Tag: 200-300

On November 5, 2007, Bahrami, Kiumars; Khodaei, Mohammad Mehdi; Khedri, Mohammad published an article.COA of Formula: C13H11BrS The title of the article was A novel method for the deoxygenation of sulfoxides with the PPh3/Br2/CuBr system. And the article contained the following:

The combination of PPh3/Br2/CuBr was an effective promoter for the deoxygenation of diaryl, dibenzyl, aryl benzyl, dialkyl, and cyclic sulfoxides and gave the corresponding sulfides in excellent yield in MeCN under refluxing conditions. This reagent system is chemoselective, tolerating various functional groups such as C-C double bond and ketone. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).COA of Formula: C13H11BrS

The Article related to sulfoxide deoxygenation phosphine bromine cuprous bromide reagent, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfoxides and Sulfones and other aspects.COA of Formula: C13H11BrS

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Malik, Qasim M.; Ijaz, Sadia; Craig, Donald C.; Try, Andrew C. published an article in 2011, the title of the article was Synthesis and reactivity of dimethoxy-functionalized Troeger’s base analogs.Recommanded Product: 4-Bromo-5-methoxy-2-methylaniline And the article contains the following content:

Troeger’s base analogs were prepared bearing methoxy groups in the 1,7-, 2,8-, 3,9- or 4,10-positions. These compounds were converted to their dihydroxy analogs in excellent yields upon treatment with boron tribromide and the 4,10-dihydroxy analog could be prepared by directly from 4-hydroxyaniline. The synthetic utility of the dihydroxy-functionalized compounds as building blocks was demonstrated by the synthesis of a dialkoxy and a diester Troeger’s base analog. The experimental process involved the reaction of 4-Bromo-5-methoxy-2-methylaniline(cas: 152626-77-2).Recommanded Product: 4-Bromo-5-methoxy-2-methylaniline

The Article related to troeger base dihydroxy preparation alkylation acylation, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Recommanded Product: 4-Bromo-5-methoxy-2-methylaniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 21, 2022, Ito, Mamoru; Onoda, Hideaki; Takaki, Asahi; Shibata, Takanori published an article.COA of Formula: C15H13NO The title of the article was Gold-Catalyzed Cascade and Divergent Synthesis of Indolobenzazepines and Indoloquinolines from Nitrogen-Tethered 1,8-Diynes. And the article contained the following:

Authors describe the divergent construction of two nitrogen-containing polycyclic systems by gold-catalyzed cycloisomerizations. The gold-catalyzed cascade hydroamination and 7-endo-dig-selective cycloisomerization of nitrogen-tethered 1,8-diynes yielded indolo[1,7-ab]benzazepines in one pot. In contrast, when Johnphos-coordinated gold catalyst was used, the same 1,8-diynes were transformed into indolo[1,2-a]quinolines by 6-endo-dig-selective cycloisomerization along with rearrangement of the substituent on one of the alkynes. The reaction of a naphthalene-tethered substrate provided a helically chiral aza[6]helicene. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).COA of Formula: C15H13NO

The Article related to indolobenzazepine indoloquinoline preparation, nitrogen tethered diyne tandem hydroamination cycloisomerization rearrangement gold, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C15H13NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yao, Lingyun; Shang, Yan; Wang, Jian-Shu; Pan, Ailin; Ying, Jun; Wu, Xiao-Feng published an article in 2021, the title of the article was Palladium-catalyzed carbonylative cyclization of 2-alkynylanilines and aryl iodides to access N-acyl indoles.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

A palladium-catalyzed carbonylative synthesis of N-acyl indoles I (R = Ph, 2-methylphenyl, 4-chloropenyl, 3,4-dimethylphenyl, etc.; R1 = Ph, 3-methylphenyl, 4-methylphenyl, 4-methoxyphenyl, 4-fluorophenyl; R2 = H, F) from 2-alkynylanilines 2-NH25-R2C6H3CCR1 and aryl iodides RI has been developed. Using benzene-1,3,5-triyl triformate (TFBen) as the CO source, the reaction produced a variety of N-acyl indoles I in a facile manner with high yields. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to acyl indole preparation, alkynylaniline aryl iodide benzenetriyl triformate carbonylative cyclization palladium catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 17, 2016, Nagamochi, Masatoshi; Gotanda, Kentoku; Noguchi, Tetsuji; Goto, Taiji; Sasaki, Junko; Torihata, Munefumi; Yoshino, Toshiharu; Isobe, Takashi; Ramadass, Venkataramanan published a patent.Recommanded Product: 4-Bromo-5-methoxy-2-methylaniline The title of the patent was Preparation of carboxylic acid derivatives as RORγt (retinoic acid receptor-related orphan receptor γt) inhibitors. And the patent contained the following:

Title compounds I [R1 = alkyl, cycloalkyl or phenyl; R2 = H, halo, alkyl, etc.; R3 = H, carboxy-alkyl or hydroxy; R4 = halo or alkyl; R5 = H or alkyl; R6 = H, halo or alkyl; R7 = H, halo, alkyl, etc.; R8 = hydroxy, alkoxy, monoalkylamino, etc.; L = single bond, methylene or oxygen atom; E = phenylene (optionally substituted with halo, alkyl or alkylsulfonyl), pyridinylene (optionally substituted with halo, alkyl or alkylsulfonyl), thienylene, etc.; Q1 = nitrogen atom or CH; Q2 = nitrogen atom or CH; -U-T- = -CH2CH2- or -CH:CH-; Y = methylene or oxygen atom; V = nitrogen atom or C(R9); R9 = H, alkyl, cycloalkyl, etc.; or pharmaceutically acceptable salts thereof], useful for the treatment of psoriasis, psoriatic arthritis, etc., were prepared For example, EDCI-mediated amidation of II [R = OH] (prepared from 1-bromo-4-iodo-2-methylbenzene in a multi-step process) with methylamine·HCl afforded compound II [R = NHMe]. In IL-17 production inhibition assay, 81-example of I showed IC50 values (nM) ranging from 4.48 to 1110, e.g., IC50 of II [R = NHMe] was 4.48 nM. Pharmaceutical compositions comprising I are disclosed. The experimental process involved the reaction of 4-Bromo-5-methoxy-2-methylaniline(cas: 152626-77-2).Recommanded Product: 4-Bromo-5-methoxy-2-methylaniline

The Article related to carboxylic acid preparation ror gamma t inhibitor, psoriasis psoriatic arthritis treatment ror gamma t inhibition, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 4-Bromo-5-methoxy-2-methylaniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On December 31, 2022, Mutra, Mohana Reddy; Wang, Jeh-Jeng published an article.Synthetic Route of 157869-15-3 The title of the article was Photoinduced ynamide structural reshuffling and functionalization. And the article contained the following:

In this paper, photoinduced radical trigger regio- and chemoselective ynamide bond fission, structural reshuffling and functionalization of 2-alkynyl-ynamides 4-R-2-(CCR1)C6H3N(Ts)CCR2 (R = H, Me, Et, n-bu, Cl, Br; R1 = Ph, n-Bu, cyclopropyl, etc.; R2 = Ph, 2H-1,3-benzodioxol-5-yl, 2-phenylethyl, etc.) to prepare synthetically inaccessible/challenging chalcogen-substituted indole derivatives I [R3 = tosyl, ethanesulfonyl, cyclopropanesulfonyl, etc.; R4 = I, SeC6H5, Se(CH2)4CH3, etc] with excellent step/atom economy were observed The key breakthroughs of this work include, ynamide bond cleavage, divergent radical precursors, broad scope, easy to handle, larger-scale reactions, and generation of multiple bonds (N-C(sp2), C(sp2)-C(sp2), C(sp2)-SO2R/C-SR, and C-I/C-Se/C-H) in a few minutes without photocatalysts, metals, oxidants, additives. Control experiments and 13C-labeling experiments support the conclusion that sulfone radicals contribute to ynamide structural reshuffling processes via a radical pathway. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Synthetic Route of 157869-15-3

The Article related to indole preparation regioselective chemoselective photochem, alkynyl ynamide sulfonyl compound heterocyclization, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Synthetic Route of 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On October 28, 2015, Li, Yin-Long; Li, Jian; Yu, Sheng-Nan; Wang, Ji-Bo; Yu, Yan-Min; Deng, Jun published an article.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline The title of the article was A concise approach for the synthesis of 3-iodoindoles and 3-iodobenzo[b]furans via Ph3P-catalyzed iodocyclization. And the article contained the following:

A variety of 3-iodoindole and 3-iodobenzo[b]furan derivatives were conveniently prepared from the corresponding 2-alkynylanilines and 2-alkynylphenols through Ph3P-catalyzed iodocyclization in the presence of N-iodosuccinimide. This protocol provides a rapid access to 3-iodoindoles and 3-iodobenzo[b]furans in good to excellent yields under mild conditions. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to iodoindole iodobenzofuran preparation, iodocyclization alkynylphenol alkynylaniline triphenylphosphine catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 3, 2017, Li, Yi-Jin; Yan, Na; Liu, Chun-Hua; Yu, Yang; Zhao, Yu-Long published an article.Application In Synthesis of 2-((4-Methoxyphenyl)ethynyl)aniline The title of the article was Gold/Copper-Co-catalyzed Tandem Reactions of 2-Alkynylanilines: A Synthetic Strategy for the C2-Quaternary Indolin-3-ones. And the article contained the following:

A new strategy for direct and highly efficient synthesis of 2,3′-bisindolin-3-ones has been developed via a gold/copper-co-catalyzed tandem reactions of 2-alkynylanilines using TBHP as the terminal oxidant and oxygen-atom source. The single-step process involves a novel tandem intermol. nucleophilic addition, intramol. cyclization/oxidative cross-dehydrogenative coupling where up to four new bonds and two indole rings were created simultaneously in one-pot manner. The reaction features a broad substrate scope, good functional group tolerance, and high atom-economy. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Application In Synthesis of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to bisindolinone preparation, gold copper cocatalyst alkynylaniline, aniline alkynyl gold copper cocatalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application In Synthesis of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 7, 2020, Yuan, Shuo; Zhang, Dan-Qing; Zhang, Jing-Ya; Yu, Bin; Liu, Hong-Min published an article.HPLC of Formula: 157869-15-3 The title of the article was Palladium-Catalyzed Ligand-Free Double Cyclization Reactions for the Synthesis of 3-(1′-Indolyl)-phthalides. And the article contained the following:

Indole and phthalide are privileged heterocyclic scaffolds in numerous natural products and bioactive mols. The synthesis and biol. evaluation of the compounds combining these two scaffolds have rarely been reported. The first palladium-catalyzed ligand-free double cyclization reactions that enable efficient synthesis of 3-(1′-indolyl)-phthalides, e.g., I, under mild conditions is reported. Notably, only 1.0 mol % of catalyst loading is used, suggesting high efficiency. Late-stage elaborations give highly functionalized analogs. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).HPLC of Formula: 157869-15-3

The Article related to ethynylaniline formylbenzoic acid palladium catalyst cascade cyclization, indolyl phthalide preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.HPLC of Formula: 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 14, 2018, Chaisan, Nattawadee; Kaewsri, Wilailak; Thongsornkleeb, Charnsak; Tummatorn, Jumreang; Ruchirawat, Somsak published an article.Category: ethers-buliding-blocks The title of the article was PtCl4-catalyzed cyclization of N-acetyl-2-alkynylanilines: A mild and efficient synthesis of N-acetyl-2-substituted indoles. And the article contained the following:

An efficient synthesis of N-acetyl-2-substituted indole derivatives via direct intramol. hydroamination of N-acetyl-2-alkynylaniline derivatives was developed. The reaction could be applied to a wide range of substrates employing only 1-2 mol% of PtCl4 as the catalyst to furnish the desired indole products in moderate to excellent yields. The current protocol is efficient, reliable and scalable, and could serve as an important tool for convenient and rapid access to this important class of N-heterocyclic skeleton from readily available substrates. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Category: ethers-buliding-blocks

The Article related to indole acetyl substituted preparation acetylalkynylaniline cyclization platinum chloride catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem