Tag: 200-300

In 2019,Organic & Biomolecular Chemistry included an article by Shaifali; Ram, Shankar; Thakur, Vandna; Das, Pralay. Formula: C7H7IO. The article was titled 《Synthesis of α,β-alkynyl ketones via the nickel catalyzed carbonylative Sonogashira reaction using oxalic acid as a sustainable C1 source》. The information in the text is summarized as follows:

An efficient and economic nickel-dppb catalyzed-carbonylative Sonogashira cross-coupling reaction was demonstrated to provide rapid access to various α,β-alkynyl ketones RC(O)C≡CR1 [R = Ph, 4-MeC6H4, 4-BrC6H4, etc.; R1 = Ph, 2-ClC6H4, 4-MeOC6H4, etc.] from aryl iodides and terminal alkynes using oxalic acid as the ex-situ C1 source in a double vial (DV) system. Notably, the role of the ligand in combination with the Ni catalyst for the selective formation of carbonylative Sonogashira products was investigated and supported with control experiments In this process, for the first time, oxalic acid was used as an ex-situ solid, bench stable, easy to handle and efficient CO surrogate in a DV-system for the carbonylative Sonogashira coupling reaction with vast substrate scope. The results came from multiple reactions, including the reaction of 1-Iodo-2-methoxybenzene(cas: 529-28-2Formula: C7H7IO)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Formula: C7H7IO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2017,Zhang, Huaiying; Aonbangkhen, Chanat; Tarasovetc, Ekaterina V.; Ballister, Edward R.; Chenoweth, David M.; Lampson, Michael A. published 《Optogenetic control of kinetochore function》.Nature Chemical Biology published the findings.SDS of cas: 139115-91-6 The information in the text is summarized as follows:

Kinetochores act as hubs for multiple activities during cell division, including microtubule interactions and spindle checkpoint signaling. Each kinetochore can act autonomously, and activities change rapidly as proteins are recruited to, or removed from, kinetochores. Understanding this dynamic system requires tools that can manipulate kinetochores on biol. relevant temporal and spatial scales. Optogenetic approaches have the potential to provide temporal and spatial control with mol. specificity. Here we report new chem. inducers of protein dimerization that allow us to both recruit proteins to and release them from kinetochores using light. We use these dimerizers to manipulate checkpoint signaling and mol. motor activity. Our findings demonstrate specialized properties of the CENP-E (kinesin-7) motor for directional chromosome transport to the spindle equator and for maintenance of metaphase alignment. This work establishes a foundation for optogenetic control of kinetochore function, which is broadly applicable to exptl. probing of other dynamic cellular processes. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6SDS of cas: 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. SDS of cas: 139115-91-6 Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2016,Chu, Hualei; Song, Yuanqing; Li, Jiehua; Luo, Feng; Tan, Hong; Huang, Guangsu; Fu, Qiang published 《A novel phosphatidylcholine-modified polyisoprene: synthesis and characterization》.Colloid and Polymer Science published the findings.Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

Polyisoprene (PI) is the main component of natural rubber. To imitate natural rubber and understand the function of phospholipid in natural rubber, a novel phosphatidylcholine (PC)-modified polyisoprene (PI-pc) was synthesized using a PC and a com. PI. The PI is firstly brominated by N-bromosuccinimide, and then, di-Et malonate is introduced as a branch chain of PI. In sequence, the PC is imported into the branch chain of PI via condensation of the activated ester terminals in di-Et malonate and the amino terminals in PC to obtain the desired product PI-pc. The bulk structure of the prepared PI-pc is carefully characterized with NMR spectra (1H and 31P NMR), Fourier transform IR spectroscopy (FT-IR), gel permeation chromatograph (GPC), and differential scanning calorimetry (DSC). The introduction of PC to the branch chain of PI increases the mol. weight and also the glass transition (Tg) of the PI. The increment of Tgs and melting enthalpy for the PI-pcs from both solution and emulsion indicates that the attached PC is beneficial to the self-assembly of PI chains and thus promotes the crystallization Our present work provides a new method for importing PC to PI to imitate natural rubber, and also, the results could be a footstone for us to explore the effect of phospholipid on the property of natural rubber. The results came from multiple reactions, including the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2011,Spaeth, Andreas; Gonschor, Janina; Koenig, Burkhard published 《Synthesis and binding properties of guanidinium biscarboxylates》.Monatshefte fuer Chemie published the findings.COA of Formula: C9H19NO4 The information in the text is summarized as follows:

The ammonium ion binding site of the enzyme glutaminase HisF inspired the design of guanidinium biscarboxylates as potential self-organized ionophores in mol. recognition. The syntheses of the title compounds based on aliphatic and aromatic building blocks, along with a general method for the preparation of δ-aminoethoxyacetic acids, are presented. Investigation of the binding properties of the title compounds in DMSO and methanol solution revealed no ammonium ion affinity, but interaction of the guanidinium moiety with acetate ions. In the experimental materials used by the author, we found tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6COA of Formula: C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. COA of Formula: C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application In Synthesis of 1,2-DiphenyldisulfaneIn 2020 ,《Rhodium(III)-catalyzed carboxylate-directed ortho-selective thiolation of benzoic acids》 was published in Organic Chemistry Frontiers. The article was written by Wang, Dongjie; Zhou, Kehan; Zhang, Jingyu; Zhao, Yingsheng. The article contains the following contents:

A regioselective rhodium-catalyzed carboxylate-directed thiolation process was developed. Several benzoic-acid derivatives 2-R-3-R1-4-R2-5-R3-C6HC(O)OH (R = H, Me, Et, OMe, Ph, Cl, OPh; R1 = H, Me, Cl, OMe, OEt; R2 = H, Me, OMe, OEt, OBn, pentyl; R3 = H, Me) and disulfides R4SSR4 (R4 = propan-2-yl, cyclohexyl, Ph, etc.) were found to be well-tolerated, and they yielded the corresponding products 2-R-3-R1-4-R2-5-R3-6-S(R4)-C6C(O)OH in moderate to good yields. Compounds such as the key precursor of roflumilast can be obtained via this reaction, thereby highlighting the potential of this synthetic approach. In the experimental materials used by the author, we found 1,2-Diphenyldisulfane(cas: 882-33-7Application In Synthesis of 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Application In Synthesis of 1,2-DiphenyldisulfaneAlthough ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C10H20O5In 2020 ,《Oriented proton-conductive nano-sponge-facilitated polymer electrolyte membranes》 appeared in Energy & Environmental Science. The author of the article were Liu, Xin; Zhang, Junfeng; Zheng, Chenyang; Xue, Jiandang; Huang, Tong; Yin, Yan; Qin, Yanzhou; Jiao, Kui; Du, Qing; Guiver, Michael D.. The article conveys some information:

Achieving high power output from proton exchange membrane fuel cells (PEMFCs) requires efficient proton transport in proton exchange membranes (PEMs). Since proton conductivity is closely related to membrane moisture content, operation at low relative humidity (RH) and elevated temperature has become a critical bottleneck for the practical application of PEMFCs due to severe PEM dehydration. While several strategies have sought to mitigate this, including external thermal and water management, coating of nano-cracked hydrophobic layers and optimization of membrane intrinsic water retention, only partial improvements have been realized. Here, using a membrane formulation of ferrocyano-coordinated poly(4-vinylpyridine) (CP4VP), phosphotungstic acid (PWA) and polysulfone (PSf), novel highly water-retentive PEMs are fabricated via a strong magnetic field. During magnetic-assisted membrane casting, CP4VP and PWA form a microporous Prussian blue analog (PBA) framework with the new type of Fe-C≡N-W bonding, which is paramagnetic and is thus simultaneously aligned in the through-plane (TP) direction of the membrane. The neutral PSf membrane component affords mech. strength to the embedded TP-aligned conducting channels. This new type of microporous PBA framework is highly hydrophilic and proton conductive, with micropores of ∼5.4 Å diameter, which act as nano-sponges to absorb only more retentive non-freezable water, effective for proton conduction. These nano-sponges display efficient water absorption and retention at low RH and elevated temperatures, together with a much faster hydration process than the dehydration process. Furthermore, the TP-aligned PBA channels also enable faster water transport to promote PEM proton conduction beyond any previously reported water-retentive membrane. Consequently, the novel nano-sponge-like PEMs exhibit remarkable performance in both ex situ and in situ evaluations, especially at low RH and elevated temperature, largely prevailing over the com. benchmark Nafion 212. In the part of experimental materials, we found many familiar compounds, such as 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Synthetic Route of C10H20O5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Synthetic Route of C10H20O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xu, Hang; Yamaguchi, Sho; Mitsudome, Takato; Mizugaki, Tomoo published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《A copper nitride catalyst for the efficient hydroxylation of aryl halides under ligand-free conditions》.Name: 1-Iodo-2-methoxybenzene The article contains the following contents:

Copper nitride(Cu3N) was used as a heterogeneous catalyst for the hydroxylation of aryl halides RX (R = 4-methoxyphenyl, Ph, 1-naphthyl, pyridin-3-yl, etc.; X = I, Br, Cl) under ligand-free conditions. The cubic Cu3N nanoparticles showed high catalytic activity, comparable to those of conventional Cu catalysts with nitrogen ligands, demonstrating that the nitrogen atoms in Cu3N act as functional ligands that promote hydroxylation. In the part of experimental materials, we found many familiar compounds, such as 1-Iodo-2-methoxybenzene(cas: 529-28-2Name: 1-Iodo-2-methoxybenzene)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Name: 1-Iodo-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Selectfluor-initiated cyanation of disulfides to thiocyanates》 was published in Journal of Chemical Research in 2020. These research results belong to Zhou, Pengpeng; Chen, Chuan; Li, Shubai. HPLC of Formula: 882-33-7 The article mentions the following:

A Selectfluor-initiated cyanation of disulfides to thiocyanates was developed. In this process, Selectfluor was employed as the oxidant and trimethylsilyl cyanide was used as the cyanation reagent. It provides an eco-friendly and simple way to synthesize the thiocyanates. In the experiment, the researchers used 1,2-Diphenyldisulfane(cas: 882-33-7HPLC of Formula: 882-33-7)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. HPLC of Formula: 882-33-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《A Selectfluor-promoted oxidative reaction of disulfides and amines: access to sulfinamides》 was published in Organic & Biomolecular Chemistry in 2020. These research results belong to Mei, Haibo; Liu, Jiang; Pajkert, Romana; Roschenthaler, Gerd-Volker; Han, Jianlin. Formula: C12H10S2 The article mentions the following:

An unprecedented transition-metal-free oxidative reaction of disulfides and amines with Selectfluor as a mild oxidant under aerobic conditions was developed. This reaction was conducted under mild conditions and tolerated a wide range of coupling partners including disulfides and amines, affording the corresponding sulfinamide products in good chem. yields. Furthermore, this reaction could be used in gram-scale synthesis. This reaction enriches the research content of Selectfluor and provides a valuable vista for the convenient synthesis of sulfinamides. After reading the article, we found that the author used 1,2-Diphenyldisulfane(cas: 882-33-7Formula: C12H10S2)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Formula: C12H10S2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Green synthesis and antibacterial activity of chalcogenoesters》 was published in Monatshefte fuer Chemie in 2020. These research results belong to da Silva, Rafael S.; Junior, Guerino B.; Soares, Letiere C.; da Rosa, Fernanda H.; Ravanello, Bruno B.; Dornelles, Luciano; Barboza, Victor dos S.; Vaucher, Rodrigo de A.; Santos, Roberto C. V.; Baldisserotto, Bernardo; Rodrigues, Oscar E. D.. COA of Formula: C12H10S2 The article mentions the following:

A new variation for an eco-friendly methodol. for the synthesis of chalcogenoester RC(O)YAr (R = 4-CH3C6H4, 4-O2NC6H4, 2-ClC6H4, 4-(CH3)3CC6H4; Ar = C6H5, 2-CH3OC6H4, 4-CH3C6H4, 4-ClC6H4; Y = Se, S) in good-to-excellent yields in a short time, with an easy work-up/purification step, and in a greenest methodol., affording the min. generation of solid and liquid waste, in comparison to that described in the literature has been described. Addnl., some selected compounds RC(O)YAr (R = 4-CH3C6H4, Ar = C6H5, Y = Se; R = 4-O2NC6H4, Ar = C6H5, Y = Se; R = Ar = 4-CH3C6H4, Y = Se; R = 4-CH3C6H4, Ar = 4-ClC6H4, Y = S; R = 4-O2NC6H4, Ar = 4-ClC6H4, Y = S) were evaluated as antimicrobial agents, showing moderate activity against a variety of microorganisms including the K. pneumonia, P. aeruginosa and also some selected fish pathogenic bacteria. In the experimental materials used by the author, we found 1,2-Diphenyldisulfane(cas: 882-33-7COA of Formula: C12H10S2)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. COA of Formula: C12H10S2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem