Synthesis and characterization of aryloxy derivatives of bis-azetinone for anticancer activity was written by Pramila, T.. And the article was included in Journal of Pharmaceutical Sciences and Research in 2020.Related Products of 1877-75-4 This article mentions the following:
A series of novel aryloxy bis azetinones have been synthesized using benzocaine as a starting compound Benzocaine reacted with benzyl bromide to give N-benzylated benzocaine which underwent nucleophillic addition reaction with hydrazine hydrate to yield 4-(benzylamino)benzohydrazide, further treatment with palladium catalyst gave 4-aminobenzohydrazide. 4-Aminobenzohydrazide was reacted with benzaldehyde to yield (4E,10E)-N’-benzylidene-4-(benzylideneamino)benzohydrazide, which on further reacting with different substituted phenoxyacetyl chlorides gave aryloxy bis azetinone derivatives I (R = H, 4-OMe, 3-Br, etc.). The synthesized compounds were screened for in-vitro anticancer activity and were found to be active. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Related Products of 1877-75-4).
2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Related Products of 1877-75-4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem