Tag: 200-300

On January 1, 2021, Hao, Guiyun; Li, Hao; Yang, Fei; Dong, Duoling; Li, Zezhong; Ding, Yingying; Pan, Wei; Wang, Enduo; Liu, Rujuan; Zhou, Huchen published an article.Computed Properties of 53136-21-3 The title of the article was Discovery of benzhydrol-oxaborole derivatives as Streptococcus pneumoniae leucyl-tRNA synthetase inhibitors. And the article contained the following:

1-Hydroxy-2,1-benzoxaboroles I were prepared and examined for inhibitory activity against leucyl-tRNA synthetase (LeuRS) and antibacterial activity against multidrug-resistant S. pneumoniae pathogen. Pneumonia caused by bacterium S. pneumoniae is a severe acute respiratory infectious disease with high morbidity and mortality, especially for children and immunity-compromised patients. The emergence of multidrug-resistant S. pneumoniae also presents a challenge to human health. Leucyl-tRNA synthetase (LeuRS) catalyzes the attachment of L-leucine to tRNALeu, which plays an essential role in protein translation and is considered an attractive antimicrobial drug target. In the present work, benzhydrol-oxaborole hybrid compounds were designed and synthesized as inhibitors of S. pneumoniae LeuRS. Exploration of the Ph ring near Lysine 389 eventually yielded compounds 46 and 54 with submicromolar inhibitory potency. The co-crystal of compound 54 in the editing domain pocket of SpLeuRS was obtained and confirmed the formation of an addnl. hydrogen bond between the carbonyl of 54 and Lysine 389. It also showed anti-pneumococcal activity in vitro. The structure-activity relationship was discussed. This work will provide an essential foundation for the further development of anti-pneumococcal agents by targeting LeuRS. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Computed Properties of 53136-21-3

The Article related to benzoxaborole boronate preparation leucyl trna synthetase inhibitor antibacterial agent, streptococcus pneumoniae leucyl trna synthetase inhibitor antibacterial agent preparation, anti-pneumonia, benzhydrol-oxaborole, s. pneumonia leurs (spleurs), structure-activity relationship and other aspects.Computed Properties of 53136-21-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ajarul, Sk; Kayet, Anirban; Pati, Tanmay K.; Maiti, Dilip K. published an article in 2020, the title of the article was A competitive and highly selective 7-, 6- and 5-annulation with 1,3-migration through C-H and N-H – alkyne coupling.COA of Formula: C15H13NO And the article contains the following content:

A highly competitive and selective C-C and N-C cross-coupled 7-, 6- and 5-annulation was described utilizing 2-ethynylanilides to afford functionalized 1H-benzo[b]azepin-2(5H)-ones I [R1 = Me, Et, Ph, 4-O2NC6H4; R2 = Ph, 4-MeC6H4, 4-FC6H4, etc.; R3 = H, 7-Me, 7-Cl, 8-Cl], 2-quinolinones II [R4 = Me, Et, Ph, etc.; R5 = H, Ph, 4-O2NC6H4, etc.; R6 = H, 6-Me, 7-Cl, etc.] and 3-acylindoles III [R7 = Me, Et, Ph, 4-MeC6H4; R8 = Ph, 4-MeOC6H4, 4-BrC6H4; R9 = H, Me, Cl, Br] resp., with high yields and operational simplicity. Zinc chloride was found to be the smart catalyst for 7- and 5-annulation with 1,3-migration through C-H and N-H functionalization, resp., whereas mol. iodine performed the C-H functionalized 6-annulation with a non-conventional 1,3 H-shift. The mechanism was investigated by intermediate trapping, control and labeling experiments The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).COA of Formula: C15H13NO

The Article related to benzoazepinone selective preparation, alkynyl aniline dicarbonyl compound annulation zinc catalyst, quinolinone selective preparation, aniline dicarbonyl compound alkynyl annulation iodine catalyst, acylindole selective preparation, acyl alkynyl aniline annulation zinc catalyst and other aspects.COA of Formula: C15H13NO

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Ether – Wikipedia,
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On September 1, 2000, Park, Lee Soon; Han, Yoon Soo; Hwang, Jin Sang; Kim, Sang Dae published an article.Application of 146370-51-6 The title of the article was Synthesis of conjugated polymers containing anthracene moiety and their electro-optical properties. And the article contained the following:

Both fully conjugated polymer poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylene vinylene-alt-9,10-anthrylene vinylene] [poly(MEHPV-AV)] and conjugated/non-conjugated block copolymers poly(alkanedioxy-2-methoxy-1,4-phenylene-1,2-ethenylene-9,10-anthrylene-1,2-ethenylene-3-methoxy-1,4-phenylene)[poly(BFMPx-AV), (x = 4, 8, and 12)] were synthesized by Horner-Emmons reaction utilizing potassium tert-butoxide. Of these synthesized polymers poly(BFMP4-AV) and poly(BFMP8-AV), which has four and six methylene groups as solubility spacer in the main chain exhibited liquid crystalline to isotropic transition in addition to the two first order transitions. Light-emitting diode (LED)s made from the organic solvent soluble poly(BFMP12-AV) as emitting layer showed blue shift in the emission spectrum compared to the one made from fully conjugated poly(MEHPV-AV). Although poly(BFMP12-AV) had higher barrier to the electron injection from cathode than poly(MEHPV-AV), the luminance efficiency of LED made from poly(BFMP12-AV) was about 25 times higher than the one made from poly(MEHPV-AV), which had fully conjugated structure. LEDs fabricated by both poly(BFMP12-AV) and poly(MEHPV-AV) exhibited Stoke’s shift in the range of 155 to 168 nm from the absorption maximum due to the excimer formation between the ground and excited state anthracene groups. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).Application of 146370-51-6

The Article related to anthracene containing aromatic dialdehyde diphosphonate polymerization potassium tertbutoxide catalyst, liquid crystalline anthracene containing polyphenylenevinylene synthesis, electroluminescence light emitting diode anthracene containing partially conjugated polymer and other aspects.Application of 146370-51-6

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On November 21, 2001, Peng, Kang-Yung; Chen, Show-An; Fann, Wun-Shain published an article.Recommanded Product: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene The title of the article was Efficient Light Harvesting by Sequential Energy Transfer across Aggregates in Polymers of Finite Conjugational Segments with Short Aliphatic Linkages. And the article contained the following:

A series of light-harvesting polymers (poly-DSBs) of dialkyloxy- or dialkyl-substituted distyrylbenzene ( substituents = methoxy, 2-ethylhexyloxy, and cyclohexyl) with methylene or ethylene spacers were prepared The interactions between lumophores and the role of chem. structure of poly-DSBs on the absorption, emission, and excitation spectra were studied. The proximity of distyrylbenzene lumophores was critical to effective interactions and to the energy-transfer processes. In concentrated solutions and solid films, intermol. aggregates exist resulting from different extents of interactions between lumophores and involve at least three species: loose, compact, and aligned aggregates as observed by photoluminescence and excitation spectroscopy. Sequential energy transfer was directly observed from individual lumophores to the most compact, aligned aggregates via looser intermol. aggregates by time-resolved fluorescence spectroscopy. This process mimics energy transfer in photosynthesis and is highly efficient; fluorescence can be red-shifted drastically by the presence of comparatively few aggregates and light from concentrated solutions and films of poly-DSBs is entirely or almost due to aggregation emission. Although sequential energy-transfer in fully conjugated electro/photoluminescent polymers due to inhomogeneity other than distributed conjugation length has never been directly observed at room temperature, events similar to those observed in poly-DSBs could occur but on a much shorter time scale, i.e., a few picoseconds. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).Recommanded Product: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene

The Article related to alkyl substituted styrylbenzene light harvesting polymer preparation, aggregation conjugated polymer alkyl substituted styrylbenzene lumophore, energy transfer aggregate alkyl substituted styrylbenzene polymer, conjugated polymer alkyl alkoxy substituted styrylbenzene and other aspects.Recommanded Product: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gao, Fei; Wang, Jiu-Tao; Liu, Lin-Lin; Ma, Na; Yang, Chao; Gao, Yuan; Xia, Wujiong published an article in 2017, the title of the article was Synthesis of carbonylated heteroaromatic compounds via visible-light-driven intramolecular decarboxylative cyclization of o-alkynylated carboxylic acids.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

An efficient strategy for the easy access to carbonylated heteroaromatic compounds was developed via a visible-light-promoted intramol. decarboxylative cyclization reaction of o-alkynylated carboxylic acids. This method was characterized by its benign conditions and the tolerance to a wide range of functionalities. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to propynylphenylamino acetic acid preparation photochem decarboxylative cyclization carbonylation, acylindole preparation, propynylphenyloxy acetic acid preparation photochem decarboxylative cyclization carbonylation, acylbenzofuran preparation, propynylphenylthio acetic acid preparation photochem decarboxylative cyclization carbonylation and other aspects.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

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Ether – Wikipedia,
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On July 3, 2008, Adams, Ruth S.; Duffey, Matthew; Gould, Alexandra E.; Greenspan, Paul D.; Kulkarni, Bheemashankar A.; Vos, Tricia J. published a patent.Related Products of 887581-09-1 The title of the patent was Preparation of pyrazoline derivatives with Raf kinase inhibitory activity. And the patent contained the following:

The present invention provides certain pyrazoline compounds (shown as I; variables defined below; e.g. 2-[3-(pyridin-3-yl)-1-[[5-(pyridin-2-yl)-2-thienyl]carbonyl]-4,5-dihydro-1H-pyrazol-5-yl]phenol) useful as inhibitors of Raf kinases. The invention also provides pharmaceutical compositions and methods of using the compositions in the treatment of cancer. Semiquant. IC50 values for B-Raf kinase are reported for many examples of I. For I: R1 is a (un)substituted 5- or 6-membered N-containing heteroaryl ring, which ring optionally is fused to an aryl, heteroaryl, heterocyclyl, or cycloaliphatic ring, each of which is (un)substituted. R2 is a (un)substituted 5- or 6-membered aryl or heteroaryl ring, which ring optionally is fused to an aryl, heteroaryl, heterocyclyl, or cycloaliphatic ring, each of which is (un)substituted. R3 = H, fluoro, C1-4 aliphatic, and C1-4 fluoroaliph.; R4 is H, fluoro, or a C1-4 aliphatic or C1-4 fluoroaliph. (un)substituted, or R3 and R4, taken together with the C to which they are bound, form an (un)substituted 3- to 6-membered cycloaliphatic or 4- to 7-membered heterocyclic ring. L1 = -C(O)NRa(CRbRc)m-, -C(O)C(Rb):C(Rb)(CRbRc)m-, -C(O)(CRbRc)m-, and -SO2(CRbRc)m-, wherein the C(O) or SO2 functionality, resp., is bound to the N of the pyrazoline ring; Cy1 is a bivalent radical derived from a ring system = (un)substituted 5- or 6-membered aromatic rings having 0-4 ring N atoms and optionally 1-2 addnl. ring heteroatoms = O and S, which 5- or 6-membered aromatic ring optionally is fused to an aryl, heteroaryl, heterocyclyl, or cycloaliphatic ring, each of which is (un)substituted; et al. L2 is -(CRbRc)- or -(CRbRc)nX(CRbRc)n-; X = -O-, -C(O)-, -S-, -SO-, -SO2-, -NRa-, -C(Rf):C(Rf)-, -CC-, -NRaC(O)-, – C(O)NRa-, -SO2NRa, -NRaSO2-, and -NRaC(O)NRa-; Cy2 is a radical derived from a ring system = (un)substituted 5- or 6-membered aromatic rings having 0-4 ring N atoms and optionally 1-2 addnl. ring heteroatoms = O and S, which 5- or 6-membered aromatic ring optionally is fused to an aryl, heteroaryl, heterocyclyl, or cycloaliphatic ring, each of which is (un)substituted; et al; provided that R1 is not 6-bromo-1,2-dihydro-2-oxo-4-phenyl-3-quinolinyl; addnl. details are given in the claims. Although the methods of preparation are not claimed, preparations and/or characterization data for >400 examples of I are included. For example, 2-[3-(pyridin-3-yl)-1-[[5-(pyridin-2-yl)-2-thienyl]carbonyl]-4,5-dihydro-1H-pyrazol-5-yl]phenol was prepared in 3 steps (73, 94, and 72 % yields, resp.) starting from salicylaldehyde and 1-(pyridin-3-yl)ethanone and involving the following intermediates: (2E)-3-(2-hydroxyphenyl)-1-(pyridin-3-yl)prop-2-en-1-one and 2-[5-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-3-yl]phenol. The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Related Products of 887581-09-1

The Article related to pyrazoline derivative preparation raf kinase inhibitor potential cancer drug, phenol pyrazolinyl preparation raf kinase inhibitor potential cancer drug, semicarbazone heterocyclic preparation raf kinase inhibitor potential cancer drug, alkylidenehydrazide heterocyclic preparation raf kinase inhibitor potential cancer drug and other aspects.Related Products of 887581-09-1

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On May 24, 2021, Ftouh, Soumia; Bourgeade-Delmas, Sandra; Belkadi, Mohamed; Deraeve, Celine; Hemmert, Catherine; Valentin, Alexis; Gornitzka, Heinz published an article.COA of Formula: C13H11BrS The title of the article was Synthesis, Characterization, and Antileishmanial Activity of Neutral Gold(I) Complexes with N-heterocyclic Carbene Ligands Bearing Sulfur-Containing Side Arms. And the article contained the following:

With an estimated annual incidence of one million cases, leishmaniasis is one of the top five vector-borne diseases. Currently available medical treatments involve side effects, including toxicity, nonspecific targeting, and resistance development. Thus, new antileishmanial chem. entities are of the utmost importance to fight against this disease. The authors showed in previous studies that Au(I) complexes bearing N-heterocyclic carbene (NHC) ligands with N- or S-containing side arms have interesting biol. activities in the field of cancer, malaria and leishmaniasis. The present study evaluates the in vitro antileishmanial effects on L. infantum axenic amastigotes and their cytotoxicity for the human THP1 cell line of a new family of six new imidazolium salts and their corresponding neutral (NHC)AuICl complexes. All new compounds were characterized by classical anal. methods, and five Au complexes were analyzed by x-ray structure determinations One proligand has moderate activity (IC50 = 8.24μM) while four of the six Au complexes have IC50 values in the low or sub μM range (0.15-1.3μM), including three with selectivity index (SI) values between 46 and 108. These results suggest remarkable leishmanicidal activity in vitro for three new neutral (NHC)Au(I)Cl complexes, making them candidates for further in vivo studies, which are under study. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).COA of Formula: C13H11BrS

The Article related to gold arylimidazolylidene complex sulfur side arm preparation antileishmanial activity, crystal structure gold arylimidazolylidene complex sulfur containing side arm, mol structure gold arylimidazolylidene complex sulfur containing side arm, arylimidazolylidene ligand preparation reaction gold chloride and other aspects.COA of Formula: C13H11BrS

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 17, 2017, Ali, Wajid; Dahiya, Anjali; Pandey, Ramdhari; Alam, Tipu; Patel, Bhisma K. published an article.Electric Literature of 157869-15-3 The title of the article was Microwave-Assisted Cascade Strategy for the Synthesis of Indolo[2,3-b]quinolines from 2-(Phenylethynyl)anilines and Aryl Isothiocyanates. And the article contained the following:

Indoloquinolines I (R = Ph, 4-MeC6H4, 4-MeOC6H4, 4-FC6H4, 1-naphthyl; R1 = H, Me, F, Br; R2 = H, Me, t-Bu, MeO, Cl, F) were prepared in 59-83% yields by the cyclocondensation of o-(arylalkynyl)anilines 2-(RCC)-4-R1C6H3NH2 (R = Ph, 4-MeC6H4, 4-MeOC6H4, 4-FC6H4, 1-naphthyl; R1 = H, Me, F, Br) with aryl isothiocyanates 4-R2C6H4NCS (R2 = H, Me, t-Bu, MeO, Cl, F) mediated by Ag2CO3 in DMSO under microwave irradiation at 130°. A phenylethynylphenyl Ph thiourea underwent cyclocondensation in the presence of Ag2CO3, while a phenylethynylphenyl Ph carbodiimide underwent cyclization in both the presence of absence of Ag2CO3; Ag2S was formed as a monoclinic acanthite phase from the reaction as characterized by powder X-ray diffraction and energy-dispersive X-ray diffraction. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Electric Literature of 157869-15-3

The Article related to indoloquinoline preparation, silver mediated cyclocondensation aryl isothiocyanate arylalkynylaniline microwave irradiation, cascade reaction aryl isothiocyanate arylalkynylaniline mediated silver carbonate, mechanism cascade reaction aryl isothiocyanate arylalkynylaniline mediated silver carbonate and other aspects.Electric Literature of 157869-15-3

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Ether – Wikipedia,
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On October 12, 2006, Connolly, Stephen; Linnanen, Tero; Skrinjar, Marco published a patent.Recommanded Product: 66855-92-3 The title of the patent was Preparation of novel diazaspiroalkanes and their use for treatment of CCR8 mediated diseases. And the patent contained the following:

The title compounds I [R = II, III (wherein R2, R3 = NR8C(O)CO2H, O(alkyl)CO2H, alkyl(CO2H), CO2H; R4, R5 = halo, CF3, alkyl; p, q = 0-2; R8 = H, alkyl); R1 = IV, V; R6, R7 = H, OMe, OEt], useful in treating CCR8 mediated diseases such as asthma, COPD and rhinitis, were prepared E.g., a multi-step synthesis of VI, starting from tert-Bu 3,9-diazaspiro[5.5]undecane-3-carboxylate hydrochloride and 2-phenoxybenzaldehyde, was given. VI showed IC50 of 0.643 μM against human recombinant chemokine CCR8 receptor binding. Pharmaceutical compositions containing compounds I and their use in therapy are disclosed. The experimental process involved the reaction of 3-(2-Methoxyphenoxy)benzaldehyde(cas: 66855-92-3).Recommanded Product: 66855-92-3

The Article related to diazaspiroalkane diazaspiroundecane preparation chemokine ccr8 mediated disease treatment, antiasthmatic diazaspiroalkane diazaspiroundecane preparation, chronic obstructive pulmonary disease diazaspiroalkane diazaspiroundecane preparation, rhinitis diazaspiroalkane diazaspiroundecane preparation and other aspects.Recommanded Product: 66855-92-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On October 12, 2006, Connolly, Stephen; Skrinjar, Marco published a patent.Quality Control of 3-(2-Methoxyphenoxy)benzaldehyde The title of the patent was Preparation of novel diazaspiroalkanes and their use for treatment of CCR8 mediated diseases. And the patent contained the following:

The title compounds I [R = (un)substituted pyridin-2-one or N-alkyl pyridin-2-one; R1 = II, III; R3, R4 = OMe, OEt], useful in treating CCR8 mediated diseases such as asthma, COPD and rhinitis, were prepared E.g., a multi-step synthesis of IV, starting from tert-Bu 3,9-diazaspiro[5.5]undecane-3-carboxylate hydrochloride and 2-(2-methoxyphenoxy)benzaldehyde, was given. IV showed IC50 of 0.044 μM against human recombinant chemokine CCR8 receptor binding. Pharmaceutical compositions containing compounds I and their use in therapy are disclosed. The experimental process involved the reaction of 3-(2-Methoxyphenoxy)benzaldehyde(cas: 66855-92-3).Quality Control of 3-(2-Methoxyphenoxy)benzaldehyde

The Article related to diazaspiroalkane diazaspiroundecane preparation chemokine ccr8 mediated disease treatment, antiasthmatic diazaspiroalkane diazaspiroundecane preparation, chronic obstructive pulmonary disease diazaspiroalkane diazaspiroundecane preparation, rhinitis diazaspiroalkane diazaspiroundecane preparation and other aspects.Quality Control of 3-(2-Methoxyphenoxy)benzaldehyde

Referemce:
Ether – Wikipedia,
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