Tag: 200-300

On October 28, 2015, Li, Yin-Long; Li, Jian; Yu, Sheng-Nan; Wang, Ji-Bo; Yu, Yan-Min; Deng, Jun published an article.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline The title of the article was A concise approach for the synthesis of 3-iodoindoles and 3-iodobenzo[b]furans via Ph3P-catalyzed iodocyclization. And the article contained the following:

A variety of 3-iodoindole and 3-iodobenzo[b]furan derivatives were conveniently prepared from the corresponding 2-alkynylanilines and 2-alkynylphenols through Ph3P-catalyzed iodocyclization in the presence of N-iodosuccinimide. This protocol provides a rapid access to 3-iodoindoles and 3-iodobenzo[b]furans in good to excellent yields under mild conditions. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to iodoindole iodobenzofuran preparation, iodocyclization alkynylphenol alkynylaniline triphenylphosphine catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 3, 2017, Li, Yi-Jin; Yan, Na; Liu, Chun-Hua; Yu, Yang; Zhao, Yu-Long published an article.Application In Synthesis of 2-((4-Methoxyphenyl)ethynyl)aniline The title of the article was Gold/Copper-Co-catalyzed Tandem Reactions of 2-Alkynylanilines: A Synthetic Strategy for the C2-Quaternary Indolin-3-ones. And the article contained the following:

A new strategy for direct and highly efficient synthesis of 2,3′-bisindolin-3-ones has been developed via a gold/copper-co-catalyzed tandem reactions of 2-alkynylanilines using TBHP as the terminal oxidant and oxygen-atom source. The single-step process involves a novel tandem intermol. nucleophilic addition, intramol. cyclization/oxidative cross-dehydrogenative coupling where up to four new bonds and two indole rings were created simultaneously in one-pot manner. The reaction features a broad substrate scope, good functional group tolerance, and high atom-economy. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Application In Synthesis of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to bisindolinone preparation, gold copper cocatalyst alkynylaniline, aniline alkynyl gold copper cocatalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application In Synthesis of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 7, 2020, Yuan, Shuo; Zhang, Dan-Qing; Zhang, Jing-Ya; Yu, Bin; Liu, Hong-Min published an article.HPLC of Formula: 157869-15-3 The title of the article was Palladium-Catalyzed Ligand-Free Double Cyclization Reactions for the Synthesis of 3-(1′-Indolyl)-phthalides. And the article contained the following:

Indole and phthalide are privileged heterocyclic scaffolds in numerous natural products and bioactive mols. The synthesis and biol. evaluation of the compounds combining these two scaffolds have rarely been reported. The first palladium-catalyzed ligand-free double cyclization reactions that enable efficient synthesis of 3-(1′-indolyl)-phthalides, e.g., I, under mild conditions is reported. Notably, only 1.0 mol % of catalyst loading is used, suggesting high efficiency. Late-stage elaborations give highly functionalized analogs. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).HPLC of Formula: 157869-15-3

The Article related to ethynylaniline formylbenzoic acid palladium catalyst cascade cyclization, indolyl phthalide preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.HPLC of Formula: 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 14, 2018, Chaisan, Nattawadee; Kaewsri, Wilailak; Thongsornkleeb, Charnsak; Tummatorn, Jumreang; Ruchirawat, Somsak published an article.Category: ethers-buliding-blocks The title of the article was PtCl4-catalyzed cyclization of N-acetyl-2-alkynylanilines: A mild and efficient synthesis of N-acetyl-2-substituted indoles. And the article contained the following:

An efficient synthesis of N-acetyl-2-substituted indole derivatives via direct intramol. hydroamination of N-acetyl-2-alkynylaniline derivatives was developed. The reaction could be applied to a wide range of substrates employing only 1-2 mol% of PtCl4 as the catalyst to furnish the desired indole products in moderate to excellent yields. The current protocol is efficient, reliable and scalable, and could serve as an important tool for convenient and rapid access to this important class of N-heterocyclic skeleton from readily available substrates. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Category: ethers-buliding-blocks

The Article related to indole acetyl substituted preparation acetylalkynylaniline cyclization platinum chloride catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On September 15, 2022, Baugh, Simon David Peter; Freeman, Kathryn B.; Pelletier, Jeffrey Claude; Reitz, Allen B.; Scott, Richard W.; Weaver, Damian G.; Whitman, David B. published a patent.Application of 152626-77-2 The title of the patent was Novel heteroaromatic compounds exhibiting antifungal activity and their method of use and preparation. And the patent contained the following:

Pharmaceutical compositions of the invention comprise heteroaromatic compounds of formula I having a disease-modifying action in the treatment of fungal infections and diseases associated with fungal infection. Compounds of formula I wherein A1 is (un)substituted thiazolyl, (un)substituted thiadiazolyl, (un)substituted imidazolyl, (un)substituted pyrazinyl, etc.; A2 is (un)substituted pyrimidinyl, (un)substiuted pyrazinyl, (un)substituted oxadiazolyl, (un)substituted thiadiazolyl, etc.; A3 is (CH2)0-2NHC:NHNH2 and derivatives, (CH2)0-2C:NHNH2 and derivatives, OCH2CH2NHC:NHNH2 and derivatives, etc.; A4 is (CH2)0-3NHC:NHNH2 and derivatives, (CH2)0-3C:NHNH2 and derivatives, OCH2CH2NHC:NHNH2 and derivatives, etc.; R1 is H, C1-4 alkyl and C3-5 branched alkyl; and enantiomers, diastereomers, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, are claimed. Example compound II•2TFA was prepared by a multistep procedure (procedure given). The invention compound were evaluated for their antifungal activity (data given). The experimental process involved the reaction of 4-Bromo-5-methoxy-2-methylaniline(cas: 152626-77-2).Application of 152626-77-2

The Article related to heteroaromatic preparation antifungal, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Application of 152626-77-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Shiri, Lotfi; Narimani, Hojatollah; Kazemi, Mosstafa published an article in 2018, the title of the article was Synthesis and characterization of sulfamic acid supported on Fe3O4 nanoparticles: A green, versatile and magnetically separable acidic catalyst for oxidation reactions and Knoevenagel condensation.Application In Synthesis of Benzyl(4-bromophenyl)sulfane And the article contains the following content:

Sulfamic acid immobilized on diethylenetriamine functionalized Fe3O4 nanoparticles (SA-DETA-Fe3O4) was successfully prepared and characterized by X-ray diffraction (XRD), Fourier transform IR spectroscopy (FT-IR), vibrating sample magnetometer (VSM), thermo gravimetric anal. (TGA), X-Ray diffraction (XRD) and SEM (SEM). The sulfamic acid was found as a magnetically separable and highly active catalyst for the oxidative coupling of thiols and oxidation of sulfides. Furthermore, the SA-DETA-Fe3O4 showed high catalytic activity in Knoevenagel condensation of aromatic aldehydes with active methylene compounds (malononitrile and Et cynoacetate). The nanosolid catalyst could be easily recovered by a simple magnetic separation and reused for many cycles without deterioration in catalytic activity. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Application In Synthesis of Benzyl(4-bromophenyl)sulfane

The Article related to oxidation thiol sulfide iron oxide sulfamic acid supported catalyst, knoevenagel condensation iron oxide sulfamic acid supported catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.Application In Synthesis of Benzyl(4-bromophenyl)sulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On September 16, 1993, James, Donald R.; Baker, Don R.; Mielich, Steven D.; Michaely, William J.; Fitzjohn, Steven; Knudsen, Christopher G.; Mathews, Christopher; Gerdes, John M. published a patent.Category: ethers-buliding-blocks The title of the patent was Preparation of arylindazoles and their use as herbicides. And the patent contained the following:

Title compounds I (R1 = H, halo; R2 = H, O2N, halo, alkyl, NC, alkylthio, alkylsulfinyl, alkylsulfonyl, alkoxy, AcNH, H2N; R3 = H, halo, haloalkyl, haloalkoxy, NC, H2N, R13OyS wherein R13 = alkyl, haloalkyl, y = 0-2; R4, R5, R6 = H, halo, O2N, HO, NC, alkyl, alkoximinoalkyl, hydroxyalkyl, haloalkyl, CHO, etc.; R7 = H, halo, alkyl, O2N; R8 = H, halo; X = N, R14C wherein R14 = H, halo, haloalkyl, NC, etc.) and salts thereof, are prepared 6-Imidazolol in DMF was reacted with K2CO3 followed by MeI to give 6-methoxyindazole which in DMF was treated with 3,5,4-Cl2FC6H2CF3 and K2CO3 to give I (R1 = R4 = R5 = R7 = R8 = H, R2 = Cl, R3 = F3C, R6 = MeO, X = ClC) (II) in preemergence application II at 4 kg/ha showed 100% herbicidal effect against green foxtail, watergrass, wild mustard, velvetleaf, etc. A large number of I were prepared and evaluated both pre- and postemergence. The experimental process involved the reaction of 4-Bromo-5-methoxy-2-methylaniline(cas: 152626-77-2).Category: ethers-buliding-blocks

The Article related to indazole aryl preparation herbicide, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Liang, Shengzong; Hammond, Luisa; Xu, Bo; Hammond, Gerald B. published an article in 2016, the title of the article was Commercial Supported Gold Nanoparticles Catalyzed Alkyne Hydroamination and Indole Synthesis.Formula: C15H13NO And the article contains the following content:

Com. gold nanoparticles supported on titanium dioxide (TiO2) were found to be a highly efficient catalyst for alkyne hydroamination. Terminal alkynes could easily undergo intermol. hydroamination with low catalyst loadings (0.2 mol% Au) under solvent-free conditions. Indoles were efficiently synthesized using microwave heating through intramol. hydroamination. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Formula: C15H13NO

The Article related to hydroamination alkyne alkynylaniline gold nanoparticle titanium dioxide catalyst, indole preparation intramol hydroamination microwave assisted, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Formula: C15H13NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 30, 2020, He, Jiaming; Yu, Yue; Guo, Pengfeng; Liu, Xiang; Zhu, Baofu; Cao, Hua published an article.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline The title of the article was Palladium-Catalyzed C-N Bond Formation: A Straightforward Alkoxymethylation Process for the Synthesis of the C1 and C3-Dialkoxy Indoles. And the article contained the following:

A novel approach for the synthesis of the C1 and C3-dialkoxy indoles was developed for using 2-(phenylethynyl)aniline with formaldehyde and alcs. under the catalysis of acid and palladium acetate. This multicomponent reaction that provided a straightforward alkoxymethylation process constructed substituted indoles was expected to be an important method for the synthesis of indole derivatives The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to phenylethynyl aniline formaldehyde alc palladium carbon nitrogen bond formation, alkoxymethyl phenylindolyl methanol preparation regioselective, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Heng; Zhu, Yan; Jiang, Cong; Wei, Jia; Liu, Ping; Sun, Peipei published an article in 2022, the title of the article was HOAc catalyzed three-component reaction for the synthesis of 3,3′-(arylmethylene)bis(1H-indoles).SDS of cas: 157869-15-3 And the article contains the following content:

An efficient HOAc catalyzed three-component cyclization and cascade condensation of o-alkynyl anilines with aromatic aldehydes of 2-(arylethynyl)anilines with arylaldehydes was achieved, which leads to the generation of 3,3′-(arylmethylene)bis(1H-indoles) I [R1 = Ph, 4-MeC6H4, 4-FC6H4, etc.; R2 = 5-Me, 5-Cl, 6-Me, etc.; R3 = Ph, 4-MeC6H4, 4-BrC6H4, etc.] with good to excellent yields and high regioselectivity under transition-metal-free conditions. Four new C-C and C-N bonds were effectively formed in a one-pot procedure. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).SDS of cas: 157869-15-3

The Article related to arylmethylene bis indole green regioselective preparation, ortho alkynyl aniline benzaldehyde three component cyclization cascade condensation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.SDS of cas: 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem