Tag: 200-300

Youn, So Won; Lee, So Ra published an article in 2015, the title of the article was Unusual 1,2-aryl migration in Pd(II)-catalyzed aza-Wacker-type cyclization of 2-alkenylanilines.Reference of 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

Inspired by the Hegedus aza-Wacker indole synthesis, we were intrigued with the fate of the aminopalladation intermediate if syn β-hydrogen is made inaccessible or unavailable. In contrast to our previously reported β-carbon elimination, cyclization of a variety of 2-alkenylaniline substrates under electrophilic palladium conditions unexpectedly afforded C3-substituted indoles. This unusual 1,2-migratory process was found to be operative across a variety of substrates with predictable migratory aptitude. A mechanistic proposal was put forward to rationalize the observed substrate dependence, and this unexpected finding could provide an opportunity for other related processes. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Reference of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to alkenylaniline palladium aza wacker cyclization aryl migration catalyst, indole aryl preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Reference of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On December 3, 2021, Khandelia, Tamanna; Ghosh, Subhendu; Panigrahi, Pritishree; Shome, Rajib; Ghosh, Siddhartha Sankar; Patel, Bhisma K. published an article.Recommanded Product: 157869-15-3 The title of the article was Copper(I)-Mediated Cascade Annulation via Dual C-H/C-H Activation: Access to Benzo[a]carbazolic AEEgens. And the article contained the following:

A Cu(I)-mediated cascade cyclization/annulation of unprotected o-alkynylanilines 2-RNH-R1C6H3CCC6H4R2 (R = H, Me; R1 = H, 4-CF3, 4-Me, 5-Cl, etc.; R2 = H, 4-tert-Bu, 3-fluoro, 4-Me, etc.), 2-[2-(thiophen-2-yl)ethynyl]aniline with maleimides I (R3 = H, Et, benzyl, cyclohexyl, etc.) in one pot is developed. The protocol offers sequential formation of one C-N and two C-C bonds to deliver fused benzo[a]carbazoles II (R4 = H, 11-CF3, 11-Me, 10-Cl, etc.; R5 = H, 5-tert-Bu, 6-fluoro, 5-Me, etc.), 5-ethylpyrrolo[3,4-c]thieno[2,3-a]carbazole-4,6(5H,11H)-dione having free NH skeletons. The annulated products display fluorescence emission in the range of 485-502 nm with a large Stokes shift and fluorescence lifetime of ~17 ns. The annulated II (R = R4 = R5 = H, R3 = Et) displays AEE behavior in the ethanol/hexane system and possesses marigold-flower-like morphol. at the aggregated state. Cell viability assays enumerate biocompatible AEEgens, while their high intracellular fluorescence depicts cell imaging applicability. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Recommanded Product: 157869-15-3

The Article related to benzopyrrolocarbazole preparation regioselective photoluminescence anticancer activity dft study, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 157869-15-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Shang, Qian; Tang, Haifang; Liu, Yongping; Yin, MingMing; Su, Lebin; Xie, Shimin; Liu, Lixin; Yang, Wen; Chen, Yi; Dong, Jianyu; Zhou, Yongbo; Yin, Shuang-Feng published an article in 2022, the title of the article was Cu(I) catalysis for selective condensation/bicycloaromatization of two different arylalkynes: direct and general construction of functionalized C-N axial biaryl compounds.Application In Synthesis of 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

Selective condensation/bicycloaromatization of two different arylalkynes is firstly developed under ligand-free copper(I)-catalysis, which allows the direct synthesis of C-N axial biaryl compounds in high yields with excellent selectivity and functional group tolerance. Due to the critical effects of Cu(I) catalyst and HFIP, many easily occurring undesired reactions are suppressed, and the coupled five-six aromatic rings are constructed via the selective formation of two C(sp2)-N(sp2) bonds and four C(sp2)-C(sp2) bonds. The achievement of moderate enantioselectivity verifies its potential for the simplest asym. synthesis of atropoisomeric biaryls. Western blotting demonstrated that the newly developed compounds are promising targets in biol. and pharmaceuticals. This unique reaction can construct structurally diverse C-N axial biaryl compounds that have never been reported by other methods, and might be extended to various applications in materials, chem., biol., and pharmaceuticals. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Application In Synthesis of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to axial biaryl compound preparation, arylalkyne condensation bicycloaromatization copper catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application In Synthesis of 2-((4-Methoxyphenyl)ethynyl)aniline

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jillella, Raveendra; Oh, Dong hwan; Oh, Chang Ho published an article in 2018, the title of the article was Di-tert-butyl-hydroxyphenyl phenyl-indolyl methyl aromatic aldehyde prepn via Gold-catalyzed tandem reaction of 2-alkynylanilines followed by 1,6-conjugate addition to p-quinone methides..Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

A simple, mild, efficient and chemoselective catalytic method for the straightforward synthesis of an interesting class of 2-aryl/alkyl-substituted-3-diaryl indolyl methanes in high yield was reported. This atom-efficient method proceeded via a gold-catalyzed one-pot sequential intramol. hydroamination (C-N bond formation) of 2-alkynylanilines followed by a 1,6-conjugate addition to p-quinonemethides. The p-quinonemethides, which contain aldehyde functional groups, preferentially participate in 1,6-conjugate addition, while the aldehyde functional group remains unreactive. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to diarylindolylmethane preparation, alkynylaniline quinone methide gold catalyst tandem addition, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Jiangjie; Wang, Shangyuan; Wang, Jian-Shu; Ying, Jun; Wu, Xiao-Feng published an article in 2022, the title of the article was Palladium-catalyzed carbonylative synthesis of indole-3-carboxamides from 2-ethynylanilines and nitroarenes.HPLC of Formula: 157869-15-3 And the article contains the following content:

A palladium-catalyzed carbonylative cyclization of 2-ethynylanilines with nitroarenes has been developed for the rapid synthesis of indole-3-carboxamide skeletons. By using nitroarenes as the nitrogen source and Mo(CO)6 as the CO surrogate, the reaction proceeded smoothly to furnish various indole-3-carboxamide derivatives in moderate to high yields. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).HPLC of Formula: 157869-15-3

The Article related to indole carboxamide preparation, ethynylaniline nitroarene carbonylative cyclization palladium, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.HPLC of Formula: 157869-15-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On December 25, 2016, Zohreh, Nasrin; Hosseini, Seyed Hassan; Pourjavadi, Ali; Soleyman, Rouhollah; Bennett, Craig published an article.HPLC of Formula: 53136-21-3 The title of the article was Immobilized tungstate on magnetic poly(2-ammonium ethyl acrylamide): A high loaded heterogeneous catalyst for selective oxidation of sulfides using H2O2. And the article contained the following:

A heterogeneous tungstate-based catalyst has been prepared for selective oxidation of sulfides to sulfoxides in the presence of 30% H2O2. The catalyst was prepared via immobilization of high amounts of WO2-4 onto the cross-linked poly(ammonium Et acrylamide) coated magnetic nanoparticles (MNP). FT-IR, TEM, TGA, VSM, XRD, EDX, and CHN anal. were used for characterization of catalyst. Variety of sulfides successfully converted to the related sulfoxides using 1 mol% of catalyst at room temperature in high yields. The catalyst was easily recovered and reused up to 6 times without loss of activity. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).HPLC of Formula: 53136-21-3

The Article related to magnetic polyaminoethyl acrylamide support tungstate catalyst selective sulfide oxidation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.HPLC of Formula: 53136-21-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 21, 2022, Ito, Mamoru; Onoda, Hideaki; Takaki, Asahi; Shibata, Takanori published an article.COA of Formula: C15H13NO The title of the article was Gold-Catalyzed Cascade and Divergent Synthesis of Indolobenzazepines and Indoloquinolines from Nitrogen-Tethered 1,8-Diynes. And the article contained the following:

Authors describe the divergent construction of two nitrogen-containing polycyclic systems by gold-catalyzed cycloisomerizations. The gold-catalyzed cascade hydroamination and 7-endo-dig-selective cycloisomerization of nitrogen-tethered 1,8-diynes yielded indolo[1,7-ab]benzazepines in one pot. In contrast, when Johnphos-coordinated gold catalyst was used, the same 1,8-diynes were transformed into indolo[1,2-a]quinolines by 6-endo-dig-selective cycloisomerization along with rearrangement of the substituent on one of the alkynes. The reaction of a naphthalene-tethered substrate provided a helically chiral aza[6]helicene. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).COA of Formula: C15H13NO

The Article related to indolobenzazepine indoloquinoline preparation, nitrogen tethered diyne tandem hydroamination cycloisomerization rearrangement gold, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C15H13NO

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yao, Lingyun; Shang, Yan; Wang, Jian-Shu; Pan, Ailin; Ying, Jun; Wu, Xiao-Feng published an article in 2021, the title of the article was Palladium-catalyzed carbonylative cyclization of 2-alkynylanilines and aryl iodides to access N-acyl indoles.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

A palladium-catalyzed carbonylative synthesis of N-acyl indoles I (R = Ph, 2-methylphenyl, 4-chloropenyl, 3,4-dimethylphenyl, etc.; R1 = Ph, 3-methylphenyl, 4-methylphenyl, 4-methoxyphenyl, 4-fluorophenyl; R2 = H, F) from 2-alkynylanilines 2-NH25-R2C6H3CCR1 and aryl iodides RI has been developed. Using benzene-1,3,5-triyl triformate (TFBen) as the CO source, the reaction produced a variety of N-acyl indoles I in a facile manner with high yields. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to acyl indole preparation, alkynylaniline aryl iodide benzenetriyl triformate carbonylative cyclization palladium catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 17, 2016, Nagamochi, Masatoshi; Gotanda, Kentoku; Noguchi, Tetsuji; Goto, Taiji; Sasaki, Junko; Torihata, Munefumi; Yoshino, Toshiharu; Isobe, Takashi; Ramadass, Venkataramanan published a patent.Recommanded Product: 4-Bromo-5-methoxy-2-methylaniline The title of the patent was Preparation of carboxylic acid derivatives as RORγt (retinoic acid receptor-related orphan receptor γt) inhibitors. And the patent contained the following:

Title compounds I [R1 = alkyl, cycloalkyl or phenyl; R2 = H, halo, alkyl, etc.; R3 = H, carboxy-alkyl or hydroxy; R4 = halo or alkyl; R5 = H or alkyl; R6 = H, halo or alkyl; R7 = H, halo, alkyl, etc.; R8 = hydroxy, alkoxy, monoalkylamino, etc.; L = single bond, methylene or oxygen atom; E = phenylene (optionally substituted with halo, alkyl or alkylsulfonyl), pyridinylene (optionally substituted with halo, alkyl or alkylsulfonyl), thienylene, etc.; Q1 = nitrogen atom or CH; Q2 = nitrogen atom or CH; -U-T- = -CH2CH2- or -CH:CH-; Y = methylene or oxygen atom; V = nitrogen atom or C(R9); R9 = H, alkyl, cycloalkyl, etc.; or pharmaceutically acceptable salts thereof], useful for the treatment of psoriasis, psoriatic arthritis, etc., were prepared For example, EDCI-mediated amidation of II [R = OH] (prepared from 1-bromo-4-iodo-2-methylbenzene in a multi-step process) with methylamine·HCl afforded compound II [R = NHMe]. In IL-17 production inhibition assay, 81-example of I showed IC50 values (nM) ranging from 4.48 to 1110, e.g., IC50 of II [R = NHMe] was 4.48 nM. Pharmaceutical compositions comprising I are disclosed. The experimental process involved the reaction of 4-Bromo-5-methoxy-2-methylaniline(cas: 152626-77-2).Recommanded Product: 4-Bromo-5-methoxy-2-methylaniline

The Article related to carboxylic acid preparation ror gamma t inhibitor, psoriasis psoriatic arthritis treatment ror gamma t inhibition, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 4-Bromo-5-methoxy-2-methylaniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On December 31, 2022, Mutra, Mohana Reddy; Wang, Jeh-Jeng published an article.Synthetic Route of 157869-15-3 The title of the article was Photoinduced ynamide structural reshuffling and functionalization. And the article contained the following:

In this paper, photoinduced radical trigger regio- and chemoselective ynamide bond fission, structural reshuffling and functionalization of 2-alkynyl-ynamides 4-R-2-(CCR1)C6H3N(Ts)CCR2 (R = H, Me, Et, n-bu, Cl, Br; R1 = Ph, n-Bu, cyclopropyl, etc.; R2 = Ph, 2H-1,3-benzodioxol-5-yl, 2-phenylethyl, etc.) to prepare synthetically inaccessible/challenging chalcogen-substituted indole derivatives I [R3 = tosyl, ethanesulfonyl, cyclopropanesulfonyl, etc.; R4 = I, SeC6H5, Se(CH2)4CH3, etc] with excellent step/atom economy were observed The key breakthroughs of this work include, ynamide bond cleavage, divergent radical precursors, broad scope, easy to handle, larger-scale reactions, and generation of multiple bonds (N-C(sp2), C(sp2)-C(sp2), C(sp2)-SO2R/C-SR, and C-I/C-Se/C-H) in a few minutes without photocatalysts, metals, oxidants, additives. Control experiments and 13C-labeling experiments support the conclusion that sulfone radicals contribute to ynamide structural reshuffling processes via a radical pathway. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Synthetic Route of 157869-15-3

The Article related to indole preparation regioselective chemoselective photochem, alkynyl ynamide sulfonyl compound heterocyclization, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Synthetic Route of 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem