Tag: 200-300

In 2019,Inorganic Chemistry included an article by Zhang, Congcong; Hou, Guohua; Zi, Guofu; Ding, Wanjian; Walter, Marc D.. Quality Control of 1,2-Diphenyldisulfane. The article was titled 《An Alkali-Metal Halide-Bridged Actinide Phosphinidiide Complex》. The information in the text is summarized as follows:

The salt metathesis reaction of the thorium Me chloride complex [η5-1,3-(Me3C)2C5H3]2Th(Cl)Me (3) with 2,4,6-(Me3C)3C6H2PHK in benzene furnishes an alkali-metal halide-bridged phosphinidiide actinide metallocene, {[η5-1,3-(Me3C)2C5H3]2Th(:P-2,4,6-tBu3C6H2)(ClK)}2 (4), whose structure and reactivity was investigated in detail. On the basis of d. functional theory (DFT) studies, the 5f orbitals in the model complex [η5-1,3-(Me3C)2C5H3]2Th(:P-2,4,6-tBu3C6H2) (4′) contribute significantly to the bonding of the phosphinidene Th:P(2,4,6-tBu3C6H2) moiety. Furthermore, compared to the related thorium imido complex, the bonds between the [η5-1,3-(Me3C)3C5H2]2Th2+ and [P-2,4,6-tBu3C6H2]2- fragments are more covalent. The reactivity of compound 4 toward alkynes and a variety of heterounsatd. mols. such as nitriles, isonitriles, carbodiimides, imines, isothiocyanates, aldehydes, ketones, thiazoles, quinolines, organic azides, pyridines, and imidazoles, forming metallacycles, phospholes, imidos, metallaheterocycles, sulfidos, oxidos, pinacolates, pseudophosphinimidos, and phosphidos, was comprehensively studied. Moreover, complex 4 reacts with elemental selenium and PhSSPh, yielding selenido and sulfido compounds, resp. DFT computations were performed to complement these exptl. investigations and to provide further insights. After reading the article, we found that the author used 1,2-Diphenyldisulfane(cas: 882-33-7Quality Control of 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Quality Control of 1,2-Diphenyldisulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2015,Li, Daliang; Liu, Lin; Li, Wen-Hong published 《Genetic Targeting of a Small Fluorescent Zinc Indicator to Cell Surface for Monitoring Zinc Secretion》.ACS Chemical Biology published the findings.Computed Properties of C9H19NO4 The information in the text is summarized as follows:

Numerous mammalian cells contain Zn2+ in their secretory granules. During secretion, Zn2+ is coreleased with granular cargos into extracellular medium so Zn2+ serves as a convenient surrogate marker for tracking the dynamics of secretion. Fluorescent Zn2+ sensors that can be selectively targeted to cells of interest would be invaluable tools for imaging Zn2+ release in multicellular systems including tissues and live animals. Exploiting the HaloTag labeling technol. and using an optimized linker, the authors have engineered a fluorescent Zn2+ indicator that displayed a 15-fold fluorescence enhancement upon Zn2+ binding while reacting efficiently with a HaloTag enzyme in a cellular environment. Two-color imaging of ZIMIR-HaloTag and a red-emitting calcium indicator in pancreatic islet beta cells demonstrated that photoactivation of a channelrhodopsin was able to induce exocytosis of Zn2+/insulin granules and revealed heterogeneity in secretory activity along the cell membrane that was uncoupled from cellular Ca2+ activity. This integrated photonic approach for imaging and controlling the release of large dense core granules provides exquisite cellular selectivity and should facilitate future studies of stimulus-secretion coupling and paracrine signaling in secretory cells. In addition to this study using tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate, there are many other studies that have used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Computed Properties of C9H19NO4) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Computed Properties of C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Kinetic resolution of mandelate esters via stereoselective acylation catalyzed by lipase PS-30》 was written by Chen, Peiran; Yang, Wenhong. Application In Synthesis of 2-Hydroxy-2-(4-propoxyphenyl)acetic acid And the article was included in Tetrahedron Letters on April 2 ,2014. The article conveys some information:

By using lipase PS-30 as catalyst, the kinetic resolution of a series of racemic mandelate esters has been achieved via stereoselective acylation. The value of kinetic enantiomeric ratio (E) reached up to 197.5. Substituent effect is briefly discussed. In the experimental materials used by the author, we found 2-Hydroxy-2-(4-propoxyphenyl)acetic acid(cas: 79694-16-9Application In Synthesis of 2-Hydroxy-2-(4-propoxyphenyl)acetic acid)

2-Hydroxy-2-(4-propoxyphenyl)acetic acid(cas: 79694-16-9) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Application In Synthesis of 2-Hydroxy-2-(4-propoxyphenyl)acetic acid They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Gold/photoredox-cocatalyzed atom transfer thiosulfonylation of alkynes: stereoselective synthesis of vinylsulfones》 was written by Song, Tingting; Li, Haoyu; Wei, Fang; Tung, Chen-Ho; Xu, Zhenghu. Product Details of 882-33-7This research focused onvinylsulfone regioselective preparation stereoselective; benzenesulfonothioate alkyne thiosulfonylation gold photoredox cocatalyst. The article conveys some information:

A series of vinylsulfones I [R = Me, Ph, 4-MeC6H4, etc.; R1 = cyclopropyl, Ph, 3-thienyl, etc.; R2 = H, n-Bu] was synthesized via gold and photoredox-cocatalyzed thiosulfonylation of benzenesulfonothioates and alkynes. Key features of this method included very mild conditions, broad substrate scope, excellent regio- and stereoselectivties, radical approach and 100% atom economy. In addition to this study using 1,2-Diphenyldisulfane, there are many other studies that have used 1,2-Diphenyldisulfane(cas: 882-33-7Product Details of 882-33-7) was used in this study.

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Product Details of 882-33-7Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《A Thioxanthenothioxanthene-based Hole Transporter with 2D Molecular Stacking for Efficient and Thermostable Perovskite Solar Cells》 was written by Zheng, Aibin; Ren, Ming; Zhang, Yuyan; Cai, Yaohang; Zhang, Jing; Yuan, Yi; Lei, Ming; Wang, Peng. Application of 101-70-2This research focused onthioxanthenothioxanthene hole transporter perovskite solar cell. The article conveys some information:

Maintaining persistent thin-film morphol. under certain thermal stress is desirable for durable operation of multi-layer organic optoelectronic devices. a thioxanthenothioxanthene-centered hole-transporter (N3,N3,N9,N9-tetrakis(4-methoxyphenyl)thioxantheno[2,1,9,8-klmna]thioxanthene-3,9-diamine, TXTX-OMeDPA) characteristic of two-dimensional mol. stacking in a single crystal is reported. TXTX-OMeDPA can be solution-processed into smooth thin films with suitable energy level and good hole mobility, allowing for the fabrication of perovskite solar cells with an impressive power conversion efficiency of 22.2% when measured under illumination of AM 1.5G sunlight. The remarkable morphol. stability of TXTX-OMeDPA-based thin film ensures good stability for perovskite solar cells not only stored at 60° in the dark but also operated under equivalent full sunlight at 60°. The experimental process involved the reaction of Bis(4-methoxyphenyl)amine(cas: 101-70-2Application of 101-70-2)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Application of 101-70-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Quality Control of 1,4,7,10,13-PentaoxacyclopentadecaneIn 2019 ,《Effect of Copper Substrate Surface Orientation on the Reductive Functionalization of Graphene》 was published in Chemistry of Materials. The article was written by Zhang, Xu; Luo, Da; Zhang, Hanyang; Hwang, Dae Yeon; Park, Sung O.; Li, Bao-Wen; Biswal, Mandakini; Jiang, Yi; Huang, Yuan; Kwak, Sang Kyu; Bielawski, Christopher W.; Ruoff, Rodney S.. The article contains the following contents:

Although substrate composition can influence the chem. reactivity of graphene, substrate lattice orientation provides a valuable alternative. The effect of Cu surface orientation on the reactivity of graphene was explored through a reductive transformation. Among the substrates tested, only Cu(111) led to the efficient, fast and uniform functionalization of graphene, as demonstrated by Raman mapping, and this arose from compressive strain induced by Cu(111). Functionalization effectively relaxes the strain, which can be subsequently reintroduced after thermal treatment. Theor. calculations showed how compression facilitates the reduction and hybridization of carbon atoms, while coupling experiments revealed how kinetics may be used to control the reaction. The number of graphene layers and their stacking modes were also found to be important factors. In a broader context, a description of how graphene undergoes chem. modification when positioned on certain metal substrates is provided.1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Quality Control of 1,4,7,10,13-Pentaoxacyclopentadecane) was used in this study.

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Quality Control of 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《A MedChem toolbox for cereblon-directed PROTACs》 were Steinebach, Christian; Sosic, Izidor; Lindner, Stefanie; Bricelj, Alesa; Kohl, Franziska; Ng, Yuen Lam Dora; Monschke, Marius; Wagner, Karl G.; Kroenke, Jan; Guetschow, Michael. And the article was published in MedChemComm in 2019. Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The author mentioned the following in the article:

A modular chem. toolbox was developed for cereblon-directed PROTACs. A variety of linkers was attached to a CRBN ligand via the 4-amino position of pomalidomide. We used linkers of different constitution to modulate physicochem. properties. We equipped one terminus of the linker with a set of functional groups, e.g. protected amines, protected carboxylic acids, alkynes, chloroalkanes, and protected alcs., all of which are considered to be attractive for PROTAC design. We also highlight different opportunities for the expansion of the medicinal chemists’ PROTAC toolbox towards heterobifunctional mols., e.g. with biotin, fluorescent, hydrophobic and peptide tags. In the experimental materials used by the author, we found tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateAlthough ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Dalton Transactions included an article by Janicki, Rafal; Mondry, Anna. Safety of 1,4,7,10,13-Pentaoxacyclopentadecane. The article was titled 《Structural and thermodynamic aspects of hydration of Gd(III) systems》. The information in the text is summarized as follows:

X-ray crystal structures of Gd(III) and Lu(III) aqua ions as well as their complexes with polyaminopolycarboxylates (EDTA, CDTA, EGTA, DTPA, DOTA) were determined: [Gd(H2O)9](CF3SO3)3, [Gd(H2O)8]Cl3·C10H20O5, [Lu(H2O)8]Cl3·C12H24O6·4H2O, [C(NH2)3][Gd(EDTA)(H2O)3], [C(NH2)3]2[Lu(EDTA)(H2O)2]ClO4·6H2O, [C(NH2)3][Lu(CDTA)(H2O)2]·6H2O, [C(NH2)3][Gd(EGTA)(H2O)]·2H2O, [C(NH2)2(N2H4)][Gd(HDTPA)(H2O)]·2H2O, Na[Gd(DOTA)(H2O)]·4H2O, and K2[Lu(DOTA)]Cl·4.6H2O. The weighted sums of UV absorption spectra of appropriate crystals were used to reproduce the spectra of the Gd(III) aqueous solutions in the temperature range 276-363 K. In aqueous solution the Gd(III)-EGTA, Gd(III)-DTPA and Gd(III)-DOTA complexes exist as almost pure monohydrate [GdL(H2O)]n- species, while in the case of the Gd(III) aqua ion, Gd(III)-EDTA and Gd(III)-CDTA systems the equilibrium between variously hydrated species were found. The derived molar fractions of these species were used to determine the ΔG, ΔH and ΔS of hydration. These thermodn. functions may be derived not only from the spectra of the hypersensitive transitions, but from other f-f transitions as well. Next the ΔG, ΔH and ΔS values of hydration for the other Ln(III)-EDTA systems (Ln = Pr, Nd, Sm, Eu) were determined The ΔG298 values of the dehydration reaction for Ln(III)-EDTA complexes (Ln = Pr, Nd, Sm, Eu, Gd, Ho, Er) were almost linearly dependent on the number of 4f electrons in the whole series of lanthanides. Also, the point, where the ratio of [LnL(H2O)n] : [LnL(H2O)n-1] is 1, shifts along the lanthanide series depending on the ligand denticity – the higher the ligand denticity, the farther the point of the equimolar ratio in the lanthanide series. The presented results are the 1st systematic exptl. study on the thermodn. description of the hydration equilibrium of Gd(III) compounds In the experiment, the researchers used many compounds, for example, 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Safety of 1,4,7,10,13-Pentaoxacyclopentadecane)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Safety of 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2017,Wieczorek, Achim; Werther, Philipp; Euchner, Jonas; Wombacher, Richard published 《Green- to far-red-emitting fluorogenic tetrazine probes – synthetic access and no-wash protein imaging inside living cells》.Chemical Science published the findings.Synthetic Route of C9H19NO4 The information in the text is summarized as follows:

Fluorogenic probes for bioorthogonal labeling chem. are highly beneficial to reduce background signal in fluorescence microscopy imaging. 1,2,4,5-Tetrazines are known substrates for the bioorthogonal inverse electron demand Diels-Alder reaction (DAinv) and tetrazine substituted fluorophores can exhibit fluorogenic properties. Herein, we report the synthesis of a palette of novel fluorogenic tetrazine dyes derived from widely-used fluorophores that cover the entire emission range from green to far-red. We demonstrate the power of the new fluorogenic probes in fixed and live cell labeling experiments and present the first example of intracellular live cell protein imaging using tetrazine-based probes under no-wash conditions. In the experiment, the researchers used many compounds, for example, tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Synthetic Route of C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Synthetic Route of C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2015,Kim, Eunha; Yang, Katherine S.; Kohler, Rainer H.; Dubach, John M.; Mikula, Hannes; Weissleder, Ralph published 《Optimized Near-IR Fluorescent Agents for in Vivo Imaging of Btk Expression》.Bioconjugate Chemistry published the findings.Application of 139115-91-6 The information in the text is summarized as follows:

Bruton’s tyrosine kinase (Btk) is intricately involved in anti-apoptotic signaling pathways in cancer and in regulating innate immune response. A number of Btk inhibitors are in development for use in treating B-cell malignancies and certain immunol. diseases. To develop robust companion imaging diagnostics for in vivo use, we set out to explore the effects of red wavelength fluorochrome modifications of two highly potent irreversible Btk inhibitors, Ibrutinib and AVL-292. Surprisingly, we found that subtle chem. differences in the fluorochrome had considerable effects on target localization. Based on iterative designs, we developed a single optimized version with superb in vivo imaging characteristics enabling single cell Btk imaging in vivo. This agent (Ibrutinib-SiR-COOH) is expected to be a valuable chem. tool in deciphering Btk biol. in cancer and host cells in vivo. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Application of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Application of 139115-91-6 Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem