Tag: 200-300

《Permeation selectivity of alkali metal ions through crown ether based ion channels》 was published in Journal of Molecular Liquids in 2020. These research results belong to Ahmed, Arsalan; Hashmi, Muhammad Ali; Ayub, Khurshid. Safety of 1,4,7,10,13-Pentaoxacyclopentadecane The article mentions the following:

Synthetic ion channels mimic the natural ion channels for various biol. activities such as drug delivery, signal transduction, as biosensors and as antibacterial agents. Among the synthetic ion channels, crown ether-based ion channels show greater selectivity for K+ and Na+, compared to other metal ions. These synthetic ion channels can therefore be utilized for the selective transport of K+ and Na+ which is important for various biol. processes. In this work, theor. insight for the permeability and selectivity of crown ether-based ion channels is provided. Permeability is studied by passing the alkali metal ion directly through the crown ether macrocyclic cavity, as well as through the empty spaces present in the packings. For this purpose, 18-crown-6, 15-crown-5 ether and their substituted derivatives have been studied. The results show that 18-crown-6-ethers are more selective for K+, while 15-crown-5 ethers are selective for Li+. Moreover, the results show that the ion transport can also occur through the empty spaces present in crown ether packings. The factors responsible for the greater selectivity of ions through a certain system are the sizes of the ion and cavity. Furthermore, substituents on the crown ether cycle help the system to form columnar packing which is found to decrease the permeation barrier for passing ions.1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Safety of 1,4,7,10,13-Pentaoxacyclopentadecane) was used in this study.

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Safety of 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Visible light induced 3-position-selective addition of arylpropiolic acids with ethers via C(sp3)-H functionalization》 was published in Organic & Biomolecular Chemistry in 2020. These research results belong to Wan, Zi-juan; Yuan, Xiao-feng; Luo, Jun. COA of Formula: C7H7IO The article mentions the following:

An intriguing and mild method for visible light induced regioselective addition of arylpropiolic acids by attacking exclusively at the 3-position with cyclic/acyclic ethers was developed. A variety of 3,3-bis-substituted acrylic acids were successfully obtained in moderate to excellent yields. A plausible reaction mechanism involving an energy transfer induced radical addition in the presence of visible light and photocatalyst was proposed. In the part of experimental materials, we found many familiar compounds, such as 1-Iodo-2-methoxybenzene(cas: 529-28-2COA of Formula: C7H7IO)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.COA of Formula: C7H7IO

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Ether – Wikipedia,
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《Native amine-directed site-selective C(sp3)-H arylation of primary aliphatic amines with aryl iodides》 was published in Chinese Chemical Letters in 2020. These research results belong to Pramanick, Pranab K.; Zhou, Zhibing; Hou, Zhenlin; Ao, Yufei; Yao, Bo. Product Details of 529-28-2 The article mentions the following:

A simple and efficient method for site-selective C(sp3)-H arylation of primary aliphatic amines by aryl iodides were established. In the presence of only 5 mol% Pd(OAc)2, a wide range of aliphatic amines including O-benzyl and O-silyl amino alcs. were arylated at γ- or δ-positions by aryl iodides containing a broad scope of functional groups. The synthetic application of this method had also been demonstrated by large-scale synthesis, the synthesis of a fingolimod analog and the conjugation with natural D-menthol and fluorescent 1,8-naphthalimide. In the part of experimental materials, we found many familiar compounds, such as 1-Iodo-2-methoxybenzene(cas: 529-28-2Product Details of 529-28-2)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Product Details of 529-28-2

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Hole-Transporting Materials Incorporating Carbazole into Spiro-Core for Highly Efficient Perovskite Solar Cells》 were Zhu, Xiang-Dong; Ma, Xing-Juan; Wang, Ya-Kun; Li, Yun; Gao, Chun-Hong; Wang, Zhao-Kui; Jiang, Zuo-Quan; Liao, Liang-Sheng. And the article was published in Advanced Functional Materials in 2019. Application In Synthesis of Bis(4-methoxyphenyl)amine The author mentioned the following in the article:

Hole-transporting materials (HTMs) play a significant role in hole transport and extraction for perovskite solar cells (PeSCs). As an important type of HTMs, the spiro-architecture-based material is widely used as small organic HTM in PeSCs with good photovoltaic performances. The skeletal modification of spiro-based HTMs is a critical way of modifying energy level and hole mobility. Thus, many spiro alternatives are developed to optimize the spiro-type HTMs. Herein, a novel carbazole-based single-spiro-HTM named SCZF-5 is designed and prepared for efficient PeSCs. In addition, another single-spiro HTM SAF-5 with reported 10-phenyl-10H-spiro[acridine-9,9′-fluorene] (SAF) core is also synthesized for comparison. Through varying from SAF core to SCZF core as well as comparing with the classic 9,9′-spiro-bifluorene, it is found that the new HTM SCZF-5 exhibits more impressive power conversion efficiency (PCE) of 20.10% than SAF-5 (13.93%) and the com. HTM spiro-OMeTAD (19.11%). On the other hand, the SCZF-5-based device also has better durability in lifetime testing, indicating the newly designed SCZF by integrating carbazole into the spiro concept has good potential for developing effective HTMs. In the experiment, the researchers used Bis(4-methoxyphenyl)amine(cas: 101-70-2Application In Synthesis of Bis(4-methoxyphenyl)amine)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Application In Synthesis of Bis(4-methoxyphenyl)amine

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Organic & Biomolecular Chemistry included an article by Kumar, Vipin; Banert, Klaus; Ray, Devalina; Saha, Biswajit. Application of 882-33-7. The article was titled 《An atom-economical and regioselective metal-free C-5 chalcogenation of 8-aminoquinolines under mild conditions》. The information in the text is summarized as follows:

A general and simple metal-free protocol for expedient C-H functionalization leading to the regioselective generation of C-5 chalcogenated 8-aminoquinoline analogs I [R = H, Me, 5-(((tert-butoxy)carbonyl)amino)pentan-2-yl; R1 = H, OMe, Me; R2 = Ph, Pr, 4-chlorophenyl, etc.; Z = S, Se] in up to 90% yield at room temperature (25 °C) has been established. This methodol. is an eco-friendly approach to the atom-economical utilization of diaryl/dialkyl chalcogenides R2ZZR2 for direct access to chalcogenated quinolines and is scalable to the gram scale without considerable decrease in the yield of the product. It represents a practical alternative to the existing metal-catalyzed functionalization of 8-aminoquinoline derivatives with broad functional group tolerance. The controlled experiments suggest that the reaction possibly proceeds through an ionic pathway at room temperature Furthermore, the potentiality for the functionalization of free amines in chalcogenated-8-aminoquinolines I provides an attractive perspective for further elaboration of the amine substituent through chem. manipulations. The applicability of the standardized method has been augmented through late-stage antimalarial drug diversification of primaquine analogs. In the experiment, the researchers used 1,2-Diphenyldisulfane(cas: 882-33-7Application of 882-33-7)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Application of 882-33-7 They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Directed oxidative coupling of thiols in the synthesis of unsymmetrical disulfides》 was written by Burmistrova, D. A.; Smolyaninov, I. V.; Berberova, N. T.. Recommanded Product: 1,2-DiphenyldisulfaneThis research focused onunsym disulfide preparation; thiol oxidative coupling. The article conveys some information:

Oxidative coupling of two different thiols bearing aliphatic, alicyclic, aromatic, and hetero-aromatic moieties promoted by mild oxidizing agents, viz., sterically hindered o-benzo(imino)-quinones, carried out in N-methylpyrrolidone at room temperature led to unsym. disulfides RSSR1 [R = n-Pr, c-hexyl, Ph, etc.; R1 = c-pentyl, Ph, 4-pyridyl, etc.]. Among the studied oxidizers, the most active was 3,6-di-tert-butyl-o-benzoquinone, which, in contrast to 3,5-di-tert-butyl-o-benzoquinone, was not involved in the Michael addition Under the optimal reaction conditions, the yields of the target unsym. disulfides reach 81%. In the experiment, the researchers used 1,2-Diphenyldisulfane(cas: 882-33-7Recommanded Product: 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Recommanded Product: 1,2-Diphenyldisulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Safety of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateIn 2011 ,《Small-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins》 was published in Nature Chemical Biology. The article was written by Neklesa, Taavi K.; Tae, Hyun Seop; Schneekloth, Ashley R.; Stulberg, Michael J.; Corson, Timothy W.; Sundberg, Thomas B.; Raina, Kanak; Holley, Scott A.; Crews, Craig M.. The article contains the following contents:

The ability to regulate any protein of interest in living systems with small mols. remains a challenge. The authors hypothesized that appending a hydrophobic moiety to the surface of a protein would mimic the partially denatured state of the protein, thus engaging the cellular quality control machinery to induce its proteasomal degradation The authors designed and synthesized bifunctional small mols. to bind a bacterial dehalogenase (the HaloTag protein) and present a hydrophobic group on its surface. Hydrophobic tagging of the HaloTag protein with an adamantyl moiety induced the degradation of cytosolic, isoprenylated and transmembrane HaloTag fusion proteins in cell culture. The authors demonstrated the in vivo utility of hydrophobic tagging by degrading proteins expressed in zebrafish embryos and by inhibiting Hras1G12V-driven tumor progression in mice. Therefore, hydrophobic tagging of HaloTag fusion proteins affords small-mol. control over any protein of interest, making it an ideal system for validating potential drug targets in disease models. The experimental process involved the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Safety of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Safety of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Computed Properties of C12H10S2In 2019 ,《In situ Formation of RSCl/ArSeCl and Their Oxidative Coupling with Enaminone Derivatives Under Transition-metal Free Conditions》 was published in Advanced Synthesis & Catalysis. The article was written by Shang, Zhenhua; Chen, Qingyu; Xing, Linlin; Zhang, Yilin; Wait, Laura; Du, Yunfei. The article contains the following contents:

The reaction of diorganyl disulfides or diselenides RX2R (R = Ph, 4-chlorophenyl, 1,3-benzothiazol-2-yl, etc.; X = Se, S) with PhICl2 in DMF at room temperature led to the in situ formation of the reactive organosulfenyl chloride (RSCl) or selenyl chloride (RSeCl), which reacted with enaminone compounds (E)-R2NHC(R1)=CHR3 (R1 = Me, Ph, thiophen-2-yl, etc.; R2 = H, Ph, Bn; R3 = methoxycarbonyl, benzoyl, CN, N-phenylcarbamoyl; R1R3 = -C(O)(CH2)3-) to afford a series of α-thioenaminones/α-selenylenaminones (E)-R2NHC(R1)=C(R3)XR resp., including the bioactive inhibitor for Cdc25B and its analog, via the intermol. oxidative C(sp2)-S/Se cross coupling reactions under metal-free conditions. The results came from multiple reactions, including the reaction of 1,2-Diphenyldisulfane(cas: 882-33-7Computed Properties of C12H10S2)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Computed Properties of C12H10S2Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 1,4,7,10,13-PentaoxacyclopentadecaneIn 2020 ,《Specific Host-Guest Interactions in the Crown Ether Complexes with K+ and NH4+ Revealed from the Vibrational Relaxation Dynamics of the Counteranion》 was published in Journal of Physical Chemistry B. The article was written by Zhou, Dexia; Hao, Hongxing; Ma, Yinhua; Zhong, Hongmei; Dai, Ya’nan; Cai, Kaicong; Mukherjee, Somnath; Liu, Jing; Bian, Hongtao. The article contains the following contents:

The specific host-guest interactions in the corresponding complexes of K+ and NH4+ with typical crown ethers were investigated by using FTIR and ultrafast IR spectroscopies. The counteranions, i.e., SCN-, were employed as a local vibrational probe to report the structural dynamics of the complexation. It was found that the vibrational relaxation dynamics of the SCN- was strongly affected by the cations confined in the cavities of the crown ethers. The time constant of the vibrational population decay of SCN- in the complex of NH4+ with the 18-crown-6 was determined to be 6 ± 2 ps, which is ~30 times faster than that in the complex of K+ with the crown ethers. Control experiments showed that the vibrational population decay of SCN- depended on the size of the cavities of the crown ethers. A theor. calculation further indicated that the nitrogen atom of SCN- showed preferential coordination to the K+ ions hosted by the crown ethers, while the NH4+ can form hydrogen bonds with the oxygen atoms in the studied crown ethers. The geometric constraints formed in the complex of crown ethers can cause a specific interaction between the NH4+ and SCN-, which can facilitate the intermol. vibrational energy redistribution of the SCN-. The experimental process involved the reaction of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Recommanded Product: 1,4,7,10,13-Pentaoxacyclopentadecane)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Recommanded Product: 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

COA of Formula: C9H19NO4In 2018 ,《Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome》 appeared in ACS Infectious Diseases. The author of the article were Webster, Lauren A.; Thomas, Michael; Urbaniak, Michael; Wyllie, Susan; Ong, Han; Tinti, Michele; Fairlamb, Alan H.; Boesche, Markus; Ghidelli-Disse, Sonja; Drewes, Gerard; Gilbert, Ian H.. The article conveys some information:

The folate pathway has been extensively studied in a number of organisms, with its essentiality exploited by a number of drugs. However, there has been little success in developing drugs that target folate metabolism in the kinetoplastids. Despite compounds being identified which show significant inhibition of the parasite enzymes, this activity does not translate well into cellular and animal models of disease. Understanding to which enzymes antifolates bind under physiol. conditions and how this corresponds to the phenotypic response could provide insight on how to target the folate pathway in these organisms. To facilitate this, the authors have adopted a chem. proteomics approach to study binding of compounds to enzymes of folate metabolism Clin. and literature antifolate compounds were immobilized onto resins to allow for “”pull-down”” of the proteins in the “”folateome””. Using competition studies, proteins which bind the beads specifically and nonspecifically were identified in parasite lysate (Trypanosoma brucei and Leishmania major) for each antifolate compound followed by tryptic digest, Tandem Mass Tag (TMT) labeling of peptides and LC-MS/MS. This method was further exploited by creating a combined folate resin (Folate beads). The resin could pull down upto 9 proteins from the “”folateome””. This information could be exploited to better understand folate metabolism in kinetoplastids and other organisms. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6COA of Formula: C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. COA of Formula: C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem