Tag: 100-200

Enantioselective Functionalization of Inactive sp³ C-H Bonds Remote to Functional Group by Metal/Organo Cooperative Catalysis was written by Zhou, Xiao-Le;Wang, Pu-Sheng;Zhang, Da-Wei;Liu, Peng;Wang, Cheng-Ming;Gong, Liu-Zhu. And the article was included in Organic Letters in 2015.Computed Properties of C9H10O4 This article mentions the following:

A metal/organo cooperative catalysis to enable the enantioselective functionalization of inactive C-H bonds γ to the formyl group in aliphatic aldehydes has been established. Instead of using enals as substrates in traditional organocatalytic cyclization reactions, the aliphatic aldehydes directly participated in [4 + 2] cyclization with quinone derivatives exploiting mol. oxygen as oxidants to afford optically active cyclic mols. with excellent levels of enantioselectivity. This method features a combination of pot, step, and atom economy. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7Computed Properties of C9H10O4).

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Computed Properties of C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Composition of tall oil rosin. II. Hydrocarbons derived by dehydration of sterols was written by Lehtinen, Timo;Elomaa, Eero;Alhojarvi, Juha;Bruun, Henrik H.. And the article was included in Suomen Kemistilehti B in 1965.Application of 3929-47-3 This article mentions the following:

Acid matter was removed from the rosin by extraction with 1% aqueous KOH and the neutral matter, recovered from the ether solution, subjected to adsorption chromatography on a silicic acid column. The hydrocarbons eluted with petroleum ether (b.p. 40-60°) amounted to 12% of the neutral matter (2.3% of the total rosin). The main hydrocarbon component was separated by adsorption chromatography on silica gel impregnated with AgNO₃, followed by elution with petroleum ether. The hydrocarbons of tall oil rosin are mainly secondary products formed by dehydration of sterols during distillation The main hydrocarbon component was identified as a conjugated Δ³.⁵-diene (C₂₉H₄₈) derived from β-sitosterol. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Application of 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Application of 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Strategies to tackle the waste water from α-tocopherol-derived surfactant chemistry was written by Krell, Christoph;Schreiber, Robert;Hueber, Lukas;Sciascera, Luca;Zheng, Xiaoming;Clarke, Adrian;Haenggi, Ruedi;Parmentier, Michael;Baguia, Hajar;Rodde, Stephane;Gallou, Fabrice. And the article was included in Organic Process Research & Development in 2021.Related Products of 111-77-3 This article mentions the following:

The implications of the use of surfactant TPGS-750-M in water as a micellar reaction medium on the concomitant aqueous waste streams and their sustainable disposal have been studied. Biodegradability, log P_ow, solubility, and German water hazard class of the surfactant have been determined and enabled establishment of a waste water concept, which builds on the lipophilicity and ester group lability of the mol. The presented data and examples suggest preferred ways for designing surfactant processes and their aqueous waste streams in a sustainable manner. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Related Products of 111-77-3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Related Products of 111-77-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and Studies of Potential Inhibitors of CD73 Based on a Triazole Scaffold was written by Grosjean, Felix;Cros-Perrial, Emeline;Braka, Abdenour;Uttaro, Jean-Pierre;Chaloin, Laurent;Jordheim, Lars Petter;Peyrottes, Suzanne;Mathe, Christophe. And the article was included in European Journal of Organic Chemistry in 2022.SDS of cas: 3929-47-3 This article mentions the following:

The ecto-5-nucleotidase CD73 is involved in the production of immunosuppressive adenosine in the tumoral microenvironment and recently became a validated target in immuno-oncol. To avoid formation of CD73-produced adenosine, several series of potential inhibitors of the target enzyme based on a triazole scaffold were synthesized and evaluated on recombinant purified hCD73 and in cell-based assays. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3SDS of cas: 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.SDS of cas: 3929-47-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

CaO Catalyzed Transesterification of Ethyl 10-Undecenoate as a Model Reaction for Efficient Conversion of Plant Oils and Their Application to Depolymerization of Aliphatic Polyesters was written by Sudhakaran, Swetha;Siddiki, S. M. A. Hakim;Kitiyanan, Boonyarach;Nomura, Kotohiro. And the article was included in ACS Sustainable Chemistry & Engineering in 2022.Category: ethers-buliding-blocks This article mentions the following:

Transesterification of Et 10-undecenoate (derived from castor oil) with cyclohexanemethanol over a CaO catalyst (prebaked at 300°C) gave undec-10-enoate exclusively (yield 92%, selectivity 95-98%) at 100°C, and the activity increased at 120°C with maintaining the high selectivity (97-98%). The transesterification with other alcs., especially primary alcs. (2-ethyl-1-butanol, 1-hexanol, 3-buten-1-ol, and 10-undecen-1-ol), afforded the corresponding esters with high selectivity, indicating the possibility for application of efficient conversion of plant oils to various fine chems. including the monomer for the synthesis of polyesters. Efficient acid-, base-free depolymerization of aliphatic polyesters, poly(ethylene adipate) and poly(butylene adipate), has been demonstrated in this catalysis by transesterification with ethanol and cyclohexanemethanol, affording corresponding adipates and ethylene glycol or butylene glycol exclusively: the reusability of a CaO catalyst has also been demonstrated. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Category: ethers-buliding-blocks).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

F^–-Free Deoxyhydrotrifluoromethylation of α-Keto Esters with Ph₃P⁺CF₂CO₂^–: Synthesis of α-CF₃-Substituted Esters was written by Zheng, Ying;Jia, Yimin;Yuan, Yuan;Jiang, Zhong-Xing;Yang, Zhigang. And the article was included in Journal of Organic Chemistry in 2020.Formula: C5H12O3 This article mentions the following:

Trifluoromethylated compounds are usually obtained via trifluoromethylation reaction by the use of CF₃SiMe₃ and NaSO₂CF₃, Umemoto’s and Togni’s reagents. Here, an external fluorine anion-free direct deoxyhydrotrifluoromethylation of α-keto esters with a difluoromethylating reagent has been achieved, in which the employment of water can promote the dissociation of the CF₂ group to form a CF₃ moiety, which provides the successful transformation. The current protocol demonstrates one of the most practical approaches to generate α-trifluoromethyl esters with a broad substrate scope and high functional group compatibility, in which it is applicable to late-stage modification of biol. active compounds and can be readily scaled up. Mechanistic investigation reveals that an in situ-generated gem-difluoroalkene intermediate is decomposed by water, giving rise to acid fluoride and HF. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Formula: C5H12O3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Formula: C5H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Water-Processable Self-Doped Conducting Polymers via Direct (Hetero)arylation Polymerization was written by Beaumont, Catherine;Turgeon, Josyane;Idir, Mael;Neusser, David;Lapointe, Rosalie;Caron, Samuel;Dupont, William;D’Astous, Dominic;Shamsuddin, Sareeha;Hamza, Sarah;Landry, Eric;Ludwigs, Sabine;Leclerc, Mario. And the article was included in Macromolecules (Washington, DC, United States) in 2021.Recommanded Product: 2-(2-Methoxyethoxy)ethanol This article mentions the following:

The synthesis of water-processable self-doped polymers has been achieved by direct (hetero)arylation polymerization (DHAP) using water as a cosolvent. The introduction of a counterion covalently attached to the backbone of the polymers enhanced their solubility and the stability of the solutions Those polymers have shown air-stable elec. conductivities up to 50 S cm^-1 without the use of any post-treatment. The good water processability of these conducting polymers is promising for printed electronics in a wide range of applications. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Recommanded Product: 2-(2-Methoxyethoxy)ethanol).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Recommanded Product: 2-(2-Methoxyethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and characterization of zinc sensors based on a monosubstituted fluorescein platform was written by Nolan, Elizabeth M.;Burdette, Shawn C.;Harvey, Jessica H.;Hilderbrand, Scott A.;Lippard, Stephen J.. And the article was included in Inorganic Chemistry in 2004.Synthetic Route of C8H9NO3 This article mentions the following:

The synthesis of a new fluorescein carboxaldehyde asym. substituted on the xanthene (top) ring is reported. This mol. is a key precursor for two of three monofunctionally derivatized fluorescein-based Zn(II) sensors presented in this work. Detailed preparative routes to, and photophys. characterization of, these sensors are described. The sensors are based on the previously reported ZP4 motif by the authors (2003) and incorporate a di(2-picolyl)amine-containing aniline-derivatized ligand framework. By varying the nature of the substituent para to the aniline nitrogen atom, which is responsible for photoinduced electron transfer quenching the unbound ZP dye, we investigated the extent to which such electronic tuning might improve the fluorescent properties of asym. ZP sensors. Although a comparison of probes with X = H, F, Cl, OMe reveals that the photophys. behavior of these dyes is not readily predictable, our methodol. illustrates the ease with which aniline-based ligands may be linked to fluorescein dyes. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Synthetic Route of C8H9NO3).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Synthetic Route of C8H9NO3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Using choline nitrate as solvent and oxidant in direct oxidation of organic halides and alcohols to aldehyde and its derivatives was written by Jafari, Mohammadreza;Heydari, Akbar. And the article was included in Journal of Molecular Structure in 2022.Application In Synthesis of (4-Methoxyphenyl)methanol This article mentions the following:

Choline nitrate was prepared by the anion exchange of choline chloride and sodium nitrate. Also, choline chloride gave a low m.p. mixture in the presence of aluminum nitrate. The use of choline nitrate as a safe and environmentally friendly solvent and reagent provided an efficient procedure, simple and mild for oxidizing alcs. and organic halides to aldehydes and ketones R-R¹ [R = Ph, 3-MeC₆H₄, 2-ClC₆H₄, etc.; R¹ = CHO, C(O)Me]. Aldehydes using choline nitrate and trimethylsilyl chloride mixture as a selective oxidant and without using catalysts were synthesized from alcs. and the relevant halides. Benzyl chloride in the presence of choline nitrate and trimethylsilyl chloride at 70°C produced the corresponding aldehyde product with 87% efficiency, while benzyl alc. at 50°C with 90% efficiency performed this conversion. The prepared aldehyde was easily separated from the reaction medium by vacuum distillation or extraction by organic solvent without the need for further purification In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Application In Synthesis of (4-Methoxyphenyl)methanol).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Application In Synthesis of (4-Methoxyphenyl)methanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nucleophilic substitutions on bromotriazolopyridines – an improved route to 2,6-disubstituted pyridines and to 1,3-disubstituted isoquinolines was written by Abarca, Belen;Ballesteros, Rafael;Jones, Gurnos;Mojarrad, Fatemeh. And the article was included in Tetrahedron Letters in 1986.Recommanded Product: (6-Methoxypyridin-2-yl)methanol This article mentions the following:

2,6-Disubstituted pyridines I (R = OMe, R¹ = R² = H; R = piperidino, R¹ = Me, R² = Ac), II (R = 4-MeOC₆H₄O, OMe), and 1-formyl-3-methoxyisoquinoline (III) were prepared by ring opening of the triazolopyridines IV and triazoloisoquinolines V. IV and V (R = Li) were brominated to IV and V (R = Br), which were treated with nucleophiles to give IV and V (R = OMe, OC₆H₄OMe-4, SPh, piperidino, NHNH₂; R³ = H, Me, CONEt₂). Ring opening of IV and V with SeO₂ or acid gave I, II, and 3-methoxyisoquinoline-1-carboxaldehyde. In the experiment, the researchers used many compounds, for example, (6-Methoxypyridin-2-yl)methanol (cas: 63071-12-5Recommanded Product: (6-Methoxypyridin-2-yl)methanol).

(6-Methoxypyridin-2-yl)methanol (cas: 63071-12-5) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Recommanded Product: (6-Methoxypyridin-2-yl)methanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem