Nucleophilic substitutions on bromotriazolopyridines – an improved route to 2,6-disubstituted pyridines and to 1,3-disubstituted isoquinolines was written by Abarca, Belen;Ballesteros, Rafael;Jones, Gurnos;Mojarrad, Fatemeh. And the article was included in Tetrahedron Letters in 1986.Recommanded Product: (6-Methoxypyridin-2-yl)methanol This article mentions the following:
2,6-Disubstituted pyridines I (R = OMe, R1 = R2 = H; R = piperidino, R1 = Me, R2 = Ac), II (R = 4-MeOC6H4O, OMe), and 1-formyl-3-methoxyisoquinoline (III) were prepared by ring opening of the triazolopyridines IV and triazoloisoquinolines V. IV and V (R = Li) were brominated to IV and V (R = Br), which were treated with nucleophiles to give IV and V (R = OMe, OC6H4OMe-4, SPh, piperidino, NHNH2; R3 = H, Me, CONEt2). Ring opening of IV and V with SeO2 or acid gave I, II, and 3-methoxyisoquinoline-1-carboxaldehyde. In the experiment, the researchers used many compounds, for example, (6-Methoxypyridin-2-yl)methanol (cas: 63071-12-5Recommanded Product: (6-Methoxypyridin-2-yl)methanol).
(6-Methoxypyridin-2-yl)methanol (cas: 63071-12-5) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Recommanded Product: (6-Methoxypyridin-2-yl)methanol
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem