Tag: 200-300

In 2014,Noguchi, Takao; Roy, Bappaditya; Yoshihara, Daisuke; Tsuchiya, Youichi; Yamamoto, Tatsuhiro; Shinkai, Seiji published 《Translation of Dicarboxylate Structural Information to Fluorometric Optical Signals through Self-Assembly of Guanidinium-Tethered Oligophenylenevinylene》.Chemistry – A European Journal published the findings.Computed Properties of C9H19NO4 The information in the text is summarized as follows:

Although self-assembly has realized the spontaneous formation of nanoarchitectures, the nanoscopic expression of chem. structural information at the mol. level can alternatively be regarded as a tool to translate mol. structural information with high precision. A newly developed guanidinium-tethered oligophenylenevinylene exhibits characteristic fluorescence (FL) responses toward L- and meso-tartarate, wherein the different self-assembly modes, termed J- or H-type aggregation, are directed according to the mol. information encoded as the chem. structure. This morphol. difference originates from the geometric anti vs. gauche conformational difference between L- and meso-tartarate. A similar morphol. difference can be reproduced with the geometric C=C bond difference between fumarate and maleate. In the present system, the dicarboxylate structural information is embodied in the inherent threshold concentration of the FL response, the signal-to-noise ratio, and the maximum FL wavelength. Self-assembly is meticulous enough to sense subtle differences in mol. information and thus demonstrate the potential ability of self-assembly for the expression of a FL sensory system. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Computed Properties of C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Computed Properties of C9H19NO4

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Ether | (C2H5)2O – PubChem

Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateIn 2022 ,《Detecting the insoluble protein aggregates in live cells using an AIE derivative of fluorescent protein chromophore》 appeared in Sensors and Actuators, B: Chemical. The author of the article were Liu, Lihua; Jin, Wenhan; Huang, Yanan; Dai, Jianan; Zheng, Xuwei; Liu, Yu; Ju, Minzi; Shen, Baoxing. The article conveys some information:

Many incurable or unmanageable human protein conformational diseases are associated with the misfolding or aggregation of the aberrantly processed or mutant proteins. In this work, we report an aggregation-induced emission (AIE) derivative of fluorescent protein chromophore used to detect the insoluble protein aggregates in live cells. Based on the 4-hydroxybenzylidene-imidazolinone (HBI), we designed and synthesized a series of AIEgens that span a wide range of viscosity coefficients (χ), thus mimicking the viscous microenvironment of a wide variety of amorphous protein aggregates. The mechanism of these AIEgens were systematically investigated using a combination of photophys. studies, computational analyses and structure-function studies. With the aid of the AggTag method, the optimized probe was used to realize the imaging of the aggregated proteome under the control of the proteostasis network. Besides, we also described the formation and decomposition of protein aggregates under the control of small mol. proteostasis regulators. Briefly, we developed a series of AIEgens that explore varying viscosity sensitivities to visualize protein aggregation in live cells as well as study other biol. processes that associated with local viscosity changes. The results came from multiple reactions, including the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

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Ether | (C2H5)2O – PubChem

In 2022,Ch. Gagieva, Svetlana; Kurmaev, Dmitrii A.; Tuskaev, Vladislav A.; Khrustalev, Viktor N.; Churakov, Andrei V.; Golubev, Evgenii K.; Sizov, Alexander I.; Zvukova, Tamara M.; Buzin, Mikhail I.; Nikiforova, Galina G.; Evseeva, Maria D.; Bulychev, Boris M. published an article in European Polymer Journal. The title of the article was 《First example of cationic titanium (III) complexes with crown ether as catalysts for ethylene polymerization》.Recommanded Product: 33100-27-5 The author mentioned the following in the article:

Complex cations with a vacant coordination site are considered as the most plausible catalytically active centers of metallocene and post-metallocene polymerization catalysts. For the first time we demonstrated that cationic titanium (III) complexes stabilized with crown ether can be used as pre-catalysts for ethylene polymerization In the presence of alkyl aluminum chlorides and MgBu2 as cocatalysts, these complexes catalyze ethylene polymerization to produce Ultra High Mol. Weight Polyethylene (UHMWPE) with productivity up to 4650 kgPE/molTi h·atm and mol. weight up to 1.8·106 Da. UHMWPE powders were processed by the solid-phase method with subsequent orientation drawing into high-strength (1.4-2.1 GPa) and high-modulus (91-118 GPa) films. In the part of experimental materials, we found many familiar compounds, such as 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Recommanded Product: 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Recommanded Product: 33100-27-5

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bessam, S.; Reguig, F. Hamza; Krallafa, A. M.; Martinez-Haya, B. published their research in Physical Chemistry Chemical Physics in 2021. The article was titled 《Dynamics of coordination of H3O+ and NH4+ in crown ether cavities》.Recommanded Product: 1,4,7,10,13-Pentaoxacyclopentadecane The article contains the following contents:

Crown ethers stand out for their ability to form inclusion complexes with metal cations and pos. charged mol. moieties. Hydronium and ammonium interact strongly with crown ethers and potentially modulate their ionophoric activity in protic solvents and physiol. environments commonly involved in (bio)technol. applications. In this work, Born-Oppenheimer mol. dynamics (BOMD) computations are employed to gain insights into the coordination arrangements of H3O+ and NH4+ in the complexes with the native crown ethers 15-crown-5 (15c5) and 18-crown-6 (18c6). Both cations display dynamic changes in coordination inside the cavities of the crown ethers. On the one hand, hydronium explores different coordination arrangements, through rotation around its C3 axis in the 15c5 complex, and through breathing motions, involving rapid inversions of the O atom along the C3 axis in the 18c6 complex. On the other hand, ammonium undergoes a facile rotation in three dimensional space, leading to frequent changes in the NH bonds involved in the coordination with the crown ether. The reduced host-guest symmetry matching of the 15c5 macrocycle enhances the reorientation dynamics and, in the case of H3O+, it promotes short H-bonding distances yielding events of proton transfer to the crown ether. The IR vibrational spectra predicted by the BOMD computations within this dynamic framework reproduce with remarkable accuracy the action spectra of the isolated complexes obtained in previous IR laser spectroscopy experiments The exptl. observed band positions and broadening can then be rationalized in terms of orientational diffusion of the cations, changes in the coordinating H-bonding pairs sustaining the complex and eventual proton bridge formation. In addition to this study using 1,4,7,10,13-Pentaoxacyclopentadecane, there are many other studies that have used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Recommanded Product: 1,4,7,10,13-Pentaoxacyclopentadecane) was used in this study.

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Recommanded Product: 1,4,7,10,13-Pentaoxacyclopentadecane

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Tetrasubstituted Thieno[3,2-b]thiophenes as Hole-Transporting Materials for Perovskite Solar Cells》 was written by Urieta-Mora, Javier; Garcia-Benito, Ines; Zimmermann, Iwan; Arago, Juan; Molina-Ontoria, Agustin; Orti, Enrique; Martin, Nazario; Nazeeruddin, Mohammad Khaja. Electric Literature of C14H15NO2 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

Three hole-transporting materials (HTMs) were prepared following a straightforward synthetic route by crosslinking arylamine-based ligands with a simple thieno[3,2-b]thiophene (TbT) core. The novel HTMs were fully characterized with standard techniques to gain insight into their optical and electrochem. properties and were incorporated in solution-processed mesoporous (FAPbI3)0.85(MAPbBr3)0.15 perovskite-based solar cells. The similar mol. structure of the synthesized HTMs was leveraged to investigate the role that the bridging units between the conjugated TbT core and the peripheral arylamine units plays on their properties and thereby on the photovoltaic response. A remarkable power conversion efficiency exceeding 18% was achieved for one of the TbT derivatives, which was slightly higher than the value measured for the benchmark spiro-OMeTAD. The results came from multiple reactions, including the reaction of Bis(4-methoxyphenyl)amine(cas: 101-70-2Electric Literature of C14H15NO2)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Electric Literature of C14H15NO2

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Palladium-catalyzed β-arylation of cyclic α,β,-unsaturated O-methyl oximes with aryl iodides》 was published in Chemical & Pharmaceutical Bulletin in 2020. These research results belong to Akagi, Yusuke; Fukuyama, Shiori; Komatsu, Toshiya. Electric Literature of C7H7IO The article mentions the following:

A Pd-catalyzed β-arylation of cyclic α,β-unsaturated O-Me oximes with substituted iodobenzenes was reported. This reaction showed complete regioselectivity and excellent functional group tolerance. The β-arylation of 2-cyclohexen-1-one O-Me oxime (existing as 2:1 E/Z mixture) with certain aryl iodides such as 4-iodoanisole afforded only β-arylated (E)-O-Me oximes. The results came from multiple reactions, including the reaction of 1-Iodo-2-methoxybenzene(cas: 529-28-2Electric Literature of C7H7IO)

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Electric Literature of C7H7IO

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Diindolotriazatruxene-Based Hole-Transporting Materials for High-Efficiency Planar Perovskite Solar Cells》 were Li, Xiang-Chun; Tu, Yong-Guang; Meng, Cheng; Song, Wan; Cheng, Tao; Gong, Yan-Ting; Min, Jie; Zhu, Rui; Lai, Wen-Yong; Huang, Wei. And the article was published in ACS Applied Materials & Interfaces in 2019. Quality Control of Bis(4-methoxyphenyl)amine The author mentioned the following in the article:

A novel set of hole-transporting materials (HTMs) based on π-extended diindolotriazatruxene (DIT) core structure with electron-rich methoxy-engineered functional groups were designed and synthesized via a facile two-step procedure. All compounds were afforded from inexpensive precursors without a complex purification process. Cyclic voltammograms indicate that the resulting HTMs exhibit suitable HOMO (HOMO) energy levels, which facilitate efficient hole injection from the valence band of perovskites into the HOMO of DIT-based HTMs as confirmed by time-resolved photoluminescence. Notable power conversion efficiency of the planar perovskite solar cells with low-temperature device fabrication achieved 18.21% utilizing D2, which is competitive with the corresponding devices based on the common Spiro-OMeTAD-based HTMs. The results manifest that DIT-based compounds are promising HTMs for constructing high-efficiency planar perovskite solar cells with low-cost solution processing procedures. The results came from multiple reactions, including the reaction of Bis(4-methoxyphenyl)amine(cas: 101-70-2Quality Control of Bis(4-methoxyphenyl)amine)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Quality Control of Bis(4-methoxyphenyl)amine

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2016,Almaliti, Jehad; Al-Hamashi, Ayad A.; Negmeldin, Ahmed T.; Hanigan, Christin L.; Perera, Lalith; Pflum, Mary Kay H.; Casero, Robert A.; Tillekeratne, L. M. Viranga published 《Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue》.Journal of Medicinal Chemistry published the findings.Category: ethers-buliding-blocks The information in the text is summarized as follows:

A number of analogs of the marine-derived histone deacetylase inhibitor largazole incorporating major structural changes in the depsipeptide ring were synthesized. Replacing the thiazole-thiazoline fragment of largazole with a bipyridine group gave analog (I) with potent cell growth inhibitory activity and an activity profile similar to that of largazole, suggesting that conformational change accompanying switching hybridization from sp3 to sp2at C-7 is well tolerated. Analog I was more class I selective compared to largazole, with at least 464-fold selectivity for class I HDAC proteins over class II HDAC6 compared to a 22-fold selectivity observed with largazole. To our knowledge I represents the first example of a potent and highly cytotoxic largazole analog not containing a thiazoline ring. The elimination of a chiral center derived from the unnatural amino acid (R)-α-methylcysteine makes the mol. more amenable to chem. synthesis and, coupled with its increased class I selectivity, I could serve as a new lead compound for developing selective largazole analogs. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Category: ethers-buliding-blocks)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Category: ethers-buliding-blocks

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application In Synthesis of 2-Methoxy-5-(trifluoromethoxy)anilineOn March 23, 2017, Deng, Yonghong; Sun, Cuixiang; Hunt, Diana K.; Fyfe, Corey; Chen, Chi-Li; Grossman, Trudy H.; Sutcliffe, Joyce A.; Xiao, Xiao-Yi published an article in Journal of Medicinal Chemistry. The article was 《Heterocyclyl Tetracyclines. 1. 7-Trifluoromethyl-8-Pyrrolidinyltetracyclines: Potent, Broad Spectrum Antibacterial Agents with Enhanced Activity against Pseudomonas aeruginosa》. The article mentions the following:

Utilizing a total synthesis approach, the first 8-heterocyclyltetracyclines were designed, synthesized, and evaluated against panels of tetracycline- and multidrug-resistant Gram-pos. and Gram-neg. pathogens. Several compounds with balanced, highly potent in vitro activity against a broad range of bacterial isolates were identified through structure-activity relationships (SAR) studies. One compound I demonstrated the best antibacterial activity against Pseudomonas aeruginosa both in vitro and in vivo for tetracyclines reported to date. The experimental part of the paper was very detailed, including the reaction process of 2-Methoxy-5-(trifluoromethoxy)aniline(cas: 660848-57-7Application In Synthesis of 2-Methoxy-5-(trifluoromethoxy)aniline)

2-Methoxy-5-(trifluoromethoxy)aniline(cas: 660848-57-7) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Application In Synthesis of 2-Methoxy-5-(trifluoromethoxy)aniline

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 101-70-2In 2021 ,《Tetraphenylethylene-Arylamine Derivatives as Hole Transporting Materials for Perovskite Solar Cells》 was published in ACS Applied Materials & Interfaces. The article was written by Zhang, Xianfu; Liu, Xuepeng; Ghadari, Rahim; Li, Maohui; Zhou, Zi’an; Ding, Yong; Cai, Molang; Dai, Songyuan. The article contains the following contents:

A series of hole transporting materials (HTMs) with fused tetraphenylethylene cores (9,9′-bifluorenylidene and dibenzo[g,p]chrysene) as well as different substitution positions of arylamine side arms has been designed and synthesized. A reference HTM with a non-fused tetraphenylethylene core is also prepared for a comparative study. It is noted that fused tetraphenylethylene mols. show a bathochromic spectral shift, electroneg. character, and lower reorganization energies than the non-fused ones. Furthermore, the mols. with side arms located on the meta-position on the tetraphenylethylene core in terms of a double bond exhibit a deeper HOMO level than those of the para-position-based ones whether tetraphenylethylene is fused or not. Moreover, the reorganization energies of fused meta-position-based HTMs are lower than those of para-position-based HTMs. Fused tetraphenylethylene HTMs own a better hole-extraction capability than the non-fused ones. When used in perovskite solar cells, all devices with fused tetraphenylethylene HTMs display better performance than those of the non-fused ones. The HTMs based on dibenzo[g,p]chrysene exhibit better performance than those of bifluorenylidene. Moreover, the devices with HTMs with side arms located on the meta-position on the tetraphenylethylene core display higher power conversion efficiency than those of the para-position-based ones. The results give some new insight and reference to develop ideal HTMs for perovskite solar cells. In the experiment, the researchers used Bis(4-methoxyphenyl)amine(cas: 101-70-2Recommanded Product: 101-70-2)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Recommanded Product: 101-70-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem