Tag: 200-300

Safety of 1,2-DiphenyldisulfaneIn 2021 ,《Programmed Formation of HCN Oligomers through Organosulfur Catalysis》 appeared in Journal of Organic Chemistry. The author of the article were Grundke, Caroline; Kong, Caleb; Kampf, Christopher J.; Gupton, B. Frank; McQuade, D. Tyler; Opatz, Till. The article conveys some information:

An efficient, inexpensive, and reliable synthesis of diaminomaleonitrile (DAMN, 1) is described starting from readily available acetone cyanohydrin as the source of hydrogen cyanide (HCN). Diaminomaleonitrile (DAMN) is known to be an important intermediate in heterocyclic and medicinal chem. as well as being a possible precursor for the origin of life’s hypothesis within prebiotic chem. The mechanism of its formation through organosulfur catalysis has been investigated by electrospray ionization mass spectrometry (ESI-MS) using two newly synthesized cationic “”marker”” mols. as a tool that allows for sensitive detection. As a result, the proposed mechanism of a thiocyanate-mediated synthesis of the HCN tetramer DAMN starting from organic disulfides was confirmed. The results came from multiple reactions, including the reaction of 1,2-Diphenyldisulfane(cas: 882-33-7Safety of 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Safety of 1,2-Diphenyldisulfane They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Steen, Jorn D.; Volker, Anouk; Duijnstee, Daniel R.; Sardjan, Andy S.; Browne, Wesley R. published an article in Journal of Physical Chemistry C. The title of the article was 《pH-Induced Changes in the SERS Spectrum of Thiophenol at Gold Electrodes during Cyclic Voltammetry》.Safety of 1,2-Diphenyldisulfane The author mentioned the following in the article:

Thiophenol is a model compound used in the study of self-assembly of arylthiols on Au surfaces. In particular, changes in the surface-enhanced Raman scattering (SERS) spectra of these self-assembled monolayers (SAMs) with a change of conditions were ascribed to, for example, differences in orientation with respect to the surface, protonation state, and electrode potential. Here, potential-induced changes in the SERS spectra of SAMs of thiophenol on electrochem. roughened Au surfaces can be due to local pH changes at the electrode. The changes observed during the potential step and cyclic voltammetry experiments are identical to those induced by acid-base switching experiments in a protic solvent. The potential-dependent spectral changes, assigned earlier to changes in mol. orientation with respect to the surface, can be ascribed to changes in the pH locally at the electrode. The pH at the electrode can change as much as several pH units during electrochem. measurements that reach pos. potentials where oxidation of adventitious H2O can occur. Also, once perturbed by applying pos. potentials, the pH at the electrode takes considerable time to recover to that of the bulk solution The changes in pH even during cyclic voltammetry in organic solvents can be equivalent to the addition of strong acids, such as CF3SO3H, and such effects should be considered in the study of the redox chem. of pH-sensitive redox systems and potential-dependent SERS in particular. In the experiment, the researchers used many compounds, for example, 1,2-Diphenyldisulfane(cas: 882-33-7Safety of 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Safety of 1,2-Diphenyldisulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Product Details of 139115-91-6In 2018 ,《Tracking down protein-protein interactions via a FRET-system using site-specific thiol-labeling》 appeared in Organic & Biomolecular Chemistry. The author of the article were Soveges, B.; Imre, T.; Poti, A. L.; Sok, P.; Kele, Zs.; Alexa, A.; Kele, P.; Nemeth, K.. The article conveys some information:

Forster resonance energy transfer is among the most popular tools to follow protein-protein interactions. Although limited to certain cases, site-specific fluorescent labeling of proteins via natural functions by chem. manipulations can redeem laborious protein engineering techniques. Herein the authors report on the synthesis of a heterobifunctional tag and its use in site-specific protein labeling studies aiming at exploring protein-protein interactions. The oxadiazole-methylsulfonyl functionality serves as a thiol specific warhead that enables easy and selective installation of fluorescent labels through a bioorthogonal motif. Mitogen activated protein kinase (MAPK14) and its substrate mitogen activated protein kinase activated kinase (MAPKAP2) or its docking motif, a 22 amino acid-long peptide fragment, were labeled with a donor and an acceptor, resp. Evolution of strong FRET signals upon protein-protein interactions supported the specific communication between the partners. Using an efficient FRET pair allowed the estimation of dissociation constants for protein-protein and peptide-protein interactions (145 nM and 240 nM, resp.). In the experimental materials used by the author, we found tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Product Details of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Product Details of 139115-91-6Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateIn 2019 ,《endo-Hydroxamic Acid Monomers for the Assembly of a Suite of Non-native Dimeric Macrocyclic Siderophores Using Metal-Templated Synthesis》 appeared in Inorganic Chemistry. The author of the article were Brown, Christopher J. M.; Gotsbacher, Michael P.; Holland, Jason P.; Codd, Rachel. The article conveys some information:

An expedited synthesis of endo-hydroxamic acid aminocarboxylic acid (endo-HXA) compounds was developed. These monomeric ligands are relevant to the synthesis of metal-macrocycle complexes using metal-templated synthesis (MTS), and the downstream production of apomacrocycles. Macrocycles can display useful drug properties and be used as ligands for radiometals in medical imaging applications, which supports methodol. advances in accessing this class of mol. Six endo-HXA ligands were prepared that contained methylene groups, ether atoms, or thioether atoms in different regions of the monomer (1-6). MTS using a 1:2 Fe(III)/ligand ratio furnished six dimeric hydroxamic acid macrocycles complexed with Fe(III) (1a-6a). The corresponding apomacrocycles (1b-6b) were produced upon treatment with diethylenetriaminepentaacetic acid (DTPA). Constitutional isomers of the apomacrocycles that contained one ether oxygen atom in the diamine-containing (2b) or dicarboxylic acid-containing (3b) region were well resolved by reverse-phase HPLC (RP-HPLC). D. functional theory calculations were used to compute the structures and solvated mol. properties of 1b-6b and showed that the orientation of the amide bonds relative to the pseudo-C2 axis was close to parallel in 1b, 2b, and 4b-6b but tended toward perpendicular in 3b. This conformational constraint in 3b reduced the polarity compared with 2b, consistent with the exptl. trend in polarity observed using RP-HPLC. The improved synthesis of endo-HXA ligands allows expanded structural diversity in MTS-derived macrocycles and the ability to modulate macrocycle properties. The results came from multiple reactions, including the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Lin, Yeo-Sin; Abate, Seid Yimer; Wang, Chun-I.; Wen, Yuh-Sheng; Chen, Chih-I.; Hsu, Chao-Ping; Chueh, Chu-Chen; Tao, Yu-Tai; Sun, Shih-Sheng published an article in 2021. The article was titled 《Low-Cost Hole-Transporting Materials Based on Carbohelicene for High-Performance Perovskite Solar Cells》, and you may find the article in ACS Applied Materials & Interfaces.SDS of cas: 101-70-2 The information in the text is summarized as follows:

Two hole-transporting materials (HTMs) based on carbohelicene cores, CH1 and CH2, are developed and used in fabricating efficient and stable perovskite solar cells (PSCs). Owing to the rigid conformation of the helicene core, both compounds possess unique CH-π interactions in the crystalline packing pattern and good phase stability, which are distinct from the π-π intermol. interactions of conventional planar and spiro-type mols. PSCs based on CH1 and CH2 as HTMs deliver excellent device efficiencies of 19.36 and 18.71%, resp., outperforming the control device fabricated with spiro-OMeTAD (18.45%). Furthermore, both PSCs exhibit better ambient stability, with 90% of initial performance retained after aging with a 50-60% relative humidity at 25°C for 500 h. Due to the low production cost of both compounds, these newly designed carbohelicene-type HTMs have the potential for the future commercialization of PSCs. In addition to this study using Bis(4-methoxyphenyl)amine, there are many other studies that have used Bis(4-methoxyphenyl)amine(cas: 101-70-2SDS of cas: 101-70-2) was used in this study.

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.SDS of cas: 101-70-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《PEGylated AdipoRon derivatives improve glucose and lipid metabolism under insulinopenic and high-fat diet conditions》 was written by Onodera, Toshiharu; Ghazvini Zadeh, Ebrahim; Xu, Peng; Gordillo, Ruth; Guo, Zheng; Joffin, Nolwenn; Yu, Biao; Scherer, Philipp E.; Li, Wen-hong. Synthetic Route of C9H19NO4 And the article was included in Journal of Lipid Research in 2021. The article conveys some information:

The pleiotropic actions of adiponectin in improving cell survival and metabolism have motivated the development of small-mol. therapeutic agents for treating diabetes and lipotoxicity. AdipoRon is a synthetic agonist of the adiponectin receptors, yet is limited by its poor solubility and bioavailability. In this work, we expand on the protective effects of AdipoRon in pancreatic β-cells and examine how structural modifications could affect the activity, pharmacokinetics, and bioavailability of this small mol. We describe a series of AdipoRon analogs containing amphiphilic ethylene glycol (PEG) chains. Among these, AdipoRonPEG5 induced pleiotropic effects in mice under insulinopenic and high-fat diet (HFD) conditions. While both AdipoRon and AdipoRonPEG5 substantially attenuate palmitate-induced lipotoxicity in INS-1 cells, only AdipoRonPEG5 treatment is accompanied by a significant reduction in cytotoxic ceramides. In vivo, AdipoRonPEG5 can substantially reduce pancreatic, hepatic, and serum ceramide species, with a concomitant increase in the corresponding sphingoid bases and improves insulin sensitivity of mice under HFD feeding conditions. Furthermore, hyperglycemia in streptozotocin (STZ)-induced insulinopenic adiponectin-null mice is also attenuated upon AdipoRonPEG5 treatment. Our results suggest that AdipoRonPEG5 is more effective in reducing ceramides and dihydroceramides in the liver of HFD-fed mice than AdipoRon, consistent with its potent activity in activating ceramidase in vitro in INS-1 cells. Addnl., these results indicate that the beneficial effects of AdipoRonPEG5 can be partially attributed to improved pharmacokinetics as compared with AdipoRon, thus suggesting that further derivatization may improve affinity and tissue-specific targeting. In the experimental materials used by the author, we found tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Synthetic Route of C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Synthetic Route of C9H19NO4 The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Energy alignment and recombination in perovskite solar cells: weighted influence on the open circuit voltage》 were Gelmetti, Ilario; Montcada, Nuria F.; Perez-Rodriguez, Ana; Barrena, Esther; Ocal, Carmen; Garcia-Benito, Ines; Molina-Ontoria, Agustin; Martin, Nazario; Vidal-Ferran, Anton; Palomares, Emilio. And the article was published in Energy & Environmental Science in 2019. Product Details of 101-70-2 The author mentioned the following in the article:

In this work, we assess the possible reasons for the differences observed in open circuit voltage (VOC) in mixed cation perovskite solar cells when comparing four different hole transport materials (HTMs), namely TAE-1, TAE-3, TAE-4 and spiro-OMeTAD. All these HTMs present close chem. and phys. properties, however, once they are finally deposited onto the perovskite layer, the HTMs provide different performance characteristics. Addnl. to the evaluation of the HTM influence on recombination, we find that, upon deposition of the organic HTM on top of the perovskite, there is an important change in the energy level position, and the impact on the device VOC is discussed. We consider that this exptl. observation could be general for other organic HTMs and would justify the difficulties in finding mols. and materials that could improve the efficiency of perovskite solar cells overcoming the solar-to-energy conversion efficiency of solar cells made using spiro-OMeTAD as a hole selective contact. In the experimental materials used by the author, we found Bis(4-methoxyphenyl)amine(cas: 101-70-2Product Details of 101-70-2)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Product Details of 101-70-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Copper/Nickel-Catalyzed Selective C-S/S-S Bond Formation Starting from O-Alkyl Phenylcarbamothioates》 was published in European Journal of Organic Chemistry in 2020. These research results belong to Peng, Kang; Gao, Ming-Yuan; Yi, Yu-Yan; Guo, Jia; Dong, Zhi-Bing. Electric Literature of C7H7IO The article mentions the following:

A convenient and effective method is described to construct C-S/S-S bond starting from O-alkyl phenylcarbamothioates, giving diverse O-alkyl S-Ph phenylcarbonimidothioates and isothiourea disulfides, resp. The C-S bond formation products (O-alkyl S-Ph phenylcarbonimidothioates) were synthesized by using Cu2O as catalyst in water (without phase-transfer catalyst), and the S-S bond formation product (isothiourea disulfides) could be furnished catalyzed by NiBr2 at room temperature These transformations feature easy control, environmental friendliness, and good to excellent yields, which could be attractive in the selective C-S/S-S bond formation.1-Iodo-2-methoxybenzene(cas: 529-28-2Electric Literature of C7H7IO) was used in this study.

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Electric Literature of C7H7IO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Advanced Synthesis & Catalysis included an article by Choudhuri, Khokan; Maiti, Saikat; Mal, Prasenjit. Formula: C12H10S2. The article was titled 《Iodine(III) Enabled Dehydrogenative Aryl C-S Coupling by in situ Generated Sulfenium Ion》. The information in the text is summarized as follows:

An umpolung based one pot and direct C-S coupling approach under metal free and mild condition were described. Electrophile sulfenium ions were generated in situ from thiols RSH (R = Ph, Et, 4-nitrophenyl, 3-chlorophenyl, etc.) using iodine(III) reagent PhI(OAc)2 (PIDA) and subsequently used for aromatic electrophilic substitution (EArS) to synthesize diaryl sulfides R1SR (R1 = 2,4,6-trimethylphenyl, 4-methoxyphenyl, 2,4-dimethylphenyl, etc.). Also by using of appropriate amount of PIDA, cascaded synthesis of C-S and S=O bonds led to aryl sulfinyl arenes R1S(O)R in one pot. Covalent self-sorting or competitive experiments further confirmed the involvement of sulfenium ion in the EArS. The results came from multiple reactions, including the reaction of 1,2-Diphenyldisulfane(cas: 882-33-7Formula: C12H10S2)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Formula: C12H10S2 Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2018,Meng, Qingqing; Wang, Zengtao; Cui, Jiahua; Cui, Qing; Dong, Jinyun; Zhang, Qijing; Li, Shaoshun published 《Design, Synthesis, and Biological Evaluation of Cytochrome P450 1B1 Targeted Molecular Imaging Probes for Colorectal Tumor Detection》.Journal of Medicinal Chemistry published the findings.HPLC of Formula: 139115-91-6 The information in the text is summarized as follows:

Cytochrome P 450 1B1 (CYP1B1) was found to be universally expressed in various tumors. Herein, we reported near-IR fluorescent imaging probes for tumor detection via visualizing CYP1B1. After introducing the linker to a CYP1B1 selective inhibitor we found previously, we got the resulting compound 5b which kept strong inhibition ability against CYP1B1 (IC50 = 8.7 ± 1.2 nM) and high selectivity. Then, in vitro microscope studies and cell binding assay of probes indicated that the corresponding probe 6b could specifically be accumulated in CYP1B1 overexpressed colorectal cancer cell HCT-15 and showed satisfying binding affinity to target. During the in vivo noninvasive optical imaging, 6b was proved to rapidly lighten tumor in vivo as early as 6 h after injection. This work is the first attempt to visualize CYP1B1 for noninvasive imaging of tumor which could provide new approach for tumor diagnosis. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6HPLC of Formula: 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. HPLC of Formula: 139115-91-6 The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem