Tag: 200-300

In 2019,ChemistrySelect included an article by Mahadik, Suraj S.; Chacko, Sajeev; Kamble, Rajesh M.. Application In Synthesis of Bis(4-methoxyphenyl)amine. The article was titled 《2,3-Di(thiophen-2-yl)quinoxaline Amine Derivatives: Yellow-Blue Fluorescent Materials for Applications in Organic Electronics》. The information in the text is summarized as follows:

In this work, we have designed and synthesized new donor-acceptor (D-A) type, 2,3-di(thiophen-2-yl)quinoxaline based amine derivatives (2-10). These compounds contain diaryl/heterocyclic amine segment and quinoxaline core as an electron donor and acceptor resp. The synthesized mols. were fully characterized by standard spectroscopic techniques. Absorption spectra of all compounds showed intramol. charge transfer (ICT) transition in the range of 390 to 461 nm. Dyes emit in yellow-blue region with emission maxima within 465 to 566 nm on excitation at their resp. ICT absorption maxima. Moreover, compound 2, 3 and 9 exhibit aggregation induced emission in THF:water system due to the formation of nanoaggregates. Electrochem. properties of 2-10 were studied by cyclic voltammetry. The HOMO and LUMO energy level were found in the range of -4.90 to -5.70 eV and -3.10 to -3.36 eV resp., with an electrochem. band gap (Eg) from 1.72 to 2.48 eV. Mols. showed good thermal stability. Theor. studies were also carried out by using DFT and TD-DFT calculation Based on photophys. and electrochem. properties these derivatives could be used as solid state emitter and ambipolar charge transport materials in optoelectronic devices. In addition to this study using Bis(4-methoxyphenyl)amine, there are many other studies that have used Bis(4-methoxyphenyl)amine(cas: 101-70-2Application In Synthesis of Bis(4-methoxyphenyl)amine) was used in this study.

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Application In Synthesis of Bis(4-methoxyphenyl)amine

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2018,Sameshima, Tomoya; Yamamoto, Takeshi; Sano, Osamu; Sogabe, Satoshi; Igaki, Shigeru; Sakamoto, Kotaro; Ida, Koh; Gotou, Mika; Imaeda, Yasuhiro; Sakamoto, Junichi; Miyahisa, Ikuo published 《Discovery of an Irreversible and Cell-Active BCL6 Inhibitor Selectively Targeting Cys53 Located at the Protein-Protein Interaction Interface》.Biochemistry published the findings.Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

B-cell lymphoma 6 (BCL6) is the most frequently involved oncogene in diffuse large B-cell lymphomas (DLBCLs). BCL6 shows potent transcriptional repressor activity through interactions with its corepressors, such as BCL6 corepressor (BCOR). The inhibition of the protein-protein interaction (PPI) between BCL6 and its corepressors suppresses the growth of BCL6-dependent DLBCLs, thus making BCL6 an attractive drug target for lymphoma treatments. However, potent small-mol. PPI inhibitor identification remains challenging because of the lack of deep cavities at PPI interfaces. This paper reports the discovery of a potent, cell-active, small-mol. BCL6 inhibitor, BCL6-i (8), that operates through irreversible inhibition. First, we synthesized an irreversible lead compound 4, which targets Cys53 in a cavity on the BCL6 BTB domain dimer by introducing an irreversible warhead to a high-throughput screening hit compound 1. Further chem. optimization of 4 based on kinact/KI evaluation produced BCL6-i with a kinact/KI value of 1.9 × 104 M-1s-1, corresponding to a 670-fold improvement in potency compared to 4. By exploiting the property of irreversible inhibition, engagement of BCL6-i to intracellular BCL6 was confirmed. BCL6-i showed intracellular PPI inhibitory activity between BCL6 and its corepressors, thus resulting in BCL6-dependent DLBCL cell-growth inhibition. BCL6-i is a cell-active chem. probe with the most potent BCL6 inhibitory activity reported to date. The discovery process of BCL6-i illustrates the utility of irreversible inhibition for identifying potent chem. probes for intractable target proteins. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C9H19NO4In 2017 ,《Assaying RNA Localization in Situ with Spatially Restricted Nucleobase Oxidation》 was published in ACS Chemical Biology. The article was written by Li, Ying; Aggarwal, Mahima B.; Nguyen, Kim; Ke, Ke; Spitale, Robert C.. The article contains the following contents:

The authors report herein a novel chem.-genetic method for assaying RNA localization within living cells. RNA localization is critical for normal physiol. as well as the onset of cancer and neurodegenerative disorders. Despite its importance, there is a real lack of chem. methods to directly assay RNA localization with high resolution in living cells. The authors’ novel approach relies on in situ nucleobase oxidation by singlet oxygen generated from spatially confined fluorophores. The authors’ novel method can identify RNA mols. localized within specific cellular compartments. The authors anticipate that this platform will provide the community with a much-needed methodol. for tracking RNA localization within living cells and set the stage for systematic large scale anal. of RNA localization in living systems. In the experiment, the researchers used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Synthetic Route of C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Synthetic Route of C9H19NO4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Poe, Todd N.; Molinari, Sarah; Beltran-Leiva, Maria J.; Celis-Barros, Cristian; Ramanantoanina, Harry; Albrecht-Schonzart, Thomas E. published their research in Inorganic Chemistry in 2021. The article was titled 《Influence of Outer-Sphere Anions on the Photoluminescence from Samarium(II) Crown Complexes》.HPLC of Formula: 33100-27-5 The article contains the following contents:

Three Sm(II) crown ether complexes, [Sm(15-crown-5)2]I2 (1), [Sm(15-crown-5)2]I2·MeCN (2), and [Sm(benzo-15-crown-5)2]I2 (3), were prepared via the reaction of SmI2 with the corresponding crown ether in either THF or MeCN in good to moderate yields. The compounds were characterized by single crystal x-ray diffraction and a variety of spectroscopic techniques. In all cases, the Sm(II) centers are sandwiched between two crown ether mols. and are bound by the five etheric O atoms from each crown ether to yield 10-coordinate environments. Despite the higher symmetry crystal class of 1 (R3c), the Sm center resides on a general position, whereas in 2 and 3 (both in P21/c) the metal centers lie upon inversion centers. Also, the complexes in 2 and 3 are approximated well by D5d symmetry. The mol. in 1, however, is distorted from idealized D5d symmetry, and the crown ethers are more puckered than observed in 2 and 3. All three complexes luminesce in the NIR at low temperatures However, the nature of the luminescence differs between the three compounds 1 Exhibits broadband photoluminescence at 20° but at low temperatures transitions to narrow peaks. 2 Only exhibits nonradiative decay at 20° and at low temperatures retains a mixture of broadband and fine transitions. Finally, 3 displays broadband luminescence regardless of temperature Spin-orbit (SO) CASSCF calculations reveal that the outer-sphere iodide anions influence whether broadband luminescence from 5d → 4f or fine 4f → 4f transitions occur through the alteration of symmetry around the metal centers and the nature of the excited states as a function of temperature In addition to this study using 1,4,7,10,13-Pentaoxacyclopentadecane, there are many other studies that have used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5HPLC of Formula: 33100-27-5) was used in this study.

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. HPLC of Formula: 33100-27-5

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Liquid-liquid extraction of Eu(lll) using synergic mixture of 1-phenyl-3-methyl-4-trifluoroacetyl-2-pyrazolin-5-one and crown ethers》 was written by Ghani, Lubna; Shahida, Shabnam; Ali, Akbar; Khan, Muhammad Haleem; Aziz, Bushra; Masood, M.; Badshah, Syed Lal; Khan, Mumtaz. Computed Properties of C10H20O5 And the article was included in SN Applied Sciences in 2020. The article conveys some information:

Synergic extraction of Eu(III) as representative of rare earth elements was conducted with 0.01 mol dm-3 of trifluoroacetyl-pyrazolin-5-one (HPMTFP) and then with synergic mixture of HPMTFP and crown ethers (benzo-15-crown-5, 18-crown-6, 15-crown-5) in dichloromethane (DCM) from aqueous solution having pH 1.0-3.5. Slope anal. method was used for determining the composition of the synergic adduct i.e. Eu(PMTFP)3 that came out to be Eu(PMTFP)3·2S, where S = neutral oxo-donor and -PMTFP = conjugate base of HPMTFP mol. Selective extraction of Eu(III) was found in the presence of various masking agents like citrate, oxalate, bromide, thiosulfate, chromate ions and of some cations. The accuracy of the developed procedure was checked by analyzing real lake sample (IAEA-SL-3) as a reference material. The results came from multiple reactions, including the reaction of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Computed Properties of C10H20O5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Computed Properties of C10H20O5

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Unexpected ortho-Heck Reaction under the Catellani Conditions》 was published in Organic Letters in 2020. These research results belong to Rago, Alexander J.; Dong, Guangbin. HPLC of Formula: 529-28-2 The article mentions the following:

An unexpected ortho-Heck reaction was discovered during the study of palladium/norbornene (Pd/NBE) catalysis. Under the Catellani reaction conditions in the presence of lithium salts and olefins, Heck coupling takes place at the ortho position instead of the commonly observed ipso position; meanwhile, a norbornyl group was introduced at the arene ipso position. Systematic deuterium labeling and crossover experiments suggest an unusual 1,4-palladium migration/intramol. hydrogen transfer pathway. The knowledge gained in this study could provide insights for the future development of Pd/NBE catalysis. In addition to this study using 1-Iodo-2-methoxybenzene, there are many other studies that have used 1-Iodo-2-methoxybenzene(cas: 529-28-2HPLC of Formula: 529-28-2) was used in this study.

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.HPLC of Formula: 529-28-2

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Tailoring of the self-assembled structures and optical waveguide behaviour of arylaminofluorenone derivatives》 were Manni, Francesca; Fabiano, Eduardo; Clarkson, Guy J.; Accorsi, Gianluca; Fieramosca, Antonio; Nobile, Concetta; Saracino, Michela; Zanelli, Alberto; Farran, Angeles; Sanvitto, Daniele; Gigli, Giuseppe; Capodilupo, Agostina-Lina. And the article was published in Dyes and Pigments in 2019. HPLC of Formula: 101-70-2 The author mentioned the following in the article:

In this work, the fluorenone mol. was sym. difunctionalized in the 3,6-positions with four different arylamine moieties. Using slow evaporation, the four fluorenone derivatives exhibit good ability to arrange into microstructures in the solid state. The electronic and steric effects of arylamine substituents influence both optical features and aggregation processes, as evidenced by photophys. and XRD characterization. SEM investigations have shown that the four FO1-4 derivatives arrange in four different microstructures. More specifically, the self-assembled 1D microribbon – shaped structure of FO1 exhibited an excellent optical loss coefficient (α) as low as 0.006 dBμm-1, suggesting a potential use of these materials in the field of optical waveguide. In the part of experimental materials, we found many familiar compounds, such as Bis(4-methoxyphenyl)amine(cas: 101-70-2HPLC of Formula: 101-70-2)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.HPLC of Formula: 101-70-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Chemical Science included an article by Szkop, Kevin M.; Geeson, Michael B.; Stephan, Douglas W.; Cummins, Christopher C.. Product Details of 33100-27-5. The article was titled 《Synthesis of acyl(chloro)phosphines enabled by phosphinidene transfer》. The information in the text is summarized as follows:

Acyl(chloro)phosphines RC(O)P(Cl)(t-Bu) have been prepared by formal insertion of tert-Bu phosphinidene (t-Bu-P) from t-BuPA (A = C14H10 or anthracene) into the C-Cl bond of acyl chlorides. We show that the under-explored acyl(chloro)phosphine functional group provides an efficient method to prepare bis(acyl)phosphines, which are important precursors to compounds used industrially as radical polymerization initiators. Exptl. and computational investigations into the mechanism of formation of acyl(chloro)phosphines by our synthetic method reveal a pathway in which chloride attacks a phosphonium intermediate and leads to the reductive loss of anthracene from the phosphorus center in a P(V) to P(III) process. The synthetic applicability of the acyl(chloro)phosphine functional group has been demonstrated by reduction to an acylphosphide anion, which can in turn be treated with an acyl chloride to furnish dissym. bis(acyl)phosphines. In addition to this study using 1,4,7,10,13-Pentaoxacyclopentadecane, there are many other studies that have used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Product Details of 33100-27-5) was used in this study.

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Product Details of 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Triptolide Directly Inhibits dCTP Pyrophosphatase》 was written by Corson, Timothy W.; Cavga, Hueseyin; Aberle, Nicholas; Crews, Craig M.. Computed Properties of C9H19NO4This research focused ontriptolide dCTP pyrophosphatase inhibitor biotinylated derivative preparation cytotoxicity. The article conveys some information:

Triptolide is a potent natural product, with documented antiproliferative, immunosuppressive, anti-inflammatory, antifertility, and antipolycystic kidney disease effects. Despite a wealth of knowledge about the biol. of this compound, direct intracellular target proteins have remained elusive. The authors synthesized a biotinylated photoaffinity derivative of triptolide, and used it to identify dCTP pyrophosphatase 1 (DCTPP1) as a triptolide-interacting protein. Free triptolide interacts directly with recombinant DCTPP1, and inhibits the enzymic activity of this protein. Triptolide is thus the first dCTP pyrophosphatase inhibitor identified, and DCTPP1 is a biophys. validated target of triptolide. In addition to this study using tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate, there are many other studies that have used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Computed Properties of C9H19NO4) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Computed Properties of C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Product Details of 139115-91-6In 2021 ,《Reversible covalent locking of a supramolecular hydrogel via UV-controlled anthracene dimerization》 was published in Polymer Chemistry. The article was written by Hou, Zhanyao; Nau, Werner M.; Hoogenboom, Richard. The article contains the following contents:

Supramol. hydrogels gained significant attention as shear-thinning, self-healing materials. However, the introduction of non-covalent crosslinks inherently decreases the strength and stability of the hydrogel. In this work, we developed a novel supramol. hydrogel that undergoes a reversible transformation to the corresponding covalently crosslinked hydrogel upon UV-irradiation The supramol. hydrogel was developed based on the ternary host-guest interaction of two anthracene moieties and one large macrocyclic host. Anthracene functionalized poly(N-acryloylmorpholine)s were synthesized by post-polymerization modification of a copolymer consisting of N-acryloylmorpholine and an activated ester comonomer, whereby two different polymers were prepared having either neutral anthracene side-chains or carrying a pos. charge next to the anthracene to enhance the interaction with the host. The binding affinity of the anthracene side chains with and without an addnl. cationic charge were studied with two macrocyclic hosts, namely cucurbit[8]uril and γ-cyclodextrin (γ-CD) by UV-Vis titration revealing a markedly stronger binding in the presence of the cationic charge due to addnl. ion-dipole one of the macrocyclic hosts, cucurbit[8]uril. Subsequently, the effect of the binding affinity on the hydrogelation was investigated, indicating that the stronger binding affinity facilitated the hydrogel formation at lower concentration Finally, the reversible transformation of the supramol. hydrogel to a chem. hydrogel by anthracene dimerization was studied by the UV irradiation of the hydrogel at 365 nm for covalent crosslinking or at 254 nm for decrosslinking. It could be demonstrated that the dynamic nature of the hydrogel, that is responsible for the shear-thinning behavior, was indeed lost upon UV-irradiation indicative of the formation of a covalently crosslinked hydrogel. The capabilities of the formed supramol. hydrogel that is easily processable and able to reversibly convert to a chem. hydrogel, provides potential applications in applying mech. robust covalently crosslinked hydrogels in complex shapes and difficult to reach locations making use of the dynamic nature of the supramol. crosslinks. In the experiment, the researchers used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Product Details of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Product Details of 139115-91-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem