Tag: 200-300

Schwertz, Geoffrey; Frei, Michelle S.; Witschel, Matthias C.; Rottmann, Matthias; Leartsakulpanich, Ubolsree; Chitnumsub, Penchit; Jaruwat, Aritsara; Ittarat, Wanwipa; Schaefer, Anja; Aponte, Raphael A.; Trapp, Nils; Mark, Kerstin; Chaiyen, Pimchai; Diederich, Francois published an article in 2017, the title of the article was Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs.Computed Properties of 53136-21-3 And the article contains the following content:

Malaria remains a major threat to mankind due to the perpetual emergence of resistance against marketed drugs. Twenty-one pyrazolopyran-based inhibitors bearing terminal biphenyl, aryl sulfonamide, or aryl sulfone motifs were synthesized and tested towards serine hydroxymethyltransferase (SHMT), a key enzyme of the folate cycle. The best ligands inhibited Plasmodium falciparum (Pf) and Arabidopsis thaliana (At) SHMT in target, as well as PfNF54 strains in cell-based assays in the low nanomolar range (18-56 nM). Seven cocrystal structures with P. vivax (Pv) SHMT were solved at 2.2-2.6 脜 resolution The authors observed an unprecedented influence of the torsion angle of ortho-substituted biphenyl moieties on cell-based efficacy. The peculiar lipophilic character of the sulfonyl moiety was highlighted in the complexes with aryl sulfonamide analogs, which bind in their preferred staggered orientation. The results are discussed within the context of conformational preferences in the ligands. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Computed Properties of 53136-21-3

The Article related to conformation sulfonamide serine hydroxymethyltransferase inhibitor, crystal structure, co-crystal structures, conformation analysis, drug design, plasmodium, serine hydroxymethyltransferase and other aspects.Computed Properties of 53136-21-3

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Li, Beibei; Ju, Zhanfeng; Zhou, Mi; Su, Kongzhao; Yuan, Daqiang published an article in 2019, the title of the article was A Reusable MOF-Supported Single-Site Zinc(II) Catalyst for Efficient Intramolecular Hydroamination of o-Alkynylanilines.Electric Literature of 157869-15-3 And the article contains the following content:

The exploitation of new and active earth-abundant metal catalysts is critical for sustainable chem. production Herein, we demonstrate the design of highly efficient, robust, and reusable ZnII-bipyridine-based metal-organic framework (MOF) catalysts for the intramol. hydroamination of o-alkynylanilines to indoles. Under similar conditions homogeneous catalytic systems mainly provide hydrolyzate. Our results prove that MOFs support unique internal environments that can affect the direction of chem. reactions. The ZnII-catalyzed hydroamination reaction can be conducted without addnl. ligands, base, or acid, and is thus a very clean reaction system with regard to its environmental impact. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Electric Literature of 157869-15-3

The Article related to alkynylaniline intramol hydroamination metal organic framework supported zinc catalyst, indole preparation, heterogeneous catalysis, hydroamination, indoles, metal-organic frameworks, zinc and other aspects.Electric Literature of 157869-15-3

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On March 12, 2012, Zang, Qin; Javed, Salim; Porubsky, Patrick; Ullah, Farman; Neuenswander, Benjamin; Lushington, Gerald H.; Basha, Fatima Z.; Organ, Michael G.; Hanson, Paul R. published an article.Quality Control of (2-Bromo-5-methoxyphenyl)methanamine The title of the article was Synthesis of a unique isoindoline/tetrahydroisoquinoline-based tricyclic sultam library utilizing a Heck-aza-Michael strategy. And the article contained the following:

The synthesis of a unique isoindoline- and tetrahydroisoquinoline (THIQ)-containing tricyclic sultam library, utilizing a Heck-aza-Michael strategy is reported. Both isoindoline and THIQ rings are installed through a Heck reaction on a vinylsulfonamide, followed by one-pot deprotection and intramol. aza-Michael reaction. Subsequent cyclization with either paraformaldehyde condensation or 1,1′-carbonyldiimidazole coupling generates a variety of tricyclic sultams, e.g., I. Overall, a 160-member library of these sultams, together with their isoindolines/THIQ and secondary sulfonamides precursors, were constructed using this strategy. The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Quality Control of (2-Bromo-5-methoxyphenyl)methanamine

The Article related to bromoarylalkylamine vinylsulfonamide hexk reaction, aminoalkylarylvinylsulfonamide preparation aza michael reaction, isoindolylmethylsulfonamide preparation cyclization, tricyclic sultam preparation and other aspects.Quality Control of (2-Bromo-5-methoxyphenyl)methanamine

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Ether – Wikipedia,
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On February 25, 2021, de Souza, Wanderson C.; Matsuo, Bianca T.; Matos, Priscilla M.; Correia, Jose Tiago M.; Santos, Marilia S.; Koenig, Burkhard; Paixao, Marcio W. published an article.Product Details of 157869-15-3 The title of the article was Photocatalyzed Intramolecular [2+2] Cycloaddition of N-Alkyl-N-(2-(1-arylvinyl)aryl)cinnamamides. And the article contained the following:

N-Alkyl-N-(2-(1-arylvinyl)aryl)cinnamamides were converted into natural product inspired scaffolds via iridium photocatalyzed intramol. [2+2] photocycloaddition The protocol had a broad substrate scope, while operating under mild reaction conditions. Tethering four components forming a trisubstituted cyclobutane core builds rapidly high mol. complexity. This approach allowed the design and synthesis of a variety of tetrahydrocyclobuta[c]quinolin-3(1H)-ones, in yields ranging between 20-99%, and with excellent regio- and diastereoselectivity. Moreover, it was demonstrated that the intramol. [2+2]-cycloaddition of 1,7-enynes-after fragmentation of the cyclobutane ring-leads to enyne-metathesis-like products. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Product Details of 157869-15-3

The Article related to alkyl arylvinyl arylcinnamamide preparation iridium diastereoselective regioselective photochem cycloaddition, diaryl alkyltetrahydrocyclobutaquinolinone preparation, catalysis, cycloaddition, dienes, energy transfer, photocatalysis and other aspects.Product Details of 157869-15-3

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Ether – Wikipedia,
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Sharghi, Hashem; Ghaderi, Iman; Doroodmand, Mohammad Mahdi published an article in 2017, the title of the article was Eco-compatible three component strategies for C-S bond formation in thioether and S-aryl-carbamodithioate compounds catalyzed by copper(II) nanoparticles supported on modified AlPO4.Safety of Benzyl(4-bromophenyl)sulfane And the article contains the following content:

One-pot and three components C-S bond formation reactions in thioethers ArCH(X)SAr1 (Ar = C6H5, 4-BrC6H4, 4-H2C=CHC6H4; X = H, CH3; Ar1 = C6H5, 4-CH3C6H4, 4-ClC6H4, etc.) and S-aryl-carbamodithioates YC(S)SAr1 (Y = morpholinyl, piperidinyl, (diethylamino), etc.) have been catalyzed by a copper heterogeneous nano-catalyst supported on modified AlPO4 under different reaction conditions. The above-mentioned nano-catalyst has been characterized by various techniques such as SEM, TEM, AFM, XRD, FT-IR, UV-Vis, CV, BET, TGA, ICP and XPS spectrometry and its particle size was estimated to be between 60-110 nm. Finally, the reusability of the catalyst up to ten cycles without any significant leaching is one of the outstanding properties of the catalyst. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Safety of Benzyl(4-bromophenyl)sulfane

The Article related to thioether preparation green chem, thiourea arylhalide benzyl halide three component copper nanocatalyst, dithiocarbamate aryl preparation green chem, secondary amine carbon disulfide aryliodide three component copper nanocatalyst and other aspects.Safety of Benzyl(4-bromophenyl)sulfane

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Ether – Wikipedia,
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On June 12, 2017, Zhu, Lei; Qi, Xiaotian; Li, Yingzi; Duan, Meng; Zou, Lufeng; Bai, Ruopeng; Lan, Yu published an article.Product Details of 1417036-28-2 The title of the article was Ir(III)/Ir(V) or Ir(I)/Ir(III) Catalytic Cycle? Steric-Effect-Controlled Mechanism for the para-C-H Borylation of Arenes. And the article contained the following:

A potential energy surface for iridium-catalyzed C-H-borylation of aromatic compounds was calculated; while bulky phosphine ligands favor Ir(I)-Ir(III) C-H activation, small amine ligands promote formation of triboryl Ir(V) intermediates. D. functional theory method N12 was used to study the mechanism of the [Ir(cod)OH]2/Xyl-MeO-BIPHEP-catalyzed para-selective C-H borylation reaction. The results revealed that the use of a bulky diphosphine ligand such as Xyl-MeO-BIPHEP was unfavorable for the previously proposed iridium(III)/iridium(V) catalytic cycle because it resulted in considerable steric repulsion in the hepta-coordinated iridium(V) intermediate. Inspired by this steric effect, we have proposed a novel iridium(I)/iridium(III)-based catalytic cycle for this transformation and shown that it can be used to account for the exptl. results. The iridium(I)/iridium(III) catalytic cycle induced by this steric effect consists of several steps, including: (i) the oxidative addition of the C-H bond of the substrate to an active iridium(I) boryl complex; (ii) the reductive elimination of a C-B bond; (iii) the oxidative addition of B2pin2 to an iridium(I) hydride complex; and (iv) the reductive elimination of a B-H bond. Notably, the computed regioselectivity of this reaction was consistent with the exptl. observations. The high para-selectivity of this reaction was also explained using structural anal. and a 2D contour model, which revealed that the strong steric repulsion between the diphosphine ligand and the meta-substituents resulted in a higher energy barrier for meta-C-H activation. The experimental process involved the reaction of 2-(3-Methoxy-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1417036-28-2).Product Details of 1417036-28-2

The Article related to potential energy surface direct ch borylation arene iridium catalyst, diphosphine diamine iridium complex catalyst arene borylation intermediate geometry, steric effect ligand mechanism direct borylation arene iridium catalyst and other aspects.Product Details of 1417036-28-2

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On April 4, 2000, Neef, C. J.; Ferraris, J. P. published an article.Related Products of 146370-51-6 The title of the article was MEH-PPV: Improved Synthetic Procedure and Molecular Weight Control. And the article contained the following:

Mechanistic studies on the polymerization of α,α’-dibromo-2-methoxy-5-(2-ethylhexyloxy)xylene have been performed. Polymerizations were initially carried out by adding potassium tert-butoxide to monomer in the presence of a chain transfer agent, anthracene. Anthracene showed little effect on the mol. weight of the resulting polymer, suggesting that the major polymerization route was not radically initiated. Polymerizations were also carried out by adding monomer to potassium tert-butoxide in presence of a nucleophile, 4-methoxyphenol. The mol. weight of the resulting polymer scaled linearly with the amount of 4-methoxyphenol, suggesting an anionic mechanism. In addition, each polymerization was monitored by in-situ torque measurements to further elucidate the polymerization mechanism and optimize polymerization conditions. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).Related Products of 146370-51-6

The Article related to polyphenylenevinylene methoxy ethylhexyloxy conjugated polymer preparation, chain transfer agent anthracene polyphenylenevinylene preparation, nucleophile methoxyphenol polyphenylenevinylene anionic polymerization preparation and other aspects.Related Products of 146370-51-6

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On October 18, 2002, Capozzi, Maria Annunziata M.; Cardellicchio, Cosimo; Naso, Francesco; Rosito, Valerio published an article.Safety of Benzyl(4-bromophenyl)sulfane The title of the article was A Straightforward Enantioselective Route to Dialkyl Sulfoxides Based upon Two Carbon-for-Carbon Substitution Reactions on the Sulfinyl Group. And the article contained the following:

(R)-Benzyl p-bromophenyl sulfoxide (I) was obtained on a multigram scale and in an enantiomerically pure form by enantioselective catalytic oxidation of benzyl p-bromophenyl sulfide with tert-Bu hydroperoxide in the presence of chiral titanium complexes. Some mechanistic and stereochem. features of the process were also studied. I was then subjected to two consecutive substitution reactions with different Grignard reagents, which caused two sequentially stereocontrolled carbon-for-carbon displacements, leading to chiral nonracemic dialkyl sulfoxides. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Safety of Benzyl(4-bromophenyl)sulfane

The Article related to sulfoxide dialkyl chiral enantioselective preparation, sulfide benzyl bromophenyl chiral titanium complex catalyzed enantioselective oxidation, benzylsulfoxide bromophenyl preparation stereoselective grignard substitution and other aspects.Safety of Benzyl(4-bromophenyl)sulfane

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 25, 2021, de Souza, Wanderson C.; Matsuo, Bianca T.; Matos, Priscilla M.; Correia, Jose Tiago M.; Santos, Marilia S.; Koenig, Burkhard; Paixao, Marcio W. published an article.Product Details of 157869-15-3 The title of the article was Photocatalyzed Intramolecular [2+2] Cycloaddition of N-Alkyl-N-(2-(1-arylvinyl)aryl)cinnamamides. And the article contained the following:

N-Alkyl-N-(2-(1-arylvinyl)aryl)cinnamamides were converted into natural product inspired scaffolds via iridium photocatalyzed intramol. [2+2] photocycloaddition The protocol had a broad substrate scope, while operating under mild reaction conditions. Tethering four components forming a trisubstituted cyclobutane core builds rapidly high mol. complexity. This approach allowed the design and synthesis of a variety of tetrahydrocyclobuta[c]quinolin-3(1H)-ones, in yields ranging between 20-99%, and with excellent regio- and diastereoselectivity. Moreover, it was demonstrated that the intramol. [2+2]-cycloaddition of 1,7-enynes-after fragmentation of the cyclobutane ring-leads to enyne-metathesis-like products. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Product Details of 157869-15-3

The Article related to alkyl arylvinyl arylcinnamamide preparation iridium diastereoselective regioselective photochem cycloaddition, diaryl alkyltetrahydrocyclobutaquinolinone preparation, catalysis, cycloaddition, dienes, energy transfer, photocatalysis and other aspects.Product Details of 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sharghi, Hashem; Ghaderi, Iman; Doroodmand, Mohammad Mahdi published an article in 2017, the title of the article was Eco-compatible three component strategies for C-S bond formation in thioether and S-aryl-carbamodithioate compounds catalyzed by copper(II) nanoparticles supported on modified AlPO4.Safety of Benzyl(4-bromophenyl)sulfane And the article contains the following content:

One-pot and three components C-S bond formation reactions in thioethers ArCH(X)SAr1 (Ar = C6H5, 4-BrC6H4, 4-H2C=CHC6H4; X = H, CH3; Ar1 = C6H5, 4-CH3C6H4, 4-ClC6H4, etc.) and S-aryl-carbamodithioates YC(S)SAr1 (Y = morpholinyl, piperidinyl, (diethylamino), etc.) have been catalyzed by a copper heterogeneous nano-catalyst supported on modified AlPO4 under different reaction conditions. The above-mentioned nano-catalyst has been characterized by various techniques such as SEM, TEM, AFM, XRD, FT-IR, UV-Vis, CV, BET, TGA, ICP and XPS spectrometry and its particle size was estimated to be between 60-110 nm. Finally, the reusability of the catalyst up to ten cycles without any significant leaching is one of the outstanding properties of the catalyst. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Safety of Benzyl(4-bromophenyl)sulfane

The Article related to thioether preparation green chem, thiourea arylhalide benzyl halide three component copper nanocatalyst, dithiocarbamate aryl preparation green chem, secondary amine carbon disulfide aryliodide three component copper nanocatalyst and other aspects.Safety of Benzyl(4-bromophenyl)sulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem