity when utilized in subsequent reactions. Characterization of synthesized pyrano-pyrazole derivatives I were wdone by IR, 1H and 13C NMR spectral data as well as HOMO-LUMO calculations In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Category: ethers-buliding-blocks)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Song, Ran; Lian, Zhendong; Feng, Wei; Guan, Tianyi; Si, Wen; Yang, Daoshan; Lv, Jian published an article in 2022. The article was titled 《Palladium-catalyzed decarboxylative O-allylation of phenols with γ-methylidene-δ-valerolactones》, and you may find the article in Organic Chemistry Frontiers.Safety of m-Methoxyphenol The information in the text is summarized as follows:

A novel palladium-catalyzed decarboxylative O-allylation of phenols ArOH (Ar = C6H5, 4-FC6H4, 2-naphthyl, etc.) and 1-OH-2-(CH(OH)R1)C6H3R (R = 5-F, 3-Cl, 3-Me, etc.; R1 = C6H5, 4-FC6H4, 2-naphthyl, etc.) was developed, in which γ-methylidene-δ-valerolactones I (R2 = Me, Ph, 2-thienyl, etc.; R3 = Me, Et) (GMDV) were found to be an efficient and selective allylation reagent, affording the target allyl Ph ethers ArOCH2C(=CH2)CH2CH(R2)C(O)2R3 and II (R4 = 4-F, 5-Cl, 5-Me, etc.) in up to 92% yields under mild conditions. After reading the article, we found that the author used m-Methoxyphenol(cas: 150-19-6Safety of m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneSafety of m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Han; Sheng, Jie; Wu, Bing-Bing; Li, Yan; Wang, Xi-Sheng published an article in 2021. The article was titled 《Nickel-Catalyzed Cross-Coupling of Ethyl Chlorofluoroacetate with Aryl Bromides》, and you may find the article in Chemistry – An Asian Journal.Computed Properties of C7H7BrO The information in the text is summarized as follows:

A combinatorial nickel-catalyzed monofluoroalkylation of aryl bromides with the industrial raw regent Et chlorofluoroacetate has been developed. The two key factors to successful conversion are the combination of nickel with readily available nitrogen and phosphine ligands and the using of a mixture of different solvents. Mechanistic investigations indicated a new zinc regent might generated in situ and be involved in the reaction process. The experimental process involved the reaction of 1-Bromo-3-methoxybenzene(cas: 2398-37-0Computed Properties of C7H7BrO)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Computed Properties of C7H7BrO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem