Tag: 100-200

Trisulfide-Bearing PEG Brush Polymers Donate Hydrogen Sulfide and Ameliorate Cellular Oxidative Stress was written by Dao, Nam V.;Ercole, Francesca;Kaminskas, Lisa M.;Davis, Thomas P.;Sloan, Erica K.;Whittaker, Michael R.;Quinn, John F.. And the article was included in Biomacromolecules in 2020.Product Details of 111-77-3 This article mentions the following:

A potential approach to combat cellular dysfunction is to manipulate cell communication and signaling pathways to restore physiol. functions while protecting unaffected cells. For instance, delivering the signaling mol. H₂S to certain cells has been shown to restore cell viability and re-normalize cell behavior. We have previously demonstrated the ability to incorporate a trisulfide-based H₂S-donating moiety into linear polymers with good in vitro releasing profiles and demonstrated their potential for ameliorating oxidative stress. Herein, we report two novel series of brush polymers decorated with higher numbers of H₂S-releasing segments. These materials contain two trisulfide-based monomers co-polymerized with oligo(ethylene glycol Me ether methacrylate) via reversible addition-fragmentation chain-transfer polymerization The macromols. were characterized to have a range of trisulfide densities with similar, well-defined mol. weight distribution, good H₂S-releasing profiles, and high cellular tolerance. Using an amperometric technique, the H₂S liberated and total sulfide release were found to depend on concentrations and chem. nature of triggering mols. (glutathione and cysteine) and, importantly, the position of reactive groups within the brush structure. Notably, when introduced to cells at well-tolerated doses, two macromol. donors which have the same proportion as of the H₂S-donating monomer (30%) but differ in releasing moiety location show similar cellular H₂S-releasing kinetics. These donors can restore reactive oxygen species levels to baseline values, when polymer pretreated cells are exposed to exogenous oxidants (H₂O₂). Our work opens up a new aspect in preparing H₂S macromol. donors and their application to arresting cellular oxidative cascades. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Product Details of 111-77-3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Product Details of 111-77-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

High yield total syntheses of XH-14 derivatives using Sonogashira coupling reaction was written by Bang, Hyun Bae;Han, Su Young;Choi, Da Hye;Hwang, Jung Woon;Jun, Jong-Gab. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2008.Synthetic Route of C11H16O3 This article mentions the following:

A method for the title compounds is reported here. XH-14 [i.e., 2-(4-hydroxy-3-methoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-3-benzofurancarboxaldehyde salvinal] is isolated from the root of Salvia miltiorrhiza Bunge (Chinese DanShen). A high yielding synthetic route to XH-14 derivatives is described using a Sonogashira reaction as a key step. Introduction of iodine into the structure and optimization of the synthetic sequence were essential for the successful syntheses of XH-14 derivatives The nine-step reaction sequence gave 2-(4-hydroxy-3-methoxyphenyl)-5-(3-hydroxypropyl)-5-methoxy-3-benzofurancarboxaldehyde and 2-(4-hydroxy-3-methoxyphenyl)-6-(3-hydroxypropyl)-5-methoxy-3-benzofurancarboxaldehyde in 30% and 55% overall yields, resp. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Synthetic Route of C11H16O3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Synthetic Route of C11H16O3

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Ether – Wikipedia,
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Enamines. Part V. Synthesis of substituted phenyl benzyl ketones and 2-arylisatogens was written by Kulkarni, Ssheshgiri N.;Kamath, H. V.;Bhamare, N. K.. And the article was included in Indian Journal of Chemistry in 1988.SDS of cas: 5367-32-8 This article mentions the following:

Isatogens I (R¹ = H, OMe; R² = H, OMe, Me) were prepared from nitrodeoxybenzoins II. β-Aminostyrenes were acylated by 2-O₂NC₆H₄COCl, and the products were hydrolyzed to give II. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8SDS of cas: 5367-32-8).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.SDS of cas: 5367-32-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Influence of in situ photo-induced silver nanoparticles on the ageing of acrylate materials was written by Zouari, H. B.;Dabert, M.;Asia, L.;Wong-Wah-Chung, P.;Baba, M.;Balan, L.;Israeli, Y.. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2021.Name: 2-(2-Methoxyethoxy)ethanol This article mentions the following:

The present work aims to investigate the impact of a low amount of photo-induced silver nanoparticles (0.2 and 0.4 weight% of Ag NPs) on the stability of acrylate materials (carriers of ester and ether groups) under the combined effect of oxygen and light. Different techniques were implemented to monitor the structural changes at different scales. The determination of the influence of AgNPs required a preliminary investigation of the pure acrylate polymer under the same exptl. conditions. The polymer underwent a post-polymerization of the residual vinyl groups and a photo-oxidative degradation This degradation induced chem. modifications evidenced by IR spectroscopy and architectural changes resulting from chain scission reactions. These reactions were not only responsible for the steaming of volatile organic compounds, detected by HS-SPME/GC-MS but also for the increase in mesh size controlled by thermoporosimetry. As regards the polymer/Ag NPs composite, the higher the amount of filler dispersed in the matrix, the greater the rate of degradation-. This behavior was due to the photocatalytic effect of Ag NPs, regardless of the loading in nanoparticles. As a result of irradiation, the nanoparticles migrate to the surface of the film and coalesce, thus inducing an increase in size distribution and a gradient structuring as revealed by TEM anal. The outcomes of this investigation are important for the development of new composite material with new functionalities (antibacterial, optical, conductive properties) for industrial applications as in textile industry. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Name: 2-(2-Methoxyethoxy)ethanol).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Name: 2-(2-Methoxyethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chemoselective N- and O-Difluoromethylation of 2-Pyridones, Isoquinolinones, and Quinolinones with TMSCF₂Br was written by Zhu, Ziyue;Krishnamurti, Vinayak;Ispizua-Rodriguez, Xanath;Barrett, Colby;Prakash, G. K. Surya. And the article was included in Organic Letters in 2021.SDS of cas: 112-49-2 This article mentions the following:

An operationally simple protocol for direct N- and O-difluoromethylation of 2-pyridones, quinolinones, and isoquinolinones using com. available TMSCF₂Br was disclosed. The chemoselectivity was modulated by simple variations in temperature, solvent, and strength of the base. Diverse, synthetically relevant functional groups were tolerated, including functional groups that have reported reactivity with TMSCF₂Br. Gram-scale reactions to prepare both N- and O-difluoromethyl compounds were included. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2SDS of cas: 112-49-2).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.SDS of cas: 112-49-2

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pd-Catalyzed Direct Deoxygenative Arylation of Non-π-Extended Benzyl Alcohols with Boronic Acids via Transient Formation of Non-Innocent Isoureas was written by Toupalas, Georgios;Thomann, Gianin;Schlemper, Lukas;Rivero-Crespo, Miguel A.;Schmitt, Hendrik L.;Morandi, Bill. And the article was included in ACS Catalysis in 2022.Recommanded Product: (4-Methoxyphenyl)methanol This article mentions the following:

Authors report the direct arylation of non-derivatized alcs. with boronic acids and demonstrate that a Pd catalyst, in combination with a carbodiimide, can be used to forge a C-C bond via the transient formation of non-innocent isoureas from the corresponding alcs. Besides further polarizing the C-O bond, the transiently generated isourea contains a masked base that is released during the reaction to enable catalytic turnover under exogenous base-free conditions. The developed concept was benchmarked against the coupling of non-π-extended benzyl alcs. and boronic acids and led to the formation of a C-C bond between differently decorated coupling partners. Notably, the strategic generation of non-innocent isoureas endows this C-O cleavage reaction with high orthogonality over conventional electrophiles and enables the employment of highly base-sensitive boronic acids. Addnl., the preformed isoureas can be leveraged for rapid (5 min reaction time) exogenous base-free coupling reactions, which work under conventional thermal conditions and do not rely on customized catalysts or specialized equipment. The synthetic investigations were also complemented by preliminary mechanistic studies. More broadly, the presented work bridges a conceptual gap between two important research areas, i.e., carbodiimide-mediated alc. activation and deoxygenative transition metal-catalyzed coupling chem., providing a promising blueprint for direct catalytic deoxygenative reactions. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Recommanded Product: (4-Methoxyphenyl)methanol).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Recommanded Product: (4-Methoxyphenyl)methanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and characterization of aryloxy derivatives of bis-azetinone for anticancer activity was written by Pramila, T.. And the article was included in Journal of Pharmaceutical Sciences and Research in 2020.Related Products of 1877-75-4 This article mentions the following:

A series of novel aryloxy bis azetinones have been synthesized using benzocaine as a starting compound Benzocaine reacted with benzyl bromide to give N-benzylated benzocaine which underwent nucleophillic addition reaction with hydrazine hydrate to yield 4-(benzylamino)benzohydrazide, further treatment with palladium catalyst gave 4-aminobenzohydrazide. 4-Aminobenzohydrazide was reacted with benzaldehyde to yield (4E,10E)-N’-benzylidene-4-(benzylideneamino)benzohydrazide, which on further reacting with different substituted phenoxyacetyl chlorides gave aryloxy bis azetinone derivatives I (R = H, 4-OMe, 3-Br, etc.). The synthesized compounds were screened for in-vitro anticancer activity and were found to be active. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Related Products of 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Related Products of 1877-75-4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and antioxidant activities of Coenzyme Q analogues was written by Wang, Jin;Li, Shuo;Yang, Tao;Yang, Jian. And the article was included in European Journal of Medicinal Chemistry in 2014.Category: ethers-buliding-blocks This article mentions the following:

A series of 2,3-dimethoxy-5-methyl-1,4-benzoquinones (Coenzyme Q) substituted at the C-6 position with various groups were designed and synthesized based on the Coenzyme Q₁₀ as potent antioxidant. In vitro antioxidant activities of these compounds were evaluated and compared with com. antioxidant Coenzyme Q₁₀ employing DPPH assay. All these synthesized Coenzyme Q analogs exhibit good antioxidant activities. Of which Compound I bearing a N-benzoylpiperazine group at the C-6 position showed more potent inhibition of DPPH radical than Coenzyme Q₁₀. All these results suggested the applicability of the Coenzyme Q analogs as potent antioxidants for combating oxidative stress. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7Category: ethers-buliding-blocks).

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Estimation of log P_ow values for neutral and basic compounds by microchip microemulsion electrokinetic chromatography with indirect fluorimetric detection (μMEEKC-IFD) was written by Tu, Jian;Halsall, H. Brian;Seliskar, Carl J.;Limbach, Patrick A.;Arias, Francisco;Wehmeyer, Kenneth R.;Heineman, William R.. And the article was included in Journal of Pharmaceutical and Biomedical Analysis in 2005.Synthetic Route of C8H9NO3 This article mentions the following:

Microchip microemulsion electrokinetic chromatog. with indirect fluorimetric detection (μMEEKC-IFD) was used to obtain log P octanol/water (log P_ow) values for neutral and basic compounds Six compounds, with log P_ow values between 0.38 and 5.03, were used to create a calibration curve relating the log of retention factors (log k) obtained from μMEEKC-IFD with the known log P_ow values. The log P_ow values for six addnl. compounds were determined using the log k values obtained by μMEEKC-IFD and the linear relationship between log P_ow and log k established for the standard compounds The μMEEKC-IFD buffer was composed of 50 mM 3-[cyclohexylamino]-1-propane-sulfonic acid (CAPS) buffer (pH 10.4) containing 1.2% n-heptane (volume/volume), 2% sodium dodecylsulfate (w/v), 8% 1-butanol (volume/volume) and 4 μM 5-carboxytetramethyl-rhodamine (TAMRA) as the fluorophore probe for indirect detection. The μMEEKC-IFD provided an accurate method for estimating log P_ow values and also a means for analyzing compounds that are non-fluorescent. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Synthetic Route of C8H9NO3).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Synthetic Route of C8H9NO3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reinforced catalytic oxidation of polyoxometalate@charge transfer complex by on-site heating from photothermal conversion was written by Chen, Xiaofei;Yang, Aibing;Wang, Gengxin;Wei, Mingfeng;Liu, Ning;Li, Bao;Wu, Lixin. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2022.Related Products of 105-13-5 This article mentions the following:

Near IR (NIR) absorption at low energy region has been demonstrated to devoted to photothermal conversion efficiently. This process provides a possibility for valuable extension in emerging photothermal catalysis following a specific approach of mol. composition To exploit novel photothermal materials in increasing the catalytic activity of comment catalysts, a typical yet unnoticed charge transfer (CT) complex of 3,3�5,5�tetramethylbenzidine (TMB_CT) is used here as an on-site heater. Through the electrostatic complexation of cationic CT complex bearing strong NIR absorption with series polyanionic clusters, composite catalysts are prepared These nano-assembled catalysts in size of 5-10 nm display integrated NIR photothermal effect and highly enhanced catalysis for the mild oxidation of toluene and its derivatives into corresponding alcs. with high conversion and selection. While NIR photothermal stability of TMB_CT is maintained, the catalytic activity of inorganic clusters is largely improved. The increments in conversion unattainable under external heating condition are realized and the extension to the mild oxidation of thioethers and olefins into sulfoxides and epoxides with acceptable catalytic recyclability and structural stability are demonstrated. All results from the detailed characterizations figure out the applicability of the NIR photothermal conversion to the catalytic reactions with similar catalytic centers. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Related Products of 105-13-5).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Related Products of 105-13-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem