Tag: 200-300

Reference of 1,2-DiphenyldisulfaneIn 2020 ,《C-N, C-S and S-S Bond Cleavage by Rhodium PCcarbeneP Pincer Complexes》 was published in Chemistry – An Asian Journal. The article was written by Tinnermann, Hendrik; Young, Rowan D.. The article contains the following contents:

Rhodium carbene pincer complexes I·BArF4 [1-L, L = PPh3, PPh2(C6F5)] react with isothiocyanate, carbodiimide and disulfide to enable C-S, C-N and S-S bond cleavage. The cleaved mols. are sequestered by the metal center and the pincer alkylidene linkage, forming η2-coordinated sulfide or imide centered pincer complexes. When a C-S or S-S bond is cleaved, the resulting complexes can bridge two rhodium centers through sulfur forming dimeric complexes and eliminating a monodentate phosphine ligand. In the part of experimental materials, we found many familiar compounds, such as 1,2-Diphenyldisulfane(cas: 882-33-7Reference of 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Reference of 1,2-Diphenyldisulfane The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 139115-91-6In 2018 ,《Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis》 appeared in Nature (London, United Kingdom). The author of the article were Wyllie, Susan; Thomas, Michael; Patterson, Stephen; Crouch, Sabrinia; De Rycker, Manu; Lowe, Rhiannon; Gresham, Stephanie; Urbaniak, Michael D.; Otto, Thomas D.; Stojanovski, Laste; Simeons, Frederick R. C.; Manthri, Sujatha; MacLean, Lorna M.; Zuccotto, Fabio; Homeyer, Nadine; Pflaumer, Hannah; Boesche, Markus; Sastry, Lalitha; Connolly, Paul; Albrecht, Sebastian; Berriman, Matt; Drewes, Gerard; Gray, David W.; Ghidelli-Disse, Sonja; Dixon, Susan; Fiandor, Jose M.; Wyatt, Paul G.; Ferguson, Michael A. J.; Fairlamb, Alan H.; Miles, Timothy J.; Read, Kevin D.; Gilbert, Ian H.. The article conveys some information:

Visceral leishmaniasis causes considerable mortality and morbidity in many parts of the world. There is an urgent need for the development of new, effective treatments for this disease. Here we describe the development of an anti-leishmanial drug-like chem. series based on a pyrazolopyrimidine scaffold. The leading compound from this series (7, DDD853651/GSK3186899) is efficacious in a mouse model of visceral leishmaniasis, has suitable physicochem., pharmacokinetic and toxicol. properties for further development, and has been declared a preclin. candidate. Detailed mode-of-action studies indicate that compounds from this series act principally by inhibiting the parasite cdc-2-related kinase 12 (CRK12), thus defining a druggable target for visceral leishmaniasis. The experimental process involved the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Application of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Application of 139115-91-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Journal of Medicinal Chemistry included an article by Yokoyama, Takeshi; Mizuguchi, Mineyuki. Electric Literature of C10H20O5. The article was titled 《Crown Ethers as Transthyretin Amyloidogenesis Inhibitors》. The information in the text is summarized as follows:

Transthyretin (TTR) is a tetrameric protein found in human serum and associated with amyloid diseases. Because the tetramer dissociation and misfolding of the monomer precede amyloid fibril formation, development of a small mol. that binds to TTR and stabilizes the TTR tetramer is an efficient strategy for the treatment of amyloidosis. Here, we report our discovery of the anti-TTR amyloidogenesis activities of crown ethers. X-ray crystallog. anal., binding assay, and chem. crosslinking assay showed that 4′-carboxybenzo-18C6 (4) stabilized the TTR tetramer by binding to the allosteric sites on the mol. surface of the TTR tetramer. In addition, 4 synergistically increased the stabilization activity of diflunisal, one of the most potent TTR amyloidogenesis inhibitors. These exptl. evidences establish that 4 is a valuable template compound as an allosteric inhibitor of TTR amyloidogenesis. The results came from multiple reactions, including the reaction of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Electric Literature of C10H20O5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Electric Literature of C10H20O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Category: ethers-buliding-blocksIn 2021 ,《Modular Entry to Functionalized Tetrahydrobenzo[b]azepines via the Palladium/Norbornene Cooperative Catalysis Enabled by a C7-Modified Norbornene》 was published in Journal of the American Chemical Society. The article was written by Liu, Xin; Wang, Jianchun; Dong, Guangbin. The article contains the following contents:

Here, the authors report a straightforward method to synthesize THBAs (tetrahydrobenzo[b]azepines), e.g., I, directly from simple aryl iodides RI (R = 3-chlorophenyl, quinolin-6-yl, 4-(morpholinyl)-2-methylphenyl, etc.) via palladium/norbornene (Pd/NBE) cooperative catalysis. Capitalizing on an olefin-tethered electrophilic amine reagent, an ortho amination followed by 7-exo-trig Heck cyclization furnishes the seven-membered heterocycle. To overcome the difficulty with ortho-unsubstituted aryl iodide substrates, a unique C7-bromo-substituted NBE, II, to offer the desired reactivity and selectivity was discovered. In addition to THBAs, synthesis of other benzo-seven-membered ring compounds e.g., III, can also be promoted by II. Combined exptl. and computational studies show that the C7-bromo group in II plays an important and versatile role in this catalysis, including promoting β-carbon elimination, suppressing benzocyclobutene formation, and stabilizing reaction intermediates. The mechanistic insights gained could guide future catalyst design. The synthetic utility has been demonstrated in a streamlined synthesis of tolvaptan (IV) and forming diverse pharmaceutically relevant THBA derivatives Finally, a complementary and general catalytic condition to access C6-substituted THBAs from ortho-substituted aryl iodides has also been developed.1-Iodo-2-methoxybenzene(cas: 529-28-2Category: ethers-buliding-blocks) was used in this study.

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C7H7IOIn 2019 ,《Synthetic utilization of tetrafluoroethylene-containing silyl reagent (CH2=CHCF2CF2SiEt3) in Cu(I)-mediated cross-coupling reaction with various iodoarenes》 was published in Journal of Fluorine Chemistry. The article was written by Yakushijin, Ryosuke; Yamada, Shigeyuki; Konno, Tsutomu. The article contains the following contents:

The synthetic utilization of thermally stable as well as easy-handling tri-Et (1,1,2,2-tetrafluorobut-3-en-1-yl)silane as the tetrafluoroethylenating agent through Cu(I)-mediated cross-coupling reaction with various iodoarenes, which offered a promising building block for versatile CF2CF2-containing organic mols. through easy carbon chain elongation at both ends were revealed. Specifically, the above tetrafluoroethylene-containing silyl reagent, readily prepared from com. available 4-bromo-3,3,4,4-tetrafluorobut-1-ene, smoothly reacted with various iodoarenes in the presence of Cu(I), Ag(I) and pyridine in DMF at 60° for 16 h, the corresponding CF2CF2-containing aromatic compounds being afforded in moderate to good yields. Addnl., it was revealed that the coupling reaction dramatically facilitated when iodoarenes with an ortho-directing group, e.g., COOMe, were used as an electrophile, in which the acceleration effect was theor. proved to stabilize the whole reaction system by coordination of the carbonyl oxygen to the copper atom. After reading the article, we found that the author used 1-Iodo-2-methoxybenzene(cas: 529-28-2Synthetic Route of C7H7IO)

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Synthetic Route of C7H7IO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateIn 2015 ,《Protease-triggered siRNA delivery vehicles》 appeared in Journal of Controlled Release. The author of the article were Rozema, David B.; Blokhin, Andrei V.; Wakefield, Darren H.; Benson, Jonathan D.; Carlson, Jeffrey C.; Klein, Jason J.; Almeida, Lauren J.; Nicholas, Anthony L.; Hamilton, Holly L.; Chu, Qili; Hegge, Julia O.; Wong, So C.; Trubetskoy, Vladimir S.; Hagen, Collin M.; Kitas, Eric; Wolff, Jon A.; Lewis, David L.. The article conveys some information:

The safe and efficacious delivery of membrane impermeable therapeutics requires cytoplasmic access without the toxicity of nonspecific cytoplasmic membrane lysis. We have developed a mechanism for control of cytoplasmic release which utilizes endogenous proteases as a trigger and results in functional delivery of small interfering RNA (siRNA). The delivery approach is based on reversible inhibition of membrane disruptive polymers with protease-sensitive substrates. Proteolytic hydrolysis upon endocytosis restores the membrane destabilizing activity of the polymers thereby allowing cytoplasmic access of the co-delivered siRNA. Protease-sensitive polymer masking reagents derived from polyethylene glycol (PEG), which inhibit membrane interactions, and N-acetylgalactosamine, which targets asialoglycoprotein receptors on hepatocytes, were synthesized and used to formulate masked polymer-siRNA delivery vehicles. The size, charge and stability of the vehicles enable functional delivery of siRNA after s.c. administration and, with modification of the targeting ligand, have the potential for extrahepatic targeting. The results came from multiple reactions, including the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Rakipov, Ilnaz T.; Semenov, Konstantin N.; Petrov, Artem A.; Akhmadiyarov, Aydar A.; Khachatrian, Artashes A.; Fakhurtdinova, Aliya R.; Solomonov, Boris N. published an article in 2021. The article was titled 《Thermochemistry of Solution, Solvation and Hydrogen Bonding of Chloroform in Linear and Cyclic Ethers》, and you may find the article in Journal of Solution Chemistry.Quality Control of 1,4,7,10,13-Pentaoxacyclopentadecane The information in the text is summarized as follows:

In this work the thermochem. of solution, solvation and hydrogen bond formation of chloroform in linear and cyclic ethers was studied. The infinite dilution solution enthalpies of chloroform in di-Et ether, diglyme, 1,4-dioxane, THF, 12-crown-4 and 15-crown-5 were measured at 298.15 K. The solvation and hydrogen bonding enthalpies of chloroform in the ethers were calculated It was found that the hydrogen bonding enthalpies of chloroform in the ethers are significantly higher for linear than for cyclic ethers. The hydrogen bonding of ethers with chloroform was discussed in cases when ethers act as a solute or solvent. The experimental part of the paper was very detailed, including the reaction process of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Quality Control of 1,4,7,10,13-Pentaoxacyclopentadecane)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Quality Control of 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Santos, Jose; Calbo, Joaquin; Sandoval-Torrientes, Rafael; Garcia-Benito, Ines; Kanda, Hiroyuki; Zimmermann, Iwan; Arago, Juan; Nazeeruddin, Mohammad Khaja; Orti, Enrique; Martin, Nazario published an article in 2021. The article was titled 《Hole-Transporting Materials for Perovskite Solar Cells Employing an Anthradithiophene Core》, and you may find the article in ACS Applied Materials & Interfaces.Product Details of 33100-27-5 The information in the text is summarized as follows:

A decade after the report of the first efficient perovskite-based solar cell, development of novel hole-transporting materials (HTMs) is still one of the main topics in this research field. Two of the main advance vectors of this topic lie in obtaining materials with enhanced hole-extracting capability and in easing their synthetic cost. The use of anthra[1,9-bc:5,10-b′c′]dithiophene (ADT) as a flat π-conjugated frame for bearing arylamine electroactive moieties allows obtaining two novel highly efficient HTMs from very cheap precursors. The solar cells fabricated making use of the mixed composition (FAPbI3)0.85(MAPbBr3)0.15 perovskite and the novel ADT-based HTMs show power conversion efficiencies up to 17.6% under 1 sun illumination compared to the 18.1% observed when using the benchmark compound 2,2′,7,7′-tetrakis(N,N-di-p-methoxyphenylamine)-9,9′-spirobifluorene (spiro-OMeTAD). Detailed d. functional theory calculations allow rationalization of the observed opto-electrochem. properties and predict a flat mol. structure with a low reorganization energy that supports the high conductivity measured for the best-performing HTM. The experimental part of the paper was very detailed, including the reaction process of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Product Details of 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Product Details of 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Subtype-Selective Fluorescent Ligands as Pharmacological Research Tools for the Human Adenosine A2A Receptor》 was written by Comeo, Eleonora; Kindon, Nicholas D.; Soave, Mark; Stoddart, Leigh A.; Kilpatrick, Laura E.; Scammells, Peter J.; Hill, Stephen J.; Kellam, Barrie. Related Products of 139115-91-6 And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

Among class A G protein-coupled receptors (GPCR), the human adenosine A2A receptor (hA2AAR) remains an attractive drug target. However, translation of A2AAR ligands into the clinic has proved challenging and an improved understanding of A2AAR pharmacol. could promote development of more efficacious therapies. Subtype-selective fluorescent probes would allow detailed real-time pharmacol. investigations both in vitro and in vivo. In the present study, two families of fluorescent probes were designed around the known hA2AAR selective antagonist preladenant (SCH 420814). Both families of fluorescent antagonists retained affinity at the hA2AAR, selectivity over all other adenosine receptor subtypes and allowed clear visualization of specific receptor localization through confocal imaging. Furthermore, the Alexa Fluor 647-labeled conjugate allowed measurement of ligand binding affinities of unlabeled hA2AAR antagonists using a bioluminescence resonance energy transfer (NanoBRET) assay. The fluorescent ligands developed here can therefore be applied to a range of fluorescence-based techniques to further interrogate hA2AAR pharmacol. and signaling.tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Related Products of 139115-91-6) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Related Products of 139115-91-6Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Alternating Current Electrolysis for the Electrocatalytic Synthesis of Mixed Disulfide via Sulfur-Sulfur Bond Metathesis towards Dynamic Disulfide Libraries》 was published in Chemistry – A European Journal in 2020. These research results belong to Sattler, Lars Erik; Otten, Chris Josef; Hilt, Gerhard. Safety of 1,2-Diphenyldisulfane The article mentions the following:

A novel approach of electrolysis using a.c. was applied in the S-S bond metathesis of sym. disulfides towards unsym. disulfides. As initially expected, a statistical distribution in disulfides was obtained. Also, the influence of electrode polarization by a.c. was studied on a two-disulfide matrix. The highly dynamic nature of this chem. resulted in the creation of dynamic disulfide libraries by expansion of the matrixes, consisting of up to six sym. disulfides. Mixing of matrixes and stepwise expanding of a matrix by using a.c. electrolysis were realized. After reading the article, we found that the author used 1,2-Diphenyldisulfane(cas: 882-33-7Safety of 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Safety of 1,2-Diphenyldisulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem