Tag: 200-300

Ghasemisarabbadieh, Mostafa; Gizurarson, Sveinbjorn; Sveinbjornsson, Benjamin Ragnar published an article in 2021. The article was titled 《Effect of 18-Crown-6 on Oxytocin Stability in Aqueous Buffer Solutions》, and you may find the article in ACS Omega.Application In Synthesis of 1,4,7,10,13-Pentaoxacyclopentadecane The information in the text is summarized as follows:

In this study, the effect of 18-crown-6 on the stability of oxytocin in aqueous solution was explored. The study found that while 12-crown-4 and 15-crown-5 do not stabilize oxytocin, 18-crown-6 does have a stabilizing effect in citrate/phosphate buffer at pH 4.5. However, in acetate buffer at the same pH, the presence of 18-crown-6 had a destabilizing effect, possibly leading to a different degradation pathway. Both the stabilizing and destabilizing effects, depending on the buffer used, are concentration dependent where a higher concentration of 18-crown-6 is linked to a stronger effect. It is hypothesized that this effect may be linked to 18-crown-6 binding to the protonated ammonium group of oxytocin. Upon changing the mobile phase used in high-performance liquid chromatog. experiments, we observed evidence supporting this binding hypothesis. When an acidic mobile phase was used (0.01% trifluoroacetic acid (TFA)), a partial shift in oxytocin retention time was observed for samples in acetate buffers in the presence of 18-crown-6 when using a 150 mm column (C18). The amount of the peak that shifted depended on the 18-crown-6 concentration used. A similar shift in oxytocin peak retention time was observed for samples in both acetate and citrate/phosphate buffers when using a 250 mm column (C18), but the peak completely shifted in those samples. When using an even more acidic mobile phase (0.1% TFA), the oxytocin peaks all had the same retention time again. UV and NMR spectroscopy experiments also showed that the presence of 18-crown-6 has an observable effect on the resulting oxytocin spectra. In the experiment, the researchers used many compounds, for example, 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Application In Synthesis of 1,4,7,10,13-Pentaoxacyclopentadecane)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Application In Synthesis of 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bonnin, Maxime A.; Feldmann, Claus published an article in 2021. The article was titled 《Insights of the Structure and Luminescence of Mn2+/Sn2+-Containing Crown-Ether Coordination Compounds》, and you may find the article in Inorganic Chemistry.Reference of 1,4,7,10,13-Pentaoxacyclopentadecane The information in the text is summarized as follows:

Crown-ether coordination compounds with Mn2+ and Sn2+ as cations and 12-crown-4, 15-crown-5, and 18-crown-6 as ligands are synthesized. Their luminescence properties and quantum yields are compared and correlated with their structural features. Thus, MnI2(15-crown-5) (1), MnCl2(15-crown-5) (2), [Mn(12-crown-4)2]2[N(Tf)2]2(12-crown-4) (3), Sn3I6(15-crown-5)2 (4), and SnI2(18-crown-6) (5) are obtained by an ionic-liquid-based reaction of MX2 (M: Mn, Sn; X: Cl, I) and the resp. crown ether. Whereas 1, 2, and 5 exhibit a centric coordination of Mn2+/Sn2+ by the crown ether, 3 and 4 show a sandwich-like coordination of the cation with two crown-ether mols. All title compounds show visible emission, whereof 1, 2, and 5 have good luminescence efficiencies with quantum yields of 47, 39, and 21%, resp. These luminescence properties are compared with recently realized compounds such as Mn3Cl6(18-crown-6)2, MnI2(18-crown-6), Mn3I6(18-crown-6)2, or Mn2I4(18-crown-6), which have significantly higher quantum yields of 98 and 100%. Based on a comparison of altogether nine crown-ether coordination compounds, the structural features can be correlated with the luminescence efficiency, which allows extraction of those conditions encouraging intense emission and high quantum yields. The results came from multiple reactions, including the reaction of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Reference of 1,4,7,10,13-Pentaoxacyclopentadecane)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Reference of 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sun, Lihe; Ouyang, Juan; Ma, Yunqing; Zeng, Zhuo; Zeng, Cheng; Zeng, Fang; Wu, Shuizhu published an article in 2021. The article was titled 《An Activatable Probe with Aggregation-Induced Emission for Detecting and Imaging Herbal Medicine Induced Liver Injury with Optoacoustic Imaging and NIR-II Fluorescence Imaging》, and you may find the article in Advanced Healthcare Materials.Application In Synthesis of Bis(4-methoxyphenyl)amine The information in the text is summarized as follows:

Whilte herbal medicines are widely used for health promotion and therapy for chronic conditions, inappropriate use of them may cause adverse effects like liver injury, and accurately evaluating their hepatotoxicity is of great significance for public health. Herein, an activatable probe QY-N for diagnosing herbal-medicine-induced liver injury by detecting hepatic NO with NIR-II fluorescence and multispectral optoacoustic tomog. (MSOT) imaging is demonstrated. The probe includes a bismethoxyphenyl-amine-containing dihydroxanthene serving as electron donor, a quinolinium as electron acceptor, and a butylamine as recognition group and fluorescence quencher. The hepatic level of NO reacts with butylamine, thereby generating the activated probe QY-NO which exhibits a red-shifted absorption band (700-850 nm) for optoacoustic imaging and generates strong emission (910-1110 nm) for NIR-II fluorescence imaging. QY-NO is aggregation-induced-emission (AIE) active, which ensures strong emission in aggregated state. QY-N is utilized in the triptolide-induced liver injury mouse model, and exptl. results demonstrate the QY-N can be activated by hepatic NO and thus be used in detecting herbal-medicine-induced liver injury. The temporal and spatial information provided by three-dimensional MSOT images well delineates the site and size of liver injury. Moreover, QY-N has also been employed to monitor rehabilitation of liver injury during treatment process.Bis(4-methoxyphenyl)amine(cas: 101-70-2Application In Synthesis of Bis(4-methoxyphenyl)amine) was used in this study.

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Application In Synthesis of Bis(4-methoxyphenyl)amine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yin, Jie; Zhang, Jinrui; Wang, Chao; Lv, Naixia; Jiang, Wei; Liu, Hui; Li, Hongping; Zhu, Wenshuai; Li, Huaming; Ji, Hongbing published their research in Journal of Molecular Liquids in 2021. The article was titled 《Theoretical insights into CO2/N2 selectivity of the porous ionic liquids constructed by ion-dipole interactions》.HPLC of Formula: 33100-27-5 The article contains the following contents:

Porous liquids, a new class of materials, containing solid pores and liquid properties, have greatly aroused attention. In terms of gas absorption, porous liquids exhibit excellent advantages. Nevertheless, a variety of reports still lack the understanding of its absorption mechanism at the mol. level. Herein, we have figured out the factors contributing to the formation of porous liquids made of porous organic cages that can be dissolved in the crown ether, and the absorption mechanism of carbon dioxide, as well as CO2/N2 selectivity. Through charge and Wiberg index anal., the results show that crown ethers can interact with alkali metals to form alkali metal complexes by ion-dipole interactions, the dominant driving force of which is electrostatic interaction rather than coordination effect. Besides, the metal complexes should be regarded as a whole entity, which increases the steric hindrance of the cations and greatly reduces the probability of the crown ether blocking the cavity. The porous organic cage does provide unoccupied pores for gas storage. Furthermore, compared with N2, cages prefer to absorb CO2 mainly through hydrogen bonding. It is hoped that this work can facilitate the design and synthesis of porous liquids for gas absorption and selectivity. The results came from multiple reactions, including the reaction of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5HPLC of Formula: 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. HPLC of Formula: 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Synthesis and biological evaluation of berberine derivatives as a new class of broad-spectrum antiviral agents against Coxsackievirus B》 was published in Bioorganic Chemistry in 2020. These research results belong to Zeng, Qing-Xuan; Wang, Hui-Qiang; Wei, Wei; Guo, Ting-Ting; Yu, Lian; Wang, Yan-Xiang; Li, Yu-Huan; Song, Dan-Qing. Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The article mentions the following:

A series of novel berberine (BBR) analogs were prepared and tested for their antiviral potencies against six different genotype Coxsackievirus B (CVB1-6) strains, taking BBR core for structural modification. Structure-activity relationship (SAR) research revealed that introduction of a primary amine through a linker at position 3 might be beneficial for both antiviral activity and safety. Compound 14c displayed most promising inhibitory potency with IC50 values of 3.08-9.94μM against tested CVBs 2-6 strains and satisfactory SI value of 34.3 on CVB3, better than that of BBR. Also, 14c could inhibit CVB3 replication through down-regulating the expression of VP1 protein and VP1 RNA. The mechanism revealed that 14c could suppress host components JNK-MAPK, ERK-MAPK and p38-MAPK activation. Therefore, BBR derivatives were considered to be a new class of anti-CVB agents with an advantage of broad-spectrum anti-CVB potency. In the experimental materials used by the author, we found tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Phenyl Disulfide Additive for Solution-Mediated Carbon Dioxide Utilization in Li-CO2 Batteries》 were Pipes, Robert; Bhargav, Amruth; Manthiram, Arumugam. And the article was published in Advanced Energy Materials in 2019. Reference of 1,2-Diphenyldisulfane The author mentioned the following in the article:

Ph disulfide (PDS) is employed as an electrolyte additive in lithium-carbon dioxide (Li-CO2) batteries to allow for a solution-mediated carbon dioxide reduction pathway. Thiophenolate anions, generated via electrochem. reduction of PDS, act as CO2 capture agents by forming the adduct S-Ph carbonothioate (SPC-) in solution A mechanism of SPC–mediated CO2 capture and utilization is proposed and supported via carbon-13 NMR spectroscopy and Fourier-transform IR spectroscopy. Reversible formation and decomposition of lithium carbonate and amorphous carbon during cycling, facilitated by the solution-mediated pathway, are demonstrated with an array of characterization techniques. Li-CO2 batteries employing the PDS additive show vastly improved capacity, energy efficiency, and cycle life. The enhanced Li-CO2 battery performance offered by the proposed solution-mediated reaction pathway offers a compelling step forward in the pursuit of reversible CO2 utilization.1,2-Diphenyldisulfane(cas: 882-33-7Reference of 1,2-Diphenyldisulfane) was used in this study.

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Reference of 1,2-Diphenyldisulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bourque, Jeremy L.; Nanni, Robert A.; Biesinger, Mark C.; Baines, Kim M. published their research in Inorganic Chemistry in 2021. The article was titled 《Synthesis and Reactivity of Cationic Gallium(I) [12]Crown-4 Complexes》.Related Products of 33100-27-5 The article contains the following contents:

The synthesis and reactivity of a Ga(I) cationic complex using [12]crown-4 as a stabilizing ligand were explored. The synthesis of [Ga([12]crown-4)][GaCl4] was achieved in one step from com. available starting materials. Anion exchange was used to replace the reactive tetrachlorogallate anion for the perfluorophenylborate anion. [Ga([12]crown-4)][B(C6F5)4] was analyzed using XPS, which allowed for the classification of the Ga(I)-crown ether complex as electron-deficient. Reactions of the Ga(I)-crown ether complex with Cp*K and cryptand[2.2.2] demonstrated the facile synthesis of a known Ga(I) compound as well as the generation of new Ga(I) complexes, highlighting the use of the Ga(I)-crown ether complex as an effective starting material for new Ga(I) complexes. In addition to this study using 1,4,7,10,13-Pentaoxacyclopentadecane, there are many other studies that have used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Related Products of 33100-27-5) was used in this study.

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Related Products of 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cassiano, Chiara; Morretta, Elva; Costantini, Matteo; Fassi, Enrico M. A.; Colombo, Giorgio; Sattin, Sara; Casapullo, Agostino published their research in Bioorganic Chemistry in 2021. The article was titled 《Analysis of Hsp90 allosteric modulators interactome reveals a potential dual action mode involving mitochondrial MDH2》.Related Products of 139115-91-6 The article contains the following contents:

Hsp90 (i.e., Heat shock protein 90) is a well-established therapeutic target for several diseases, ranging from misfolding-related disfunctions to cancer. In this framework, we have developed in recent years a family of benzofuran compounds that act as Hsp90 allosteric modulators. Such mols. can interfere with the stability of some relevant Hsp90 client oncoproteins, showing a low μM cytotoxic activity in vitro in cancer cell lines. Here we identify the target profile of these chem. probes by means of chem. proteomics, which established MDH2 (mitochondrial malate dehydrogenase) as an addnl. relevant cellular target that might help elucidate the mol. mechanism of their citotoxicity. Western blotting, DARTS (i.e., Drug Affinity Responsive Target Stability) and enzymic assays data confirmed a dose-dependent interaction of MDH2 with several members of the benzofuran Hsp90 modulators family and a computational model allowed to interpret the observed interactions. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Related Products of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Related Products of 139115-91-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Metal-free synthesis of 3-chalcogenyl chromones from alkynyl aryl ketones and diorganyl diselenides/disulfides mediated by PIFA》 was published in Organic Chemistry Frontiers in 2020. These research results belong to Ai, Zhenkang; Xiao, Jiaxi; Li, Yadong; Guo, Boying; Du, Yunfei; Zhao, Kang. Reference of 1,2-Diphenyldisulfane The article mentions the following:

The 3-selenyl/sulfenyl chromones/thiochromones I (R = Ph, Me, 4-chlorophenyl, etc.; R1 = H, 7-Me, 6-Cl, 5-CF3, etc.; R2 = Ph, cyclopropyl, thiophen-3-yl, etc.) were conveniently synthesized from the PIFA-mediated reactions between alkynyl aryl ketones bearing an ortho-methoxy/methylthio group R1-2-XMe-C6H3C(O)CCR2 and diorganyl diselenides/disulfides RYYR (Y = Se/S). This metal-free approach is postulated to first undergo the formation of the reactive RSeOCOCF3 or RSOCOCF3 from the reaction of diorganyl diselenides or disulfides with PIFA, followed by the electrophilic cyclization of alkynyl aryl ketones enabled by the electrophilic species generated herein. In the part of experimental materials, we found many familiar compounds, such as 1,2-Diphenyldisulfane(cas: 882-33-7Reference of 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Reference of 1,2-Diphenyldisulfane They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《A practical ortho-acylation of aryl iodides enabled by moisture-insensitive activated esters via palladium/norbornene catalysis》 was published in Organic Chemistry Frontiers in 2020. These research results belong to Feng, Yunxia; Wang, Yangyang; Zhao, Shen; Zhang, Dao-Peng; Li, Xinjin; Liu, Hui; Dong, Yunhui; Sun, Feng-Gang. Computed Properties of C7H7IO The article mentions the following:

Polysubstituted aryl ketones I [R1 = 6-Me, 6-Cl, 4,6-di-Me, etc.] and II [R1 = C(O)Et, C(O)OEt, C(O)OtBu; R2 = cyclohexyl, thiophene-2-yl, 3-MeOC6H4, etc.] were synthesized via palladium/norbornene cooperative system catalyzed ortho-arene C-H acylation of aryl iodides using triazine esters. This ortho-acylation even proceeded smoothly in water. Preliminary mechanistic experiments indicated that the strong electron-withdrawing ability and coordination chem. of triazine play crucial roles in this transformation. In the part of experimental materials, we found many familiar compounds, such as 1-Iodo-2-methoxybenzene(cas: 529-28-2Computed Properties of C7H7IO)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Computed Properties of C7H7IO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem