Kim, Wan Shin; Shalit, Zachary A.; Nguyen, Sidney M.; Schoepke, Emmalie; Eastman, Alan; Burris, Thomas P.; Gaur, Arti B.; Micalizio, Glenn C. published their research in Nature Communications on December 31 ,2019. The article was titled 《A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ》.Name: (3-Methoxy-2-methylphenyl)methanol The article contains the following contents:
A concise asym. route to forging natural and unnatural (enantiomeric) C19 and C20 tetracyclic terpenoid skeletons (1S,13S,15R)/(1R,13R,15S)/(1S,13R,15S)/(1R,13S,15R)-I (R = H, Me) and (2S,13S,15R)/(2R,13R,15S)-II (R1 = H, Me) suitable to drive medicinal exploration was reported. While efforts have been focused on establishing the chem. science, early investigations reveal that the emerging chem. technol. can deliver compositions of matter that are potent and selective agonists of the estrogen receptor beta, and that are selectively cytotoxic in two different glioblastoma cell lines (U251 and U87). In the experiment, the researchers used many compounds, for example, (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Name: (3-Methoxy-2-methylphenyl)methanol)
(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Name: (3-Methoxy-2-methylphenyl)methanol
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem