Tag: 200-300

On February 19, 2013, Chen, Wei; Loury, David J. published a patent.COA of Formula: C14H21BO3 The title of the patent was Preparation of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine derivatives as Btk kinase inhibitors. And the patent contained the following:

The invention related to pyrazolo[3,4-d]pyrimidine derivatives of formula I, pharmaceutical composition comprising them, their preparations and use as Bruton’s tyrosine kinase (Btk) inhibitors thereof. Compounds of formula I wherein X is a bond; Y is (un)substituted (hetero)arylene; Z is CO, CS, S(O)1-2, NHCO and derivatives, and NHSO1-2 and derivatives; R1 and R2 are independently H, (un)substituted (hetero)aryl, heterocycloalkyl, C1-4 alkyl and C3-6 cycloalkyl; or R1R2 taken together form a heterocycloalkyl ring; each R3 is independently halo, C1-4 alkyl, CF3, CN, NO2, NH2, OH and OMe; m is 1 – 3; and their pharmaceutically acceptable salt, are claimed. Example compound II was prepared by amination of (R)-tert-Bu 3-hydroxy-1-pyrrolidinecarboxylate with 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine,the resulting substituted pyrazolopyrimidine underwent deprotection followed by N-acylation with 4-(dimethylamino)but-2-enoic acid to afford 2-(E)-1-((R)-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidin-1-yl)-4-(dimethylamino)but-2-en-1-one, which underwent coupling reaction with 4-chlorophenylboronic acid to afford compound II. All the invention compounds were evaluated for their Btk inhibitory activity. From the assay, it was determined that example compound II exhibited IC50 value of < 100 nM. The experimental process involved the reaction of 2-(3-Methoxy-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1417036-28-2).COA of Formula: C14H21BO3

The Article related to pyrazolopyrimidine preparation btk kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.COA of Formula: C14H21BO3

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Yuan, Jiwen; Ma, Xu; Yi, Hong; Liu, Chao; Lei, Aiwen published an article in 2014, the title of the article was I2-catalyzed oxidative C(sp3)-H/S-H coupling: utilizing alkanes and mercaptans as the nucleophiles.Quality Control of Benzyl(4-bromophenyl)sulfane And the article contains the following content:

By using alkanes and mercaptans as the nucleophiles with di-tert-Bu peroxide (DTBP) as the oxidant, I2-catalyzed oxidative C(sp3)-H/S-H coupling was achieved. This protocol provides a novel process to construct C(sp3)-S bonds from com. available hydrocarbons and mercaptans. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Quality Control of Benzyl(4-bromophenyl)sulfane

The Article related to alkane mercaptan oxidative coupling, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Alcohols and Thiols and other aspects.Quality Control of Benzyl(4-bromophenyl)sulfane

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On October 29, 1999, Xiao, Yang; Yu, Wang-Lin; Pei, Jian; Chen, Zhikuan; Huang, Wei; Heeger, Alan J. published an article.Recommanded Product: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene The title of the article was Conjugated copolymers of 2-methoxy-5-2′-ethyl-hexyloxy-1,4-phenylenevinylene and 2,5-dicyano-1,4-phenylenevinylene as materials for polymer light-emitting diodes. And the article contained the following:

A series of electroluminescent polymers was prepared, which incorporates segments of 2,5-dicyano-1,4-phenylenevinylene (DCN-PV) into the backbone of poly(2-methoxy-5-(2′-ethyl-hexyloxy)-p-phenylene vinylene) (MEH-PPV). The copolymers have optical properties similar to those of MEH-PPV. The oxidation potential of the copolymers is slightly larger than that of MEH-PPV. The copolymers exhibit pre-reduction processes, beginning at about -0.9 V (vs. SCE), before the main reduction processes. The pre-reduction feature promotes electron injection, consequently, it improves electroluminescence (EL) performance. The improved EL performance of the copolymers in comparison with MEH-PPV was demonstrated by a single-layer copolymer as emitter layer in a light-emitting diode (PLED) test device. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).Recommanded Product: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene

The Article related to dicyanophenylenevinylene copolymer preparation electroluminescence prereduction process, polyphenylenevinylene cyanophenylene substituent preparation conjugated polymer, Physical Properties of Synthetic High Polymers: Physical Properties Of Polymers and other aspects.Recommanded Product: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene

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On June 30, 2000, Park, Lee Soon; Han, Yoon Soo; Kim, Sang Dae; Kim, Woo Sik; Lee, Dong Ho; Min, Kyung Eun; Seo, Kwan Ho; Kang, Inn Kyu published an article.SDS of cas: 146370-51-6 The title of the article was Synthesis of conjugated copolymers containing biphenyl group and their electroluminescence characteristics. And the article contained the following:

Poly(2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylene vinylene) (MEH-PPV) and poly(2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylene vinylene-co-1,1′-biphenyl-4,4′-xylene vinylene) [poly(MEHPV-co-BPV)] with a different feed ratio of biphenyl group in the main chain were synthesized by α-elimination reaction. Poly(2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylene vinylene-alt-1,1′-biphenyl-4,4′-xylene vinylene) [poly(MEHPV-alt-BPV)], which has alternating repeat unit, and poly(1,8-octanedioxy-2-methoxy-,4-phenylene-1,2-ethenylene-,1′-biphenyl-4,4′-xylene-1,2-ethenylene-3-methoxy-1,4- phenylene)[poly(BFMP8-BPV)] and poly(1,12-dodecanedioxy-2-ethoxy-1,4-phenylene-1,2-ethenylene 1,1′-biphenyl-4,4′-xylene-1,2-ethene-3-thoxy-1,4-phenylene) [poly(BFMP12-BPV)] containing both conjugated and non-conjugated group in the main chain were synthesized by the Honer-Emmons reaction Single layer type light-emitting diode (LED)s were fabricated utilizing the prepared polymers as the emitting layer and their electrooptical properties were examined The solubility of poly(MEHPV-co-BPV)s in common organic solvents decreased rapidly with the increasing amount of BPV units in the copolymer. Emission spectrum of poly(MEHPV-co-BPV)s had two peaks corresponding to MEHPV (586 nm) and BPV (469, 495 nm) moiety, resp. However, LED fabricated with poly(MEHPV-alt-BPV) showed relatively sharp single peak (544 nm) in the middle of the two peaks. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).SDS of cas: 146370-51-6

The Article related to polyphenylenevinylene synthesis electroluminescence luminescence, Physical Properties of Synthetic High Polymers: Physical Properties Of Polymers and other aspects.SDS of cas: 146370-51-6

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Ether – Wikipedia,
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On July 8, 2013, Khoshkhoo, Mahdi Samadi; Taromi, Faramarz Afshar; Kowsari, Elaheh; Shalamzari, Elham Khodabakhshi published an article.Application of 146370-51-6 The title of the article was Contribution of chromophores with different numbers of repeat units to overall emission of MEH-PPV: An experimental and simulation study. And the article contained the following:

In the present study, poly[1-methoxy-4-(2′-ethylhexyloxy)-p-phenylenevinylene] (MEH-PPV) was synthesized, modified and characterized by FTIR, NMR, GPC, UV/vis absorption, fluorescence, and mass spectroscopy. The effective conjugation length was controlled by introducing phys. and chem. defects into the chain backbone. It was observed that absorption and emission spectra of polymer chains were blue-shifted by importing structural deficiencies. Chem. defects were introduced by controlled oxidation of vinylene double bonds using m-chloroperbenzoic acid and phys. defects were induced by tuning polymer-solvent interactions (varying solvent quality). It was shown for the first time that the recorded fluorescence spectrum of MEH-PPV can be reconstructed using the emission data of oligomeric constituents and the contribution of chromophores with different numbers of repeat units to overall emission can be quantified. The effect of excitation energy on the emission pattern was also investigated. It was shown that the emission contribution of shorter chromophores to overall emission is detectable using high excitation energies. Finally, atomistic mol. dynamic (MD) simulation was used to investigate the polymer chain conformation in methanol and chloroform. The results obtained from torsional angles studies confirmed the presence of a great number of induced phys. defects in the backbone and, hence, a collapsed conformation of polymer chains in methanol. Evaluations of phys. defects along the chain proposed the average number of coplanar Ph rings of ∼5 and 14 for polymer chains in methanol and chloroform resp. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).Application of 146370-51-6

The Article related to meh ppv emission chromophore repeating unit effect, Physical Properties of Synthetic High Polymers: Physical Properties Of Polymers and other aspects.Application of 146370-51-6

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Ether – Wikipedia,
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Li, Yiming; Xie, Weisi; Jiang, Xuefeng published an article in 2015, the title of the article was Mechanistic Study of a Photocatalyzed C-S Bond Formation Involving Alkyl/Aryl Thiosulfate.Safety of Benzyl(4-bromophenyl)sulfane And the article contains the following content:

This study presents thioether construction involving alkyl/aryl thiosulfates and diazonium salt catalyzed by visible-light-excited [Ru(bpy)3Cl2] at room temperature in 44-86 % yield. ESR studies found that thiosulfate radical formation was promoted by K2CO3. Conversely, radicals generated from BnSH or BnSSBn (Bn=benzyl) were clearly suppressed, demonstrating the special property of thiosulfate in this system. Transient absorption spectra confirmed the electron-transfer process between [Ru(bpy)3Cl2] and 4-MeO-Ph diazonium salt, which occurred with a rate constant of 1.69×109 m-1 s-1. The corresponding radical trapping product was confirmed by X-ray diffraction. The full reaction mechanism was determined together with emission quenching data. Furthermore, this system efficiently avoided the over-oxidation of sulfide caused by H2O in the photoexcited system containing Ru2+. Both aryl and heteroaryl diazonium salts with various electronic properties were investigated for synthetic compatibility. Both alkyl- and aryl-substituted thiosulfates could be used as substrates. Notably, pharmaceutical derivatives afforded late-stage sulfuration smoothly under mild conditions. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Safety of Benzyl(4-bromophenyl)sulfane

The Article related to carbon sulfur bond formation photocatalysis alkyl aryl thiosulfate, bond formation, mechanistic study, organic thiosulfates, pharmaceuticals sulfuration, photocatalysis, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Safety of Benzyl(4-bromophenyl)sulfane

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On February 28, 2013, Zhao, Lifeng; Li, Ruyu; Tao, Haiyan; Wang, Zhenjiang; Wu, Shuilin; Li, Chengyu; Li, Shengbiao; Huang, Wei published an article.Product Details of 146370-51-6 The title of the article was Novel hyperbranched polyphenylene vinylenes with nitro group: synthesis, characterization and photophysical properties. And the article contained the following:

Novel PPV derivates with nitro group were designed and successfully synthesized through Gilch reaction. The reaction intermediate and polymers were characterized by 1H NMR, GPC and Elemental Anal. (EA). The photophysics properties, thermal property, electrochem. property were investigated, these polymers are soluble in common organic solvents and they have good thermal stability. The onset weights loss temperature of polymers were 386.6, 370.4 and 397.8°C for P1, P2 and P3, resp. In comparison with the solution absorption spectra, the absorption bands of polymers (P1, P2 and P3) in thin films were red-shifted. These polymers may be promising materials for solar cells. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).Product Details of 146370-51-6

The Article related to hyperbranched polyphenylene vinylene dendrimer synthesis, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Product Details of 146370-51-6

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On January 12, 2004, Li, Hongchao; Zhang, Yanguang; Hu, Yufeng; Ma, Dongge; Wang, Lixiang; Jing, Xiabin; Wang, Fosong published an article.Reference of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene The title of the article was Novel soluble N-phenyl-carbazole-containing PPVs for light-emitting devices: Synthesis, electrochemical, optical, and electroluminescent properties. And the article contained the following:

Novel PPV derivatives (PCA8-PV and PCA8-MEHPV) containing N-phenyl-carbazole units on the backbone were successfully synthesized by the Wittig polycondensation of 3,6-bisformyl-N-(4-octyloxy-phenyl)carbazole with the corresponding tri-Bu phosphonium salts in good yields. The newly formed and dominant trans vinylene double bonds were confirmed by FT-IR and NMR spectroscopy. The polymers (with M̅w of 6289 for PCA8-PV and 7387 for PCA8-MEHPV) were soluble in common organic solvents and displayed high thermal stability (Tgs are 110.7°C for PCA8-PV and 92.2°C for PCA8-MEHPV, resp.) because of the incorporation of the N-phenyl-carbazole units. Cyclic voltammetry investigations (onsets: 0.8 V for PCA8-PV and 0.7 V for PCA8-MEHPV) suggested that the polymers possess enhanced hole injection/transport properties, which can be also attributed to the N-phenyl-carbazole units on the backbone. Both the single-layer and the double-layer light-emitting diodes (LEDs) that used the polymers as the active layer emitted a greenish-blue or bluish-green light (the maximum emissions located 494 nm for PCA8-PV and 507 nm for PCA8-MEHPV, resp.). Compared with those of the single-layer devices, the emission efficiencies of the double-layer devices, in which an electron-transporting layer (Alq3) was added, were enhanced by a factor of 10, implying that the better hole-electron balance is achieved because of the incorporation of the electron-transporting layer. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).Reference of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene

The Article related to bisformyloctyloxyphenylcarbazole tributyl phosphonium, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Reference of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene

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On August 27, 2004, Xue, Cuihua; Luo, Fen-Tair published an article.SDS of cas: 146370-51-6 The title of the article was Novel p-phenylene-vinylene-dithienylene type copolymer: potential red-emitting materials. And the article contained the following:

The p-phenylene-vinylene-dithienylene type copolymers (PPV-DT) with or without cyano group on the vinylene moiety were synthesized by Wittig-Horner-Emmons reaction and palladium-catalyzed homo-coupling reaction. The photophys. and optoelectronic properties of these copolymers as potential red-emitting materials were discussed. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).SDS of cas: 146370-51-6

The Article related to thiophene polyphenylenevinylene luminescence band gap, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.SDS of cas: 146370-51-6

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On April 30, 2010, Wu, Wei; Zhang, Xiao-yun; Kang, Shou-xing published an article.Recommanded Product: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene The title of the article was Synthesis and light-emitting performance of MEH-PPV-type monomer 2,5-bis(4-bromo-2,5-dimethoxyphenylvinylene)-1-methoxy-4-(2-ethylhexyloxy)benzene. And the article contained the following:

A method for the preparation of a green light-emitting monomer [i.e., bis[(4-bromo-2,5-dimethoxyphenyl)vinylene]-1-methoxy-4-[(2-ethylhexyl)oxy]benzene, 1,4-bis[2-(4-bromo-2,5-dimethoxyphenyl)ethenyl]-2-[(2-ethylhexyl)oxy]-5-methoxybenzene] was designed and the synthesis of the target compound was achieved (44.7% yield) by a Wittig-Horner reaction of 2,5-dimethoxy-4-bromobenzaldehyde with P,P’-[[2-[(2-ethylhexyl)oxy]-5-methoxy-1,4-phenylene]bis(methylene)]bis[phosphonic acid] P,P,P’,P’-tetraethyl ester and the product thus obtained was confirmed by 1H-NMR, 13C-NMR, elemental anal. The light-emitting performance of that compound was also determined by UV-Vis and fluorescence anal. and the results showed that λmax of UV-Vis and fluorescence (FL) were 410 nm and 479 nm, 497 nm, resp. The title compound is a MEH-PPV-type monomer used for light-emitting diodes. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).Recommanded Product: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene

The Article related to phenylvinylene monomer luminescent substance green, Chemistry of Synthetic High Polymers: Monomers and Reagents Used In Polymerization and other aspects.Recommanded Product: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene

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